Thymopentin_MIA PaCa-2 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Thymopentin perturbation in MIA PaCa-2 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Thymopentin_MIA PaCa-2 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
ERRFI1 ERBB receptor feedback inhibitor 1 0.112503
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0909688
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0601131
SPAG9 sperm associated antigen 9 0.0581925
RTN4 reticulon 4 0.0496022
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0474329
KMT2E lysine (K)-specific methyltransferase 2E 0.0467546
CAPRIN2 caprin family member 2 0.0456817
MATR3 matrin 3 0.0361759
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0352967
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0349812
ADAM17 ADAM metallopeptidase domain 17 0.0341105
TXNRD1 thioredoxin reductase 1 0.0338866
FTH1 ferritin, heavy polypeptide 1 0.0333525
HSPA8 heat shock 70kDa protein 8 0.0323147
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0320266
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0319636
NUP58 nucleoporin 58 0.0317052
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0314917
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0313494
KDM3A lysine (K)-specific demethylase 3A 0.0303212
OGA O-GlcNAcase 0.030126
EREG epiregulin 0.0296818
RPL35A ribosomal protein L35a 0.0294846
CAMTA1 calmodulin binding transcription activator 1 0.0292593
GOLGA4 golgin A4 0.0292088
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0290942
TMEM41B transmembrane protein 41B 0.0290176
ARHGAP5 Rho GTPase activating protein 5 0.0284926
RPL4 ribosomal protein L4 0.0284827
ZFAND3 zinc finger, AN1-type domain 3 0.0279729
TRIP12 thyroid hormone receptor interactor 12 0.0261691
RB1CC1 RB1-inducible coiled-coil 1 0.025836
PUM2 pumilio RNA-binding family member 2 0.0258242
SRSF4 serine/arginine-rich splicing factor 4 0.025377
MYH9 myosin, heavy chain 9, non-muscle 0.0250521
GPAT3 glycerol-3-phosphate acyltransferase 3 0.0250307
BIRC2 baculoviral IAP repeat containing 2 0.0246569
DSCAM Down syndrome cell adhesion molecule 0.0243202
SDC4 syndecan 4 0.0234246
EZR ezrin 0.0233649
NCKAP1 NCK-associated protein 1 0.0232091
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0231932
ARRDC3 arrestin domain containing 3 0.0230491
CAPN2 calpain 2, (m/II) large subunit 0.0230118
PHLDB2 pleckstrin homology-like domain, family B, member 2 0.0229851
TENT2 terminal nucleotidyltransferase 2 0.0226235
CLTC clathrin, heavy chain (Hc) 0.0225441
NAMPT nicotinamide phosphoribosyltransferase 0.0224919
VMP1 vacuole membrane protein 1 0.0223948
USP9X ubiquitin specific peptidase 9, X-linked 0.0223501
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 0.0223142
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma 0.0217421
NBAS neuroblastoma amplified sequence 0.0216841
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 0.0214754
HLA-B major histocompatibility complex, class I, B 0.0214171
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0210223
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta 0.020886
ANKRD11 ankyrin repeat domain 11 0.0208382
TM4SF1 transmembrane 4 L six family member 1 0.0208294
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 0.0207207
COG5 component of oligomeric golgi complex 5 0.0206396
CHD1 chromodomain helicase DNA binding protein 1 0.0205434
NEK7 NIMA-related kinase 7 0.0204837
FAR1 fatty acyl CoA reductase 1 0.0204306
SBF2 SET binding factor 2 0.0202003
PNISR PNN-interacting serine/arginine-rich protein 0.0201646
HOOK2 hook microtubule-tethering protein 2 0.0201565
DST dystonin 0.0201518
RNF145 ring finger protein 145 0.0200349
ECT2 epithelial cell transforming 2 0.019882
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 0.0198809
MEMO1 mediator of cell motility 1 0.0198694
MARCHF6 membrane associated ring-CH-type finger 6 0.0198673
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 0.0196671
HELZ helicase with zinc finger 0.0194041
THOC1 THO complex 1 0.0193533
ECPAS Ecm29 proteasome adaptor and scaffold 0.0192052
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 0.0191322
RPL38 ribosomal protein L38 0.0191112
RPL28 ribosomal protein L28 0.0190698
SNX14 sorting nexin 14 0.0189833
PTBP2 polypyrimidine tract binding protein 2 0.0189203
SUCO SUN domain containing ossification factor 0.0189134
BCAR3 breast cancer anti-estrogen resistance 3 0.0186537
SEPTIN2 septin 2 0.0186535
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0185898
SPIRE1 spire-type actin nucleation factor 1 0.0185898
TPT1 tumor protein, translationally-controlled 1 0.0183191
CDC73 cell division cycle 73 0.0182408
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0180178
ACTR3 ARP3 actin-related protein 3 homolog (yeast) 0.0179845
MINDY2 MINDY lysine 48 deubiquitinase 2 0.0179746
SLK STE20-like kinase 0.0178463
TM9SF3 transmembrane 9 superfamily member 3 0.0178213
RPL3 ribosomal protein L3 0.0178047
RAB1A RAB1A, member RAS oncogene family 0.0177173
PDE4D phosphodiesterase 4D, cAMP-specific 0.017679
GIGYF2 GRB10 interacting GYF protein 2 0.0176461
WAC WW domain containing adaptor with coiled-coil 0.0175722

decreased expression

Symbol Name Standardized Value
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.134259
VIM vimentin -0.129792
TP63 tumor protein p63 -0.117227
MT2A metallothionein 2A -0.0973522
TMSB10 thymosin beta 10 -0.0843623
CD44 CD44 molecule (Indian blood group) -0.083999
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 -0.083479
DLG1 discs, large homolog 1 (Drosophila) -0.082289
ZDHHC14 zinc finger, DHHC-type containing 14 -0.0737423
POTEF POTE ankyrin domain family, member F -0.0710281
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0635814
EHBP1 EH domain binding protein 1 -0.0631463
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C -0.0627993
PTMA prothymosin, alpha -0.0616594
PTPRF protein tyrosine phosphatase, receptor type, F -0.0610377
CADM2 cell adhesion molecule 2 -0.060243
CFAP299 cilia and flagella associated protein 299 -0.0591512
PSD3 pleckstrin and Sec7 domain containing 3 -0.0556691
DPYD dihydropyrimidine dehydrogenase -0.0546111
RNF213 ring finger protein 213 -0.0515786
EPHA4 EPH receptor A4 -0.0491002
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0456556
RUNX1 runt-related transcription factor 1 -0.0434892
SDCCAG8 serologically defined colon cancer antigen 8 -0.0429648
RAI1 retinoic acid induced 1 -0.0426985
EXOC4 exocyst complex component 4 -0.0421177
SP100 SP100 nuclear antigen -0.042037
RAD51B RAD51 paralog B -0.0402553
TNS3 tensin 3 -0.0391108
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like -0.0377686
ZFP36L1 ZFP36 ring finger protein-like 1 -0.035673
DNER delta/notch-like EGF repeat containing -0.0356608
LDHA lactate dehydrogenase A -0.0356443
HDAC9 histone deacetylase 9 -0.0352614
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0350404
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0323921
RIGI RNA sensor RIG-I -0.0322898
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0322611
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0307653
NPAS2 neuronal PAS domain protein 2 -0.0300943
SLC38A2 solute carrier family 38, member 2 -0.0295389
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0290277
CSMD3 CUB and Sushi multiple domains 3 -0.0290226
PODXL podocalyxin-like -0.028399
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 -0.0279818
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 -0.0274917
LPP LIM domain containing preferred translocation partner in lipoma -0.0273041
TMEM123 transmembrane protein 123 -0.0271465
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0269557
CDK6 cyclin-dependent kinase 6 -0.0261681
ACTG1 actin gamma 1 -0.0261497
RPS3 ribosomal protein S3 -0.0260279
ITGB4 integrin, beta 4 -0.0257844
DPH6 diphthamine biosynthesis 6 -0.0255143
RPL18 ribosomal protein L18 -0.0255016
TPI1 triosephosphate isomerase 1 -0.0250222
TSC22D1 TSC22 domain family, member 1 -0.0245353
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 -0.0244979
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0244333
WSB1 WD repeat and SOCS box containing 1 -0.0244024
SGK1 serum/glucocorticoid regulated kinase 1 -0.0238739
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0231625
MT1X metallothionein 1X -0.0230046
BPTF bromodomain PHD finger transcription factor -0.0225959
TBC1D5 TBC1 domain family, member 5 -0.0224618
WDR27 WD repeat domain 27 -0.0223771
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 -0.0222195
MYADM myeloid-associated differentiation marker -0.022034
EFNA5 ephrin-A5 -0.0220001
COL5A2 collagen, type V, alpha 2 -0.0219287
BSG basigin (Ok blood group) -0.0218836
ANGPTL4 angiopoietin-like 4 -0.0217674
HSPG2 heparan sulfate proteoglycan 2 -0.0214641
PATJ PATJ crumbs cell polarity complex component -0.0213027
LMNA lamin A/C -0.0210106
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0209692
PMP22 peripheral myelin protein 22 -0.0208439
ZMYND8 zinc finger, MYND-type containing 8 -0.0208333
MYC v-myc avian myelocytomatosis viral oncogene homolog -0.0207777
EGR1 early growth response 1 -0.0207529
CUX1 cut-like homeobox 1 -0.020632
NDRG1 N-myc downstream regulated 1 -0.0206092
TOMM20 translocase of outer mitochondrial membrane 20 homolog (yeast) -0.0203848
MYOF myoferlin -0.020201
TIMP2 TIMP metallopeptidase inhibitor 2 -0.0201729
MCTP1 multiple C2 domains, transmembrane 1 -0.0199622
STXBP5 syntaxin binding protein 5 (tomosyn) -0.0199504
PARP9 poly (ADP-ribose) polymerase family, member 9 -0.0198967
PLEKHA4 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 4 -0.0198508
ALDH7A1 aldehyde dehydrogenase 7 family, member A1 -0.0197981
ENO2 enolase 2 (gamma, neuronal) -0.019617
CUBN cubilin (intrinsic factor-cobalamin receptor) -0.0195012
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0194753
HELZ2 helicase with zinc finger 2, transcriptional coactivator -0.0194263
PDE10A phosphodiesterase 10A -0.0193881
PLK2 polo-like kinase 2 -0.0193535
SPIDR scaffolding protein involved in DNA repair -0.0193345
FOXN3 forkhead box N3 -0.0193042
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 -0.0192932
GNPDA1 glucosamine-6-phosphate deaminase 1 -0.0192324