Thymopentin_NCI-H1573 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Thymopentin perturbation in NCI-H1573 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Thymopentin_NCI-H1573 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FAM13A family with sequence similarity 13, member A 0.0902306
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0725285
RNF145 ring finger protein 145 0.0610874
NGLY1 N-glycanase 1 0.0562181
TMEM165 transmembrane protein 165 0.055084
FNDC3B fibronectin type III domain containing 3B 0.0544614
MT2A metallothionein 2A 0.0531136
TSC22D2 TSC22 domain family, member 2 0.0488024
ADAM17 ADAM metallopeptidase domain 17 0.0458424
ANKRD10 ankyrin repeat domain 10 0.0457683
KDM6A lysine (K)-specific demethylase 6A 0.0451593
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) 0.0431982
NAMPT nicotinamide phosphoribosyltransferase 0.0430894
GRB10 growth factor receptor-bound protein 10 0.0416993
TENT5A terminal nucleotidyltransferase 5A 0.0413616
NDUFV2 NADH dehydrogenase (ubiquinone) flavoprotein 2, 24kDa 0.0405249
HELZ helicase with zinc finger 0.0398731
ATP13A3 ATPase type 13A3 0.0394793
CAMTA1 calmodulin binding transcription activator 1 0.0388213
SEC61G Sec61 gamma subunit 0.037771
RICTOR RPTOR independent companion of MTOR, complex 2 0.0376413
GSK3B glycogen synthase kinase 3 beta 0.037572
USP3 ubiquitin specific peptidase 3 0.0361554
NPTN neuroplastin 0.035453
KANSL1 KAT8 regulatory NSL complex subunit 1 0.0343061
TOP1 topoisomerase (DNA) I 0.0342047
PGK1 phosphoglycerate kinase 1 0.0334611
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 0.0322772
UVRAG UV radiation resistance associated 0.031799
ZFAND6 zinc finger, AN1-type domain 6 0.0315023
CPEB2 cytoplasmic polyadenylation element binding protein 2 0.0312749
UBA6 ubiquitin-like modifier activating enzyme 6 0.030846
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0296924
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0290921
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0289876
TPD52 tumor protein D52 0.0281049
SAMD4A sterile alpha motif domain containing 4A 0.02708
NCKAP1 NCK-associated protein 1 0.0261106
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0253768
ARL8B ADP-ribosylation factor-like 8B 0.025094
PUM2 pumilio RNA-binding family member 2 0.0245178
WAC WW domain containing adaptor with coiled-coil 0.0244563
TFG TRK-fused gene 0.0244357
PDE8A phosphodiesterase 8A 0.0244044
STRN3 striatin, calmodulin binding protein 3 0.0242604
RNMT RNA (guanine-7-) methyltransferase 0.0237872
H1-0 H1.0 linker histone 0.0236478
PTPRJ protein tyrosine phosphatase, receptor type, J 0.0235428
RAP1B RAP1B, member of RAS oncogene family 0.0232743
UBE2O ubiquitin-conjugating enzyme E2O 0.0229427
MAP3K2 mitogen-activated protein kinase kinase kinase 2 0.0229263
ARID2 AT rich interactive domain 2 (ARID, RFX-like) 0.0226422
KMT2E lysine (K)-specific methyltransferase 2E 0.0224994
ABLIM1 actin binding LIM protein 1 0.0224481
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.022198
PTBP2 polypyrimidine tract binding protein 2 0.0220386
MAP3K4 mitogen-activated protein kinase kinase kinase 4 0.0214853
QKI QKI, KH domain containing, RNA binding 0.021375
CYLD cylindromatosis (turban tumor syndrome) 0.0213355
SP3 Sp3 transcription factor 0.0212416
PAN3 PAN3 poly(A) specific ribonuclease subunit 0.0211325
TMEM167A transmembrane protein 167A 0.02112
MYO5B myosin VB 0.0207688
RAD23B RAD23 homolog B (S. cerevisiae) 0.0205248
BRWD1 bromodomain and WD repeat domain containing 1 0.0204429
ELOVL7 ELOVL fatty acid elongase 7 0.0198167
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 0.0196604
RAB6A RAB6A, member RAS oncogene family 0.0195215
PARD3 par-3 family cell polarity regulator 0.0188568
PICALM phosphatidylinositol binding clathrin assembly protein 0.0188167
OGA O-GlcNAcase 0.0181427
SNX13 sorting nexin 13 0.0179603
GPC6 glypican 6 0.0177649
PPTC7 PTC7 protein phosphatase homolog (S. cerevisiae) 0.0177361
IFNAR2 interferon (alpha, beta and omega) receptor 2 0.0177192
ECT2 epithelial cell transforming 2 0.0175106
MXI1 MAX interactor 1, dimerization protein 0.0171185
SLMAP sarcolemma associated protein 0.0171068
KCMF1 potassium channel modulatory factor 1 0.0168788
TNKS tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 0.0168661
USP9X ubiquitin specific peptidase 9, X-linked 0.0166325
CDKN2A cyclin-dependent kinase inhibitor 2A 0.0165857
GPCPD1 glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) 0.0165798
RPL35A ribosomal protein L35a 0.0163667
FOXJ3 forkhead box J3 0.016355
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0163075
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 0.0162375
MARK3 MAP/microtubule affinity-regulating kinase 3 0.016233
PPP3R1 protein phosphatase 3, regulatory subunit B, alpha 0.0161717
WASF2 WAS protein family, member 2 0.0160973
TBK1 TANK-binding kinase 1 0.0160371
BHLHE40 basic helix-loop-helix family, member e40 0.0160024
RUNX1 runt-related transcription factor 1 0.0159095
PDPK1 3-phosphoinositide dependent protein kinase 1 0.0157666
BACE2 beta-site APP-cleaving enzyme 2 0.0157039
UBE2D3 ubiquitin-conjugating enzyme E2D 3 0.0155234
NDFIP1 Nedd4 family interacting protein 1 0.0154282
VIM vimentin 0.015392
PDE4D phosphodiesterase 4D, cAMP-specific 0.0151904
UBE2E1 ubiquitin-conjugating enzyme E2E 1 0.0150967

decreased expression

Symbol Name Standardized Value
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.218506
TXNRD1 thioredoxin reductase 1 -0.207423
EGFR epidermal growth factor receptor -0.164098
ASPH aspartate beta-hydroxylase -0.113709
LAMC2 laminin, gamma 2 -0.112861
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.109291
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) -0.108737
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C -0.0968332
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0957158
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0792508
NDRG1 N-myc downstream regulated 1 -0.078006
CAV1 caveolin 1, caveolae protein, 22kDa -0.0768225
PKM pyruvate kinase, muscle -0.0735521
RNF213 ring finger protein 213 -0.072656
LDHA lactate dehydrogenase A -0.0718245
EFNA5 ephrin-A5 -0.0690485
ACTG1 actin gamma 1 -0.0684551
PPFIA1 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 -0.0657651
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5 -0.0646623
OSMR oncostatin M receptor -0.0646557
DOCK5 dedicator of cytokinesis 5 -0.0622298
STC1 stanniocalcin 1 -0.0618691
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0613168
LOC112694756 uncharaterized LOC112694756 -0.060267
DSCAM Down syndrome cell adhesion molecule -0.0589334
LMO7 LIM domain 7 -0.0585282
KRT18 keratin 18, type I -0.055951
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0532619
PATJ PATJ crumbs cell polarity complex component -0.052673
LPP LIM domain containing preferred translocation partner in lipoma -0.0518404
CES1 carboxylesterase 1 -0.0518116
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.0515585
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) -0.0514279
AKR1C1 aldo-keto reductase family 1, member C1 -0.0511659
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0509633
DSPP dentin sialophosphoprotein -0.0507549
JMJD1C jumonji domain containing 1C -0.0491426
UBC ubiquitin C -0.0477128
RALGAPA2 Ral GTPase activating protein, alpha subunit 2 (catalytic) -0.0472342
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.0461581
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 -0.0454001
BZW1 basic leucine zipper and W2 domains 1 -0.0453031
CCND1 cyclin D1 -0.044931
GOLGB1 golgin B1 -0.0448651
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0444926
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 -0.0427736
ZMYND8 zinc finger, MYND-type containing 8 -0.0427453
SLC38A1 solute carrier family 38, member 1 -0.0427309
RPS2 ribosomal protein S2 -0.0416459
AHNAK AHNAK nucleoprotein -0.0413252
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0410124
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0401668
MYOF myoferlin -0.0401584
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0400404
MYO1E myosin IE -0.0398457
CANX calnexin -0.0393722
KRT7 keratin 7, type II -0.0391608
FZR1 fizzy/cell division cycle 20 related 1 (Drosophila) -0.0387295
ENO1 enolase 1, (alpha) -0.0386369
IGFBP5 insulin-like growth factor binding protein 5 -0.0382817
DOCK1 dedicator of cytokinesis 1 -0.0371583
EGR1 early growth response 1 -0.0371417
ANKRD12 ankyrin repeat domain 12 -0.0365438
B2M beta-2-microglobulin -0.0362563
LAMA4 laminin, alpha 4 -0.0361792
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 -0.0355392
NSUN6 NOP2/Sun domain family, member 6 -0.0350298
TRIM56 tripartite motif containing 56 -0.0346906
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific ) -0.0343752
PDIA3 protein disulfide isomerase family A, member 3 -0.0342657
TPM4 tropomyosin 4 -0.0341991
SP100 SP100 nuclear antigen -0.0337249
CST3 cystatin C -0.0328575
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.0324062
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0323564
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3 -0.0322238
IFI6 interferon, alpha-inducible protein 6 -0.0321973
USP53 ubiquitin specific peptidase 53 -0.0321096
GCLC glutamate-cysteine ligase, catalytic subunit -0.0320162
AKAP9 A kinase (PRKA) anchor protein 9 -0.0318499
MCL1 myeloid cell leukemia 1 -0.0317252
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.03157
CUX1 cut-like homeobox 1 -0.0313991
NPC1 Niemann-Pick disease, type C1 -0.0313658
RAB10 RAB10, member RAS oncogene family -0.0309005
EIF4A2 eukaryotic translation initiation factor 4A2 -0.0308016
CPE carboxypeptidase E -0.0307554
BTG1 B-cell translocation gene 1, anti-proliferative -0.0306184
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.0305144
IGFBP3 insulin-like growth factor binding protein 3 -0.0303647
SHANK2 SH3 and multiple ankyrin repeat domains 2 -0.0300616
CTTN cortactin -0.0298051
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3 -0.0295505
LRP1B low density lipoprotein receptor-related protein 1B -0.0294999
KTN1 kinectin 1 (kinesin receptor) -0.0293189
S100A10 S100 calcium binding protein A10 -0.0292007
CTNND1 catenin (cadherin-associated protein), delta 1 -0.0290065
PTPRD protein tyrosine phosphatase, receptor type, D -0.0289417
SLTM SAFB-like, transcription modulator -0.0288186
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.028431