Thymopentin_SNU-423 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Thymopentin perturbation in SNU-423 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Thymopentin_SNU-423 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
SOD2 superoxide dismutase 2, mitochondrial 0.167658
NAMPT nicotinamide phosphoribosyltransferase 0.152594
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.119654
MYH9 myosin, heavy chain 9, non-muscle 0.102227
NAV2 neuron navigator 2 0.0904738
FNDC3B fibronectin type III domain containing 3B 0.0797139
ELL2 elongation factor, RNA polymerase II, 2 0.0754916
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0748382
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0746374
FRMD4A FERM domain containing 4A 0.0719881
CD44 CD44 molecule (Indian blood group) 0.0654715
UBA6 ubiquitin-like modifier activating enzyme 6 0.0555683
UGCG UDP-glucose ceramide glucosyltransferase 0.0555185
TRIO trio Rho guanine nucleotide exchange factor 0.0491482
TNIP1 TNFAIP3 interacting protein 1 0.049018
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0481626
TENT5A terminal nucleotidyltransferase 5A 0.0480267
FN1 fibronectin 1 0.0472419
PGK1 phosphoglycerate kinase 1 0.0423202
SPAG9 sperm associated antigen 9 0.041188
PDE10A phosphodiesterase 10A 0.0409446
MXI1 MAX interactor 1, dimerization protein 0.0408278
ATP13A3 ATPase type 13A3 0.0400982
CENPF centromere protein F, 350/400kDa 0.0391219
LAMP2 lysosomal-associated membrane protein 2 0.0383379
ZNF292 zinc finger protein 292 0.0380092
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0376609
RB1CC1 RB1-inducible coiled-coil 1 0.0369034
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0368697
MSN moesin 0.0363824
RTN4 reticulon 4 0.0362783
STC1 stanniocalcin 1 0.0361029
SMAD3 SMAD family member 3 0.036016
ANLN anillin, actin binding protein 0.0351928
PHLDB2 pleckstrin homology-like domain, family B, member 2 0.0350917
SNX9 sorting nexin 9 0.0331105
VMP1 vacuole membrane protein 1 0.0312698
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.0311115
DST dystonin 0.0311062
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.031032
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 0.031015
DENND5A DENN/MADD domain containing 5A 0.0302737
SBF2 SET binding factor 2 0.0299514
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0298932
USP9X ubiquitin specific peptidase 9, X-linked 0.0298763
MKI67 marker of proliferation Ki-67 0.0296044
COL8A1 collagen, type VIII, alpha 1 0.0287875
CKAP5 cytoskeleton associated protein 5 0.0283998
SDC4 syndecan 4 0.0281078
CDCP1 CUB domain containing protein 1 0.027927
EDIL3 EGF-like repeats and discoidin I-like domains 3 0.027484
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) 0.0271253
XRN1 5'-3' exoribonuclease 1 0.0270976
TPM4 tropomyosin 4 0.0268585
FMNL2 formin-like 2 0.0254807
PARP14 poly (ADP-ribose) polymerase family, member 14 0.0251565
TXNRD1 thioredoxin reductase 1 0.0250992
SMC4 structural maintenance of chromosomes 4 0.024995
JMJD1C jumonji domain containing 1C 0.0248068
KMT2E lysine (K)-specific methyltransferase 2E 0.0247859
DIAPH3 diaphanous-related formin 3 0.0247329
APP amyloid beta (A4) precursor protein 0.0247277
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0244644
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0243425
PTBP3 polypyrimidine tract binding protein 3 0.024239
ERRFI1 ERBB receptor feedback inhibitor 1 0.0239407
IGFN1 immunoglobulin-like and fibronectin type III domain containing 1 0.0237058
WTAP Wilms tumor 1 associated protein 0.0235517
TMSB4X thymosin beta 4, X-linked 0.0235125
BIRC3 baculoviral IAP repeat containing 3 0.0233799
LCORL ligand dependent nuclear receptor corepressor-like 0.0229412
MYOF myoferlin 0.0229011
OGA O-GlcNAcase 0.0228031
PTPN1 protein tyrosine phosphatase, non-receptor type 1 0.0227346
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0224114
BIRC2 baculoviral IAP repeat containing 2 0.0223774
TPX2 TPX2, microtubule-associated 0.0221733
IL6ST interleukin 6 signal transducer 0.0220016
BRWD3 bromodomain and WD repeat domain containing 3 0.021887
AKAP12 A kinase (PRKA) anchor protein 12 0.0217019
ARRDC3 arrestin domain containing 3 0.0215668
PRKCSH protein kinase C substrate 80K-H 0.0215061
FNIP1 folliculin interacting protein 1 0.021506
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 0.0214751
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 0.0212688
HDAC8 histone deacetylase 8 0.0211559
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 0.0208298
AMPD3 adenosine monophosphate deaminase 3 0.0208146
KIF4A kinesin family member 4A 0.0207017
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0206924
ERBIN erbb2 interacting protein 0.0204871
UBE2E1 ubiquitin-conjugating enzyme E2E 1 0.0204013
SYAP1 synapse associated protein 1 0.0200012
MX1 MX dynamin-like GTPase 1 0.0195114
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0194413
TAS2R14 taste receptor, type 2, member 14 0.0193604
VCAN versican 0.0192204
ACSL4 acyl-CoA synthetase long-chain family member 4 0.0191662
WDR26 WD repeat domain 26 0.0190573
FMN1 formin 1 0.0190435

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0962527
TMSB10 thymosin beta 10 -0.0830902
FTL ferritin, light polypeptide -0.0819346
RPS6 ribosomal protein S6 -0.0796833
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0779645
MT2A metallothionein 2A -0.0714428
TPT1 tumor protein, translationally-controlled 1 -0.0674834
RPS3 ribosomal protein S3 -0.0625736
RPL37A ribosomal protein L37a -0.0536801
HLA-B major histocompatibility complex, class I, B -0.0528318
RPLP2 ribosomal protein, large, P2 -0.0516891
NDRG1 N-myc downstream regulated 1 -0.0514331
RPL23 ribosomal protein L23 -0.0514307
RPS12 ribosomal protein S12 -0.051262
VIM vimentin -0.0476329
RPS23 ribosomal protein S23 -0.0446158
IGFBP3 insulin-like growth factor binding protein 3 -0.0444162
INTS6 integrator complex subunit 6 -0.0426341
CDH13 cadherin 13 -0.0418107
RPS19 ribosomal protein S19 -0.0411973
RPS4X ribosomal protein S4, X-linked -0.0402111
RPL35A ribosomal protein L35a -0.0397503
RPL9 ribosomal protein L9 -0.0385378
IER3 immediate early response 3 -0.0382358
RPS8 ribosomal protein S8 -0.0375226
RPLP1 ribosomal protein, large, P1 -0.0358142
RPL32 ribosomal protein L32 -0.0343653
RPS13 ribosomal protein S13 -0.0335271
RPS24 ribosomal protein S24 -0.0330686
RPL19 ribosomal protein L19 -0.0316432
RPL36A ribosomal protein L36a -0.0312847
RPS10 ribosomal protein S10 -0.0311331
RPL31 ribosomal protein L31 -0.0305037
RPL26 ribosomal protein L26 -0.0300599
RPL5 ribosomal protein L5 -0.0287777
RPS29 ribosomal protein S29 -0.0280169
RPL36 ribosomal protein L36 -0.0280104
WSB1 WD repeat and SOCS box containing 1 -0.0276901
RPS14 ribosomal protein S14 -0.0270594
RPL7A ribosomal protein L7a -0.0268922
RPS27A ribosomal protein S27a -0.0263108
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 -0.0261299
RAB7A RAB7A, member RAS oncogene family -0.0253814
EGR1 early growth response 1 -0.0251534
COL5A1 collagen, type V, alpha 1 -0.0250737
RPS16 ribosomal protein S16 -0.0248424
ENO2 enolase 2 (gamma, neuronal) -0.0241401
RPL38 ribosomal protein L38 -0.0236206
TMEM132D transmembrane protein 132D -0.0231497
RACK1 receptor for activated C kinase 1 -0.0229653
ACTG1 actin gamma 1 -0.0229327
RPL35 ribosomal protein L35 -0.0227099
HLA-A major histocompatibility complex, class I, A -0.022594
RPL12 ribosomal protein L12 -0.0223933
RPS5 ribosomal protein S5 -0.0218418
RPS25 ribosomal protein S25 -0.0217825
RPS11 ribosomal protein S11 -0.0217356
RPS21 ribosomal protein S21 -0.0216222
RPL27A ribosomal protein L27a -0.0215854
RPL28 ribosomal protein L28 -0.0214707
S100A9 S100 calcium binding protein A9 -0.0214426
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0213809
RPL18 ribosomal protein L18 -0.0212447
CTSD cathepsin D -0.0210828
RPL8 ribosomal protein L8 -0.0210528
PTMA prothymosin, alpha -0.0203801
IFITM3 interferon induced transmembrane protein 3 -0.0203317
RPL13A ribosomal protein L13a -0.0202946
TGFBI transforming growth factor, beta-induced, 68kDa -0.0198461
TBCA tubulin folding cofactor A -0.0196491
RPS15 ribosomal protein S15 -0.0187772
RPL34 ribosomal protein L34 -0.0187069
RPL15 ribosomal protein L15 -0.0182187
AFF3 AF4/FMR2 family, member 3 -0.0182042
RPL37 ribosomal protein L37 -0.0180867
NAP1L1 nucleosome assembly protein 1-like 1 -0.0174015
GNAS GNAS complex locus -0.0173791
SLC25A5 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 -0.0173205
RPL7 ribosomal protein L7 -0.0172205
HMGA2 high mobility group AT-hook 2 -0.0171883
EFNA5 ephrin-A5 -0.0168353
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0167099
FRMPD4 FERM and PDZ domain containing 4 -0.0166109
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.0163812
VDAC1 voltage-dependent anion channel 1 -0.0163512
RPS20 ribosomal protein S20 -0.016245
HMGA1 high mobility group AT-hook 1 -0.0160981
RPS17 ribosomal protein S17 -0.0159723
SFTPA2 surfactant protein A2 -0.0158859
PRKCA protein kinase C, alpha -0.0158648
RPS27 ribosomal protein S27 -0.015683
EIF1 eukaryotic translation initiation factor 1 -0.01546
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0152407
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.0149828
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0148929
KDM4B lysine (K)-specific demethylase 4B -0.0148846
SAMD3 sterile alpha motif domain containing 3 -0.0148089
EIF4A1 eukaryotic translation initiation factor 4A1 -0.0147716
COL6A1 collagen, type VI, alpha 1 -0.0144493
UBA52 ubiquitin A-52 residue ribosomal protein fusion product 1 -0.0142812