Thymopentin_Hs 766T Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Thymopentin perturbation in Hs 766T cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Thymopentin_Hs 766T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
MEF2A myocyte enhancer factor 2A 0.173808
FLNB filamin B, beta 0.125951
NAMPT nicotinamide phosphoribosyltransferase 0.0997157
ITCH itchy E3 ubiquitin protein ligase 0.0903381
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0815587
ESYT2 extended synaptotagmin-like protein 2 0.0788311
RICTOR RPTOR independent companion of MTOR, complex 2 0.0765575
CEMIP cell migration inducing protein, hyaluronan binding 0.0749623
GOLGA4 golgin A4 0.0673401
CLU clusterin 0.0632992
KDM6A lysine (K)-specific demethylase 6A 0.0621877
NDRG1 N-myc downstream regulated 1 0.0611517
KMT2E lysine (K)-specific methyltransferase 2E 0.0588002
KIAA1217 KIAA1217 0.054288
OGA O-GlcNAcase 0.0541413
TRIO trio Rho guanine nucleotide exchange factor 0.0537766
PGK1 phosphoglycerate kinase 1 0.05187
EZR ezrin 0.0499425
MINDY2 MINDY lysine 48 deubiquitinase 2 0.0484828
ANLN anillin, actin binding protein 0.0482769
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 0.0466439
PDK3 pyruvate dehydrogenase kinase, isozyme 3 0.0456949
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0452452
DHRS3 dehydrogenase/reductase (SDR family) member 3 0.0448034
ZNF292 zinc finger protein 292 0.0441087
PTK2 protein tyrosine kinase 2 0.0440683
KDM3A lysine (K)-specific demethylase 3A 0.0436988
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0434203
BCL2L1 BCL2-like 1 0.0433051
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0416958
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0413551
HERC3 HECT and RLD domain containing E3 ubiquitin protein ligase 3 0.0411595
SUCO SUN domain containing ossification factor 0.0410445
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0409222
NPEPPS aminopeptidase puromycin sensitive 0.0406239
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0397157
SLK STE20-like kinase 0.0387701
KDM7A lysine (K)-specific demethylase 7A 0.0385984
PTPN1 protein tyrosine phosphatase, non-receptor type 1 0.0376766
RNF145 ring finger protein 145 0.0371497
RTN4 reticulon 4 0.0364935
H1-0 H1.0 linker histone 0.0364614
HELZ helicase with zinc finger 0.0364564
ITGA6 integrin, alpha 6 0.0361417
RBM39 RNA binding motif protein 39 0.0356344
ANXA2 annexin A2 0.0352239
PLEKHA1 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1 0.034664
KLF7 Kruppel-like factor 7 (ubiquitous) 0.0346178
COPA coatomer protein complex, subunit alpha 0.0345427
ARRDC3 arrestin domain containing 3 0.0345266
FNDC3B fibronectin type III domain containing 3B 0.0343459
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase 0.0339838
PJA2 praja ring finger 2, E3 ubiquitin protein ligase 0.0339268
HSD17B2 hydroxysteroid (17-beta) dehydrogenase 2 0.0338682
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) 0.0338098
TM9SF2 transmembrane 9 superfamily member 2 0.0335889
SQLE squalene epoxidase 0.0331355
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 0.0329517
AFAP1 actin filament associated protein 1 0.0328858
MYH9 myosin, heavy chain 9, non-muscle 0.0324795
NUP58 nucleoporin 58 0.0323192
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0321979
ANKRD33B ankyrin repeat domain 33B 0.0321795
SRP54 signal recognition particle 54kDa 0.0320579
SPAG9 sperm associated antigen 9 0.0319531
KMT2C lysine (K)-specific methyltransferase 2C 0.0319354
CTNND1 catenin (cadherin-associated protein), delta 1 0.0316985
PHF21A PHD finger protein 21A 0.0312856
UBA6 ubiquitin-like modifier activating enzyme 6 0.0312841
RAB6A RAB6A, member RAS oncogene family 0.0312268
NEK7 NIMA-related kinase 7 0.0311063
FNIP1 folliculin interacting protein 1 0.0310845
FOXO1 forkhead box O1 0.0307537
LNPEP leucyl/cystinyl aminopeptidase 0.0304848
SEMA4B sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B 0.030397
EMP1 epithelial membrane protein 1 0.0303877
KRT17 keratin 17, type I 0.0303367
NBAS neuroblastoma amplified sequence 0.0302106
CAMK2D calcium/calmodulin-dependent protein kinase II delta 0.0300769
RNF19A ring finger protein 19A, RBR E3 ubiquitin protein ligase 0.0298581
CUL4B cullin 4B 0.029852
TNKS tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 0.0297958
SLMAP sarcolemma associated protein 0.0296297
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0295751
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 0.0295408
MYOF myoferlin 0.0295108
METTL15 methyltransferase like 15 0.0293481
CPEB2 cytoplasmic polyadenylation element binding protein 2 0.0292715
NRIP1 nuclear receptor interacting protein 1 0.0291123
ANXA11 annexin A11 0.0289779
DSTN destrin (actin depolymerizing factor) 0.0289147
ACSL3 acyl-CoA synthetase long-chain family member 3 0.0288278
KDM2A lysine (K)-specific demethylase 2A 0.0287895
COG5 component of oligomeric golgi complex 5 0.0287771
GPCPD1 glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) 0.0287673
QKI QKI, KH domain containing, RNA binding 0.0287524
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.028729
ARID4B AT rich interactive domain 4B (RBP1-like) 0.028572
CDC73 cell division cycle 73 0.028483
NCOA3 nuclear receptor coactivator 3 0.0284605

decreased expression

Symbol Name Standardized Value
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.354723
TIMP3 TIMP metallopeptidase inhibitor 3 -0.139532
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 -0.129036
DPYD dihydropyrimidine dehydrogenase -0.117985
LMO7 LIM domain 7 -0.104456
PDLIM5 PDZ and LIM domain 5 -0.102422
PDE4D phosphodiesterase 4D, cAMP-specific -0.0980652
INTS6 integrator complex subunit 6 -0.0923783
PALM2AKAP2 PALM2 and AKAP2 fusion -0.0849543
SLC35F3 solute carrier family 35, member F3 -0.0735777
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0694468
HMGA2 high mobility group AT-hook 2 -0.069306
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.0664717
ALCAM activated leukocyte cell adhesion molecule -0.0659776
RIGI RNA sensor RIG-I -0.065465
TPT1 tumor protein, translationally-controlled 1 -0.065259
ABI3BP ABI family, member 3 (NESH) binding protein -0.0568827
PRSS23 protease, serine, 23 -0.0552173
RABGAP1L RAB GTPase activating protein 1-like -0.0544689
RASAL2 RAS protein activator like 2 -0.0541511
KLF5 Kruppel-like factor 5 (intestinal) -0.0506606
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0493293
ANO1 anoctamin 1, calcium activated chloride channel -0.0466298
PSD3 pleckstrin and Sec7 domain containing 3 -0.046026
SULF1 sulfatase 1 -0.0455816
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0455786
MECOM MDS1 and EVI1 complex locus -0.0454872
SULF2 sulfatase 2 -0.042191
BRIP1 BRCA1 interacting protein C-terminal helicase 1 -0.0387531
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 -0.0384316
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.0380945
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.038026
RAD51B RAD51 paralog B -0.0379625
AHNAK AHNAK nucleoprotein -0.0374396
PALLD palladin, cytoskeletal associated protein -0.0369038
CSMD2 CUB and Sushi multiple domains 2 -0.0354761
CDK6 cyclin-dependent kinase 6 -0.0343435
MTAP methylthioadenosine phosphorylase -0.0340967
RPS6 ribosomal protein S6 -0.0338203
FN1 fibronectin 1 -0.0335734
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0326348
ACTN4 actinin, alpha 4 -0.0325898
LAMC2 laminin, gamma 2 -0.0325694
CAV1 caveolin 1, caveolae protein, 22kDa -0.0318565
SAMD9 sterile alpha motif domain containing 9 -0.0317659
HSPG2 heparan sulfate proteoglycan 2 -0.0308826
ACTG1 actin gamma 1 -0.0305752
ST3GAL6 ST3 beta-galactoside alpha-2,3-sialyltransferase 6 -0.0299885
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 -0.029864
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) -0.0289463
EXT1 exostosin glycosyltransferase 1 -0.0286549
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A -0.0267473
AGO2 argonaute RISC catalytic component 2 -0.026653
SMYD3 SET and MYND domain containing 3 -0.0265388
SLCO1B3-SLCO1B7 SLCO1B3-SLCO1B7 readthrough -0.0265209
EFNA5 ephrin-A5 -0.0264692
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0263356
THSD4 thrombospondin, type I, domain containing 4 -0.0263077
TENM4 teneurin transmembrane protein 4 -0.0262155
EGFR epidermal growth factor receptor -0.0262007
CRACDL CRACD like -0.0261303
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.0259876
OGDH oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide) -0.0259651
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.025612
POTEF POTE ankyrin domain family, member F -0.0255924
UTRN utrophin -0.0255513
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0253811
THBD thrombomodulin -0.0252806
FRMD4B FERM domain containing 4B -0.0251422
DGKH diacylglycerol kinase, eta -0.0251103
KIAA1671 KIAA1671 -0.0248292
PCDH9 protocadherin 9 -0.0246105
RPS8 ribosomal protein S8 -0.0244667
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 -0.0244324
CUX1 cut-like homeobox 1 -0.0241425
RPS24 ribosomal protein S24 -0.0240251
ECE1 endothelin converting enzyme 1 -0.0239959
RPS19 ribosomal protein S19 -0.0239686
TMSB4X thymosin beta 4, X-linked -0.0236487
RPLP1 ribosomal protein, large, P1 -0.023636
WNT2B wingless-type MMTV integration site family, member 2B -0.0235502
RPS21 ribosomal protein S21 -0.0234869
EXOC4 exocyst complex component 4 -0.0234295
TJP1 tight junction protein 1 -0.0232772
SEMA4A sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A -0.0231322
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa -0.023091
VTI1A vesicle transport through interaction with t-SNAREs 1A -0.0230764
RGS4 regulator of G-protein signaling 4 -0.0229455
MACF1 microtubule-actin crosslinking factor 1 -0.0225643
CTBP2 C-terminal binding protein 2 -0.0225344
RRBP1 ribosome binding protein 1 -0.0222457
MAML2 mastermind-like 2 (Drosophila) -0.0221648
SOX5 SRY (sex determining region Y)-box 5 -0.0221493
FUS FUS RNA binding protein -0.0221061
RALY RALY heterogeneous nuclear ribonucleoprotein -0.0220152
RPLP2 ribosomal protein, large, P2 -0.0220136
TNS3 tensin 3 -0.0219844
LRRC8A leucine rich repeat containing 8 family, member A -0.021848
EGR1 early growth response 1 -0.0212537
RPL23 ribosomal protein L23 -0.0210392