Thymopentin_LS 180 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Thymopentin perturbation in LS 180 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Thymopentin_LS 180 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.205577
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.172059
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.118428
EREG epiregulin 0.117539
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.109637
FAM13A family with sequence similarity 13, member A 0.103825
GOLGA4 golgin A4 0.0899445
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b 0.0724362
KDM3A lysine (K)-specific demethylase 3A 0.0643668
DSPP dentin sialophosphoprotein 0.0555745
ANXA2 annexin A2 0.0554731
EPCAM epithelial cell adhesion molecule 0.0541562
RNF145 ring finger protein 145 0.0540503
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.0537772
OGA O-GlcNAcase 0.0513492
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0499504
RNF43 ring finger protein 43 0.0486395
TXNIP thioredoxin interacting protein 0.0482966
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.047127
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0465902
MED13L mediator complex subunit 13-like 0.0453879
RBM39 RNA binding motif protein 39 0.0451209
DSG2 desmoglein 2 0.0449973
RAB1A RAB1A, member RAS oncogene family 0.0440794
PGK1 phosphoglycerate kinase 1 0.0422785
RAB3GAP1 RAB3 GTPase activating protein subunit 1 (catalytic) 0.0422103
CLTC clathrin, heavy chain (Hc) 0.0420129
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0418233
WAC WW domain containing adaptor with coiled-coil 0.0415271
LDHA lactate dehydrogenase A 0.0408795
DERA deoxyribose-phosphate aldolase (putative) 0.0403035
CANX calnexin 0.0402836
UBA6 ubiquitin-like modifier activating enzyme 6 0.0401066
FBXW7 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase 0.0400583
PTMA prothymosin, alpha 0.0390562
TM9SF3 transmembrane 9 superfamily member 3 0.0390347
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0389865
TNKS tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 0.038842
BTBD9 BTB (POZ) domain containing 9 0.0384398
DSCAM Down syndrome cell adhesion molecule 0.0382875
PRELID2 PRELI domain containing 2 0.0382424
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0375867
KRT18 keratin 18, type I 0.0367475
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0363125
USP3 ubiquitin specific peptidase 3 0.0355827
AREG amphiregulin 0.0351
ZFAND3 zinc finger, AN1-type domain 3 0.0346519
KLF5 Kruppel-like factor 5 (intestinal) 0.0342729
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0337803
CD2AP CD2-associated protein 0.0336275
ZNF292 zinc finger protein 292 0.0335125
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 0.0331176
EPS8 epidermal growth factor receptor pathway substrate 8 0.032687
GSK3B glycogen synthase kinase 3 beta 0.0324948
GARS1 glycyl-tRNA synthetase 1 0.0323189
ESYT2 extended synaptotagmin-like protein 2 0.0323031
WDR45B WD repeat domain 45B 0.0321007
NEK7 NIMA-related kinase 7 0.03172
H1-0 H1.0 linker histone 0.0312458
NUP58 nucleoporin 58 0.0309997
SETD5 SET domain containing 5 0.0307665
SEC31A SEC31 homolog A (S. cerevisiae) 0.0304669
MON2 MON2 homolog (S. cerevisiae) 0.0298949
RLF rearranged L-myc fusion 0.0298016
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0295585
PDIA4 protein disulfide isomerase family A, member 4 0.0290792
SUCO SUN domain containing ossification factor 0.0289877
NAMPT nicotinamide phosphoribosyltransferase 0.0289336
MBNL2 muscleblind-like splicing regulator 2 0.0287186
PUM2 pumilio RNA-binding family member 2 0.0285539
ACBD3 acyl-CoA binding domain containing 3 0.0283981
EXOC1 exocyst complex component 1 0.0283702
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase 0.0282697
CALR calreticulin 0.0282479
EHF ets homologous factor 0.0280892
COPA coatomer protein complex, subunit alpha 0.0280145
ZFC3H1 zinc finger, C3H1-type containing 0.0279555
CCNY cyclin Y 0.0277342
ANKRD11 ankyrin repeat domain 11 0.0276509
KIF5B kinesin family member 5B 0.0276362
MXI1 MAX interactor 1, dimerization protein 0.0275751
HSD17B12 hydroxysteroid (17-beta) dehydrogenase 12 0.0275695
ERRFI1 ERBB receptor feedback inhibitor 1 0.0271533
YME1L1 YME1-like 1 ATPase 0.0269912
YTHDC1 YTH domain containing 1 0.0269676
ADAM17 ADAM metallopeptidase domain 17 0.0268891
KRT8 keratin 8, type II 0.0268826
RPLP0 ribosomal protein, large, P0 0.0268748
TM9SF2 transmembrane 9 superfamily member 2 0.0266399
SHROOM3 shroom family member 3 0.0265541
MINDY2 MINDY lysine 48 deubiquitinase 2 0.0264568
TFG TRK-fused gene 0.0262641
PTPRR protein tyrosine phosphatase, receptor type, R 0.0262641
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) 0.0262403
SERINC5 serine incorporator 5 0.0262311
COPB1 coatomer protein complex, subunit beta 1 0.0262048
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0261747
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0261263
GCC2 GRIP and coiled-coil domain containing 2 0.0260693
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa 0.0259694

decreased expression

Symbol Name Standardized Value
NPSR1 neuropeptide S receptor 1 -0.135828
TMSB10 thymosin beta 10 -0.117862
MUC6 mucin 6, oligomeric mucus/gel-forming -0.106819
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0925772
NALF1 NALCN channel auxiliary factor 1 -0.0804513
GMDS GDP-mannose 4,6-dehydratase -0.0776521
MUC5AC mucin 5AC, oligomeric mucus/gel-forming -0.0774023
RPS6 ribosomal protein S6 -0.073709
GRIN2B glutamate receptor, ionotropic, N-methyl D-aspartate 2B -0.0685992
GREB1L growth regulation by estrogen in breast cancer-like -0.0674679
MYO1E myosin IE -0.0631174
VCL vinculin -0.0609958
RNF217 ring finger protein 217 -0.0556224
ONECUT3 one cut homeobox 3 -0.0551644
PTPRK protein tyrosine phosphatase, receptor type, K -0.0506219
EGFR epidermal growth factor receptor -0.0480703
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0470945
CEMIP cell migration inducing protein, hyaluronan binding -0.046366
TNS4 tensin 4 -0.0452143
MAML3 mastermind-like 3 (Drosophila) -0.0438662
SLC35F3 solute carrier family 35, member F3 -0.0434519
MUC5B mucin 5B, oligomeric mucus/gel-forming -0.0429003
ANTXR2 anthrax toxin receptor 2 -0.0420959
RPS19 ribosomal protein S19 -0.0411873
POTEF POTE ankyrin domain family, member F -0.0408805
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0400107
ALCAM activated leukocyte cell adhesion molecule -0.0389682
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0381859
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0380818
PDLIM5 PDZ and LIM domain 5 -0.0380815
EXT1 exostosin glycosyltransferase 1 -0.0377871
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0367814
FLNB filamin B, beta -0.0365509
PSD3 pleckstrin and Sec7 domain containing 3 -0.035633
MBNL1 muscleblind-like splicing regulator 1 -0.0351583
PDE4D phosphodiesterase 4D, cAMP-specific -0.0329761
SAMD5 sterile alpha motif domain containing 5 -0.0326398
LOC102724023 ES1 protein homolog, mitochondrial -0.0325786
RPL36 ribosomal protein L36 -0.0323394
CCSER1 coiled-coil serine-rich protein 1 -0.032157
MT2A metallothionein 2A -0.0314407
SVIL supervillin -0.0313104
GPHN gephyrin -0.031139
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 -0.0310489
RPS29 ribosomal protein S29 -0.0309438
RPLP2 ribosomal protein, large, P2 -0.030882
ABHD2 abhydrolase domain containing 2 -0.0304383
LRCH1 leucine-rich repeats and calponin homology (CH) domain containing 1 -0.0301661
CADPS Ca++-dependent secretion activator -0.0299577
RPL37A ribosomal protein L37a -0.029788
LPP LIM domain containing preferred translocation partner in lipoma -0.0297531
FHIT fragile histidine triad -0.0296106
SMYD3 SET and MYND domain containing 3 -0.0291166
FOXP1 forkhead box P1 -0.0283994
EPHB2 EPH receptor B2 -0.0280758
CALB1 calbindin 1, 28kDa -0.0277751
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0273456
ABR active BCR-related -0.0272822
MPRIP myosin phosphatase Rho interacting protein -0.0271724
ACTN4 actinin, alpha 4 -0.0270138
SOX4 SRY (sex determining region Y)-box 4 -0.0270093
ITGA6 integrin, alpha 6 -0.0264751
PATJ PATJ crumbs cell polarity complex component -0.0264036
ARID1B AT rich interactive domain 1B (SWI1-like) -0.0262743
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 -0.0261225
RAD51B RAD51 paralog B -0.0259306
PMEPA1 prostate transmembrane protein, androgen induced 1 -0.0251316
MECOM MDS1 and EVI1 complex locus -0.0251025
EEPD1 endonuclease/exonuclease/phosphatase family domain containing 1 -0.0250602
IGF1R insulin-like growth factor 1 receptor -0.0248801
TPM4 tropomyosin 4 -0.0245221
EGR1 early growth response 1 -0.0245005
PTPRG protein tyrosine phosphatase, receptor type, G -0.0244114
SH3D19 SH3 domain containing 19 -0.0243899
ZBTB20 zinc finger and BTB domain containing 20 -0.0243469
CUX1 cut-like homeobox 1 -0.0241684
SLCO1B3-SLCO1B7 SLCO1B3-SLCO1B7 readthrough -0.0237468
BCAT1 branched chain amino-acid transaminase 1, cytosolic -0.0235341
B4GALNT3 beta-1,4-N-acetyl-galactosaminyl transferase 3 -0.023326
FOSL1 FOS-like antigen 1 -0.0231567
MUC17 mucin 17, cell surface associated -0.0229657
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme -0.0229215
RPL31 ribosomal protein L31 -0.0228171
LSAMP limbic system-associated membrane protein -0.0228156
MRPS6 mitochondrial ribosomal protein S6 -0.0227689
DGKH diacylglycerol kinase, eta -0.0227488
RABGAP1L RAB GTPase activating protein 1-like -0.0226554
GTF2IRD1 GTF2I repeat domain containing 1 -0.0226531
FAT1 FAT atypical cadherin 1 -0.0225511
TRAPPC9 trafficking protein particle complex 9 -0.0224167
PFN1 profilin 1 -0.0223466
RPS12 ribosomal protein S12 -0.0215826
FRMD5 FERM domain containing 5 -0.0211381
FOXO1 forkhead box O1 -0.0209431
FBXO11 F-box protein 11 -0.0207955
ITGB4 integrin, beta 4 -0.020693
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 -0.0205832
ST3GAL1 ST3 beta-galactoside alpha-2,3-sialyltransferase 1 -0.0205247
KANK1 KN motif and ankyrin repeat domains 1 -0.0204812
NRXN3 neurexin 3 -0.0204407