Ticagrelor Gene Set

Dataset DeepCoverMOA Drug Mechanisms of Action
Category proteomics
Type drug perturbation
External Link https://pubchem.ncbi.nlm.nih.gov/compound/9871419
Similar Terms
Downloads & Tools

Genes

198 proteins with high or low expression in Ticagrelor relative to other proteins from the DeepCoverMOA Drug Mechanisms of Action dataset.

high expression

Symbol Name Standardized Value
TCIRG1 T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 subunit A3 1.28
VPS37B vacuolar protein sorting 37 homolog B (S. cerevisiae) 1.18
ABHD2 abhydrolase domain containing 2 1.06
CHPF chondroitin polymerizing factor 0.75
MCL1 myeloid cell leukemia 1 0.72
PLXNA3 plexin A3 0.7
SEZ6L2 seizure related 6 homolog (mouse)-like 2 0.66
ATF6B activating transcription factor 6 beta 0.66
FLCN folliculin 0.53
GPRASP2 G protein-coupled receptor associated sorting protein 2 0.52
IFRD1 interferon-related developmental regulator 1 0.51
THEMIS2 thymocyte selection associated family member 2 0.5
ZNF451 zinc finger protein 451 0.5
USP20 ubiquitin specific peptidase 20 0.5
HEXIM2 hexamethylene bis-acetamide inducible 2 0.49
CECR2 cat eye syndrome chromosome region, candidate 2 0.48
PALB2 partner and localizer of BRCA2 0.47
NR1H2 nuclear receptor subfamily 1, group H, member 2 0.47
RAB27B RAB27B, member RAS oncogene family 0.47
SYN2 synapsin II 0.46
ENTPD7 ectonucleoside triphosphate diphosphohydrolase 7 0.45
TTC13 tetratricopeptide repeat domain 13 0.45
ZNF57 zinc finger protein 57 0.44
SETD5 SET domain containing 5 0.44
ZNF341 zinc finger protein 341 0.44
NRP1 neuropilin 1 0.44
PACRGL PARK2 co-regulated-like 0.44
UPP1 uridine phosphorylase 1 0.43
ERBB3 erb-b2 receptor tyrosine kinase 3 0.43
FADS3 fatty acid desaturase 3 0.42
CCDC28A coiled-coil domain containing 28A 0.41
FBXO31 F-box protein 31 0.41
ZNF675 zinc finger protein 675 0.41
SNX25 sorting nexin 25 0.41
GSTM5 glutathione S-transferase mu 5 0.4
AOC1 amine oxidase, copper containing 1 0.4
JRKL JRK-like 0.4
DERPC DERPC proline and glycine rich nuclear protein 0.39
FBXL3 F-box and leucine-rich repeat protein 3 0.39
PCNX1 pecanex 1 0.38
CLN8 ceroid-lipofuscinosis, neuronal 8 (epilepsy, progressive with mental retardation) 0.37
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.37
B3GNT3 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3 0.37
FNIP1 folliculin interacting protein 1 0.37
ZWINT ZW10 interacting kinetochore protein 0.37
LAMC2 laminin, gamma 2 0.36
ARL6IP6 ADP-ribosylation factor-like 6 interacting protein 6 0.36
ZNF564 zinc finger protein 564 0.36
RPGR retinitis pigmentosa GTPase regulator 0.36
NT5E 5'-nucleotidase, ecto (CD73) 0.35
HIST2H2AA3 histone cluster 2, H2aa3 0.35
ETV5 ets variant 5 0.35
CERK ceramide kinase 0.35
SREBF2 sterol regulatory element binding transcription factor 2 0.34
ZNF189 zinc finger protein 189 0.34
PMFBP1 polyamine modulated factor 1 binding protein 1 0.34
BCO2 beta-carotene oxygenase 2 0.34
PRELID3B PRELI domain containing 3B 0.34
C1QTNF3 C1q and tumor necrosis factor related protein 3 0.34
ZMAT5 zinc finger, matrin-type 5 0.33
RNF141 ring finger protein 141 0.33
OSBPL7 oxysterol binding protein-like 7 0.33
THAP3 THAP domain containing, apoptosis associated protein 3 0.33
STK36 serine/threonine kinase 36 0.33
RIBC2 RIB43A domain with coiled-coils 2 0.33
GPBP1 GC-rich promoter binding protein 1 0.32
SPOP speckle-type POZ protein 0.32
CCDC110 coiled-coil domain containing 110 0.32
TRAK2 trafficking protein, kinesin binding 2 0.32
NIBAN1 niban apoptosis regulator 1 0.32
RNF4 ring finger protein 4 0.32
HHEX hematopoietically expressed homeobox 0.32
GAS6 growth arrest-specific 6 0.32
GAS2L3 growth arrest-specific 2 like 3 0.32
DOCK11 dedicator of cytokinesis 11 0.32
NHEJ1 nonhomologous end-joining factor 1 0.32
BBS1 Bardet-Biedl syndrome 1 0.31
ARL13B ADP-ribosylation factor-like 13B 0.31
ERN1 endoplasmic reticulum to nucleus signaling 1 0.31
SLC44A2 solute carrier family 44 (choline transporter), member 2 0.31
UTP14C UTP14, U3 small nucleolar ribonucleoprotein, homolog C (yeast) 0.31
DCLRE1A DNA cross-link repair 1A 0.31
NUDT14 nudix (nucleoside diphosphate linked moiety X)-type motif 14 0.31
TMEM39B transmembrane protein 39B 0.31
HSPA13 heat shock protein 70kDa family, member 13 0.31
G2E3 G2/M-phase specific E3 ubiquitin protein ligase 0.31
CABLES2 Cdk5 and Abl enzyme substrate 2 0.31
BORCS7 BLOC-1 related complex subunit 7 0.3
B4GALT4 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 4 0.3
C6ORF89 chromosome 6 open reading frame 89 0.3
AHR aryl hydrocarbon receptor 0.3
AFAP1L1 actin filament associated protein 1-like 1 0.3
DEGS1 delta(4)-desaturase, sphingolipid 1 0.3
PEX7 peroxisomal biogenesis factor 7 0.3
PPP1R14B protein phosphatase 1, regulatory (inhibitor) subunit 14B 0.3
BRCA2 breast cancer 2, early onset 0.3
H6PD hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase) 0.3
PCBD1 pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha 0.3
SLC25A52 solute carrier family 25, member 52 0.3

low expression

Symbol Name Standardized Value
NRIP1 nuclear receptor interacting protein 1 -1.12
HIVEP1 human immunodeficiency virus type I enhancer binding protein 1 -0.99
IGFBP6 insulin-like growth factor binding protein 6 -0.95
DHRS3 dehydrogenase/reductase (SDR family) member 3 -0.92
SRGAP3 SLIT-ROBO Rho GTPase activating protein 3 -0.92
PPP1R12B protein phosphatase 1, regulatory subunit 12B -0.71
TSKU tsukushi, small leucine rich proteoglycan -0.71
CDC26 cell division cycle 26 -0.68
MRPL35 mitochondrial ribosomal protein L35 -0.67
MOCS1 molybdenum cofactor synthesis 1 -0.65
MIEN1 migration and invasion enhancer 1 -0.65
RAB37 RAB37, member RAS oncogene family -0.62
INPP5J inositol polyphosphate-5-phosphatase J -0.62
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.61
TMBIM6 transmembrane BAX inhibitor motif containing 6 -0.59
RNF220 ring finger protein 220 -0.59
TINAGL1 tubulointerstitial nephritis antigen-like 1 -0.58
GVINP1 GTPase, very large interferon inducible pseudogene 1 -0.57
SPATA2 spermatogenesis associated 2 -0.54
RNF145 ring finger protein 145 -0.54
ZBED4 zinc finger, BED-type containing 4 -0.54
IQCJ-SCHIP1 IQCJ-SCHIP1 readthrough -0.54
ADPRH ADP-ribosylarginine hydrolase -0.53
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific ) -0.53
CACNB3 calcium channel, voltage-dependent, beta 3 subunit -0.53
TANGO2 transport and golgi organization 2 homolog (Drosophila) -0.51
FAM89A family with sequence similarity 89, member A -0.5
GFOD2 glucose-fructose oxidoreductase domain containing 2 -0.49
INTU inturned planar cell polarity protein -0.49
UNC5B unc-5 homolog B (C. elegans) -0.48
BOK BCL2-related ovarian killer -0.47
BCL2L12 BCL2-like 12 (proline rich) -0.47
SMAD3 SMAD family member 3 -0.45
RNF170 ring finger protein 170 -0.45
BDNF brain-derived neurotrophic factor -0.44
RLIM ring finger protein, LIM domain interacting -0.44
CDON cell adhesion associated, oncogene regulated -0.44
TEP1 telomerase-associated protein 1 -0.43
ZNF174 zinc finger protein 174 -0.43
UNC13D unc-13 homolog D (C. elegans) -0.43
IFFO2 intermediate filament family orphan 2 -0.43
SPC24 SPC24, NDC80 kinetochore complex component -0.42
MTSS2 MTSS I-BAR domain containing 2 -0.42
LTBP3 latent transforming growth factor beta binding protein 3 -0.42
PKHD1L1 polycystic kidney and hepatic disease 1 (autosomal recessive)-like 1 -0.42
ANO8 anoctamin 8 -0.42
PHLPP1 PH domain and leucine rich repeat protein phosphatase 1 -0.42
SHC4 SHC (Src homology 2 domain containing) family, member 4 -0.41
KALRN kalirin, RhoGEF kinase -0.41
FBXL14 F-box and leucine-rich repeat protein 14 -0.41
FITM2 fat storage-inducing transmembrane protein 2 -0.41
GPRC5B G protein-coupled receptor, class C, group 5, member B -0.4
ZFAND3 zinc finger, AN1-type domain 3 -0.4
MED25 mediator complex subunit 25 -0.4
CNEP1R1 CTD nuclear envelope phosphatase 1 regulatory subunit 1 -0.39
MRC2 mannose receptor, C type 2 -0.39
TATDN2 TatD DNase domain containing 2 -0.39
B4GALT3 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 3 -0.38
ABHD13 abhydrolase domain containing 13 -0.38
FSD1L fibronectin type III and SPRY domain containing 1-like -0.38
KMT2B lysine (K)-specific methyltransferase 2B -0.38
ASIC1 acid sensing (proton gated) ion channel 1 -0.38
MFSD6 major facilitator superfamily domain containing 6 -0.38
STYX serine/threonine/tyrosine interacting protein -0.37
COBL cordon-bleu WH2 repeat protein -0.37
MARCHF7 membrane associated ring-CH-type finger 7 -0.37
RBL2 retinoblastoma-like 2 -0.36
RFXAP regulatory factor X-associated protein -0.36
MTRF1L mitochondrial translational release factor 1-like -0.36
PRKAA2 protein kinase, AMP-activated, alpha 2 catalytic subunit -0.35
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 -0.35
GCNT1 glucosaminyl (N-acetyl) transferase 1, core 2 -0.35
FGD6 FYVE, RhoGEF and PH domain containing 6 -0.35
TLE5 TLE family member 5, transcriptional modulator -0.34
ADM adrenomedullin -0.34
GID8 GID complex subunit 8 -0.34
MRPL34 mitochondrial ribosomal protein L34 -0.34
GATD1 glutamine amidotransferase class 1 domain containing 1 -0.33
RIOX1 ribosomal oxygenase 1 -0.33
CYP24A1 cytochrome P450, family 24, subfamily A, polypeptide 1 -0.33
VCAN versican -0.33
SMIM26 small integral membrane protein 26 -0.33
PARPBP PARP1 binding protein -0.33
DST dystonin -0.32
ACTBL2 actin, beta-like 2 -0.32
CLN3 ceroid-lipofuscinosis, neuronal 3 -0.32
AURKAIP1 aurora kinase A interacting protein 1 -0.32
CNST consortin, connexin sorting protein -0.32
HELB helicase (DNA) B -0.32
TFDP2 transcription factor Dp-2 (E2F dimerization partner 2) -0.32
APBB1 amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65) -0.32
RUSC2 RUN and SH3 domain containing 2 -0.32
TOX2 TOX high mobility group box family member 2 -0.32
BAIAP2 BAI1-associated protein 2 -0.31
NR1D2 nuclear receptor subfamily 1, group D, member 2 -0.31
SYDE2 synapse defective 1, Rho GTPase, homolog 2 (C. elegans) -0.31
RPE ribulose-5-phosphate-3-epimerase -0.31
ALDH1A3 aldehyde dehydrogenase 1 family, member A3 -0.31
ZNF827 zinc finger protein 827 -0.31