Thymopentin_NCI-H596 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Thymopentin perturbation in NCI-H596 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Thymopentin_NCI-H596 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.127127
TRIO trio Rho guanine nucleotide exchange factor 0.105421
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0959929
TSC22D2 TSC22 domain family, member 2 0.0894161
MED13L mediator complex subunit 13-like 0.0834414
SSBP2 single-stranded DNA binding protein 2 0.0831909
HELZ helicase with zinc finger 0.08146
FOXJ3 forkhead box J3 0.0778346
KDM3A lysine (K)-specific demethylase 3A 0.077494
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) 0.0757899
EPS8 epidermal growth factor receptor pathway substrate 8 0.0756041
CD109 CD109 molecule 0.0700286
MARCHF6 membrane associated ring-CH-type finger 6 0.0682105
MATR3 matrin 3 0.0679266
LIMCH1 LIM and calponin homology domains 1 0.0668052
NF1 neurofibromin 1 0.0665414
RTN4 reticulon 4 0.0662461
RBM39 RNA binding motif protein 39 0.0652341
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0625315
PCBP2 poly(rC) binding protein 2 0.0603376
PNISR PNN-interacting serine/arginine-rich protein 0.0591779
NAMPT nicotinamide phosphoribosyltransferase 0.0588451
AK1 adenylate kinase 1 0.0587368
PNPLA8 patatin-like phospholipase domain containing 8 0.0583874
TXNRD1 thioredoxin reductase 1 0.0568974
NCOR1 nuclear receptor corepressor 1 0.0558147
PTK2 protein tyrosine kinase 2 0.0547639
DENND1A DENN/MADD domain containing 1A 0.0545237
SRSF11 serine/arginine-rich splicing factor 11 0.0525291
AHNAK AHNAK nucleoprotein 0.0523446
RAB1A RAB1A, member RAS oncogene family 0.0504376
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0498732
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0494265
SPATS2L spermatogenesis associated, serine-rich 2-like 0.0478705
ZNF292 zinc finger protein 292 0.0470549
YTHDC1 YTH domain containing 1 0.0457444
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific ) 0.0439962
ANKRD17 ankyrin repeat domain 17 0.0439444
ZFAND3 zinc finger, AN1-type domain 3 0.0404844
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0395875
PRELID2 PRELI domain containing 2 0.0382042
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0352594
ERBIN erbb2 interacting protein 0.0350792
KMT2C lysine (K)-specific methyltransferase 2C 0.0346198
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0327052
NPEPPS aminopeptidase puromycin sensitive 0.0325439
MAML3 mastermind-like 3 (Drosophila) 0.0323454
RLF rearranged L-myc fusion 0.0310848
CTBP2 C-terminal binding protein 2 0.030344
TCF12 transcription factor 12 0.0297357
GLG1 golgi glycoprotein 1 0.0289782
GOLGA4 golgin A4 0.0285054
SBF2 SET binding factor 2 0.027734
RPS23 ribosomal protein S23 0.0275634
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.0273027
ANXA2 annexin A2 0.0272486
PRRC2C proline-rich coiled-coil 2C 0.0253946
S100A10 S100 calcium binding protein A10 0.0251099
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0250108
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 0.0249286
DST dystonin 0.0247549
FAM13A family with sequence similarity 13, member A 0.0245205
CLTC clathrin, heavy chain (Hc) 0.0241967
MAP3K2 mitogen-activated protein kinase kinase kinase 2 0.0240093
MYCBP2 MYC binding protein 2, E3 ubiquitin protein ligase 0.0232361
RNF213 ring finger protein 213 0.023216
VCL vinculin 0.0225643
UBE2H ubiquitin-conjugating enzyme E2H 0.0224605
TTC3 tetratricopeptide repeat domain 3 0.0224125
SETD5 SET domain containing 5 0.0219416
TPT1 tumor protein, translationally-controlled 1 0.0212273
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0206172
FMNL2 formin-like 2 0.020464
MAP4K5 mitogen-activated protein kinase kinase kinase kinase 5 0.0193811
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 0.0169402
RPLP1 ribosomal protein, large, P1 0.0164428
NAP1L1 nucleosome assembly protein 1-like 1 0.0160158
GMDS GDP-mannose 4,6-dehydratase 0.0151967
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0150406
PDE10A phosphodiesterase 10A 0.0147911
FTL ferritin, light polypeptide 0.0139179
ESYT2 extended synaptotagmin-like protein 2 0.0135898
FNDC3B fibronectin type III domain containing 3B 0.0117874
CHD9 chromodomain helicase DNA binding protein 9 0.0117697
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) 0.0114485
PAN3 PAN3 poly(A) specific ribonuclease subunit 0.0113107
BIRC6 baculoviral IAP repeat containing 6 0.010513
PARD3 par-3 family cell polarity regulator 0.0099717
ZMYM2 zinc finger, MYM-type 2 0.00935762
ATXN1 ataxin 1 0.00859754
PICALM phosphatidylinositol binding clathrin assembly protein 0.00850366
MYO1E myosin IE 0.00841096
EXT1 exostosin glycosyltransferase 1 0.00759358
WSB1 WD repeat and SOCS box containing 1 0.00669049
MDGA2 MAM domain containing glycosylphosphatidylinositol anchor 2 0.00662945
SAMD4A sterile alpha motif domain containing 4A 0.00529547
RPL31 ribosomal protein L31 0.00511583
ACTN4 actinin, alpha 4 0.00499141
ENO1 enolase 1, (alpha) 0.00483571
NALF1 NALCN channel auxiliary factor 1 0.0046846

decreased expression

Symbol Name Standardized Value
FN1 fibronectin 1 -0.216501
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) -0.145031
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.142068
VIM vimentin -0.125502
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0838143
IGFBP5 insulin-like growth factor binding protein 5 -0.0771571
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.0769844
TMSB10 thymosin beta 10 -0.0743414
PDLIM5 PDZ and LIM domain 5 -0.0741394
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) -0.0714899
PALM2AKAP2 PALM2 and AKAP2 fusion -0.0594987
ASPH aspartate beta-hydroxylase -0.0590283
GRAMD1B GRAM domain containing 1B -0.0571278
FRMD4A FERM domain containing 4A -0.0566105
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0555522
COPA coatomer protein complex, subunit alpha -0.0526984
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0519975
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 -0.0517864
LRP1B low density lipoprotein receptor-related protein 1B -0.0504974
LMO7 LIM domain 7 -0.0496295
HMGA2 high mobility group AT-hook 2 -0.0496231
B2M beta-2-microglobulin -0.0482565
ARID4B AT rich interactive domain 4B (RBP1-like) -0.047877
RPL37A ribosomal protein L37a -0.0478154
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0475581
RPL35A ribosomal protein L35a -0.0475321
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.046678
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0466482
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.0461502
LSAMP limbic system-associated membrane protein -0.0455917
AKAP12 A kinase (PRKA) anchor protein 12 -0.0455108
RPS3 ribosomal protein S3 -0.0414621
SLC38A1 solute carrier family 38, member 1 -0.0407219
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type -0.0406498
INHBA inhibin, beta A -0.0398525
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0394669
EZR ezrin -0.036902
MON2 MON2 homolog (S. cerevisiae) -0.0368647
CANX calnexin -0.0368128
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0361055
RASA3 RAS p21 protein activator 3 -0.03582
NPAS2 neuronal PAS domain protein 2 -0.0357043
IGF2 insulin-like growth factor 2 -0.035185
KDM5B lysine (K)-specific demethylase 5B -0.0350849
ACTG1 actin gamma 1 -0.0350798
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0338216
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -0.0331262
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0328661
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1 -0.0321697
PKM pyruvate kinase, muscle -0.0312336
MAP2K1 mitogen-activated protein kinase kinase 1 -0.0304689
GCC2 GRIP and coiled-coil domain containing 2 -0.0293713
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0288716
RPL12 ribosomal protein L12 -0.0275579
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) -0.0267669
PRKCA protein kinase C, alpha -0.0264588
MYOF myoferlin -0.0263748
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 -0.025898
JMJD1C jumonji domain containing 1C -0.0253904
CDH13 cadherin 13 -0.0251106
TPM4 tropomyosin 4 -0.0248809
MMP1 matrix metallopeptidase 1 -0.0245211
RPS19 ribosomal protein S19 -0.0239225
SLK STE20-like kinase -0.023919
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0238248
SRPK2 SRSF protein kinase 2 -0.0237381
RPL23 ribosomal protein L23 -0.0235592
BPTF bromodomain PHD finger transcription factor -0.0232611
NDRG1 N-myc downstream regulated 1 -0.022661
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 -0.0225352
SLC38A2 solute carrier family 38, member 2 -0.022324
PDE4D phosphodiesterase 4D, cAMP-specific -0.021634
IGFBP3 insulin-like growth factor binding protein 3 -0.0212755
SMYD3 SET and MYND domain containing 3 -0.0208699
ZBTB20 zinc finger and BTB domain containing 20 -0.0206077
GPC6 glypican 6 -0.0205821
GPBP1 GC-rich promoter binding protein 1 -0.0202435
SND1 staphylococcal nuclease and tudor domain containing 1 -0.0201162
NSMCE2 non-SMC element 2, MMS21 homolog (S. cerevisiae) -0.0198202
NKD1 naked cuticle homolog 1 (Drosophila) -0.0196632
WWP2 WW domain containing E3 ubiquitin protein ligase 2 -0.0188622
MACF1 microtubule-actin crosslinking factor 1 -0.0177791
RPS6 ribosomal protein S6 -0.0170945
CDC42BPB CDC42 binding protein kinase beta (DMPK-like) -0.015969
USP34 ubiquitin specific peptidase 34 -0.0153968
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.0153768
ERC2 ELKS/RAB6-interacting/CAST family member 2 -0.0149568
OXR1 oxidation resistance 1 -0.0148927
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) -0.0148575
RPL19 ribosomal protein L19 -0.0144678
SEC31A SEC31 homolog A (S. cerevisiae) -0.0143953
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0142214
MED13 mediator complex subunit 13 -0.013844
FLNB filamin B, beta -0.0138059
NAV2 neuron navigator 2 -0.0133728
LAMB3 laminin, beta 3 -0.0133169
SEPTIN9 septin 9 -0.0132579
TNS3 tensin 3 -0.0131016
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0127246
ARID1B AT rich interactive domain 1B (SWI1-like) -0.0115559