Thymopentin_NCI-H460 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Thymopentin perturbation in NCI-H460 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Thymopentin_NCI-H460 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PDE4D phosphodiesterase 4D, cAMP-specific 0.135956
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0834102
FNDC3B fibronectin type III domain containing 3B 0.070237
EFNA5 ephrin-A5 0.0624125
EPB41L3 erythrocyte membrane protein band 4.1-like 3 0.0541172
DST dystonin 0.0470714
MCL1 myeloid cell leukemia 1 0.0468176
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0418296
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0416283
PDE10A phosphodiesterase 10A 0.0397268
AUTS2 autism susceptibility candidate 2 0.0385614
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 0.0363513
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0334379
ESYT2 extended synaptotagmin-like protein 2 0.0330753
KDM6A lysine (K)-specific demethylase 6A 0.0329651
PRELID2 PRELI domain containing 2 0.0320147
PDE3A phosphodiesterase 3A, cGMP-inhibited 0.0309714
VMP1 vacuole membrane protein 1 0.0297315
PSD3 pleckstrin and Sec7 domain containing 3 0.0289869
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.028976
KMT2E lysine (K)-specific methyltransferase 2E 0.0281677
STARD4 StAR-related lipid transfer (START) domain containing 4 0.0276856
TTC28 tetratricopeptide repeat domain 28 0.027665
COL5A2 collagen, type V, alpha 2 0.0274356
NCAM1 neural cell adhesion molecule 1 0.0273036
PTEN phosphatase and tensin homolog 0.0265901
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0260343
ELL2 elongation factor, RNA polymerase II, 2 0.0259719
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 0.025929
SMOC1 SPARC related modular calcium binding 1 0.0255753
P3H2 prolyl 3-hydroxylase 2 0.025431
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0254161
PCBP3 poly(rC) binding protein 3 0.0253969
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0253926
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0249855
NBEAL1 neurobeachin-like 1 0.0247208
ERRFI1 ERBB receptor feedback inhibitor 1 0.0245858
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0245528
SLC2A13 solute carrier family 2 (facilitated glucose transporter), member 13 0.024377
NBAS neuroblastoma amplified sequence 0.0242651
GPC6 glypican 6 0.0240159
AKAP13 A kinase (PRKA) anchor protein 13 0.0239126
TPM3 tropomyosin 3 0.0230075
NGLY1 N-glycanase 1 0.0224652
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0221587
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.021241
ZEB2 zinc finger E-box binding homeobox 2 0.0212163
RPL3 ribosomal protein L3 0.0208643
TGFBR1 transforming growth factor, beta receptor 1 0.0207369
COPA coatomer protein complex, subunit alpha 0.0205941
ZFC3H1 zinc finger, C3H1-type containing 0.0205476
CHD1 chromodomain helicase DNA binding protein 1 0.0204829
MTR 5-methyltetrahydrofolate-homocysteine methyltransferase 0.0204244
FAM13A family with sequence similarity 13, member A 0.0203401
AKT3 v-akt murine thymoma viral oncogene homolog 3 0.0202093
LSAMP limbic system-associated membrane protein 0.0202081
TENM3 teneurin transmembrane protein 3 0.0201703
FMNL2 formin-like 2 0.020119
MACF1 microtubule-actin crosslinking factor 1 0.0200371
FNIP1 folliculin interacting protein 1 0.0196693
MAP7 microtubule-associated protein 7 0.0193324
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 0.0192744
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 0.0191928
UBA6 ubiquitin-like modifier activating enzyme 6 0.0191823
MSN moesin 0.0191593
CHD1L chromodomain helicase DNA binding protein 1-like 0.0191305
ZNF638 zinc finger protein 638 0.019058
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) 0.0189727
ANO6 anoctamin 6 0.0187897
ATP13A3 ATPase type 13A3 0.0184658
TNIP1 TNFAIP3 interacting protein 1 0.0184349
SOD2 superoxide dismutase 2, mitochondrial 0.018314
DOCK5 dedicator of cytokinesis 5 0.0182326
SSBP2 single-stranded DNA binding protein 2 0.0180169
MYH9 myosin, heavy chain 9, non-muscle 0.0179609
SDK1 sidekick cell adhesion molecule 1 0.0179442
PAG1 phosphoprotein membrane anchor with glycosphingolipid microdomains 1 0.0178166
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0176478
AVL9 AVL9 homolog (S. cerevisiase) 0.0175586
GIGYF2 GRB10 interacting GYF protein 2 0.0174246
FNDC3A fibronectin type III domain containing 3A 0.0169494
COL4A6 collagen, type IV, alpha 6 0.0169465
PICALM phosphatidylinositol binding clathrin assembly protein 0.0169152
LIMCH1 LIM and calponin homology domains 1 0.0169031
SUCO SUN domain containing ossification factor 0.0167546
DOCK4 dedicator of cytokinesis 4 0.0167432
RNF145 ring finger protein 145 0.0166229
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa 0.0161805
PTPRM protein tyrosine phosphatase, receptor type, M 0.016166
WARS1 tryptophanyl-tRNA synthetase 1 0.0161635
HELZ helicase with zinc finger 0.0157941
PHF21A PHD finger protein 21A 0.0157526
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0156276
DNER delta/notch-like EGF repeat containing 0.015526
RICTOR RPTOR independent companion of MTOR, complex 2 0.0155222
SRPK2 SRSF protein kinase 2 0.015489
MYCBP2 MYC binding protein 2, E3 ubiquitin protein ligase 0.0153694
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0153187
MAML3 mastermind-like 3 (Drosophila) 0.0151801
CDC73 cell division cycle 73 0.014843

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.220785
TMSB10 thymosin beta 10 -0.127329
FN1 fibronectin 1 -0.120985
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.108518
TPT1 tumor protein, translationally-controlled 1 -0.092095
RPS6 ribosomal protein S6 -0.0831707
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0822865
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -0.0822695
FTL ferritin, light polypeptide -0.0797066
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0785419
RPLP1 ribosomal protein, large, P1 -0.0706367
PTMA prothymosin, alpha -0.0696317
RPL26 ribosomal protein L26 -0.0640923
RPS19 ribosomal protein S19 -0.0606382
RPL12 ribosomal protein L12 -0.059323
RPL31 ribosomal protein L31 -0.058499
EIF1 eukaryotic translation initiation factor 1 -0.0582992
TFPI2 tissue factor pathway inhibitor 2 -0.0567851
RPS8 ribosomal protein S8 -0.0565581
RPL37A ribosomal protein L37a -0.0562215
RPS24 ribosomal protein S24 -0.0554959
RPL23 ribosomal protein L23 -0.0532237
RPS3 ribosomal protein S3 -0.0523555
MT2A metallothionein 2A -0.0509728
RPL35A ribosomal protein L35a -0.0498667
RPL19 ribosomal protein L19 -0.04877
RPL9 ribosomal protein L9 -0.0469131
TXNRD1 thioredoxin reductase 1 -0.0466666
ACTG1 actin gamma 1 -0.045565
VIM vimentin -0.0439727
RPL7A ribosomal protein L7a -0.0428223
RPL11 ribosomal protein L11 -0.0428054
RPS12 ribosomal protein S12 -0.042208
RPLP0 ribosomal protein, large, P0 -0.0415503
GNAS GNAS complex locus -0.0415264
RPL34 ribosomal protein L34 -0.0402982
RPL36 ribosomal protein L36 -0.0402343
HLA-B major histocompatibility complex, class I, B -0.0399005
RPS29 ribosomal protein S29 -0.0397984
RPL13A ribosomal protein L13a -0.0397194
RPLP2 ribosomal protein, large, P2 -0.0390385
RACK1 receptor for activated C kinase 1 -0.0379213
NDRG1 N-myc downstream regulated 1 -0.0377952
RPL32 ribosomal protein L32 -0.0377631
S100A10 S100 calcium binding protein A10 -0.037313
BZW1 basic leucine zipper and W2 domains 1 -0.037297
RPL36A ribosomal protein L36a -0.0367299
RPS23 ribosomal protein S23 -0.0365011
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.0361684
SLC25A5 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 -0.0360564
RPL38 ribosomal protein L38 -0.0360267
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 -0.0355353
S100A6 S100 calcium binding protein A6 -0.0351507
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 -0.0349785
TNPO1 transportin 1 -0.0343459
LDHA lactate dehydrogenase A -0.0336942
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0336034
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0331686
RPS4X ribosomal protein S4, X-linked -0.0330658
RPS21 ribosomal protein S21 -0.0326698
NCOA7 nuclear receptor coactivator 7 -0.0321617
RPL35 ribosomal protein L35 -0.0309329
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.0305767
NAP1L1 nucleosome assembly protein 1-like 1 -0.0305375
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0302184
B2M beta-2-microglobulin -0.0300813
RPS27 ribosomal protein S27 -0.0300366
EIF4A1 eukaryotic translation initiation factor 4A1 -0.0299417
RPS16 ribosomal protein S16 -0.0297572
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0295693
RPL37 ribosomal protein L37 -0.0292905
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.029103
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) -0.027422
RPS25 ribosomal protein S25 -0.0273839
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 -0.0273019
VDAC1 voltage-dependent anion channel 1 -0.0272015
WSB1 WD repeat and SOCS box containing 1 -0.0265888
LOC112694756 uncharaterized LOC112694756 -0.0264814
RPS13 ribosomal protein S13 -0.0262609
DDIT4 DNA-damage-inducible transcript 4 -0.0260787
ISG15 ISG15 ubiquitin-like modifier -0.0260258
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.0259967
RPS5 ribosomal protein S5 -0.0252295
RPS14 ribosomal protein S14 -0.0251008
SMYD3 SET and MYND domain containing 3 -0.025011
SLC25A6 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 6 -0.0249802
AKR1C1 aldo-keto reductase family 1, member C1 -0.0249194
ABCC2 ATP-binding cassette, sub-family C (CFTR/MRP), member 2 -0.0249133
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0244155
ARF1 ADP-ribosylation factor 1 -0.0242826
RPS27A ribosomal protein S27a -0.0242409
RPS11 ribosomal protein S11 -0.0238865
RPL28 ribosomal protein L28 -0.0238627
RPL5 ribosomal protein L5 -0.0238292
SRGN serglycin -0.0236527
RPL18 ribosomal protein L18 -0.0236294
SQSTM1 sequestosome 1 -0.0227842
RPS15 ribosomal protein S15 -0.0218001
IER3 immediate early response 3 -0.0217667
RPS17 ribosomal protein S17 -0.0216539