Tight junction Gene Set

Dataset KEGG Pathways 2026
Category structural or functional annotations
Type pathway
Description An occluding cell-cell junction that is composed of a branching network of sealing strands that completely encircles the apical end of each cell in an epithelial sheet; the outer leaflets of the two interacting plasma membranes are seen to be tightly apposed where sealing strands are present. Each sealing strand is composed of a long row of transmembrane adhesion proteins embedded in each of the two interacting plasma membranes. (Gene Ontology, GO_0005923)
External Link https://www.kegg.jp/entry/hsa04530
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Genes

169 proteins participating in the Tight junction pathway from the KEGG Pathways 2026 dataset.

Symbol Name
ACTG1 actin gamma 1
ACTN1 actinin, alpha 1
ACTN4 actinin, alpha 4
ACTR2 ARP2 actin-related protein 2 homolog (yeast)
ACTR3 ARP3 actin-related protein 3 homolog (yeast)
ACTR3B ARP3 actin-related protein 3 homolog B (yeast)
ACTR3C ARP3 actin-related protein 3 homolog C (yeast)
AFDN afadin, adherens junction formation factor
AMOT angiomotin
AMOTL1 angiomotin like 1
AMOTL2 angiomotin like 2
ARHGAP17 Rho GTPase activating protein 17
ARHGEF18 Rho/Rac guanine nucleotide exchange factor (GEF) 18
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ARPC1A actin related protein 2/3 complex, subunit 1A, 41kDa
ARPC1B actin related protein 2/3 complex, subunit 1B, 41kDa
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa
ARPC3 actin related protein 2/3 complex, subunit 3, 21kDa
ARPC4-TTLL3 ARPC4-TTLL3 readthrough
ARPC5 actin related protein 2/3 complex, subunit 5, 16kDa
ARPC5L actin related protein 2/3 complex, subunit 5-like
BVES blood vessel epicardial substance
CACNA1D calcium channel, voltage-dependent, L type, alpha 1D subunit
CCND1 cyclin D1
CD1B CD1b molecule
CD1C CD1c molecule
CD1D CD1d molecule
CD1E CD1e molecule
CDC42 cell division cycle 42
CDK4 cyclin-dependent kinase 4
CFTR cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)
CGN cingulin
CGNL1 cingulin-like 1
CLDN1 claudin 1
CLDN10 claudin 10
CLDN11 claudin 11
CLDN12 claudin 12
CLDN14 claudin 14
CLDN15 claudin 15
CLDN16 claudin 16
CLDN17 claudin 17
CLDN18 claudin 18
CLDN19 claudin 19
CLDN2 claudin 2
CLDN20 claudin 20
CLDN22 claudin 22
CLDN23 claudin 23
CLDN24 claudin 24
CLDN25 claudin 25
CLDN3 claudin 3
CLDN34 claudin 34
CLDN4 claudin 4
CLDN5 claudin 5
CLDN6 claudin 6
CLDN7 claudin 7
CLDN8 claudin 8
CLDN9 claudin 9
CNKSR3 CNKSR family member 3
CRB3 crumbs family member 3
CTTN cortactin
DLG1 discs, large homolog 1 (Drosophila)
EPB41L4B erythrocyte membrane protein band 4.1 like 4B
ERBB2 erb-b2 receptor tyrosine kinase 2
EZR ezrin
F11R F11 receptor
GATA4 GATA binding protein 4
HCLS1 hematopoietic cell-specific Lyn substrate 1
HSPA4 heat shock 70kDa protein 4
IGSF5 immunoglobulin superfamily, member 5
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)
JAM2 junctional adhesion molecule 2
JAM3 junctional adhesion molecule 3
JUN jun proto-oncogene
LLGL1 lethal giant larvae homolog 1 (Drosophila)
LLGL2 lethal giant larvae homolog 2 (Drosophila)
LNX1 ligand of numb-protein X 1, E3 ubiquitin protein ligase
MAP2K7 mitogen-activated protein kinase kinase 7
MAP3K1 mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase
MAP3K5 mitogen-activated protein kinase kinase kinase 5
MAPK10 mitogen-activated protein kinase 10
MAPK8 mitogen-activated protein kinase 8
MAPK9 mitogen-activated protein kinase 9
MARVELD2 MARVEL domain containing 2
MARVELD3 MARVEL domain containing 3
MICALL2 MICAL-like 2
MPP2 membrane protein, palmitoylated 2 (MAGUK p55 subfamily member 2)
MPP3 membrane protein, palmitoylated 3 (MAGUK p55 subfamily member 3)
MPP4 membrane protein, palmitoylated 4 (MAGUK p55 subfamily member 4)
MSN moesin
MYH10 myosin, heavy chain 10, non-muscle
MYH11 myosin, heavy chain 11, smooth muscle
MYH14 myosin, heavy chain 14, non-muscle
MYH9 myosin, heavy chain 9, non-muscle
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric
MYL12B myosin, light chain 12B, regulatory
MYL2 myosin, light chain 2, regulatory, cardiac, slow
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle
MYL6B myosin, light chain 6B, alkali, smooth muscle and non-muscle
MYL9 myosin, light chain 9, regulatory
NEDD4 neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase
NF2 neurofibromin 2 (merlin)
OCLN occludin
PALS1 protein associated with LIN7 1, MAGUK p55 family member
PARD3 par-3 family cell polarity regulator
PARD6A par-6 family cell polarity regulator alpha
PARD6B par-6 family cell polarity regulator beta
PARD6G par-6 family cell polarity regulator gamma
PATJ PATJ crumbs cell polarity complex component
PCNA proliferating cell nuclear antigen
POTEF POTE ankyrin domain family, member F
PPP2CA protein phosphatase 2, catalytic subunit, alpha isozyme
PPP2CB protein phosphatase 2, catalytic subunit, beta isozyme
PPP2R1A protein phosphatase 2, regulatory subunit A, alpha
PPP2R1B protein phosphatase 2, regulatory subunit A, beta
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha
PPP2R2B protein phosphatase 2, regulatory subunit B, beta
PPP2R2C protein phosphatase 2, regulatory subunit B, gamma
PPP2R2D protein phosphatase 2, regulatory subunit B, delta
PRKAA1 protein kinase, AMP-activated, alpha 1 catalytic subunit
PRKAA2 protein kinase, AMP-activated, alpha 2 catalytic subunit
PRKAB1 protein kinase, AMP-activated, beta 1 non-catalytic subunit
PRKAB2 protein kinase, AMP-activated, beta 2 non-catalytic subunit
PRKACB protein kinase, cAMP-dependent, catalytic, beta
PRKACG protein kinase, cAMP-dependent, catalytic, gamma
PRKAG1 protein kinase, AMP-activated, gamma 1 non-catalytic subunit
PRKAG2 protein kinase, AMP-activated, gamma 2 non-catalytic subunit
PRKAG3 protein kinase, AMP-activated, gamma 3 non-catalytic subunit
PRKCA protein kinase C, alpha
PRKCE protein kinase C, epsilon
PRKCI protein kinase C, iota
PRKCZ protein kinase C, zeta
RAB13 RAB13, member RAS oncogene family
RAB8A RAB8A, member RAS oncogene family
RAB8B RAB8B, member RAS oncogene family
RAP1A RAP1A, member of RAS oncogene family
RAP2C RAP2C, member of RAS oncogene family
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2
RAPGEF6 Rap guanine nucleotide exchange factor (GEF) 6
RDX radixin
RHOA ras homolog family member A
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
ROCK1 Rho-associated, coiled-coil containing protein kinase 1
ROCK2 Rho-associated, coiled-coil containing protein kinase 2
RUNX1 runt-related transcription factor 1
SCRIB scribbled planar cell polarity protein
SLC9A3R1 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1
SRC SRC proto-oncogene, non-receptor tyrosine kinase
STK11 serine/threonine kinase 11
SYMPK symplekin
SYNPO synaptopodin
TIAM1 T-cell lymphoma invasion and metastasis 1
TJAP1 tight junction associated protein 1 (peripheral)
TJP1 tight junction protein 1
TJP2 tight junction protein 2
TJP3 tight junction protein 3
TUBA1A tubulin, alpha 1a
TUBA1B tubulin, alpha 1b
TUBA1C tubulin, alpha 1c
TUBA3C tubulin, alpha 3c
TUBA3D tubulin, alpha 3d
TUBA3E tubulin, alpha 3e
TUBA4A tubulin, alpha 4a
TUBA8 tubulin, alpha 8
TUBAL3 tubulin, alpha-like 3
VASP vasodilator-stimulated phosphoprotein
WAS Wiskott-Aldrich syndrome
WHAMM WAS protein homolog associated with actin, golgi membranes and microtubules
YBX3 Y box binding protein 3