Thymopentin_SW 1088 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Thymopentin perturbation in SW 1088 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Thymopentin_SW 1088 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
SPARC secreted protein, acidic, cysteine-rich (osteonectin) 0.114346
ZC3HAV1 zinc finger CCCH-type, antiviral 1 0.0935784
RNF145 ring finger protein 145 0.0773188
UBA6 ubiquitin-like modifier activating enzyme 6 0.0766256
IGFBP7 insulin-like growth factor binding protein 7 0.0737913
KMT2E lysine (K)-specific methyltransferase 2E 0.0686954
TNKS tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 0.0626526
SBF2 SET binding factor 2 0.0624836
CALD1 caldesmon 1 0.0598491
TENT5A terminal nucleotidyltransferase 5A 0.0561817
KLF7 Kruppel-like factor 7 (ubiquitous) 0.0509539
NAMPT nicotinamide phosphoribosyltransferase 0.0506892
RPS6 ribosomal protein S6 0.04996
CELF1 CUGBP, Elav-like family member 1 0.0488826
KYNU kynureninase 0.0484332
ANKRD11 ankyrin repeat domain 11 0.0473445
ATP13A3 ATPase type 13A3 0.0465081
PGK1 phosphoglycerate kinase 1 0.0437254
SNAP25 synaptosomal-associated protein, 25kDa 0.0433644
PSD3 pleckstrin and Sec7 domain containing 3 0.0432236
MED13L mediator complex subunit 13-like 0.0430438
COG5 component of oligomeric golgi complex 5 0.04207
RLF rearranged L-myc fusion 0.0412888
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0411622
AHR aryl hydrocarbon receptor 0.0408006
KIAA1217 KIAA1217 0.0401128
NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta 0.0394048
PRRC2C proline-rich coiled-coil 2C 0.0393266
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0390586
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.0388964
TPM3 tropomyosin 3 0.038871
ZBTB20 zinc finger and BTB domain containing 20 0.0387825
YBX1 Y box binding protein 1 0.0387358
ARHGAP32 Rho GTPase activating protein 32 0.0385861
LAMB1 laminin, beta 1 0.0385122
PICALM phosphatidylinositol binding clathrin assembly protein 0.0377179
PTBP2 polypyrimidine tract binding protein 2 0.0375371
OXSR1 oxidative stress responsive 1 0.0371792
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 0.0370385
BHLHE40 basic helix-loop-helix family, member e40 0.0369683
ELL2 elongation factor, RNA polymerase II, 2 0.0368566
PDPK1 3-phosphoinositide dependent protein kinase 1 0.0361997
YTHDC1 YTH domain containing 1 0.0359979
RPS14 ribosomal protein S14 0.0357541
RNF24 ring finger protein 24 0.0357139
JARID2 jumonji, AT rich interactive domain 2 0.0354149
VEGFA vascular endothelial growth factor A 0.0349528
RPS12 ribosomal protein S12 0.0342507
PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma) 0.0333726
APP amyloid beta (A4) precursor protein 0.0332676
GOLPH3 golgi phosphoprotein 3 (coat-protein) 0.033153
CDK5RAP2 CDK5 regulatory subunit associated protein 2 0.0327188
PRICKLE2 prickle homolog 2 (Drosophila) 0.0326907
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0322419
CCNL1 cyclin L1 0.0321741
EPS8 epidermal growth factor receptor pathway substrate 8 0.0319261
TXNRD1 thioredoxin reductase 1 0.0317437
IGF2 insulin-like growth factor 2 0.0317211
EPRS1 glutamyl-prolyl-tRNA synthetase 1 0.0315925
KIF13A kinesin family member 13A 0.0315416
NF1 neurofibromin 1 0.0314011
FAM13B family with sequence similarity 13, member B 0.0311808
TNIP1 TNFAIP3 interacting protein 1 0.0311503
TAF7 TAF7 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 55kDa 0.0311162
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta 0.0309396
SSBP2 single-stranded DNA binding protein 2 0.0307045
CD47 CD47 molecule 0.0302939
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 0.0301905
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0301244
USP24 ubiquitin specific peptidase 24 0.0300684
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0298615
PCCA propionyl CoA carboxylase, alpha polypeptide 0.0297706
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0297604
CXCL3 chemokine (C-X-C motif) ligand 3 0.0297443
RPL34 ribosomal protein L34 0.0295406
CSF1 colony stimulating factor 1 (macrophage) 0.0294546
USP3 ubiquitin specific peptidase 3 0.029413
HECTD4 HECT domain containing E3 ubiquitin protein ligase 4 0.0290905
TRAM2 translocation associated membrane protein 2 0.0289152
PKM pyruvate kinase, muscle 0.0288176
TBC1D23 TBC1 domain family, member 23 0.0288085
SETD5 SET domain containing 5 0.0287228
EIF5B eukaryotic translation initiation factor 5B 0.028273
NUP58 nucleoporin 58 0.0282026
TMEM167A transmembrane protein 167A 0.0280821
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.02795
KDM6A lysine (K)-specific demethylase 6A 0.0279056
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0278512
SRP54 signal recognition particle 54kDa 0.027809
SEPTIN9 septin 9 0.0277486
SARS1 seryl-tRNA synthetase 1 0.0276447
PLEKHA5 pleckstrin homology domain containing, family A member 5 0.0274496
MAP1B microtubule-associated protein 1B 0.0273629
BCLAF1 BCL2-associated transcription factor 1 0.0272284
FAR1 fatty acyl CoA reductase 1 0.0267641
ZNF133 zinc finger protein 133 0.0266593
PPIG peptidylprolyl isomerase G (cyclophilin G) 0.0265902
HILPDA hypoxia inducible lipid droplet-associated 0.0265001
PNN pinin, desmosome associated protein 0.0264694
REL v-rel avian reticuloendotheliosis viral oncogene homolog 0.0264216

decreased expression

Symbol Name Standardized Value
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.229732
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.227898
FN1 fibronectin 1 -0.222127
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.124676
CALU calumenin -0.107448
TMSB10 thymosin beta 10 -0.0939996
COL6A3 collagen, type VI, alpha 3 -0.0928341
UBC ubiquitin C -0.0907928
TIMP3 TIMP metallopeptidase inhibitor 3 -0.0893716
AHNAK AHNAK nucleoprotein -0.0873758
HLA-B major histocompatibility complex, class I, B -0.0866939
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II -0.0855983
LOX lysyl oxidase -0.0852832
TGFBI transforming growth factor, beta-induced, 68kDa -0.0849398
CDH13 cadherin 13 -0.0836837
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0818225
VIM vimentin -0.0786019
COL6A2 collagen, type VI, alpha 2 -0.0752876
ENO1 enolase 1, (alpha) -0.0705295
STC1 stanniocalcin 1 -0.0700035
F3 coagulation factor III (thromboplastin, tissue factor) -0.0677217
SPTBN1 spectrin, beta, non-erythrocytic 1 -0.0630375
SPAG9 sperm associated antigen 9 -0.0626925
COL6A1 collagen, type VI, alpha 1 -0.0626014
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide) -0.0612285
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0576727
LDHA lactate dehydrogenase A -0.0568774
SMYD3 SET and MYND domain containing 3 -0.0568555
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1 -0.0566492
NDRG1 N-myc downstream regulated 1 -0.0566233
CANX calnexin -0.0551541
CDK13 cyclin-dependent kinase 13 -0.0514133
ASPH aspartate beta-hydroxylase -0.0498998
TPT1 tumor protein, translationally-controlled 1 -0.0469722
PDIA4 protein disulfide isomerase family A, member 4 -0.0466824
COG6 component of oligomeric golgi complex 6 -0.0464884
INTS6 integrator complex subunit 6 -0.0452475
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.045064
ATRX alpha thalassemia/mental retardation syndrome X-linked -0.0446177
UMAD1 UBAP1-MVB12-associated (UMA) domain containing 1 -0.0427387
HS2ST1 heparan sulfate 2-O-sulfotransferase 1 -0.0425109
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A -0.0423346
ATXN1 ataxin 1 -0.0417725
SOD2 superoxide dismutase 2, mitochondrial -0.0417113
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0416121
GANAB glucosidase, alpha; neutral AB -0.0414619
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0413619
EXT1 exostosin glycosyltransferase 1 -0.0413034
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0409623
FBXL7 F-box and leucine-rich repeat protein 7 -0.0405715
FNDC3A fibronectin type III domain containing 3A -0.0391027
HIP1 huntingtin interacting protein 1 -0.0389371
BRIP1 BRCA1 interacting protein C-terminal helicase 1 -0.038665
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) -0.0385393
TAS2R14 taste receptor, type 2, member 14 -0.0385385
ANKHD1 ankyrin repeat and KH domain containing 1 -0.0383848
FLNA filamin A, alpha -0.0381028
AUTS2 autism susceptibility candidate 2 -0.0375487
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 -0.0375276
CENPF centromere protein F, 350/400kDa -0.037415
PDLIM5 PDZ and LIM domain 5 -0.0373908
FNIP1 folliculin interacting protein 1 -0.0370886
RIGI RNA sensor RIG-I -0.0368028
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.0367105
WSB1 WD repeat and SOCS box containing 1 -0.036414
SDC4 syndecan 4 -0.035998
AKAP12 A kinase (PRKA) anchor protein 12 -0.0358935
CDK6 cyclin-dependent kinase 6 -0.0355616
NUCB2 nucleobindin 2 -0.0351306
PALM2AKAP2 PALM2 and AKAP2 fusion -0.0350952
ANKIB1 ankyrin repeat and IBR domain containing 1 -0.0349783
VDAC1 voltage-dependent anion channel 1 -0.0345906
SPDYA speedy/RINGO cell cycle regulator family member A -0.0342599
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3 -0.0338177
MORF4L2 mortality factor 4 like 2 -0.0337705
COL5A1 collagen, type V, alpha 1 -0.0335593
ARB2A ARB2 cotranscriptional regulator A -0.0329305
FAM3C family with sequence similarity 3, member C -0.0327267
PALLD palladin, cytoskeletal associated protein -0.0325877
HMGA2 high mobility group AT-hook 2 -0.0323679
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0323303
PTTG1IP pituitary tumor-transforming 1 interacting protein -0.0323126
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.0322152
PDIA5 protein disulfide isomerase family A, member 5 -0.0320884
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0319731
UBN2 ubinuclein 2 -0.0319643
TRIO trio Rho guanine nucleotide exchange factor -0.0313334
PRSS23 protease, serine, 23 -0.0312818
MRPS6 mitochondrial ribosomal protein S6 -0.0309644
OSMR oncostatin M receptor -0.030924
ARF4 ADP-ribosylation factor 4 -0.0308828
N4BP2L2 NEDD4 binding protein 2-like 2 -0.0305038
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0304053
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2 -0.0303116
ERC2 ELKS/RAB6-interacting/CAST family member 2 -0.0302914
RPS27A ribosomal protein S27a -0.0302608
RAI14 retinoic acid induced 14 -0.0302004
SEC31A SEC31 homolog A (S. cerevisiae) -0.0299209
VPS13B vacuolar protein sorting 13 homolog B (yeast) -0.029869
PPP6R3 protein phosphatase 6, regulatory subunit 3 -0.0297654