Thymopentin_NCI-H1792 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Thymopentin perturbation in NCI-H1792 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Thymopentin_NCI-H1792 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
AKAP12 A kinase (PRKA) anchor protein 12 0.167705
SDK1 sidekick cell adhesion molecule 1 0.167673
PDE4D phosphodiesterase 4D, cAMP-specific 0.159509
NAMPT nicotinamide phosphoribosyltransferase 0.127176
FAM13A family with sequence similarity 13, member A 0.122947
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.122613
CXCL8 chemokine (C-X-C motif) ligand 8 0.108206
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0977045
PRELID2 PRELI domain containing 2 0.0940743
MEF2A myocyte enhancer factor 2A 0.0877591
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0870576
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0809692
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0808401
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1 0.0796687
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0782108
STC1 stanniocalcin 1 0.0736592
RBMS3 RNA binding motif, single stranded interacting protein 3 0.0730355
SMAD3 SMAD family member 3 0.0723484
CDH13 cadherin 13 0.070813
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0705696
EFNA5 ephrin-A5 0.0693127
TRIO trio Rho guanine nucleotide exchange factor 0.0690367
NGLY1 N-glycanase 1 0.0683339
GRB10 growth factor receptor-bound protein 10 0.0663591
CAMK1D calcium/calmodulin-dependent protein kinase ID 0.0662187
KDM2A lysine (K)-specific demethylase 2A 0.0621326
UBA6 ubiquitin-like modifier activating enzyme 6 0.0617996
ELL2 elongation factor, RNA polymerase II, 2 0.0606548
NAV2 neuron navigator 2 0.0606502
MTSS1 metastasis suppressor 1 0.0603261
GPC6 glypican 6 0.0599224
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0591481
ESYT2 extended synaptotagmin-like protein 2 0.0590338
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0585926
USP34 ubiquitin specific peptidase 34 0.0580995
PARP8 poly (ADP-ribose) polymerase family, member 8 0.0580431
ASPH aspartate beta-hydroxylase 0.0573632
SOD2 superoxide dismutase 2, mitochondrial 0.0560447
PDK3 pyruvate dehydrogenase kinase, isozyme 3 0.0552194
DST dystonin 0.0541994
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0529971
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 0.0529272
DLG1 discs, large homolog 1 (Drosophila) 0.0523398
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0511697
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0509037
PIAS2 protein inhibitor of activated STAT, 2 0.0507145
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 0.0498908
RUNX1 runt-related transcription factor 1 0.0482034
ZNF292 zinc finger protein 292 0.0479143
RICTOR RPTOR independent companion of MTOR, complex 2 0.0465453
ADD3 adducin 3 (gamma) 0.0459168
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 0.0454333
CANX calnexin 0.0447402
TAS2R14 taste receptor, type 2, member 14 0.0443504
FN1 fibronectin 1 0.0432553
AKAP13 A kinase (PRKA) anchor protein 13 0.043128
MYH9 myosin, heavy chain 9, non-muscle 0.0411136
GOLGA4 golgin A4 0.0402637
CA12 carbonic anhydrase XII 0.0402367
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6 0.0401889
BIRC3 baculoviral IAP repeat containing 3 0.0399912
CACNA2D3 calcium channel, voltage-dependent, alpha 2/delta subunit 3 0.0399212
PFKP phosphofructokinase, platelet 0.039479
GALNT18 polypeptide N-acetylgalactosaminyltransferase 18 0.0394201
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0392962
RAI14 retinoic acid induced 14 0.0391308
TFPI2 tissue factor pathway inhibitor 2 0.0390834
KDM3A lysine (K)-specific demethylase 3A 0.0387473
RARB retinoic acid receptor, beta 0.0380637
NAP1L1 nucleosome assembly protein 1-like 1 0.0377652
ENO1 enolase 1, (alpha) 0.0376253
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.037621
FMNL2 formin-like 2 0.0375172
MACF1 microtubule-actin crosslinking factor 1 0.0374214
MYCBP2 MYC binding protein 2, E3 ubiquitin protein ligase 0.037176
PTK2 protein tyrosine kinase 2 0.0367111
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase) 0.0366436
FAM20C family with sequence similarity 20, member C 0.0364695
RIOK3 RIO kinase 3 0.0363394
LOXL2 lysyl oxidase-like 2 0.0363276
KTN1 kinectin 1 (kinesin receptor) 0.0361227
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0360969
MINDY2 MINDY lysine 48 deubiquitinase 2 0.0358489
RND3 Rho family GTPase 3 0.0356732
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0352416
LIMCH1 LIM and calponin homology domains 1 0.0346936
OXR1 oxidation resistance 1 0.0346291
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0345748
KCTD16 potassium channel tetramerization domain containing 16 0.0343561
NBAS neuroblastoma amplified sequence 0.0343124
CCNY cyclin Y 0.0342836
UBE2E2 ubiquitin-conjugating enzyme E2E 2 0.0341973
ANO6 anoctamin 6 0.0340723
PDGFA platelet-derived growth factor alpha polypeptide 0.0340591
PTPRR protein tyrosine phosphatase, receptor type, R 0.0339573
ANKRD36 ankyrin repeat domain 36 0.033744
PHF21A PHD finger protein 21A 0.0331107
ZNF638 zinc finger protein 638 0.0330542
RAD51B RAD51 paralog B 0.032985
CHD1L chromodomain helicase DNA binding protein 1-like 0.0329474

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0803783
CD44 CD44 molecule (Indian blood group) -0.078193
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0770231
MYC v-myc avian myelocytomatosis viral oncogene homolog -0.0651486
TMSB10 thymosin beta 10 -0.0636836
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0592282
EGR1 early growth response 1 -0.0556838
GLCCI1 glucocorticoid induced 1 -0.0531112
OSMR oncostatin M receptor -0.0509983
NTN4 netrin 4 -0.0472585
TNNC1 troponin C type 1 (slow) -0.0449973
LOX lysyl oxidase -0.0424973
SIPA1L1 signal-induced proliferation-associated 1 like 1 -0.0414783
DDIT3 DNA-damage-inducible transcript 3 -0.0393395
MT2A metallothionein 2A -0.0351709
FTL ferritin, light polypeptide -0.0346555
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0320445
PCBP2 poly(rC) binding protein 2 -0.0300961
IL1R1 interleukin 1 receptor, type I -0.0292514
BLZF1 basic leucine zipper nuclear factor 1 -0.0292194
HEG1 heart development protein with EGF-like domains 1 -0.0286785
NCOA7 nuclear receptor coactivator 7 -0.0284542
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.0281372
POTEF POTE ankyrin domain family, member F -0.0280479
KSR1 kinase suppressor of ras 1 -0.0273378
ANKRD28 ankyrin repeat domain 28 -0.0266666
SPRED2 sprouty-related, EVH1 domain containing 2 -0.0255455
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0251285
SYAP1 synapse associated protein 1 -0.0245614
IER3 immediate early response 3 -0.0244299
RPLP2 ribosomal protein, large, P2 -0.0232636
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 -0.0232088
RPS19 ribosomal protein S19 -0.0230199
AADAC arylacetamide deacetylase -0.0218947
RPL35A ribosomal protein L35a -0.0218518
RPS29 ribosomal protein S29 -0.0217916
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.0212995
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) -0.0209814
ERN1 endoplasmic reticulum to nucleus signaling 1 -0.0202202
NABP1 nucleic acid binding protein 1 -0.0195082
GLIPR1 GLI pathogenesis-related 1 -0.0194311
RAP1B RAP1B, member of RAS oncogene family -0.019107
RPS6 ribosomal protein S6 -0.0189004
ZBTB38 zinc finger and BTB domain containing 38 -0.0188346
RPL36 ribosomal protein L36 -0.0177625
RNF24 ring finger protein 24 -0.0166969
RPL12 ribosomal protein L12 -0.0164552
SEC31A SEC31 homolog A (S. cerevisiae) -0.0162153
STK38L serine/threonine kinase 38 like -0.0161638
BPTF bromodomain PHD finger transcription factor -0.0159985
UBE2H ubiquitin-conjugating enzyme E2H -0.0158846
RPS16 ribosomal protein S16 -0.015807
DUSP16 dual specificity phosphatase 16 -0.0155263
RAB5A RAB5A, member RAS oncogene family -0.0148726
CALU calumenin -0.0148028
ZNF207 zinc finger protein 207 -0.0147596
MEF2D myocyte enhancer factor 2D -0.0146726
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.014576
EIF1 eukaryotic translation initiation factor 1 -0.01453
MON2 MON2 homolog (S. cerevisiae) -0.0145027
RPLP1 ribosomal protein, large, P1 -0.01447
RPL34 ribosomal protein L34 -0.0140925
SERF2 small EDRK-rich factor 2 -0.0140831
SLC38A2 solute carrier family 38, member 2 -0.0140495
RPL31 ribosomal protein L31 -0.0140489
PTPRK protein tyrosine phosphatase, receptor type, K -0.0139929
GOLGA3 golgin A3 -0.0139203
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0139024
NPC1 Niemann-Pick disease, type C1 -0.0138783
GPCPD1 glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) -0.0138088
MORF4L2 mortality factor 4 like 2 -0.0137771
FOSB FBJ murine osteosarcoma viral oncogene homolog B -0.013658
RPL37A ribosomal protein L37a -0.0136291
RALA v-ral simian leukemia viral oncogene homolog A (ras related) -0.0135464
ARF4 ADP-ribosylation factor 4 -0.0132925
RPS3 ribosomal protein S3 -0.0132236
RALY RALY heterogeneous nuclear ribonucleoprotein -0.0130757
RPL32 ribosomal protein L32 -0.013041
RPL23 ribosomal protein L23 -0.0129546
ENO2 enolase 2 (gamma, neuronal) -0.0128895
RAB7A RAB7A, member RAS oncogene family -0.0128449
ECE1 endothelin converting enzyme 1 -0.0128335
TMEM87A transmembrane protein 87A -0.0127347
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0125936
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0125355
FSCN1 fascin actin-bundling protein 1 -0.0124637
GDI2 GDP dissociation inhibitor 2 -0.0124303
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.012358
MAGT1 magnesium transporter 1 -0.0120154
ATF4 activating transcription factor 4 -0.0120012
NUP98 nucleoporin 98kDa -0.0119259
EVA1C eva-1 homolog C (C. elegans) -0.0118384
SAMD4A sterile alpha motif domain containing 4A -0.0117364
NDRG1 N-myc downstream regulated 1 -0.011704
PFN1 profilin 1 -0.0116973
TRIB1 tribbles pseudokinase 1 -0.0116669
CCNL1 cyclin L1 -0.0116645
RPS27 ribosomal protein S27 -0.0116434
HM13 histocompatibility (minor) 13 -0.0112131
LAMTOR5 late endosomal/lysosomal adaptor, MAPK and MTOR activator 5 -0.0110733