Thyroid Nodule Gene Set

Dataset DisGeNET Gene-Disease Associations
Category disease or phenotype associations
Type disease
Description Pathological nodule in the thyroid gland, often filled with colloid; some are indicative of adenoma or carcinoma. (BRENDA Tissue and Enzyme Source Ontology, BTO_0002617)
External Link https://www.disgenet.org/browser/0/1/0/C0040137
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Genes

132 genes associated with the disease Thyroid Nodule in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.

Symbol Name
ACKR3 atypical chemokine receptor 3
ACR acrosin
ADCY6 adenylate cyclase 6
ADRA1A adrenoceptor alpha 1A
ADRA2B adrenoceptor alpha 2B
ALB albumin
ALK anaplastic lymphoma receptor tyrosine kinase
ALPI alkaline phosphatase, intestinal
ALPP alkaline phosphatase, placental
ANGPT2 angiopoietin 2
APC adenomatous polyposis coli
APP amyloid beta (A4) precursor protein
AR androgen receptor
ARRB2 arrestin, beta 2
AZIN2 antizyme inhibitor 2
BIRC5 baculoviral IAP repeat containing 5
BMP1 bone morphogenetic protein 1
BRAF B-Raf proto-oncogene, serine/threonine kinase
BRS3 bombesin-like receptor 3
CALCA calcitonin-related polypeptide alpha
CCDC6 coiled-coil domain containing 6
CCND1 cyclin D1
CD274 CD274 molecule
CD47 CD47 molecule
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CHGA chromogranin A
CLU clusterin
COX2
CXCR6 chemokine (C-X-C motif) receptor 6
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
DICER1 dicer 1, ribonuclease type III
DPP4 dipeptidyl-peptidase 4
ECM1 extracellular matrix protein 1
EDNRA endothelin receptor type A
EGFR epidermal growth factor receptor
EIF1AX eukaryotic translation initiation factor 1A, X-linked
ERBB2 erb-b2 receptor tyrosine kinase 2
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1
ETV6 ets variant 6
F9 coagulation factor IX
FAM129A family with sequence similarity 129, member A
FAP fibroblast activation protein, alpha
FLVCR1 feline leukemia virus subgroup C cellular receptor 1
FOLH1 folate hydrolase (prostate-specific membrane antigen) 1
FOSL1 FOS-like antigen 1
FOXE1 forkhead box E1
GADL1 glutamate decarboxylase-like 1
GATA3 GATA binding protein 3
GDF1 growth differentiation factor 1
GDF15 growth differentiation factor 15
GFRA1 GDNF family receptor alpha 1
GH1 growth hormone 1
GHR growth hormone receptor
GNB3 guanine nucleotide binding protein (G protein), beta polypeptide 3
GPR42 G protein-coupled receptor 42 (gene/pseudogene)
GRK2 G protein-coupled receptor kinase 2
GSC goosecoid homeobox
GSTK1 glutathione S-transferase kappa 1
GSTM1 glutathione S-transferase mu 1
GSTO1 glutathione S-transferase omega 1
GSTP1 glutathione S-transferase pi 1
GSTT1 glutathione S-transferase theta 1
HLTF helicase-like transcription factor
HMGA1 high mobility group AT-hook 1
HMGA2 high mobility group AT-hook 2
HRAS Harvey rat sarcoma viral oncogene homolog
HSD11B2 hydroxysteroid (11-beta) dehydrogenase 2
IAPP islet amyloid polypeptide
IGF1 insulin-like growth factor 1 (somatomedin C)
IGFBP3 insulin-like growth factor binding protein 3
IL6 interleukin 6
IL6R interleukin 6 receptor
ITGA6 integrin, alpha 6
KCNJ6 potassium channel, inwardly rectifying subfamily J, member 6
KIDINS220 kinase D-interacting substrate, 220kDa
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
KRAS Kirsten rat sarcoma viral oncogene homolog
KRT19 keratin 19, type I
LEP leptin
LGALS3 lectin, galactoside-binding, soluble, 3
LPAR2 lysophosphatidic acid receptor 2
MAGT1 magnesium transporter 1
MMP2 matrix metallopeptidase 2
MT1A metallothionein 1A
NCAM1 neural cell adhesion molecule 1
NCOA4 nuclear receptor coactivator 4
NKX2-1 NK2 homeobox 1
NRAS neuroblastoma RAS viral (v-ras) oncogene homolog
NTRK1 neurotrophic tyrosine kinase, receptor, type 1
PAX8 paired box 8
PPARG peroxisome proliferator-activated receptor gamma
PPP1R13L protein phosphatase 1, regulatory subunit 13 like
PPP3R1 protein phosphatase 3, regulatory subunit B, alpha
PTCH1 patched 1
PTEN phosphatase and tensin homolog
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PTH parathyroid hormone
PTN pleiotrophin
PTPN11 protein tyrosine phosphatase, non-receptor type 11
QPRT quinolinate phosphoribosyltransferase
RASSF1 Ras association (RalGDS/AF-6) domain family member 1
RET ret proto-oncogene
RNH1 ribonuclease/angiogenin inhibitor 1
SFN stratifin
SHBG sex hormone-binding globulin
SHC3 SHC (Src homology 2 domain containing) transforming protein 3
SLC26A4 solute carrier family 26 (anion exchanger), member 4
SLC5A5 solute carrier family 5 (sodium/iodide cotransporter), member 5
SLCO6A1 solute carrier organic anion transporter family, member 6A1
SMUG1 single-strand-selective monofunctional uracil-DNA glycosylase 1
SST somatostatin
SSTR2 somatostatin receptor 2
SSTR4 somatostatin receptor 4
STRN striatin, calmodulin binding protein
TAS2R38 taste receptor, type 2, member 38
TERT telomerase reverse transcriptase
TFF3 trefoil factor 3 (intestinal)
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TG thyroglobulin
TGFB1 transforming growth factor, beta 1
TMPRSS4 transmembrane protease, serine 4
TNFRSF8 tumor necrosis factor receptor superfamily, member 8
TNFSF8 tumor necrosis factor (ligand) superfamily, member 8
TP53 tumor protein p53
TPM3 tropomyosin 3
TPO thyroid peroxidase
TRPM3 transient receptor potential cation channel, subfamily M, member 3
TSHR thyroid stimulating hormone receptor
TTF1 transcription termination factor, RNA polymerase I
UROD uroporphyrinogen decarboxylase
VEGFA vascular endothelial growth factor A
XRCC1 X-ray repair complementing defective repair in Chinese hamster cells 1