Thymopentin_NCI-H661 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Thymopentin perturbation in NCI-H661 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Thymopentin_NCI-H661 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PEG10 paternally expressed 10 0.106948
TSC22D2 TSC22 domain family, member 2 0.104303
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0847559
ZNF292 zinc finger protein 292 0.0661425
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0628009
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0580233
ADAM9 ADAM metallopeptidase domain 9 0.0521984
USP3 ubiquitin specific peptidase 3 0.0512224
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 0.0450197
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.044412
FXR1 fragile X mental retardation, autosomal homolog 1 0.0437212
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 0.0432889
KMT2E lysine (K)-specific methyltransferase 2E 0.0412105
PSMA6 proteasome (prosome, macropain) subunit, alpha type, 6 0.0385536
NCKAP1 NCK-associated protein 1 0.0384534
MTF2 metal response element binding transcription factor 2 0.0383873
YES1 YES proto-oncogene 1, Src family tyrosine kinase 0.0382601
MATR3 matrin 3 0.0379303
PUM1 pumilio RNA-binding family member 1 0.0374166
CDC73 cell division cycle 73 0.0373597
PDGFC platelet derived growth factor C 0.0369499
ZFAND3 zinc finger, AN1-type domain 3 0.0367417
APP amyloid beta (A4) precursor protein 0.0364444
STRN3 striatin, calmodulin binding protein 3 0.0360749
TRIO trio Rho guanine nucleotide exchange factor 0.0360723
RHEB Ras homolog enriched in brain 0.0359429
HNRNPH3 heterogeneous nuclear ribonucleoprotein H3 (2H9) 0.0352641
RTN4 reticulon 4 0.034857
ZEB2 zinc finger E-box binding homeobox 2 0.0346851
FIP1L1 factor interacting with PAPOLA and CPSF1 0.0346276
RLF rearranged L-myc fusion 0.0345873
GPBP1 GC-rich promoter binding protein 1 0.03451
LUC7L2 LUC7-like 2 (S. cerevisiae) 0.0343358
PGAP1 post-GPI attachment to proteins 1 0.0335462
FNDC3B fibronectin type III domain containing 3B 0.0332287
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0330596
PARD3 par-3 family cell polarity regulator 0.032937
RYBP RING1 and YY1 binding protein 0.0327035
SETD5 SET domain containing 5 0.0321719
TXNRD1 thioredoxin reductase 1 0.0320632
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0317064
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0315916
ANKRD33B ankyrin repeat domain 33B 0.0314853
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0311092
MEMO1 mediator of cell motility 1 0.0310361
RBM39 RNA binding motif protein 39 0.030651
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0306398
TMSB4X thymosin beta 4, X-linked 0.030612
CNOT4 CCR4-NOT transcription complex, subunit 4 0.0304509
FUBP1 far upstream element (FUSE) binding protein 1 0.0303712
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0302242
OSBPL8 oxysterol binding protein-like 8 0.0301869
MYH9 myosin, heavy chain 9, non-muscle 0.0301791
CFL2 cofilin 2 (muscle) 0.0293178
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta 0.0286562
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0286361
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0282856
ZNF608 zinc finger protein 608 0.0282828
UBE2D3 ubiquitin-conjugating enzyme E2D 3 0.0280842
NUP58 nucleoporin 58 0.0274411
ENAH enabled homolog (Drosophila) 0.0274206
POLR2B polymerase (RNA) II (DNA directed) polypeptide B, 140kDa 0.0272053
MEF2A myocyte enhancer factor 2A 0.0271688
SPAG9 sperm associated antigen 9 0.0270844
TM7SF3 transmembrane 7 superfamily member 3 0.0267633
VAPA VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa 0.0265495
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0263754
WDR43 WD repeat domain 43 0.0263735
ELF2 E74-like factor 2 (ets domain transcription factor) 0.026277
CSE1L CSE1 chromosome segregation 1-like (yeast) 0.0262554
DST dystonin 0.0262419
TPM3 tropomyosin 3 0.026225
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein 0.0260058
PRRC2C proline-rich coiled-coil 2C 0.0259719
H1-4 H1.4 linker histone, cluster member 0.0255657
QKI QKI, KH domain containing, RNA binding 0.0255329
TLK2 tousled-like kinase 2 0.0255272
OLA1 Obg-like ATPase 1 0.0254291
CLTC clathrin, heavy chain (Hc) 0.025375
ACSL3 acyl-CoA synthetase long-chain family member 3 0.0253725
NEK7 NIMA-related kinase 7 0.0251472
FEM1C fem-1 homolog c (C. elegans) 0.0249433
MED13L mediator complex subunit 13-like 0.0249426
KIF5B kinesin family member 5B 0.0248883
CTNNBL1 catenin, beta like 1 0.0248646
DNAJC1 DnaJ (Hsp40) homolog, subfamily C, member 1 0.0247674
RAB8B RAB8B, member RAS oncogene family 0.0247652
PTK2 protein tyrosine kinase 2 0.0247636
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa 0.0243533
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0243313
GSK3B glycogen synthase kinase 3 beta 0.0243099
TBC1D12 TBC1 domain family, member 12 0.0240958
KDM6A lysine (K)-specific demethylase 6A 0.0240082
PPP1R12A protein phosphatase 1, regulatory subunit 12A 0.0240048
NAMPT nicotinamide phosphoribosyltransferase 0.0239796
FNBP1L formin binding protein 1-like 0.0239181
ANKRD11 ankyrin repeat domain 11 0.0238946
FAM168A family with sequence similarity 168, member A 0.0237242
ANXA2 annexin A2 0.0234601
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0233353

decreased expression

Symbol Name Standardized Value
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.175577
CADM2 cell adhesion molecule 2 -0.171365
CDH6 cadherin 6, type 2, K-cadherin (fetal kidney) -0.126942
COL11A1 collagen, type XI, alpha 1 -0.123431
CTNNA2 catenin (cadherin-associated protein), alpha 2 -0.12085
ERBB4 erb-b2 receptor tyrosine kinase 4 -0.119217
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0910902
PCDH9 protocadherin 9 -0.0902136
CDH10 cadherin 10, type 2 (T2-cadherin) -0.0813263
HS3ST5 heparan sulfate (glucosamine) 3-O-sulfotransferase 5 -0.0799761
ADGRL2 adhesion G protein-coupled receptor L2 -0.0773082
ADGRV1 adhesion G protein-coupled receptor V1 -0.0768189
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0642704
CTNNA3 catenin (cadherin-associated protein), alpha 3 -0.0640596
RALGAPA1 Ral GTPase activating protein, alpha subunit 1 (catalytic) -0.0639049
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0626791
HCN1 hyperpolarization activated cyclic nucleotide gated potassium channel 1 -0.0614756
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats -0.059369
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0591408
TMSB10 thymosin beta 10 -0.0591377
SIPA1L3 signal-induced proliferation-associated 1 like 3 -0.056828
PHIP pleckstrin homology domain interacting protein -0.0556391
GPC3 glypican 3 -0.055248
PCLO piccolo presynaptic cytomatrix protein -0.0545763
SLIT2 slit homolog 2 (Drosophila) -0.0539765
LRRC4C leucine rich repeat containing 4C -0.052222
NEBL nebulette -0.0512202
PARD3B par-3 family cell polarity regulator beta -0.0510165
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) -0.045843
NHSL1 NHS-like 1 -0.0447801
SMYD3 SET and MYND domain containing 3 -0.0445547
CSMD3 CUB and Sushi multiple domains 3 -0.043898
RAD51B RAD51 paralog B -0.0429073
RPS8 ribosomal protein S8 -0.0417338
HMCN1 hemicentin 1 -0.0404599
HS6ST2 heparan sulfate 6-O-sulfotransferase 2 -0.0399057
BACH2 BTB and CNC homology 1, basic leucine zipper transcription factor 2 -0.0377057
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C -0.0375267
GULP1 GULP, engulfment adaptor PTB domain containing 1 -0.0357547
NTM neurotrimin -0.0355365
MDK midkine (neurite growth-promoting factor 2) -0.035298
KCTD16 potassium channel tetramerization domain containing 16 -0.0349946
WSB1 WD repeat and SOCS box containing 1 -0.0346192
RPS27A ribosomal protein S27a -0.0342477
COLGALT2 collagen beta(1-O)galactosyltransferase 2 -0.0341116
TPT1 tumor protein, translationally-controlled 1 -0.0329086
COL5A2 collagen, type V, alpha 2 -0.0326919
ADGRL3 adhesion G protein-coupled receptor L3 -0.0325488
TENM3 teneurin transmembrane protein 3 -0.0324454
CDH19 cadherin 19, type 2 -0.0318619
TAS2R14 taste receptor, type 2, member 14 -0.0317785
CUX1 cut-like homeobox 1 -0.0316569
CDK13 cyclin-dependent kinase 13 -0.0308091
ENO1 enolase 1, (alpha) -0.03073
FOXP2 forkhead box P2 -0.0306652
GALNTL6 polypeptide N-acetylgalactosaminyltransferase-like 6 -0.0305876
BPTF bromodomain PHD finger transcription factor -0.0305556
GNAS GNAS complex locus -0.0304991
MEF2C myocyte enhancer factor 2C -0.0304797
RPS6 ribosomal protein S6 -0.030473
GSE1 Gse1 coiled-coil protein -0.0303337
NXN nucleoredoxin -0.0300248
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 -0.0290922
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 -0.029043
RPL37A ribosomal protein L37a -0.0289144
NRG1 neuregulin 1 -0.0287229
MEIS2 Meis homeobox 2 -0.0285696
SAMD4A sterile alpha motif domain containing 4A -0.0282974
SCFD1 sec1 family domain containing 1 -0.0282573
PRELID2 PRELI domain containing 2 -0.0280268
SLC44A5 solute carrier family 44, member 5 -0.0276432
SIK2 salt-inducible kinase 2 -0.0273942
CDH4 cadherin 4, type 1, R-cadherin (retinal) -0.0271437
VPS13B vacuolar protein sorting 13 homolog B (yeast) -0.0270382
NCAM2 neural cell adhesion molecule 2 -0.0267902
COL3A1 collagen, type III, alpha 1 -0.0264628
PBX3 pre-B-cell leukemia homeobox 3 -0.025306
ACTG1 actin gamma 1 -0.0251697
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0250372
GPATCH8 G patch domain containing 8 -0.0249915
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0249338
FST follistatin -0.0246374
INTS6 integrator complex subunit 6 -0.0245932
NPAS3 neuronal PAS domain protein 3 -0.024175
GARRE1 granule associated Rac and RHOG effector 1 -0.0241319
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 -0.0241248
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0237899
RPL9 ribosomal protein L9 -0.0236441
IRF2BP2 interferon regulatory factor 2 binding protein 2 -0.0235095
FAM177A1 family with sequence similarity 177, member A1 -0.0233577
AKAP9 A kinase (PRKA) anchor protein 9 -0.023287
PHACTR4 phosphatase and actin regulator 4 -0.0232365
ADGRG6 adhesion G protein-coupled receptor G6 -0.0230697
ZFPM2 zinc finger protein, FOG family member 2 -0.0228985
RPS16 ribosomal protein S16 -0.0227616
KDM4B lysine (K)-specific demethylase 4B -0.0227391
BCAS3 breast carcinoma amplified sequence 3 -0.0223815
RPL37 ribosomal protein L37 -0.0223676
RPL23 ribosomal protein L23 -0.0222925
SREBF2 sterol regulatory element binding transcription factor 2 -0.0222635