Tirabrutinib (hydrochloride)_A-172 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Tirabrutinib (hydrochloride) perturbation in A-172 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Tirabrutinib (hydrochloride)_A-172 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.15315
FTH1 ferritin, heavy polypeptide 1 0.143101
BHLHE40 basic helix-loop-helix family, member e40 0.134408
AHNAK AHNAK nucleoprotein 0.126176
SQSTM1 sequestosome 1 0.118889
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.112243
EEF2 eukaryotic translation elongation factor 2 0.105104
VIM vimentin 0.104456
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0936918
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0889899
SOD2 superoxide dismutase 2, mitochondrial 0.0810612
COL5A1 collagen, type V, alpha 1 0.0762326
LMNA lamin A/C 0.0742428
CALR calreticulin 0.0714472
FLNA filamin A, alpha 0.0700406
CDH13 cadherin 13 0.0699203
CANX calnexin 0.0698297
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.0652923
TNIP1 TNFAIP3 interacting protein 1 0.063735
CCND1 cyclin D1 0.063432
ANXA2 annexin A2 0.0625405
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 0.06248
NDRG1 N-myc downstream regulated 1 0.0622179
RND3 Rho family GTPase 3 0.059118
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0571621
HLA-E major histocompatibility complex, class I, E 0.0552345
IGFBP3 insulin-like growth factor binding protein 3 0.0529144
FN1 fibronectin 1 0.0523374
ZFP36L1 ZFP36 ring finger protein-like 1 0.0510951
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0508368
TRIO trio Rho guanine nucleotide exchange factor 0.0498214
PLEC plectin 0.0498184
MSI2 musashi RNA-binding protein 2 0.0488807
PTMA prothymosin, alpha 0.0488453
KRT18 keratin 18, type I 0.047757
MYH9 myosin, heavy chain 9, non-muscle 0.0475099
PODXL podocalyxin-like 0.047358
LOC112694756 uncharaterized LOC112694756 0.0473437
SPTBN1 spectrin, beta, non-erythrocytic 1 0.046654
ZEB1 zinc finger E-box binding homeobox 1 0.0459406
ADM adrenomedullin 0.0450099
JUN jun proto-oncogene 0.0441673
SFTPA2 surfactant protein A2 0.0438282
HLA-B major histocompatibility complex, class I, B 0.0421896
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II 0.0420408
GOLGA4 golgin A4 0.0418537
EIF1 eukaryotic translation initiation factor 1 0.0408997
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0402899
FSTL1 follistatin-like 1 0.0396501
DDIT4 DNA-damage-inducible transcript 4 0.0393711
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0393697
ABI3BP ABI family, member 3 (NESH) binding protein 0.038666
GARS1 glycyl-tRNA synthetase 1 0.0385344
LOXL2 lysyl oxidase-like 2 0.0382054
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma 0.0375347
AKAP12 A kinase (PRKA) anchor protein 12 0.0374244
LDHA lactate dehydrogenase A 0.0368003
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b 0.0361497
HDLBP high density lipoprotein binding protein 0.0353122
PALM2AKAP2 PALM2 and AKAP2 fusion 0.034982
TPT1 tumor protein, translationally-controlled 1 0.0345172
THBS2 thrombospondin 2 0.0343006
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3 0.034016
VEGFA vascular endothelial growth factor A 0.0339125
NEFL neurofilament, light polypeptide 0.0334691
TM4SF1 transmembrane 4 L six family member 1 0.0328838
CALU calumenin 0.0327424
INSIG1 insulin induced gene 1 0.0321941
HLA-A major histocompatibility complex, class I, A 0.0319875
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon 0.0319284
WAC WW domain containing adaptor with coiled-coil 0.0318915
TTC3 tetratricopeptide repeat domain 3 0.031134
RAD23B RAD23 homolog B (S. cerevisiae) 0.0310557
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 0.0310408
IARS1 isoleucyl-tRNA synthetase 1 0.0309833
COL6A1 collagen, type VI, alpha 1 0.0305497
GOLGA2 golgin A2 0.0303794
TMSB10 thymosin beta 10 0.0302537
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0296164
GNPDA1 glucosamine-6-phosphate deaminase 1 0.0293362
RAB7A RAB7A, member RAS oncogene family 0.0293091
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0287849
HILPDA hypoxia inducible lipid droplet-associated 0.0286584
FSCN1 fascin actin-bundling protein 1 0.028649
SLC39A11 solute carrier family 39, member 11 0.0285033
EGLN1 egl-9 family hypoxia-inducible factor 1 0.0282544
SP100 SP100 nuclear antigen 0.0281684
COL4A2 collagen, type IV, alpha 2 0.0276286
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide 0.0273897
RAB1A RAB1A, member RAS oncogene family 0.0273511
TMSB4X thymosin beta 4, X-linked 0.0272
KLF6 Kruppel-like factor 6 0.0264118
AKT3 v-akt murine thymoma viral oncogene homolog 3 0.0262451
IRF1 interferon regulatory factor 1 0.0260533
APP amyloid beta (A4) precursor protein 0.025244
COPA coatomer protein complex, subunit alpha 0.0249944
L1CAM L1 cell adhesion molecule 0.0249917
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 0.024779
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0247441
FMNL2 formin-like 2 0.0245795

decreased expression

Symbol Name Standardized Value
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.271559
PLAT plasminogen activator, tissue -0.11387
CD44 CD44 molecule (Indian blood group) -0.0832139
NAV1 neuron navigator 1 -0.0654721
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0543136
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0540076
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0525324
MT2A metallothionein 2A -0.0501589
WWTR1 WW domain containing transcription regulator 1 -0.0449303
ZBTB20 zinc finger and BTB domain containing 20 -0.0440202
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) -0.0399155
SVIL supervillin -0.0376402
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0360403
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0348505
MB21D2 Mab-21 domain containing 2 -0.0335388
NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta -0.0301715
FNDC3B fibronectin type III domain containing 3B -0.0296887
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -0.0265414
S100A10 S100 calcium binding protein A10 -0.0260147
DHRSX dehydrogenase/reductase (SDR family) X-linked -0.0252577
GLIS3 GLIS family zinc finger 3 -0.0241345
AVL9 AVL9 homolog (S. cerevisiase) -0.0239391
MYADM myeloid-associated differentiation marker -0.0238066
GPC6 glypican 6 -0.0237574
ANKRD36 ankyrin repeat domain 36 -0.0235739
SP3 Sp3 transcription factor -0.0232745
NEK7 NIMA-related kinase 7 -0.0231139
RFTN1 raftlin, lipid raft linker 1 -0.0223037
KLF7 Kruppel-like factor 7 (ubiquitous) -0.0222179
TENT5A terminal nucleotidyltransferase 5A -0.0221898
RAI14 retinoic acid induced 14 -0.0219675
TDRD7 tudor domain containing 7 -0.021545
KIFAP3 kinesin-associated protein 3 -0.0213303
RIPK1 receptor (TNFRSF)-interacting serine-threonine kinase 1 -0.0209414
LHFPL6 LHFPL tetraspan subfamily member 6 -0.0208976
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) -0.0208161
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0203288
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.0198352
SLFN5 schlafen family member 5 -0.0196534
FER fer (fps/fes related) tyrosine kinase -0.0193814
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like -0.0190769
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0188435
ATP13A3 ATPase type 13A3 -0.0186533
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) -0.0185141
YEATS2 YEATS domain containing 2 -0.0181647
RASA2 RAS p21 protein activator 2 -0.018163
PSD3 pleckstrin and Sec7 domain containing 3 -0.017678
SPDL1 spindle apparatus coiled-coil protein 1 -0.0175465
C1GALT1 core 1 synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1 -0.0174292
RNF144A ring finger protein 144A -0.017241
STC1 stanniocalcin 1 -0.0170386
OSMR oncostatin M receptor -0.0169034
LRRTM4 leucine rich repeat transmembrane neuronal 4 -0.0166528
DKK1 dickkopf WNT signaling pathway inhibitor 1 -0.0166401
CFLAR CASP8 and FADD-like apoptosis regulator -0.0166062
LYST lysosomal trafficking regulator -0.0165809
MTSS1 metastasis suppressor 1 -0.0164842
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1 -0.0163958
HGSNAT heparan-alpha-glucosaminide N-acetyltransferase -0.0161964
SIPA1L3 signal-induced proliferation-associated 1 like 3 -0.0161591
TRPC1 transient receptor potential cation channel, subfamily C, member 1 -0.0158889
RSAD2 radical S-adenosyl methionine domain containing 2 -0.0154307
PDE4D phosphodiesterase 4D, cAMP-specific -0.0153167
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0152973
SERPINB6 serpin peptidase inhibitor, clade B (ovalbumin), member 6 -0.0150714
TXNIP thioredoxin interacting protein -0.0150596
ANK2 ankyrin 2, neuronal -0.0149584
DCUN1D3 DCN1, defective in cullin neddylation 1, domain containing 3 -0.0149096
NF1 neurofibromin 1 -0.0148004
CENPF centromere protein F, 350/400kDa -0.0147898
CAPRIN1 cell cycle associated protein 1 -0.0147796
ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4 -0.0147593
ACTR2 ARP2 actin-related protein 2 homolog (yeast) -0.0146266
SPATS2L spermatogenesis associated, serine-rich 2-like -0.0145799
CEP170 centrosomal protein 170kDa -0.0144959
VOPP1 vesicular, overexpressed in cancer, prosurvival protein 1 -0.0143921
FSD1L fibronectin type III and SPRY domain containing 1-like -0.0141544
ANKRD12 ankyrin repeat domain 12 -0.0140658
S100A9 S100 calcium binding protein A9 -0.0140324
IFI44 interferon-induced protein 44 -0.0139807
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein -0.0138394
SNX14 sorting nexin 14 -0.0136624
EHBP1 EH domain binding protein 1 -0.0134311
VGLL4 vestigial-like family member 4 -0.0133934
S100A4 S100 calcium binding protein A4 -0.0133882
IDS iduronate 2-sulfatase -0.013337
RRM2 ribonucleotide reductase M2 -0.0132998
CDK19 cyclin-dependent kinase 19 -0.0132955
SMAD3 SMAD family member 3 -0.0132411
KLF12 Kruppel-like factor 12 -0.0131282
ZNF721 zinc finger protein 721 -0.013095
DYNLT1 dynein, light chain, Tctex-type 1 -0.0130532
PRKCSH protein kinase C substrate 80K-H -0.0130218
TXNRD1 thioredoxin reductase 1 -0.0128577
VEGFC vascular endothelial growth factor C -0.0128511
PPP1R12A protein phosphatase 1, regulatory subunit 12A -0.0127415
HIBCH 3-hydroxyisobutyryl-CoA hydrolase -0.0125451
ANKRD36C ankyrin repeat domain 36C -0.0125338
GSE1 Gse1 coiled-coil protein -0.0124242
PHC3 polyhomeotic homolog 3 (Drosophila) -0.0123737