| Dataset | DeepCoverMOA Drug Mechanisms of Action |
| Category | proteomics |
| Type | drug perturbation |
| External Link | https://pubchem.ncbi.nlm.nih.gov/compound/60648 |
| Similar Terms | |
| Downloads & Tools |
197 proteins with high or low expression in Tiagabine relative to other proteins from the DeepCoverMOA Drug Mechanisms of Action dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| PRKD3 | protein kinase D3 | 1.96 |
| TIMM10B | translocase of inner mitochondrial membrane 10 homolog B (yeast) | 0.84 |
| DIPK1B | divergent protein kinase domain 1B | 0.75 |
| ZNF302 | zinc finger protein 302 | 0.66 |
| RPL34 | ribosomal protein L34 | 0.58 |
| PIP4P2 | phosphatidylinositol-4,5-bisphosphate 4-phosphatase 2 | 0.56 |
| ZBED8L | ZBED8 like | 0.55 |
| RPL37A | ribosomal protein L37a | 0.53 |
| PLEK | pleckstrin | 0.53 |
| SLC3A2 | solute carrier family 3 (amino acid transporter heavy chain), member 2 | 0.52 |
| TINAGL1 | tubulointerstitial nephritis antigen-like 1 | 0.5 |
| MRPL57 | mitochondrial ribosomal protein L57 | 0.49 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.48 |
| PKM | pyruvate kinase, muscle | 0.47 |
| CCNYL1 | cyclin Y-like 1 | 0.46 |
| KCTD17 | potassium channel tetramerization domain containing 17 | 0.43 |
| YIF1B | Yip1 interacting factor homolog B (S. cerevisiae) | 0.43 |
| NLGN2 | neuroligin 2 | 0.43 |
| ZNF444 | zinc finger protein 444 | 0.42 |
| MID1IP1 | MID1 interacting protein 1 | 0.42 |
| ARL16 | ADP-ribosylation factor-like 16 | 0.41 |
| PLEKHG3 | pleckstrin homology domain containing, family G (with RhoGef domain) member 3 | 0.4 |
| TTLL4 | tubulin tyrosine ligase-like family member 4 | 0.4 |
| IRX4 | iroquois homeobox 4 | 0.4 |
| ZNF367 | zinc finger protein 367 | 0.4 |
| CCDC15 | coiled-coil domain containing 15 | 0.39 |
| POLR1D | polymerase (RNA) I polypeptide D, 16kDa | 0.38 |
| PSRC1 | proline/serine-rich coiled-coil 1 | 0.37 |
| GRAMD2B | GRAM domain containing 2B | 0.37 |
| NOVA1 | neuro-oncological ventral antigen 1 | 0.37 |
| ZNF226 | zinc finger protein 226 | 0.37 |
| TIGD1 | tigger transposable element derived 1 | 0.36 |
| MIEN1 | migration and invasion enhancer 1 | 0.35 |
| RNF26 | ring finger protein 26 | 0.34 |
| TRMT112 | tRNA methyltransferase 11-2 homolog (S. cerevisiae) | 0.34 |
| SELENOI | selenoprotein I | 0.33 |
| POLR2L | polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa | 0.33 |
| TRIP6 | thyroid hormone receptor interactor 6 | 0.33 |
| ATG101 | autophagy related 101 | 0.33 |
| ZNF362 | zinc finger protein 362 | 0.33 |
| RPL36 | ribosomal protein L36 | 0.32 |
| DHRS3 | dehydrogenase/reductase (SDR family) member 3 | 0.32 |
| COQ10B | coenzyme Q10 homolog B (S. cerevisiae) | 0.32 |
| DMAC2 | distal membrane arm assembly component 2 | 0.31 |
| PITPNM1 | phosphatidylinositol transfer protein, membrane-associated 1 | 0.31 |
| MAZ | MYC-associated zinc finger protein (purine-binding transcription factor) | 0.31 |
| CDR2 | cerebellar degeneration-related protein 2, 62kDa | 0.31 |
| FBRSL1 | fibrosin-like 1 | 0.3 |
| MRPL51 | mitochondrial ribosomal protein L51 | 0.3 |
| ANTKMT | adenine nucleotide translocase lysine methyltransferase | 0.3 |
| ELOB | elongin B | 0.3 |
| TSEN15 | TSEN15 tRNA splicing endonuclease subunit | 0.3 |
| GAMT | guanidinoacetate N-methyltransferase | 0.3 |
| PROSER3 | proline and serine rich 3 | 0.3 |
| RPL26L1 | ribosomal protein L26-like 1 | 0.3 |
| NHSL1 | NHS-like 1 | 0.29 |
| ZMYND19 | zinc finger, MYND-type containing 19 | 0.29 |
| TCEA3 | transcription elongation factor A (SII), 3 | 0.29 |
| RAB40C | RAB40C, member RAS oncogene family | 0.29 |
| HDAC1 | histone deacetylase 1 | 0.29 |
| YBX3 | Y box binding protein 3 | 0.29 |
| DCAF5 | DDB1 and CUL4 associated factor 5 | 0.29 |
| SUMO1 | small ubiquitin-like modifier 1 | 0.29 |
| ITGA7 | integrin, alpha 7 | 0.29 |
| SDF2 | stromal cell-derived factor 2 | 0.29 |
| GATD1 | glutamine amidotransferase class 1 domain containing 1 | 0.28 |
| ZNF449 | zinc finger protein 449 | 0.28 |
| TJP1 | tight junction protein 1 | 0.28 |
| KCTD12 | potassium channel tetramerization domain containing 12 | 0.28 |
| FGFR4 | fibroblast growth factor receptor 4 | 0.28 |
| SEH1L | SEH1-like (S. cerevisiae) | 0.28 |
| COMMD6 | COMM domain containing 6 | 0.27 |
| UBE2D3 | ubiquitin-conjugating enzyme E2D 3 | 0.27 |
| NAPB | N-ethylmaleimide-sensitive factor attachment protein, beta | 0.27 |
| CIAO2B | cytosolic iron-sulfur assembly component 2B | 0.27 |
| IFITM3 | interferon induced transmembrane protein 3 | 0.27 |
| PNKD | paroxysmal nonkinesigenic dyskinesia | 0.27 |
| BTBD11 | BTB (POZ) domain containing 11 | 0.27 |
| ELOC | elongin C | 0.27 |
| MPDU1 | mannose-P-dolichol utilization defect 1 | 0.27 |
| GLO1 | glyoxalase I | 0.26 |
| PBLD | phenazine biosynthesis-like protein domain containing | 0.26 |
| ZKSCAN4 | zinc finger with KRAB and SCAN domains 4 | 0.26 |
| PRPF4 | pre-mRNA processing factor 4 | 0.26 |
| MRPL34 | mitochondrial ribosomal protein L34 | 0.26 |
| CDC42SE2 | CDC42 small effector 2 | 0.26 |
| LSM1 | LSM1, U6 small nuclear RNA associated | 0.26 |
| MYNN | myoneurin | 0.26 |
| MBNL2 | muscleblind-like splicing regulator 2 | 0.26 |
| IAH1 | isoamyl acetate-hydrolyzing esterase 1 homolog (S. cerevisiae) | 0.25 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.25 |
| MAT1A | methionine adenosyltransferase I, alpha | 0.25 |
| MIEF1 | mitochondrial elongation factor 1 | 0.25 |
| RCAN1 | regulator of calcineurin 1 | 0.25 |
| FKBP4 | FK506 binding protein 4, 59kDa | 0.25 |
| MT-ATP6 | ATP synthase F0 subunit 6 | 0.25 |
| SATB1 | SATB homeobox 1 | 0.25 |
| BOLA2 | bolA family member 2 | 0.24 |
| ALG13 | ALG13, UDP-N-acetylglucosaminyltransferase subunit | 0.24 |
| Symbol | Name | Standardized Value |
|---|---|---|
| MLLT6 | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 6 | -1.22 |
| FAM135B | family with sequence similarity 135, member B | -0.72 |
| TSPAN3 | tetraspanin 3 | -0.57 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | -0.56 |
| USB1 | U6 snRNA biogenesis 1 | -0.52 |
| IL10RB | interleukin 10 receptor, beta | -0.51 |
| GAS8 | growth arrest-specific 8 | -0.47 |
| TMEM41B | transmembrane protein 41B | -0.46 |
| CD82 | CD82 molecule | -0.46 |
| ZNF446 | zinc finger protein 446 | -0.45 |
| NDFIP1 | Nedd4 family interacting protein 1 | -0.45 |
| ARMC7 | armadillo repeat containing 7 | -0.45 |
| CLCN3 | chloride channel, voltage-sensitive 3 | -0.42 |
| HPCAL4 | hippocalcin like 4 | -0.41 |
| MED7 | mediator complex subunit 7 | -0.41 |
| KDM4C | lysine (K)-specific demethylase 4C | -0.41 |
| MED8 | mediator complex subunit 8 | -0.4 |
| CNTN1 | contactin 1 | -0.39 |
| RMDN2 | regulator of microtubule dynamics 2 | -0.39 |
| ZFP1 | ZFP1 zinc finger protein | -0.39 |
| DNM1L | dynamin 1-like | -0.38 |
| RFXAP | regulatory factor X-associated protein | -0.38 |
| ABTB1 | ankyrin repeat and BTB (POZ) domain containing 1 | -0.38 |
| ZNF587 | zinc finger protein 587 | -0.38 |
| SPPL3 | signal peptide peptidase like 3 | -0.38 |
| RPL36A | ribosomal protein L36a | -0.37 |
| GID8 | GID complex subunit 8 | -0.37 |
| CCDC85B | coiled-coil domain containing 85B | -0.37 |
| PPP1R2B | PPP1R2 family member B | -0.37 |
| VGF | VGF nerve growth factor inducible | -0.35 |
| SRD5A3 | steroid 5 alpha-reductase 3 | -0.35 |
| CCNQ | cyclin Q | -0.35 |
| TAPT1 | transmembrane anterior posterior transformation 1 | -0.34 |
| CHCHD4 | coiled-coil-helix-coiled-coil-helix domain containing 4 | -0.34 |
| RNF126 | ring finger protein 126 | -0.34 |
| PEX5 | peroxisomal biogenesis factor 5 | -0.34 |
| BORCS5 | BLOC-1 related complex subunit 5 | -0.33 |
| TCP11L1 | t-complex 11, testis-specific-like 1 | -0.33 |
| CBR1 | carbonyl reductase 1 | -0.33 |
| COL13A1 | collagen, type XIII, alpha 1 | -0.32 |
| PHLDB3 | pleckstrin homology-like domain, family B, member 3 | -0.32 |
| CLTA | clathrin, light chain A | -0.32 |
| BCLAF3 | BCLAF1 and THRAP3 family member 3 | -0.32 |
| ZNF564 | zinc finger protein 564 | -0.32 |
| PDGFC | platelet derived growth factor C | -0.32 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | -0.31 |
| IP6K2 | inositol hexakisphosphate kinase 2 | -0.31 |
| SERINC5 | serine incorporator 5 | -0.31 |
| PEX14 | peroxisomal biogenesis factor 14 | -0.31 |
| BAG3 | BCL2-associated athanogene 3 | -0.31 |
| STMN2 | stathmin 2 | -0.3 |
| SLC30A7 | solute carrier family 30 (zinc transporter), member 7 | -0.3 |
| WDR25 | WD repeat domain 25 | -0.3 |
| LIMCH1 | LIM and calponin homology domains 1 | -0.3 |
| FBXW7 | F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase | -0.3 |
| HMCN1 | hemicentin 1 | -0.3 |
| COPS4 | COP9 signalosome subunit 4 | -0.3 |
| FGFBP1 | fibroblast growth factor binding protein 1 | -0.29 |
| TTC17 | tetratricopeptide repeat domain 17 | -0.29 |
| SLC25A26 | solute carrier family 25 (S-adenosylmethionine carrier), member 26 | -0.29 |
| LENG9 | leukocyte receptor cluster (LRC) member 9 | -0.29 |
| ACTN3 | actinin, alpha 3 (gene/pseudogene) | -0.29 |
| ZNF445 | zinc finger protein 445 | -0.29 |
| GCSH | glycine cleavage system protein H (aminomethyl carrier) | -0.29 |
| SYN2 | synapsin II | -0.29 |
| TPM4 | tropomyosin 4 | -0.29 |
| TMEM184C | transmembrane protein 184C | -0.29 |
| COQ4 | coenzyme Q4 | -0.28 |
| PTK6 | protein tyrosine kinase 6 | -0.28 |
| USP19 | ubiquitin specific peptidase 19 | -0.28 |
| TRAPPC6A | trafficking protein particle complex 6A | -0.28 |
| SERPINI1 | serpin peptidase inhibitor, clade I (neuroserpin), member 1 | -0.28 |
| CD2BP2 | CD2 (cytoplasmic tail) binding protein 2 | -0.28 |
| TMEM63A | transmembrane protein 63A | -0.28 |
| ZNF714 | zinc finger protein 714 | -0.28 |
| ATP5PF | ATP synthase peripheral stalk subunit F6 | -0.27 |
| ZC3H12A | zinc finger CCCH-type containing 12A | -0.27 |
| MT1X | metallothionein 1X | -0.27 |
| PAIP2 | poly(A) binding protein interacting protein 2 | -0.27 |
| HSPA12B | heat shock 70kD protein 12B | -0.27 |
| GXYLT1 | glucoside xylosyltransferase 1 | -0.27 |
| FUNDC2 | FUN14 domain containing 2 | -0.26 |
| COL14A1 | collagen, type XIV, alpha 1 | -0.26 |
| ARHGAP44 | Rho GTPase activating protein 44 | -0.26 |
| TMSB10 | thymosin beta 10 | -0.26 |
| COL6A3 | collagen, type VI, alpha 3 | -0.26 |
| COMMD2 | COMM domain containing 2 | -0.26 |
| UBE2NL | ubiquitin-conjugating enzyme E2N-like (gene/pseudogene) | -0.26 |
| FUT10 | fucosyltransferase 10 (alpha (1,3) fucosyltransferase) | -0.26 |
| CALD1 | caldesmon 1 | -0.26 |
| RNF13 | ring finger protein 13 | -0.26 |
| MT1F | metallothionein 1F | -0.25 |
| NUCB1 | nucleobindin 1 | -0.25 |
| COL7A1 | collagen, type VII, alpha 1 | -0.25 |
| GRHL1 | grainyhead-like 1 (Drosophila) | -0.25 |
| LRFN3 | leucine rich repeat and fibronectin type III domain containing 3 | -0.25 |
| DOLK | dolichol kinase | -0.25 |
| IKBKG | inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma | -0.25 |
