| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Tirabrutinib (hydrochloride) perturbation in A-427 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Tirabrutinib (hydrochloride)_A-427 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| AREG | amphiregulin | 0.181888 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.114369 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | 0.0849154 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0847478 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0551258 |
| CCNL1 | cyclin L1 | 0.0514257 |
| EIF4A2 | eukaryotic translation initiation factor 4A2 | 0.0489743 |
| CPOX | coproporphyrinogen oxidase | 0.0470933 |
| FXR1 | fragile X mental retardation, autosomal homolog 1 | 0.0417022 |
| ATP5F1B | ATP synthase F1 subunit beta | 0.0396902 |
| BIRC3 | baculoviral IAP repeat containing 3 | 0.0395407 |
| YBX1 | Y box binding protein 1 | 0.0362466 |
| PLK2 | polo-like kinase 2 | 0.0328627 |
| PUM2 | pumilio RNA-binding family member 2 | 0.0326932 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0319966 |
| NDUFV2 | NADH dehydrogenase (ubiquinone) flavoprotein 2, 24kDa | 0.031647 |
| GPBP1 | GC-rich promoter binding protein 1 | 0.0314531 |
| PCBP2 | poly(rC) binding protein 2 | 0.0313136 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0310461 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | 0.0308478 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0296448 |
| PDK4 | pyruvate dehydrogenase kinase, isozyme 4 | 0.0288477 |
| HLA-A | major histocompatibility complex, class I, A | 0.0287695 |
| ADAM17 | ADAM metallopeptidase domain 17 | 0.0277133 |
| PPP2R2A | protein phosphatase 2, regulatory subunit B, alpha | 0.0276558 |
| PNN | pinin, desmosome associated protein | 0.02598 |
| TFG | TRK-fused gene | 0.0259683 |
| NCKAP1 | NCK-associated protein 1 | 0.0257278 |
| BRD2 | bromodomain containing 2 | 0.0253993 |
| BIRC2 | baculoviral IAP repeat containing 2 | 0.0253378 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.0252299 |
| MATR3 | matrin 3 | 0.0252281 |
| TXNRD1 | thioredoxin reductase 1 | 0.0248282 |
| KIF5B | kinesin family member 5B | 0.0246384 |
| USP15 | ubiquitin specific peptidase 15 | 0.0241635 |
| ADAM9 | ADAM metallopeptidase domain 9 | 0.0241484 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | 0.024121 |
| SFTPA2 | surfactant protein A2 | 0.0239179 |
| QKI | QKI, KH domain containing, RNA binding | 0.0237093 |
| RNF145 | ring finger protein 145 | 0.0235802 |
| POTEF | POTE ankyrin domain family, member F | 0.0225196 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | 0.0222188 |
| SPAG9 | sperm associated antigen 9 | 0.0221889 |
| THOC1 | THO complex 1 | 0.0217322 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.021628 |
| PTMS | parathymosin | 0.0215574 |
| ARHGAP12 | Rho GTPase activating protein 12 | 0.0214554 |
| GOLGA4 | golgin A4 | 0.0213731 |
| MLLT10 | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 | 0.0213578 |
| PPP6R3 | protein phosphatase 6, regulatory subunit 3 | 0.021318 |
| ARL5B | ADP-ribosylation factor-like 5B | 0.0211725 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.0206388 |
| KDM6A | lysine (K)-specific demethylase 6A | 0.0203589 |
| ARRDC3 | arrestin domain containing 3 | 0.0201504 |
| UAP1 | UDP-N-acetylglucosamine pyrophosphorylase 1 | 0.0200608 |
| ECT2 | epithelial cell transforming 2 | 0.0198768 |
| PER1 | period circadian clock 1 | 0.0198753 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | 0.0196598 |
| PRKCI | protein kinase C, iota | 0.0194671 |
| SETD5 | SET domain containing 5 | 0.0192198 |
| YTHDC1 | YTH domain containing 1 | 0.0191567 |
| PNISR | PNN-interacting serine/arginine-rich protein | 0.0191506 |
| RLF | rearranged L-myc fusion | 0.0190798 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0190557 |
| CLDND1 | claudin domain containing 1 | 0.0187017 |
| RSRC2 | arginine/serine-rich coiled-coil 2 | 0.018681 |
| AFTPH | aftiphilin | 0.0181212 |
| SREK1 | splicing regulatory glutamine/lysine-rich protein 1 | 0.0181009 |
| RBM25 | RNA binding motif protein 25 | 0.0179155 |
| RPS4X | ribosomal protein S4, X-linked | 0.0177998 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | 0.01775 |
| NUP58 | nucleoporin 58 | 0.0177275 |
| PPM1D | protein phosphatase, Mg2+/Mn2+ dependent, 1D | 0.0176538 |
| CSDE1 | cold shock domain containing E1, RNA-binding | 0.0176388 |
| MED13L | mediator complex subunit 13-like | 0.0176349 |
| EEF1G | eukaryotic translation elongation factor 1 gamma | 0.0175623 |
| CHD1 | chromodomain helicase DNA binding protein 1 | 0.0175475 |
| BRWD1 | bromodomain and WD repeat domain containing 1 | 0.017254 |
| MLF1 | myeloid leukemia factor 1 | 0.0172427 |
| TSC22D2 | TSC22 domain family, member 2 | 0.017215 |
| EDN1 | endothelin 1 | 0.0171867 |
| OXR1 | oxidation resistance 1 | 0.0171766 |
| ATP2C1 | ATPase, Ca++ transporting, type 2C, member 1 | 0.0171172 |
| GARS1 | glycyl-tRNA synthetase 1 | 0.0169139 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | 0.0167297 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0167226 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0167211 |
| DYRK1A | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A | 0.0166599 |
| ATP6V1A | ATPase, H+ transporting, lysosomal 70kDa, V1 subunit A | 0.016624 |
| PRPF8 | pre-mRNA processing factor 8 | 0.0165984 |
| GABARAPL1 | GABA(A) receptor-associated protein like 1 | 0.0163934 |
| WDR43 | WD repeat domain 43 | 0.0163427 |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | 0.0160981 |
| PSMD2 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 | 0.0160932 |
| RPL3 | ribosomal protein L3 | 0.0159293 |
| PHC3 | polyhomeotic homolog 3 (Drosophila) | 0.0158996 |
| EIF2A | eukaryotic translation initiation factor 2A, 65kDa | 0.0157752 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | 0.015755 |
| COG5 | component of oligomeric golgi complex 5 | 0.0154261 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0153982 |
| Symbol | Name | Standardized Value |
|---|---|---|
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.241408 |
| NLGN1 | neuroligin 1 | -0.218341 |
| VIM | vimentin | -0.204414 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.168097 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.128799 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.113898 |
| PCDH7 | protocadherin 7 | -0.0939082 |
| ROBO2 | roundabout, axon guidance receptor, homolog 2 (Drosophila) | -0.0815846 |
| TMSB10 | thymosin beta 10 | -0.0808813 |
| HMGA2 | high mobility group AT-hook 2 | -0.0807918 |
| ACTG1 | actin gamma 1 | -0.0783116 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | -0.0693029 |
| CUBN | cubilin (intrinsic factor-cobalamin receptor) | -0.0654216 |
| ZNF804A | zinc finger protein 804A | -0.065118 |
| TAS2R14 | taste receptor, type 2, member 14 | -0.0607605 |
| EHBP1 | EH domain binding protein 1 | -0.0593231 |
| DPYD | dihydropyrimidine dehydrogenase | -0.0589299 |
| ANKRD12 | ankyrin repeat domain 12 | -0.0580789 |
| ERC1 | ELKS/RAB6-interacting/CAST family member 1 | -0.0565647 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0548671 |
| MMP12 | matrix metallopeptidase 12 | -0.053777 |
| MTAP | methylthioadenosine phosphorylase | -0.0524136 |
| TENM3 | teneurin transmembrane protein 3 | -0.0521315 |
| NHSL1 | NHS-like 1 | -0.0517518 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0515284 |
| LRRTM4 | leucine rich repeat transmembrane neuronal 4 | -0.0508718 |
| NEBL | nebulette | -0.0504524 |
| RASAL2 | RAS protein activator like 2 | -0.0481584 |
| DLC1 | DLC1 Rho GTPase activating protein | -0.0454787 |
| MYL12B | myosin, light chain 12B, regulatory | -0.0444599 |
| DST | dystonin | -0.0428518 |
| RPL35A | ribosomal protein L35a | -0.0428256 |
| RABGAP1L | RAB GTPase activating protein 1-like | -0.0422682 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0422622 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | -0.0418444 |
| EIF4G3 | eukaryotic translation initiation factor 4 gamma, 3 | -0.0417239 |
| JMJD1C | jumonji domain containing 1C | -0.0416036 |
| CELF2 | CUGBP, Elav-like family member 2 | -0.0410067 |
| YAP1 | Yes-associated protein 1 | -0.0398063 |
| PTMA | prothymosin, alpha | -0.0369729 |
| CMIP | c-Maf inducing protein | -0.0366436 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0363451 |
| CUX1 | cut-like homeobox 1 | -0.0360911 |
| ALDH1A1 | aldehyde dehydrogenase 1 family, member A1 | -0.0358776 |
| RIMS2 | regulating synaptic membrane exocytosis 2 | -0.0357711 |
| IFIH1 | interferon induced with helicase C domain 1 | -0.0352592 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0350237 |
| PDGFC | platelet derived growth factor C | -0.034918 |
| SERPINB2 | serpin peptidase inhibitor, clade B (ovalbumin), member 2 | -0.0347205 |
| LPP | LIM domain containing preferred translocation partner in lipoma | -0.0331102 |
| EXOC4 | exocyst complex component 4 | -0.0329048 |
| TPI1 | triosephosphate isomerase 1 | -0.0327604 |
| SMYD3 | SET and MYND domain containing 3 | -0.0326639 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0325966 |
| BCHE | butyrylcholinesterase | -0.0322018 |
| USP34 | ubiquitin specific peptidase 34 | -0.0316887 |
| EDARADD | EDAR-associated death domain | -0.0316142 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0314719 |
| S100A10 | S100 calcium binding protein A10 | -0.031426 |
| VTI1A | vesicle transport through interaction with t-SNAREs 1A | -0.0309063 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | -0.0308635 |
| L3MBTL4 | l(3)mbt-like 4 (Drosophila) | -0.0307906 |
| VDAC1 | voltage-dependent anion channel 1 | -0.0302341 |
| ENO1 | enolase 1, (alpha) | -0.0299048 |
| MKI67 | marker of proliferation Ki-67 | -0.0298482 |
| KCNQ5 | potassium channel, voltage gated KQT-like subfamily Q, member 5 | -0.0292456 |
| UBE2E2 | ubiquitin-conjugating enzyme E2E 2 | -0.0289769 |
| KPNB1 | karyopherin (importin) beta 1 | -0.0286028 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0285464 |
| ASPH | aspartate beta-hydroxylase | -0.0284234 |
| CCSER1 | coiled-coil serine-rich protein 1 | -0.0283479 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | -0.02797 |
| MACF1 | microtubule-actin crosslinking factor 1 | -0.0278843 |
| BRI3BP | BRI3 binding protein | -0.0277444 |
| RPS27A | ribosomal protein S27a | -0.0277085 |
| TBC1D5 | TBC1 domain family, member 5 | -0.0274892 |
| R3HDM2 | R3H domain containing 2 | -0.0274414 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | -0.0274211 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.0267616 |
| COMMD10 | COMM domain containing 10 | -0.0265112 |
| ANKRD28 | ankyrin repeat domain 28 | -0.0264994 |
| DOCK1 | dedicator of cytokinesis 1 | -0.0263705 |
| ADIPOR2 | adiponectin receptor 2 | -0.0263592 |
| PRDX1 | peroxiredoxin 1 | -0.0259161 |
| SPATS2 | spermatogenesis associated, serine-rich 2 | -0.0258552 |
| NR5A2 | nuclear receptor subfamily 5, group A, member 2 | -0.0255318 |
| RPS8 | ribosomal protein S8 | -0.0252529 |
| RPL38 | ribosomal protein L38 | -0.0250937 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0246546 |
| BABAM2 | BRISC and BRCA1 A complex member 2 | -0.0246441 |
| CLDN1 | claudin 1 | -0.0234669 |
| DTNA | dystrobrevin, alpha | -0.0232775 |
| TUBA1B | tubulin, alpha 1b | -0.0232763 |
| RNF213 | ring finger protein 213 | -0.0232231 |
| ANKRD17 | ankyrin repeat domain 17 | -0.0232188 |
| FAF1 | Fas (TNFRSF6) associated factor 1 | -0.0231035 |
| MSRB3 | methionine sulfoxide reductase B3 | -0.022351 |
| IGF2BP3 | insulin-like growth factor 2 mRNA binding protein 3 | -0.0222551 |
| MYL12A | myosin, light chain 12A, regulatory, non-sarcomeric | -0.0221704 |
| DIAPH2 | diaphanous-related formin 2 | -0.0221384 |
