| Dataset | DeepCoverMOA Drug Mechanisms of Action |
| Category | proteomics |
| Type | drug perturbation |
| External Link | https://pubchem.ncbi.nlm.nih.gov/compound/6323266 |
| Similar Terms | |
| Downloads & Tools |
199 proteins with high or low expression in Tipiracil relative to other proteins from the DeepCoverMOA Drug Mechanisms of Action dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| SH3YL1 | SH3 and SYLF domain containing 1 | 1.19 |
| SLC9B2 | solute carrier family 9, subfamily B (NHA2, cation proton antiporter 2), member 2 | 0.67 |
| PPFIBP1 | PTPRF interacting protein, binding protein 1 (liprin beta 1) | 0.58 |
| MSANTD4 | Myb/SANT-like DNA-binding domain containing 4 with coiled-coils | 0.54 |
| KLHDC10 | kelch domain containing 10 | 0.52 |
| PREX1 | phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1 | 0.51 |
| ATF6 | activating transcription factor 6 | 0.48 |
| DAP | death-associated protein | 0.47 |
| ZNF776 | zinc finger protein 776 | 0.42 |
| LYST | lysosomal trafficking regulator | 0.41 |
| ZNF594 | zinc finger protein 594 | 0.41 |
| GREB1 | growth regulation by estrogen in breast cancer 1 | 0.41 |
| ABCB1 | ATP-binding cassette, sub-family B (MDR/TAP), member 1 | 0.4 |
| CDCA4 | cell division cycle associated 4 | 0.39 |
| ZDHHC23 | zinc finger, DHHC-type containing 23 | 0.39 |
| PTMA | prothymosin, alpha | 0.38 |
| C19ORF47 | chromosome 19 open reading frame 47 | 0.37 |
| ZNF551 | zinc finger protein 551 | 0.35 |
| ZNF623 | zinc finger protein 623 | 0.35 |
| RTN4R | reticulon 4 receptor | 0.34 |
| UBE2L6 | ubiquitin-conjugating enzyme E2L 6 | 0.34 |
| ZSWIM7 | zinc finger, SWIM-type containing 7 | 0.34 |
| ZNF669 | zinc finger protein 669 | 0.33 |
| GEMIN7 | gem (nuclear organelle) associated protein 7 | 0.32 |
| MT-CO1 | cytochrome c oxidase subunit I | 0.32 |
| SIKE1 | suppressor of IKBKE 1 | 0.32 |
| JPT1 | Jupiter microtubule associated homolog 1 | 0.32 |
| FAN1 | FANCD2/FANCI-associated nuclease 1 | 0.32 |
| ISCA2 | iron-sulfur cluster assembly 2 | 0.32 |
| ARHGDIB | Rho GDP dissociation inhibitor (GDI) beta | 0.32 |
| YAF2 | YY1 associated factor 2 | 0.32 |
| DKK1 | dickkopf WNT signaling pathway inhibitor 1 | 0.31 |
| DCBLD1 | discoidin, CUB and LCCL domain containing 1 | 0.3 |
| USP37 | ubiquitin specific peptidase 37 | 0.3 |
| PEX5 | peroxisomal biogenesis factor 5 | 0.3 |
| GUCD1 | guanylyl cyclase domain containing 1 | 0.29 |
| SELENOW | selenoprotein W | 0.29 |
| DNAH14 | dynein, axonemal, heavy chain 14 | 0.29 |
| RAB27A | RAB27A, member RAS oncogene family | 0.29 |
| DALRD3 | DALR anticodon binding domain containing 3 | 0.28 |
| PTPRU | protein tyrosine phosphatase, receptor type, U | 0.28 |
| NIPA2 | non imprinted in Prader-Willi/Angelman syndrome 2 | 0.28 |
| CCNI | cyclin I | 0.28 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | 0.27 |
| SLC25A38 | solute carrier family 25, member 38 | 0.27 |
| TCEAL8 | transcription elongation factor A (SII)-like 8 | 0.27 |
| POLR2J | polymerase (RNA) II (DNA directed) polypeptide J, 13.3kDa | 0.27 |
| PARP8 | poly (ADP-ribose) polymerase family, member 8 | 0.27 |
| NUDT6 | nudix (nucleoside diphosphate linked moiety X)-type motif 6 | 0.26 |
| NEK3 | NIMA-related kinase 3 | 0.26 |
| UCK1 | uridine-cytidine kinase 1 | 0.26 |
| MFAP3L | microfibrillar-associated protein 3-like | 0.26 |
| BBS4 | Bardet-Biedl syndrome 4 | 0.26 |
| MED29 | mediator complex subunit 29 | 0.26 |
| HERC6 | HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 | 0.25 |
| PPP1R2B | PPP1R2 family member B | 0.25 |
| ABITRAM | actin binding transcription modulator | 0.25 |
| NUP62 | nucleoporin 62kDa | 0.25 |
| CNTNAP4 | contactin associated protein-like 4 | 0.25 |
| RBAK | RB-associated KRAB zinc finger | 0.25 |
| ZNF460 | zinc finger protein 460 | 0.25 |
| OPA3 | optic atrophy 3 (autosomal recessive, with chorea and spastic paraplegia) | 0.25 |
| TET2 | tet methylcytosine dioxygenase 2 | 0.25 |
| LMLN | leishmanolysin-like (metallopeptidase M8 family) | 0.24 |
| TIMM8A | translocase of inner mitochondrial membrane 8 homolog A (yeast) | 0.24 |
| BCL2L12 | BCL2-like 12 (proline rich) | 0.24 |
| MYL3 | myosin, light chain 3, alkali; ventricular, skeletal, slow | 0.24 |
| ALKBH5 | AlkB family member 5, RNA demethylase | 0.24 |
| CCDC84 | coiled-coil domain containing 84 | 0.24 |
| ZIC2 | Zic family member 2 | 0.24 |
| SFI1 | Sfi1 homolog, spindle assembly associated (yeast) | 0.24 |
| REV3L | REV3-like, polymerase (DNA directed), zeta, catalytic subunit | 0.24 |
| CGRRF1 | cell growth regulator with ring finger domain 1 | 0.24 |
| DPY30 | dpy-30 homolog (C. elegans) | 0.23 |
| TRAPPC2L | trafficking protein particle complex 2-like | 0.23 |
| SLC3A2 | solute carrier family 3 (amino acid transporter heavy chain), member 2 | 0.23 |
| SLC12A8 | solute carrier family 12, member 8 | 0.23 |
| LSM1 | LSM1, U6 small nuclear RNA associated | 0.22 |
| CDK11A | cyclin-dependent kinase 11A | 0.22 |
| SUSD1 | sushi domain containing 1 | 0.22 |
| GABPB1 | GA binding protein transcription factor, beta subunit 1 | 0.22 |
| SSH2 | slingshot protein phosphatase 2 | 0.22 |
| USP31 | ubiquitin specific peptidase 31 | 0.22 |
| STK17A | serine/threonine kinase 17a | 0.22 |
| FXN | frataxin | 0.22 |
| SP100 | SP100 nuclear antigen | 0.22 |
| COX7A2 | cytochrome c oxidase subunit VIIa polypeptide 2 (liver) | 0.22 |
| TPM4 | tropomyosin 4 | 0.22 |
| APLP1 | amyloid beta (A4) precursor-like protein 1 | 0.21 |
| MEGF9 | multiple EGF-like-domains 9 | 0.21 |
| ELOB | elongin B | 0.21 |
| MCFD2 | multiple coagulation factor deficiency 2 | 0.21 |
| ARPP19 | cAMP-regulated phosphoprotein, 19kDa | 0.21 |
| BRF2 | BRF2, RNA polymerase III transcription initiation factor 50 kDa subunit | 0.21 |
| DDTL | D-dopachrome tautomerase-like | 0.21 |
| CHCHD4 | coiled-coil-helix-coiled-coil-helix domain containing 4 | 0.21 |
| MTFR2 | mitochondrial fission regulator 2 | 0.21 |
| PHPT1 | phosphohistidine phosphatase 1 | 0.21 |
| PIP5K1C | phosphatidylinositol-4-phosphate 5-kinase, type I, gamma | 0.21 |
| Symbol | Name | Standardized Value |
|---|---|---|
| PIP | prolactin-induced protein | -1.52 |
| TOB2 | transducer of ERBB2, 2 | -0.96 |
| AZGP1 | alpha-2-glycoprotein 1, zinc-binding | -0.94 |
| ADAMTS14 | ADAM metallopeptidase with thrombospondin type 1 motif, 14 | -0.75 |
| KLHL23 | kelch-like family member 23 | -0.7 |
| VAV1 | vav 1 guanine nucleotide exchange factor | -0.67 |
| KMT2C | lysine (K)-specific methyltransferase 2C | -0.63 |
| CBR3 | carbonyl reductase 3 | -0.62 |
| VCPKMT | valosin containing protein lysine (K) methyltransferase | -0.58 |
| IER2 | immediate early response 2 | -0.57 |
| IER3IP1 | immediate early response 3 interacting protein 1 | -0.55 |
| MIPOL1 | mirror-image polydactyly 1 | -0.55 |
| DEPTOR | DEP domain containing MTOR-interacting protein | -0.5 |
| ASB7 | ankyrin repeat and SOCS box containing 7 | -0.49 |
| BAHCC1 | BAH domain and coiled-coil containing 1 | -0.48 |
| PDIK1L | PDLIM1 interacting kinase 1 like | -0.47 |
| MTSS2 | MTSS I-BAR domain containing 2 | -0.47 |
| ARFGEF3 | ARFGEF family member 3 | -0.46 |
| HERC3 | HECT and RLD domain containing E3 ubiquitin protein ligase 3 | -0.45 |
| MLH3 | mutL homolog 3 | -0.45 |
| SELENOK | selenoprotein K | -0.44 |
| FTL | ferritin, light polypeptide | -0.43 |
| MFSD6 | major facilitator superfamily domain containing 6 | -0.42 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | -0.42 |
| TECPR1 | tectonin beta-propeller repeat containing 1 | -0.42 |
| RANBP17 | RAN binding protein 17 | -0.42 |
| ABHD2 | abhydrolase domain containing 2 | -0.41 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | -0.41 |
| ONECUT2 | one cut homeobox 2 | -0.4 |
| IP6K1 | inositol hexakisphosphate kinase 1 | -0.4 |
| FSIP2 | fibrous sheath interacting protein 2 | -0.39 |
| CASP10 | caspase 10, apoptosis-related cysteine peptidase | -0.39 |
| ALKBH2 | alkB, alkylation repair homolog 2 (E. coli) | -0.39 |
| ABHD15 | abhydrolase domain containing 15 | -0.38 |
| GRN | granulin | -0.37 |
| CES2 | carboxylesterase 2 | -0.37 |
| ZFP36 | ZFP36 ring finger protein | -0.36 |
| BMERB1 | bMERB domain containing 1 | -0.36 |
| VASN | vasorin | -0.36 |
| ONECUT3 | one cut homeobox 3 | -0.36 |
| ABHD3 | abhydrolase domain containing 3 | -0.36 |
| RITA1 | RBPJ interacting and tubulin associated 1 | -0.35 |
| RPL36A | ribosomal protein L36a | -0.35 |
| CLN3 | ceroid-lipofuscinosis, neuronal 3 | -0.34 |
| ANKRD36 | ankyrin repeat domain 36 | -0.34 |
| TCP11L2 | t-complex 11, testis-specific-like 2 | -0.34 |
| ARHGAP22 | Rho GTPase activating protein 22 | -0.34 |
| CKM | creatine kinase, muscle | -0.34 |
| SLC26A6 | solute carrier family 26 (anion exchanger), member 6 | -0.34 |
| ITGB1BP1 | integrin beta 1 binding protein 1 | -0.34 |
| ABHD18 | abhydrolase domain containing 18 | -0.34 |
| COX11 | COX11 cytochrome c oxidase copper chaperone | -0.33 |
| TMCC3 | transmembrane and coiled-coil domain family 3 | -0.33 |
| RBPJL | recombination signal binding protein for immunoglobulin kappa J region-like | -0.33 |
| HSP90AB4P | heat shock protein 90kDa alpha (cytosolic), class B member 4, pseudogene | -0.33 |
| BET1L | Bet1 golgi vesicular membrane trafficking protein-like | -0.33 |
| TATDN2 | TatD DNase domain containing 2 | -0.33 |
| ABCD1 | ATP-binding cassette, sub-family D (ALD), member 1 | -0.33 |
| MPV17L2 | MPV17 mitochondrial membrane protein-like 2 | -0.33 |
| OBSL1 | obscurin-like 1 | -0.32 |
| CSNK1G3 | casein kinase 1, gamma 3 | -0.32 |
| ZNF280B | zinc finger protein 280B | -0.32 |
| LAPTM4A | lysosomal protein transmembrane 4 alpha | -0.32 |
| MAD2L1BP | MAD2L1 binding protein | -0.32 |
| CDC42SE2 | CDC42 small effector 2 | -0.32 |
| ATXN7L3B | ataxin 7-like 3B | -0.31 |
| KIAA1107 | KIAA1107 | -0.31 |
| DOCK4 | dedicator of cytokinesis 4 | -0.31 |
| HAUS7 | HAUS augmin-like complex, subunit 7 | -0.3 |
| UST | uronyl-2-sulfotransferase | -0.3 |
| CDC14A | cell division cycle 14A | -0.3 |
| CHN1 | chimerin 1 | -0.3 |
| SYTL4 | synaptotagmin-like 4 | -0.3 |
| ZNF91 | zinc finger protein 91 | -0.3 |
| AGFG2 | ArfGAP with FG repeats 2 | -0.3 |
| FAM241B | family with sequence similarity 241 member B | -0.3 |
| CDK10 | cyclin-dependent kinase 10 | -0.3 |
| CFAP410 | cilia and flagella associated protein 410 | -0.3 |
| GAREM1 | GRB2 associated regulator of MAPK1 subtype 1 | -0.29 |
| CCND3 | cyclin D3 | -0.29 |
| RAB3IP | RAB3A interacting protein | -0.29 |
| KIFC3 | kinesin family member C3 | -0.29 |
| VEZT | vezatin, adherens junctions transmembrane protein | -0.29 |
| DGCR2 | DiGeorge syndrome critical region gene 2 | -0.29 |
| TTLL4 | tubulin tyrosine ligase-like family member 4 | -0.29 |
| CYB5D2 | cytochrome b5 domain containing 2 | -0.29 |
| F2R | coagulation factor II (thrombin) receptor | -0.29 |
| FMNL1 | formin-like 1 | -0.29 |
| MOCS2 | molybdenum cofactor synthesis 2 | -0.28 |
| IGSF8 | immunoglobulin superfamily, member 8 | -0.28 |
| TMEM106C | transmembrane protein 106C | -0.28 |
| STRIP2 | striatin interacting protein 2 | -0.28 |
| CEMIP | cell migration inducing protein, hyaluronan binding | -0.28 |
| E2F4 | E2F transcription factor 4, p107/p130-binding | -0.28 |
| COX16 | COX16 cytochrome c oxidase assembly homolog (S. cerevisiae) | -0.27 |
| GOLGA7 | golgin A7 | -0.27 |
| CCDC117 | coiled-coil domain containing 117 | -0.27 |
| NDRG2 | NDRG family member 2 | -0.27 |
| ARL6IP6 | ADP-ribosylation factor-like 6 interacting protein 6 | -0.27 |
| CCT6B | chaperonin containing TCP1, subunit 6B (zeta 2) | -0.27 |
