Thyrotoxicosis Gene Set

Dataset DISEASES Text-mining Gene-Disease Association Evidence Scores 2025
Category disease or phenotype associations
Type disease
Description A thyroid gland disease that is characterized by excess thyroid hormone. (Human Disease Ontology, DOID_7997)
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Genes

245 genes co-occuring with the disease Thyrotoxicosis in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.

Symbol Name Standardized Value
TG thyroglobulin 3.513
TSHR thyroid stimulating hormone receptor 3.378
TPO thyroid peroxidase 3.172
KCNJ18 potassium channel, inwardly rectifying subfamily J, member 18 2.912
SERPINA7 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7 2.903
SLC16A2 solute carrier family 16, member 2 (thyroid hormone transporter) 2.84
THRB thyroid hormone receptor, beta 2.637
TRH thyrotropin-releasing hormone 2.637
INS insulin 2.436
PTH parathyroid hormone 2.431
POMC proopiomelanocortin 2.43
CRP C-reactive protein, pentraxin-related 2.335
DIO2 deiodinase, iodothyronine, type II 2.331
TXNRD2 thioredoxin reductase 2 2.312
SCN4A sodium channel, voltage gated, type IV alpha subunit 2.264
SHBG sex hormone-binding globulin 2.259
CTLA4 cytotoxic T-lymphocyte-associated protein 4 2.241
ACE2 angiotensin I converting enzyme 2 2.232
SLC5A5 solute carrier family 5 (sodium/iodide cotransporter), member 5 2.215
CACNA1S calcium channel, voltage-dependent, L type, alpha 1S subunit 2.205
ALB albumin 2.203
PRL prolactin 2.182
SLCO1C1 solute carrier organic anion transporter family, member 1C1 2.175
SLC16A10 solute carrier family 16 (aromatic amino acid transporter), member 10 2.159
IL6 interleukin 6 2.127
REN renin 2.115
PDCD1 programmed cell death 1 2.108
GPT glutamic-pyruvate transaminase (alanine aminotransferase) 2.097
SST somatostatin 2.083
TSHB thyroid stimulating hormone, beta 2.075
THRA thyroid hormone receptor, alpha 2.071
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2 2.061
IGF1 insulin-like growth factor 1 (somatomedin C) 2.051
ACE angiotensin I converting enzyme 2.033
CD274 CD274 molecule 2.023
IFNA1 interferon, alpha 1 2.008
KCNE3 potassium channel, voltage gated subfamily E regulatory beta subunit 3 2.007
DIO3 deiodinase, iodothyronine, type III 1.983
ATP5PO ATP synthase peripheral stalk subunit OSCP 1.975
BGLAP bone gamma-carboxyglutamate (gla) protein 1.966
TTR transthyretin 1.934
PXDNL peroxidasin-like 1.902
TNFRSF25 tumor necrosis factor receptor superfamily, member 25 1.902
PXDN peroxidasin 1.901
TMPRSS2 transmembrane protease, serine 2 1.853
CKMT2 creatine kinase, mitochondrial 2 (sarcomeric) 1.839
CKM creatine kinase, muscle 1.837
CKMT1B creatine kinase, mitochondrial 1B 1.835
IFNA2 interferon, alpha 2 1.832
CKB creatine kinase, brain 1.832
IFNA16 interferon, alpha 16 1.83
IFNA7 interferon, alpha 7 1.829
IFNA21 interferon, alpha 21 1.829
IFNA14 interferon, alpha 14 1.829
IFNA10 interferon, alpha 10 1.829
IFNA8 interferon, alpha 8 1.828
IFNA6 interferon, alpha 6 1.828
IFNA17 interferon, alpha 17 1.827
IFNA5 interferon, alpha 5 1.827
IFNA13 interferon, alpha 13 1.826
IFNA4 interferon, alpha 4 1.823
F2 coagulation factor II (thrombin) 1.781
NPPB natriuretic peptide B 1.764
MYH14 myosin, heavy chain 14, non-muscle 1.764
CD4 CD4 molecule 1.756
PTPN22 protein tyrosine phosphatase, non-receptor type 22 (lymphoid) 1.754
TNF tumor necrosis factor 1.753
DIO1 deiodinase, iodothyronine, type I 1.752
FOXE1 forkhead box E1 1.743
GCG glucagon 1.731
LEP leptin 1.718
CD8A CD8a molecule 1.706
GNAS GNAS complex locus 1.7
IL2 interleukin 2 1.695
IYD iodotyrosine deiodinase 1.652
HLA-B major histocompatibility complex, class I, B 1.64
CGA glycoprotein hormones, alpha polypeptide 1.632
IFNG interferon, gamma 1.626
PTHLH parathyroid hormone-like hormone 1.625
IL1B interleukin 1, beta 1.615
PAX8 paired box 8 1.602
VWF von Willebrand factor 1.596
HLA-DRB1 major histocompatibility complex, class II, DR beta 1 1.589
TNFRSF10A tumor necrosis factor receptor superfamily, member 10a 1.585
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha 1.578
F3 coagulation factor III (thromboplastin, tissue factor) 1.566
SLC30A10 solute carrier family 30, member 10 1.565
NPPA natriuretic peptide A 1.564
GHRH growth hormone releasing hormone 1.553
SLC30A8 solute carrier family 30 (zinc transporter), member 8 1.543
ATP12A ATPase, H+/K+ transporting, nongastric, alpha polypeptide 1.535
ATP4A ATPase, H+/K+ exchanging, alpha polypeptide 1.534
AVP arginine vasopressin 1.532
RET ret proto-oncogene 1.519
BRAF B-Raf proto-oncogene, serine/threonine kinase 1.515
SLC26A4 solute carrier family 26 (anion exchanger), member 4 1.505
UCP3 uncoupling protein 3 (mitochondrial, proton carrier) 1.504
GPT2 glutamic pyruvate transaminase (alanine aminotransferase) 2 1.502
CD40 CD40 molecule, TNF receptor superfamily member 5 1.495
TNFSF11 tumor necrosis factor (ligand) superfamily, member 11 1.492
ADRB2 adrenoceptor beta 2, surface 1.466
UCP1 uncoupling protein 1 (mitochondrial, proton carrier) 1.458
CRH corticotropin releasing hormone 1.458
THRSP thyroid hormone responsive 1.456
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8) 1.454
SPATA31D4 SPATA31 subfamily D, member 4 1.451
NKX2-1 NK2 homeobox 1 1.442
ATP2A2 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 1.441
KCNA5 potassium channel, voltage gated shaker related subfamily A, member 5 1.437
GNRH1 gonadotropin-releasing hormone 1 (luteinizing-releasing hormone) 1.437
GHRL ghrelin/obestatin prepropeptide 1.434
TAAR1 trace amine associated receptor 1 1.434
CXCL8 chemokine (C-X-C motif) ligand 8 1.433
PDCD1LG2 programmed cell death 1 ligand 2 1.42
PTPRN protein tyrosine phosphatase, receptor type, N 1.411
IL1A interleukin 1, alpha 1.407
IGF1R insulin-like growth factor 1 receptor 1.398
GAD2 glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa) 1.397
HLA-DPB1 major histocompatibility complex, class II, DP beta 1 1.396
DNAH8 dynein, axonemal, heavy chain 8 1.394
IL10 interleukin 10 1.384
ADRB1 adrenoceptor beta 1 1.381
SLC12A3 solute carrier family 12 (sodium/chloride transporter), member 3 1.375
MYH6 myosin, heavy chain 6, cardiac muscle, alpha 1.369
CASR calcium-sensing receptor 1.369
CD52 CD52 molecule 1.363
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b 1.36
C6ORF15 chromosome 6 open reading frame 15 1.348
HLA-C major histocompatibility complex, class I, C 1.336
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1 1.33
NR3C2 nuclear receptor subfamily 3, group C, member 2 1.328
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1 1.325
IL17A interleukin 17A 1.322
HLA-A major histocompatibility complex, class I, A 1.301
F13B coagulation factor XIII, B polypeptide 1.299
FGF23 fibroblast growth factor 23 1.298
KCNJ12 potassium channel, inwardly rectifying subfamily J, member 12 1.29
KCND2 potassium channel, voltage gated Shal related subfamily D, member 2 1.29
F8 coagulation factor VIII, procoagulant component 1.289
PRKAR1A protein kinase, cAMP-dependent, regulatory, type I, alpha 1.288
PPARGC1A peroxisome proliferator-activated receptor gamma, coactivator 1 alpha 1.282
TNNI3 troponin I type 3 (cardiac) 1.269
TGFB1 transforming growth factor, beta 1 1.269
SLC2A2 solute carrier family 2 (facilitated glucose transporter), member 2 1.267
SECISBP2 SECIS binding protein 2 1.265
SOST sclerostin 1.26
ACP5 acid phosphatase 5, tartrate resistant 1.258
ADIPOQ adiponectin, C1Q and collagen domain containing 1.255
COL1A2 collagen, type I, alpha 2 1.254
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 1.253
CXCL10 chemokine (C-X-C motif) ligand 10 1.251
KCNA3 potassium channel, voltage gated shaker related subfamily A, member 3 1.235
GH1 growth hormone 1 1.235
NPY neuropeptide Y 1.234
IL4 interleukin 4 1.23
TRHR thyrotropin-releasing hormone receptor 1.229
TOR1A torsin family 1, member A (torsin A) 1.22
SLC2A4 solute carrier family 2 (facilitated glucose transporter), member 4 1.219
CCL2 chemokine (C-C motif) ligand 2 1.218
SSTR2 somatostatin receptor 2 1.215
EDNRA endothelin receptor type A 1.211
GHSR growth hormone secretagogue receptor 1.209
GPX3 glutathione peroxidase 3 1.206
RYR1 ryanodine receptor 1 (skeletal) 1.205
CSF3 colony stimulating factor 3 (granulocyte) 1.203
DUOXA2 dual oxidase maturation factor 2 1.202
MB myoglobin 1.199
AKT1 v-akt murine thymoma viral oncogene homolog 1 1.194
CD28 CD28 molecule 1.185
KCNJ5 potassium channel, inwardly rectifying subfamily J, member 5 1.178
GPHB5 glycoprotein hormone beta 5 1.171
EDN1 endothelin 1 1.17
PROP1 PROP paired-like homeobox 1 1.167
FCRL3 Fc receptor-like 3 1.166
HSD11B2 hydroxysteroid (11-beta) dehydrogenase 2 1.166
FSHR follicle stimulating hormone receptor 1.165
APOB apolipoprotein B 1.163
SELENOP selenoprotein P 1.155
DUOX2 dual oxidase 2 1.152
OXT oxytocin/neurophysin I prepropeptide 1.147
CD40LG CD40 ligand 1.138
GHR growth hormone receptor 1.132
AIRE autoimmune regulator 1.131
KCND3 potassium channel, voltage gated Shal related subfamily D, member 3 1.131
FLNB filamin B, beta 1.13
TGM2 transglutaminase 2 1.129
ESR1 estrogen receptor 1 1.129
MAOB monoamine oxidase B 1.124
CA1 carbonic anhydrase I 1.123
MUSK muscle, skeletal, receptor tyrosine kinase 1.121
HP haptoglobin 1.119
PRKACB protein kinase, cAMP-dependent, catalytic, beta 1.118
SERPINA6 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 6 1.112
IL16 interleukin 16 1.107
FSHB follicle stimulating hormone, beta polypeptide 1.107
MAOA monoamine oxidase A 1.102
FOXP3 forkhead box P3 1.101
CYP3A4 cytochrome P450, family 3, subfamily A, polypeptide 4 1.1
PRKACA protein kinase, cAMP-dependent, catalytic, alpha 1.095
NUDT10 nudix (nucleoside diphosphate linked moiety X)-type motif 10 1.095
CD80 CD80 molecule 1.094
SERPINC1 serpin peptidase inhibitor, clade C (antithrombin), member 1 1.092
AFP alpha-fetoprotein 1.091
KLF9 Kruppel-like factor 9 1.09
PRKACG protein kinase, cAMP-dependent, catalytic, gamma 1.086
MTOR mechanistic target of rapamycin (serine/threonine kinase) 1.085
CFC1 cripto, FRL-1, cryptic family 1 1.084
PRTN3 proteinase 3 1.081
AMH anti-Mullerian hormone 1.076
KCNJ14 potassium channel, inwardly rectifying subfamily J, member 14 1.074
MMEL1 membrane metallo-endopeptidase-like 1 1.07
ADM adrenomedullin 1.07
DPP4 dipeptidyl-peptidase 4 1.069
YY1AP1 YY1 associated protein 1 1.068
SCN5A sodium channel, voltage gated, type V alpha subunit 1.067
IGFBP3 insulin-like growth factor binding protein 3 1.063
PPARG peroxisome proliferator-activated receptor gamma 1.062
SMPD4 sphingomyelin phosphodiesterase 4, neutral membrane (neutral sphingomyelinase-3) 1.061
CSH1 chorionic somatomammotropin hormone 1 (placental lactogen) 1.056
TRMO tRNA methyltransferase O 1.056
SLC22A24 solute carrier family 22, member 24 1.055
SLC17A4 solute carrier family 17, member 4 1.05
IFNB1 interferon, beta 1, fibroblast 1.05
TSHZ3 teashirt zinc finger homeobox 3 1.048
CYP2C9 cytochrome P450, family 2, subfamily C, polypeptide 9 1.046
AGRP agouti related neuropeptide 1.043
INSR insulin receptor 1.037
TBL1Y transducin (beta)-like 1, Y-linked 1.035
CSH2 chorionic somatomammotropin hormone 2 1.032
ADRB3 adrenoceptor beta 3 1.029
TP53 tumor protein p53 1.026
CA5A carbonic anhydrase VA, mitochondrial 1.026
GPX2 glutathione peroxidase 2 1.022
LGALS3 lectin, galactoside-binding, soluble, 3 1.021
AQP2 aquaporin 2 (collecting duct) 1.019
CYP2D6 cytochrome P450, family 2, subfamily D, polypeptide 6 1.017
KNG1 kininogen 1 1.011
IL18 interleukin 18 1.011
SLCO1A2 solute carrier organic anion transporter family, member 1A2 1.01
GPX6 glutathione peroxidase 6 1.007
GC group-specific component (vitamin D binding protein) 1.007
GPX5 glutathione peroxidase 5 1.006
F9 coagulation factor IX 1.006
KCNJ1 potassium channel, inwardly rectifying subfamily J, member 1 1.005
GPX7 glutathione peroxidase 7 1.003