Thymopentin_NCI-H23 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Thymopentin perturbation in NCI-H23 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Thymopentin_NCI-H23 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
ERRFI1 ERBB receptor feedback inhibitor 1 0.0880122
TXNRD1 thioredoxin reductase 1 0.0513599
TRIO trio Rho guanine nucleotide exchange factor 0.0464758
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0446574
ZFAND3 zinc finger, AN1-type domain 3 0.0428463
GRAMD1B GRAM domain containing 1B 0.0422963
KPNA4 karyopherin alpha 4 (importin alpha 3) 0.0384213
RTN4 reticulon 4 0.0366419
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0356131
PUM2 pumilio RNA-binding family member 2 0.0333821
CAMTA1 calmodulin binding transcription activator 1 0.0317779
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.0315397
JMJD1C jumonji domain containing 1C 0.0313314
SMYD3 SET and MYND domain containing 3 0.0298674
NIPBL Nipped-B homolog (Drosophila) 0.0289118
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.02801
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0275191
ANKRD36 ankyrin repeat domain 36 0.0271955
ANO6 anoctamin 6 0.0266529
PDE4D phosphodiesterase 4D, cAMP-specific 0.0265114
KDM3A lysine (K)-specific demethylase 3A 0.0262596
OGA O-GlcNAcase 0.0259968
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0249694
HSPA8 heat shock 70kDa protein 8 0.024375
EXOC4 exocyst complex component 4 0.023863
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0238617
KLF7 Kruppel-like factor 7 (ubiquitous) 0.023397
MYH9 myosin, heavy chain 9, non-muscle 0.0231635
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0230033
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0225623
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.0224963
MNAT1 MNAT CDK-activating kinase assembly factor 1 0.0224056
MED13L mediator complex subunit 13-like 0.0223045
PRELID2 PRELI domain containing 2 0.0219797
MARCHF4 membrane associated ring-CH-type finger 4 0.0217154
MACF1 microtubule-actin crosslinking factor 1 0.0214778
ZFC3H1 zinc finger, C3H1-type containing 0.0212572
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0209652
YAP1 Yes-associated protein 1 0.0208518
MAPK8 mitogen-activated protein kinase 8 0.0208273
WDPCP WD repeat containing planar cell polarity effector 0.0208235
CTTNBP2NL CTTNBP2 N-terminal like 0.0205478
XPO1 exportin 1 0.0203282
WWOX WW domain containing oxidoreductase 0.0201726
PPME1 protein phosphatase methylesterase 1 0.019977
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0194619
ATL2 atlastin GTPase 2 0.0194256
TAS2R14 taste receptor, type 2, member 14 0.0191678
OGT O-linked N-acetylglucosamine (GlcNAc) transferase 0.0190841
FMNL2 formin-like 2 0.019072
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 0.018894
ATP11A ATPase, class VI, type 11A 0.0188233
CUL3 cullin 3 0.0185561
IGF1R insulin-like growth factor 1 receptor 0.0184571
CDK17 cyclin-dependent kinase 17 0.018416
RPL4 ribosomal protein L4 0.0183594
RAD51B RAD51 paralog B 0.0180482
SPAG9 sperm associated antigen 9 0.017943
MEMO1 mediator of cell motility 1 0.017752
TRIM33 tripartite motif containing 33 0.0176882
CDYL chromodomain protein, Y-like 0.0174848
SPRED2 sprouty-related, EVH1 domain containing 2 0.0174746
NCKAP1 NCK-associated protein 1 0.0174704
RRM2 ribonucleotide reductase M2 0.0172297
GSK3B glycogen synthase kinase 3 beta 0.0169127
EIF4B eukaryotic translation initiation factor 4B 0.0169084
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0168696
SNRNP200 small nuclear ribonucleoprotein 200kDa (U5) 0.0168154
PTK2 protein tyrosine kinase 2 0.0168122
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0167698
FAF1 Fas (TNFRSF6) associated factor 1 0.0167483
ANXA5 annexin A5 0.0166565
PHIP pleckstrin homology domain interacting protein 0.0163792
FOXJ3 forkhead box J3 0.0160309
THSD4 thrombospondin, type I, domain containing 4 0.0158262
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0157317
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 0.0156615
PPM1L protein phosphatase, Mg2+/Mn2+ dependent, 1L 0.0155523
SMCHD1 structural maintenance of chromosomes flexible hinge domain containing 1 0.0155342
NBAS neuroblastoma amplified sequence 0.015406
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.01539
CKAP5 cytoskeleton associated protein 5 0.015326
GMDS GDP-mannose 4,6-dehydratase 0.0153172
TFPI2 tissue factor pathway inhibitor 2 0.0152238
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0151723
MDGA2 MAM domain containing glycosylphosphatidylinositol anchor 2 0.0151689
TMEM41B transmembrane protein 41B 0.0150422
LRPPRC leucine-rich pentatricopeptide repeat containing 0.0150352
RASA2 RAS p21 protein activator 2 0.0149572
CCNY cyclin Y 0.0149552
DDAH1 dimethylarginine dimethylaminohydrolase 1 0.0147411
RASAL2 RAS protein activator like 2 0.0147388
ERC1 ELKS/RAB6-interacting/CAST family member 1 0.0147282
TOP2B topoisomerase (DNA) II beta 180kDa 0.0146004
WNK1 WNK lysine deficient protein kinase 1 0.0145866
PPP3R1 protein phosphatase 3, regulatory subunit B, alpha 0.014567
VCL vinculin 0.0145289
NR6A1 nuclear receptor subfamily 6, group A, member 1 0.0144856
PSME4 proteasome (prosome, macropain) activator subunit 4 0.0144771
USP34 ubiquitin specific peptidase 34 0.0144249

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.32125
TMSB10 thymosin beta 10 -0.110423
VIM vimentin -0.103824
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0940979
PTMA prothymosin, alpha -0.087423
EGR1 early growth response 1 -0.0785719
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0729719
RPS3 ribosomal protein S3 -0.0677463
TPI1 triosephosphate isomerase 1 -0.0612624
RPS8 ribosomal protein S8 -0.0571875
POTEF POTE ankyrin domain family, member F -0.0563354
PFN1 profilin 1 -0.0548567
MT2A metallothionein 2A -0.0540576
RPL37 ribosomal protein L37 -0.0515922
RPL35A ribosomal protein L35a -0.0504777
ACTG1 actin gamma 1 -0.0460612
RPL23 ribosomal protein L23 -0.045867
AKAP12 A kinase (PRKA) anchor protein 12 -0.0454849
FTL ferritin, light polypeptide -0.0451811
RPLP1 ribosomal protein, large, P1 -0.0430021
RPS27 ribosomal protein S27 -0.0423831
RPL37A ribosomal protein L37a -0.0423406
RPL8 ribosomal protein L8 -0.0395455
EEF2 eukaryotic translation elongation factor 2 -0.039493
RPS19 ribosomal protein S19 -0.0388697
RPL26 ribosomal protein L26 -0.0387909
RPL12 ribosomal protein L12 -0.0381854
RPS6 ribosomal protein S6 -0.0380661
RPS21 ribosomal protein S21 -0.0359185
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0355672
TPM2 tropomyosin 2 (beta) -0.0353939
HLA-B major histocompatibility complex, class I, B -0.0353665
RPS15 ribosomal protein S15 -0.0344675
RPLP0 ribosomal protein, large, P0 -0.0333696
RPL31 ribosomal protein L31 -0.0332918
TPT1 tumor protein, translationally-controlled 1 -0.0327634
RPS29 ribosomal protein S29 -0.0322642
RPLP2 ribosomal protein, large, P2 -0.0310932
RPL36 ribosomal protein L36 -0.0309866
RPS4X ribosomal protein S4, X-linked -0.0308791
RPS12 ribosomal protein S12 -0.0297064
EIF1 eukaryotic translation initiation factor 1 -0.0296734
VDAC1 voltage-dependent anion channel 1 -0.0293953
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0285921
RPS10 ribosomal protein S10 -0.0281118
IGF2 insulin-like growth factor 2 -0.0273214
RACK1 receptor for activated C kinase 1 -0.0270131
LOC102724023 ES1 protein homolog, mitochondrial -0.026978
RPL9 ribosomal protein L9 -0.0266941
RPL19 ribosomal protein L19 -0.0265436
GNAS GNAS complex locus -0.0265424
RPS27A ribosomal protein S27a -0.0259615
EIF4A1 eukaryotic translation initiation factor 4A1 -0.0259455
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 -0.0257442
TPM4 tropomyosin 4 -0.0256698
KTN1 kinectin 1 (kinesin receptor) -0.0253891
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0253443
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0251789
RPS13 ribosomal protein S13 -0.0250391
RPL32 ribosomal protein L32 -0.0243632
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0243399
RPL34 ribosomal protein L34 -0.0243272
RPL7A ribosomal protein L7a -0.0235123
RPL18 ribosomal protein L18 -0.0232469
RPL28 ribosomal protein L28 -0.0232432
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0232294
ATP5F1B ATP synthase F1 subunit beta -0.0232202
RPL11 ribosomal protein L11 -0.0230839
RPL35 ribosomal protein L35 -0.0229534
RPS25 ribosomal protein S25 -0.0227066
RPL36A ribosomal protein L36a -0.022632
HMGA1 high mobility group AT-hook 1 -0.0226044
WSB1 WD repeat and SOCS box containing 1 -0.0223439
RPS17 ribosomal protein S17 -0.0219262
LMAN1 lectin, mannose-binding, 1 -0.0216741
BPTF bromodomain PHD finger transcription factor -0.0216639
CANX calnexin -0.0216172
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0212018
LDHA lactate dehydrogenase A -0.0210246
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0207744
RPS24 ribosomal protein S24 -0.0207205
RPL5 ribosomal protein L5 -0.0205968
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0205946
RPS14 ribosomal protein S14 -0.0200954
PTPRF protein tyrosine phosphatase, receptor type, F -0.0200936
CCT4 chaperonin containing TCP1, subunit 4 (delta) -0.0200435
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0200109
S100A10 S100 calcium binding protein A10 -0.0198306
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.019801
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.0197686
HDGF hepatoma-derived growth factor -0.0197379
CALR calreticulin -0.019531
CCND1 cyclin D1 -0.0193533
EIF5B eukaryotic translation initiation factor 5B -0.0192126
NAP1L1 nucleosome assembly protein 1-like 1 -0.0189868
WASF2 WAS protein family, member 2 -0.0189753
PKM pyruvate kinase, muscle -0.0184465
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.0184284
MARCKS myristoylated alanine-rich protein kinase C substrate -0.018418
S100A6 S100 calcium binding protein A6 -0.0183942