Thymopentin_SW 900 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Thymopentin perturbation in SW 900 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Thymopentin_SW 900 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.106838
NAMPT nicotinamide phosphoribosyltransferase 0.0906968
FNDC3B fibronectin type III domain containing 3B 0.0813054
FAM13A family with sequence similarity 13, member A 0.0546627
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0525548
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0460575
CD109 CD109 molecule 0.0392439
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0368684
UBA6 ubiquitin-like modifier activating enzyme 6 0.0367749
ZNF292 zinc finger protein 292 0.0359034
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.035137
RNF145 ring finger protein 145 0.0350949
MYH9 myosin, heavy chain 9, non-muscle 0.0346326
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0320705
AHR aryl hydrocarbon receptor 0.032015
CDC73 cell division cycle 73 0.0312947
PTK2 protein tyrosine kinase 2 0.0297104
RUNX2 runt-related transcription factor 2 0.0293541
CENPF centromere protein F, 350/400kDa 0.0286713
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.0285586
NUP58 nucleoporin 58 0.0277407
SUCO SUN domain containing ossification factor 0.0272737
NRIP1 nuclear receptor interacting protein 1 0.0271163
ACTR3 ARP3 actin-related protein 3 homolog (yeast) 0.0268327
ADAM17 ADAM metallopeptidase domain 17 0.0263682
EPS8 epidermal growth factor receptor pathway substrate 8 0.0262969
EYA1 EYA transcriptional coactivator and phosphatase 1 0.0262049
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0256236
MCTP2 multiple C2 domains, transmembrane 2 0.025623
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0255743
FBXL5 F-box and leucine-rich repeat protein 5 0.0254026
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 0.0250651
PRELID2 PRELI domain containing 2 0.0241922
CCNL1 cyclin L1 0.0241227
DOCK5 dedicator of cytokinesis 5 0.023957
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0238761
SMOX spermine oxidase 0.0233461
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.023151
GPCPD1 glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) 0.0228128
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 0.0226775
TFG TRK-fused gene 0.0225555
HELZ helicase with zinc finger 0.0221789
AFDN afadin, adherens junction formation factor 0.0221129
SEC23A Sec23 homolog A (S. cerevisiae) 0.0219871
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0219612
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0218184
SMAD3 SMAD family member 3 0.0217511
PTPN14 protein tyrosine phosphatase, non-receptor type 14 0.0214952
CAB39 calcium binding protein 39 0.0213936
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa 0.0212173
WDR26 WD repeat domain 26 0.0209678
DST dystonin 0.0206706
RAB8B RAB8B, member RAS oncogene family 0.0203299
TM9SF3 transmembrane 9 superfamily member 3 0.0202675
ELL2 elongation factor, RNA polymerase II, 2 0.0199405
SLTM SAFB-like, transcription modulator 0.0199183
CARD16 caspase recruitment domain family, member 16 0.0196635
SPRED1 sprouty-related, EVH1 domain containing 1 0.0191163
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0189695
UBE2E3 ubiquitin-conjugating enzyme E2E 3 0.0184786
CXCL8 chemokine (C-X-C motif) ligand 8 0.0182764
TPM3 tropomyosin 3 0.0181317
MNAT1 MNAT CDK-activating kinase assembly factor 1 0.0180417
SNX9 sorting nexin 9 0.0179041
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0178859
CHD1 chromodomain helicase DNA binding protein 1 0.0178827
BCLAF1 BCL2-associated transcription factor 1 0.0176133
ETNK1 ethanolamine kinase 1 0.0175695
USP12 ubiquitin specific peptidase 12 0.0175273
KDM6A lysine (K)-specific demethylase 6A 0.0174515
ATP13A3 ATPase type 13A3 0.0173581
MYO1B myosin IB 0.0172152
SS18 synovial sarcoma translocation, chromosome 18 0.0171913
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.017098
SREK1 splicing regulatory glutamine/lysine-rich protein 1 0.0167932
VEGFA vascular endothelial growth factor A 0.016765
MSN moesin 0.0164754
VMP1 vacuole membrane protein 1 0.0164531
ADAM9 ADAM metallopeptidase domain 9 0.0163743
CDCP1 CUB domain containing protein 1 0.0161305
VEGFC vascular endothelial growth factor C 0.016077
PTBP3 polypyrimidine tract binding protein 3 0.0158523
COPA coatomer protein complex, subunit alpha 0.0157948
NEK7 NIMA-related kinase 7 0.0157605
TENT2 terminal nucleotidyltransferase 2 0.0157401
SP3 Sp3 transcription factor 0.015239
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 0.0152249
BIRC3 baculoviral IAP repeat containing 3 0.0151275
IL6ST interleukin 6 signal transducer 0.0149312
YAP1 Yes-associated protein 1 0.0148085
ANLN anillin, actin binding protein 0.0147628
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0147302
ANKRD11 ankyrin repeat domain 11 0.0146878
KMT2E lysine (K)-specific methyltransferase 2E 0.0145193
ETV6 ets variant 6 0.0144421
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 0.0143966
XPO1 exportin 1 0.0142712
ECT2 epithelial cell transforming 2 0.0142077
DHX9 DEAH (Asp-Glu-Ala-His) box helicase 9 0.0141863
FOSL1 FOS-like antigen 1 0.0141396

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.393989
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -0.234612
PTMA prothymosin, alpha -0.172727
TMSB10 thymosin beta 10 -0.144588
FTL ferritin, light polypeptide -0.144095
HLA-B major histocompatibility complex, class I, B -0.135603
MT2A metallothionein 2A -0.127082
FN1 fibronectin 1 -0.12584
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.119385
TPT1 tumor protein, translationally-controlled 1 -0.115878
SQSTM1 sequestosome 1 -0.113018
VIM vimentin -0.110303
RPL35A ribosomal protein L35a -0.0842217
S100A6 S100 calcium binding protein A6 -0.0827782
IFI27 interferon, alpha-inducible protein 27 -0.0791567
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0788594
RPS6 ribosomal protein S6 -0.0768714
NRG1 neuregulin 1 -0.0728671
RPL31 ribosomal protein L31 -0.0716096
RPL37A ribosomal protein L37a -0.0639701
B2M beta-2-microglobulin -0.0632167
SFTPA2 surfactant protein A2 -0.0628838
RPLP1 ribosomal protein, large, P1 -0.0626433
RPS24 ribosomal protein S24 -0.0578763
RPS29 ribosomal protein S29 -0.0577167
RPS8 ribosomal protein S8 -0.0574355
IER3 immediate early response 3 -0.0574236
ACTG1 actin gamma 1 -0.0573391
S100A10 S100 calcium binding protein A10 -0.0570217
RPS19 ribosomal protein S19 -0.0555842
LMNA lamin A/C -0.0554129
EIF1 eukaryotic translation initiation factor 1 -0.0552005
RPL37 ribosomal protein L37 -0.0550594
RPL26 ribosomal protein L26 -0.0546107
RPL23 ribosomal protein L23 -0.0545787
RPS27 ribosomal protein S27 -0.0539265
RPL34 ribosomal protein L34 -0.053347
EXT1 exostosin glycosyltransferase 1 -0.0519559
GNAS GNAS complex locus -0.0503296
RPL38 ribosomal protein L38 -0.0497946
RPS27A ribosomal protein S27a -0.0494394
RACK1 receptor for activated C kinase 1 -0.0487494
RPS11 ribosomal protein S11 -0.0485772
RPS21 ribosomal protein S21 -0.0482829
RPS25 ribosomal protein S25 -0.0475266
RPL9 ribosomal protein L9 -0.0467886
IFI6 interferon, alpha-inducible protein 6 -0.0452409
CALR calreticulin -0.0438902
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0432242
RPS16 ribosomal protein S16 -0.0424252
RPS3 ribosomal protein S3 -0.0422489
TMSB4X thymosin beta 4, X-linked -0.0421186
RPLP2 ribosomal protein, large, P2 -0.0417088
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0413484
RPL12 ribosomal protein L12 -0.0410599
LOC102724023 ES1 protein homolog, mitochondrial -0.040744
RPS20 ribosomal protein S20 -0.0400346
RPS23 ribosomal protein S23 -0.0396937
RPS12 ribosomal protein S12 -0.0391009
RPL11 ribosomal protein L11 -0.0390861
INTS6 integrator complex subunit 6 -0.0390762
SOX4 SRY (sex determining region Y)-box 4 -0.0387851
RPL36 ribosomal protein L36 -0.038169
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.0381241
HLA-A major histocompatibility complex, class I, A -0.0380969
RPL19 ribosomal protein L19 -0.0366576
RPL8 ribosomal protein L8 -0.0365605
NDRG1 N-myc downstream regulated 1 -0.0362503
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0359302
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.0358915
S100A9 S100 calcium binding protein A9 -0.0346528
TPI1 triosephosphate isomerase 1 -0.0346231
SLC38A2 solute carrier family 38, member 2 -0.0343849
CANX calnexin -0.0337362
RPS5 ribosomal protein S5 -0.0335736
RPL28 ribosomal protein L28 -0.0332972
TFPI2 tissue factor pathway inhibitor 2 -0.0330122
RPLP0 ribosomal protein, large, P0 -0.0329601
LOC112694756 uncharaterized LOC112694756 -0.0325715
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II -0.032439
ENO1 enolase 1, (alpha) -0.0322337
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0319776
ARF1 ADP-ribosylation factor 1 -0.0308948
CD63 CD63 molecule -0.0307839
RPL30 ribosomal protein L30 -0.030697
SLC38A1 solute carrier family 38, member 1 -0.0305437
AEBP2 AE binding protein 2 -0.0303159
RPL32 ribosomal protein L32 -0.0292511
LGALS1 lectin, galactoside-binding, soluble, 1 -0.0289523
ENO2 enolase 2 (gamma, neuronal) -0.02895
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0285673
UGDH UDP-glucose 6-dehydrogenase -0.0285626
STC2 stanniocalcin 2 -0.028313
FTH1 ferritin, heavy polypeptide 1 -0.0277643
RPS15 ribosomal protein S15 -0.0275982
WSB1 WD repeat and SOCS box containing 1 -0.0275795
NAP1L1 nucleosome assembly protein 1-like 1 -0.0275411
HMGA1 high mobility group AT-hook 1 -0.0271963
SYT1 synaptotagmin I -0.0271297
MTDH metadherin -0.026905