Thymopentin_NCI-H2347 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Thymopentin perturbation in NCI-H2347 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Thymopentin_NCI-H2347 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FNDC3B fibronectin type III domain containing 3B 0.0712703
MYH9 myosin, heavy chain 9, non-muscle 0.0409916
GRB10 growth factor receptor-bound protein 10 0.0324002
PTK2 protein tyrosine kinase 2 0.0306511
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0301823
LPP LIM domain containing preferred translocation partner in lipoma 0.0296441
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0287086
NAV2 neuron navigator 2 0.0278074
SAMD4A sterile alpha motif domain containing 4A 0.0274978
MSN moesin 0.0259264
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0242417
TRIO trio Rho guanine nucleotide exchange factor 0.0230291
AKAP13 A kinase (PRKA) anchor protein 13 0.0215606
PPARD peroxisome proliferator-activated receptor delta 0.021366
EFNA5 ephrin-A5 0.02081
KDM6A lysine (K)-specific demethylase 6A 0.020664
PICALM phosphatidylinositol binding clathrin assembly protein 0.0188715
DTNA dystrobrevin, alpha 0.0187583
LIMCH1 LIM and calponin homology domains 1 0.0187345
DSPP dentin sialophosphoprotein 0.0186323
UBA6 ubiquitin-like modifier activating enzyme 6 0.0178911
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0168698
FHIT fragile histidine triad 0.0164125
RASA2 RAS p21 protein activator 2 0.0161055
TPM3 tropomyosin 3 0.0159265
MACF1 microtubule-actin crosslinking factor 1 0.0155213
RCOR1 REST corepressor 1 0.0150263
PDLIM5 PDZ and LIM domain 5 0.0150236
AFDN afadin, adherens junction formation factor 0.0148473
RAD51B RAD51 paralog B 0.0147788
ELL2 elongation factor, RNA polymerase II, 2 0.0146866
EXT1 exostosin glycosyltransferase 1 0.0143427
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0141957
USP9X ubiquitin specific peptidase 9, X-linked 0.0141578
NRIP1 nuclear receptor interacting protein 1 0.0139711
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0137224
NCKAP1 NCK-associated protein 1 0.0136929
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0135104
FAM13A family with sequence similarity 13, member A 0.0130578
GPCPD1 glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) 0.0127768
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.0127294
VMP1 vacuole membrane protein 1 0.0126552
ACTR3 ARP3 actin-related protein 3 homolog (yeast) 0.0124838
FNIP1 folliculin interacting protein 1 0.0122956
ZNF148 zinc finger protein 148 0.0122553
MBOAT2 membrane bound O-acyltransferase domain containing 2 0.011972
HSPA8 heat shock 70kDa protein 8 0.0119517
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.0117318
MYO6 myosin VI 0.0117209
WDFY3 WD repeat and FYVE domain containing 3 0.0116203
GSK3B glycogen synthase kinase 3 beta 0.0115875
MYO5B myosin VB 0.011465
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 0.0112479
MYO1B myosin IB 0.011036
PTBP2 polypyrimidine tract binding protein 2 0.0109595
YAP1 Yes-associated protein 1 0.0107658
CORO1C coronin, actin binding protein, 1C 0.010613
CPNE8 copine VIII 0.0105675
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0105022
ERBIN erbb2 interacting protein 0.0104563
NR3C2 nuclear receptor subfamily 3, group C, member 2 0.0104052
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.0102557
GLS2 glutaminase 2 (liver, mitochondrial) 0.0102327
FXR1 fragile X mental retardation, autosomal homolog 1 0.0102093
VPS13B vacuolar protein sorting 13 homolog B (yeast) 0.0101899
CCNY cyclin Y 0.0101696
RPL3 ribosomal protein L3 0.0100001
OCLN occludin 0.00984971
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase) 0.00982983
WAC WW domain containing adaptor with coiled-coil 0.00982135
KMT2C lysine (K)-specific methyltransferase 2C 0.0097914
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 0.00973413
ERRFI1 ERBB receptor feedback inhibitor 1 0.00954878
ATP2A2 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 0.00948316
DOCK5 dedicator of cytokinesis 5 0.00947857
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 0.00944886
PTEN phosphatase and tensin homolog 0.00937766
PAPOLA poly(A) polymerase alpha 0.00925743
SUCO SUN domain containing ossification factor 0.00918971
LNPEP leucyl/cystinyl aminopeptidase 0.00917193
SBF2 SET binding factor 2 0.00915618
DUSP10 dual specificity phosphatase 10 0.00911155
RAI14 retinoic acid induced 14 0.0090801
MICAL3 microtubule associated monooxygenase, calponin and LIM domain containing 3 0.00897955
MAP4K3 mitogen-activated protein kinase kinase kinase kinase 3 0.00891135
DST dystonin 0.0089075
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.00883973
CLTC clathrin, heavy chain (Hc) 0.00875175
UBE3A ubiquitin protein ligase E3A 0.00873815
SLMAP sarcolemma associated protein 0.00869011
ARHGEF3 Rho guanine nucleotide exchange factor (GEF) 3 0.00858483
RNF145 ring finger protein 145 0.0085573
CDKAL1 CDK5 regulatory subunit associated protein 1-like 1 0.00852827
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.00851509
UBE2E1 ubiquitin-conjugating enzyme E2E 1 0.00849976
BLTP1 bridge-like lipid transfer protein family member 1 0.00848796
WNK1 WNK lysine deficient protein kinase 1 0.00838319
TMF1 TATA element modulatory factor 1 0.00835108
PLS3 plastin 3 0.00834997
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.00834455

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.27899
FTL ferritin, light polypeptide -0.261823
PTMA prothymosin, alpha -0.179476
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.174782
ACTG1 actin gamma 1 -0.156388
TMSB10 thymosin beta 10 -0.154916
S100A6 S100 calcium binding protein A6 -0.138355
POTEF POTE ankyrin domain family, member F -0.107745
TPT1 tumor protein, translationally-controlled 1 -0.103906
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.103149
RPLP1 ribosomal protein, large, P1 -0.0931567
RPL35A ribosomal protein L35a -0.0915863
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0872209
S100A10 S100 calcium binding protein A10 -0.0773714
RPL8 ribosomal protein L8 -0.0738443
RPL34 ribosomal protein L34 -0.0715436
RPS8 ribosomal protein S8 -0.0681595
EIF1 eukaryotic translation initiation factor 1 -0.0661139
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0643689
MT2A metallothionein 2A -0.0629868
FN1 fibronectin 1 -0.0619662
RPS19 ribosomal protein S19 -0.0619541
HMGA1 high mobility group AT-hook 1 -0.0607786
RPL23 ribosomal protein L23 -0.0606382
SLC38A1 solute carrier family 38, member 1 -0.0599872
RACK1 receptor for activated C kinase 1 -0.0577704
RPS6 ribosomal protein S6 -0.0565505
LAMB3 laminin, beta 3 -0.0559538
ANXA2 annexin A2 -0.0557803
RPS3 ribosomal protein S3 -0.054833
TMSB4X thymosin beta 4, X-linked -0.0544104
RPLP2 ribosomal protein, large, P2 -0.0539622
GNAS GNAS complex locus -0.0531431
TM4SF1 transmembrane 4 L six family member 1 -0.0522135
ISG15 ISG15 ubiquitin-like modifier -0.051591
RPLP0 ribosomal protein, large, P0 -0.0510937
UBC ubiquitin C -0.0491661
RPS29 ribosomal protein S29 -0.048242
RPL12 ribosomal protein L12 -0.0478641
KRT7 keratin 7, type II -0.0477984
IFITM3 interferon induced transmembrane protein 3 -0.0477269
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0473502
RPL32 ribosomal protein L32 -0.0471723
RPS23 ribosomal protein S23 -0.0465483
BHLHE40 basic helix-loop-helix family, member e40 -0.0456463
ALCAM activated leukocyte cell adhesion molecule -0.0452837
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.044433
SQSTM1 sequestosome 1 -0.0443149
CSTB cystatin B (stefin B) -0.0441983
RPL19 ribosomal protein L19 -0.0441809
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0429464
IFI27 interferon, alpha-inducible protein 27 -0.0428394
RPS13 ribosomal protein S13 -0.0426652
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0415507
LOC112694756 uncharaterized LOC112694756 -0.041518
LMNA lamin A/C -0.0411962
LDHA lactate dehydrogenase A -0.0409707
G0S2 G0/G1 switch 2 -0.0401912
IFITM1 interferon induced transmembrane protein 1 -0.0394273
RPL30 ribosomal protein L30 -0.039352
NDRG1 N-myc downstream regulated 1 -0.0385189
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0384391
S100A9 S100 calcium binding protein A9 -0.0384273
RPL37 ribosomal protein L37 -0.0383767
RPS24 ribosomal protein S24 -0.0383125
RPS14 ribosomal protein S14 -0.0381474
ENO1 enolase 1, (alpha) -0.037463
RPL11 ribosomal protein L11 -0.0370252
CCND1 cyclin D1 -0.0368427
RPL27A ribosomal protein L27a -0.0357523
RPL28 ribosomal protein L28 -0.0355577
RPL37A ribosomal protein L37a -0.0352922
RPS27 ribosomal protein S27 -0.0350212
TPI1 triosephosphate isomerase 1 -0.0349925
RAD21 RAD21 homolog (S. pombe) -0.0348341
VIM vimentin -0.0344503
RPS27A ribosomal protein S27a -0.0343255
HMGB2 high mobility group box 2 -0.0337946
DDIT4 DNA-damage-inducible transcript 4 -0.0324831
RPS25 ribosomal protein S25 -0.0323927
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0321977
RPL15 ribosomal protein L15 -0.031784
CALR calreticulin -0.0317071
TPM4 tropomyosin 4 -0.0310856
RPL9 ribosomal protein L9 -0.0308433
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha -0.0307005
RPL36 ribosomal protein L36 -0.030665
EPCAM epithelial cell adhesion molecule -0.0306523
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0305769
PLAU plasminogen activator, urokinase -0.0305052
HLA-A major histocompatibility complex, class I, A -0.0303031
RPS5 ribosomal protein S5 -0.0300453
RPS21 ribosomal protein S21 -0.02991
RPL36A ribosomal protein L36a -0.0298615
RPL31 ribosomal protein L31 -0.0296137
CCNI cyclin I -0.0292328
RPS16 ribosomal protein S16 -0.0289748
IFI6 interferon, alpha-inducible protein 6 -0.028726
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0283742
ARF1 ADP-ribosylation factor 1 -0.0283429