Thymopentin_SW 1271 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Thymopentin perturbation in SW 1271 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Thymopentin_SW 1271 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0904234
NUP58 nucleoporin 58 0.0764819
CENPF centromere protein F, 350/400kDa 0.069723
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.065201
GOLGA4 golgin A4 0.062835
TPX2 TPX2, microtubule-associated 0.051815
LCORL ligand dependent nuclear receptor corepressor-like 0.0500886
CKAP5 cytoskeleton associated protein 5 0.0474942
ECT2 epithelial cell transforming 2 0.0467052
ZNF292 zinc finger protein 292 0.0448425
DIAPH3 diaphanous-related formin 3 0.0428281
CHD1 chromodomain helicase DNA binding protein 1 0.0389916
BIRC3 baculoviral IAP repeat containing 3 0.0368606
HJURP Holliday junction recognition protein 0.0362109
HMGB2 high mobility group box 2 0.0347751
DERA deoxyribose-phosphate aldolase (putative) 0.0346694
TMEM39A transmembrane protein 39A 0.0342089
SPAG9 sperm associated antigen 9 0.0329861
TFG TRK-fused gene 0.0321516
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa 0.0319157
KIF4A kinesin family member 4A 0.0316568
PUM2 pumilio RNA-binding family member 2 0.0314324
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0300509
CKAP2 cytoskeleton associated protein 2 0.0299283
SRP54 signal recognition particle 54kDa 0.0296877
NUF2 NUF2, NDC80 kinetochore complex component 0.0294935
KIAA1328 KIAA1328 0.0292252
CALR calreticulin 0.0291136
GOLT1B golgi transport 1B 0.0289974
ANKRD28 ankyrin repeat domain 28 0.0284974
CEP70 centrosomal protein 70kDa 0.0283392
CKAP2L cytoskeleton associated protein 2-like 0.0280958
HMMR hyaluronan-mediated motility receptor (RHAMM) 0.0280048
AP3B1 adaptor-related protein complex 3, beta 1 subunit 0.0274702
HELZ helicase with zinc finger 0.0273571
SKIC3 SKI3 subunit of superkiller complex 0.0271776
MKI67 marker of proliferation Ki-67 0.02714
PIKFYVE phosphoinositide kinase, FYVE finger containing 0.0262736
SGO2 shugoshin 2 0.0261522
AURKA aurora kinase A 0.0259176
NPTN neuroplastin 0.0258005
FBXL5 F-box and leucine-rich repeat protein 5 0.0256322
MIS18BP1 MIS18 binding protein 1 0.025268
COPB1 coatomer protein complex, subunit beta 1 0.0252582
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0251088
PRC1 protein regulator of cytokinesis 1 0.0248736
CEP192 centrosomal protein 192kDa 0.0247054
KIAA1958 KIAA1958 0.0245001
TTK TTK protein kinase 0.0244967
SMC5 structural maintenance of chromosomes 5 0.0243789
SREK1 splicing regulatory glutamine/lysine-rich protein 1 0.0237892
GPSM2 G-protein signaling modulator 2 0.0237139
WAC WW domain containing adaptor with coiled-coil 0.0235265
CCNG2 cyclin G2 0.0234318
CENPE centromere protein E, 312kDa 0.0233393
WDR36 WD repeat domain 36 0.0232085
ANKRD36 ankyrin repeat domain 36 0.0231761
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0231336
YAP1 Yes-associated protein 1 0.0228853
PTPN1 protein tyrosine phosphatase, non-receptor type 1 0.0228828
CLTC clathrin, heavy chain (Hc) 0.0228461
SS18 synovial sarcoma translocation, chromosome 18 0.0226442
G2E3 G2/M-phase specific E3 ubiquitin protein ligase 0.0226306
DLGAP5 discs, large (Drosophila) homolog-associated protein 5 0.0226117
RNF145 ring finger protein 145 0.0224535
PSME4 proteasome (prosome, macropain) activator subunit 4 0.0224529
TNRC6A trinucleotide repeat containing 6A 0.0224482
CEP250 centrosomal protein 250kDa 0.0224474
SEC23A Sec23 homolog A (S. cerevisiae) 0.0223614
PRR11 proline rich 11 0.0222679
HSPA4 heat shock 70kDa protein 4 0.022234
HP1BP3 heterochromatin protein 1, binding protein 3 0.0221898
HSPA8 heat shock 70kDa protein 8 0.021769
PDE4D phosphodiesterase 4D, cAMP-specific 0.0216324
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 0.0215657
ZNF451 zinc finger protein 451 0.021541
ARF4 ADP-ribosylation factor 4 0.0215088
NUP153 nucleoporin 153kDa 0.0213833
TXNRD1 thioredoxin reductase 1 0.0212892
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase 0.0212834
SMC4 structural maintenance of chromosomes 4 0.0212238
SEC13 SEC13 homolog (S. cerevisiae) 0.0210831
STARD4 StAR-related lipid transfer (START) domain containing 4 0.0210597
TBK1 TANK-binding kinase 1 0.0210567
SET SET nuclear proto-oncogene 0.0209996
PREPL prolyl endopeptidase-like 0.0209944
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0208738
TBC1D5 TBC1 domain family, member 5 0.0208632
CENPC centromere protein C 0.0208181
CLINT1 clathrin interactor 1 0.0207617
NAMPT nicotinamide phosphoribosyltransferase 0.0206667
RPRD1B regulation of nuclear pre-mRNA domain containing 1B 0.0206494
UBAC2 UBA domain containing 2 0.0205588
CAPN7 calpain 7 0.0203359
NCAPG2 non-SMC condensin II complex, subunit G2 0.0201513
RLF rearranged L-myc fusion 0.0200993
NBAS neuroblastoma amplified sequence 0.020025
CAMTA1 calmodulin binding transcription activator 1 0.020002
RAB22A RAB22A, member RAS oncogene family 0.019861
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0198142

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.181851
TMSB10 thymosin beta 10 -0.115623
FNDC3B fibronectin type III domain containing 3B -0.0983141
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.097421
HMGA2 high mobility group AT-hook 2 -0.0971869
LDHA lactate dehydrogenase A -0.0968585
VIM vimentin -0.0965237
PRKCA protein kinase C, alpha -0.093344
TPT1 tumor protein, translationally-controlled 1 -0.0921226
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0835222
MT2A metallothionein 2A -0.0819051
ZBTB20 zinc finger and BTB domain containing 20 -0.0757109
IGFBP3 insulin-like growth factor binding protein 3 -0.0680645
ANGPTL4 angiopoietin-like 4 -0.0675517
SLC38A2 solute carrier family 38, member 2 -0.0673586
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0653926
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0648807
SH3KBP1 SH3-domain kinase binding protein 1 -0.0619559
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0596189
POTEF POTE ankyrin domain family, member F -0.0585091
FMNL2 formin-like 2 -0.0572555
CD44 CD44 molecule (Indian blood group) -0.0559553
DST dystonin -0.0556054
PTMA prothymosin, alpha -0.0551269
IGF2 insulin-like growth factor 2 -0.0548337
NT5E 5'-nucleotidase, ecto (CD73) -0.0518853
EGR1 early growth response 1 -0.0512867
FLNB filamin B, beta -0.0507688
MACF1 microtubule-actin crosslinking factor 1 -0.0504758
AHNAK AHNAK nucleoprotein -0.0501937
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.0499455
PRSS23 protease, serine, 23 -0.0477796
PMEPA1 prostate transmembrane protein, androgen induced 1 -0.0467888
SVIL supervillin -0.0464858
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.046449
RAI14 retinoic acid induced 14 -0.0445256
RIGI RNA sensor RIG-I -0.0444221
PYGL phosphorylase, glycogen, liver -0.0435387
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0423926
ANXA2 annexin A2 -0.0423507
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) -0.0419021
BASP1 brain abundant, membrane attached signal protein 1 -0.0416645
PRR16 proline rich 16 -0.0415289
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0409268
IER3 immediate early response 3 -0.0406155
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) -0.0400209
DPYD dihydropyrimidine dehydrogenase -0.0394176
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -0.0393686
COL5A1 collagen, type V, alpha 1 -0.0391156
HLA-B major histocompatibility complex, class I, B -0.0385443
ARHGEF28 Rho guanine nucleotide exchange factor (GEF) 28 -0.0383948
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.0380066
FTL ferritin, light polypeptide -0.0379895
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0379359
WSB1 WD repeat and SOCS box containing 1 -0.0378655
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C -0.0377328
AEBP2 AE binding protein 2 -0.0373683
LOC112694756 uncharaterized LOC112694756 -0.0371622
RNF213 ring finger protein 213 -0.036714
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 -0.0367017
NDRG1 N-myc downstream regulated 1 -0.0366922
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 -0.0362029
PALM2AKAP2 PALM2 and AKAP2 fusion -0.0356919
PKM pyruvate kinase, muscle -0.0355097
N4BP2L2 NEDD4 binding protein 2-like 2 -0.0351025
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 -0.0348007
TIMP1 TIMP metallopeptidase inhibitor 1 -0.0346399
MYO9B myosin IXB -0.0338146
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0334177
RPLP1 ribosomal protein, large, P1 -0.0334161
GPC6 glypican 6 -0.0330542
CAVIN1 caveolae associated protein 1 -0.0329299
THSD4 thrombospondin, type I, domain containing 4 -0.0327745
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0327563
LPP LIM domain containing preferred translocation partner in lipoma -0.0327317
AKAP12 A kinase (PRKA) anchor protein 12 -0.032727
SEPTIN9 septin 9 -0.032671
ATG7 autophagy related 7 -0.0326293
B2M beta-2-microglobulin -0.0325818
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0322807
RPL31 ribosomal protein L31 -0.0322267
FTH1 ferritin, heavy polypeptide 1 -0.0321069
ERRFI1 ERBB receptor feedback inhibitor 1 -0.031707
ATXN1 ataxin 1 -0.0316559
PODXL podocalyxin-like -0.0315698
DNER delta/notch-like EGF repeat containing -0.0315678
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.0309091
BICD1 bicaudal D homolog 1 (Drosophila) -0.0307156
CCND1 cyclin D1 -0.0306388
RPL35A ribosomal protein L35a -0.0303571
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0303191
MAP1B microtubule-associated protein 1B -0.029643
VCL vinculin -0.029586
SQSTM1 sequestosome 1 -0.0293878
PRG2 proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein) -0.0287149
CDCP1 CUB domain containing protein 1 -0.0286748
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) -0.0284531
RPS29 ribosomal protein S29 -0.0283645
NAV3 neuron navigator 3 -0.028197
BTG1 B-cell translocation gene 1, anti-proliferative -0.0281531