Tirabrutinib (hydrochloride)_A498 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Tirabrutinib (hydrochloride) perturbation in A498 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Tirabrutinib (hydrochloride)_A498 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
MYH9 myosin, heavy chain 9, non-muscle 0.087415
FTH1 ferritin, heavy polypeptide 1 0.0862305
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0725094
SOD2 superoxide dismutase 2, mitochondrial 0.0643902
EEF2 eukaryotic translation elongation factor 2 0.0589852
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0575833
CSF1 colony stimulating factor 1 (macrophage) 0.0534842
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0515972
DDIT4 DNA-damage-inducible transcript 4 0.0468036
VCAM1 vascular cell adhesion molecule 1 0.0435247
ICAM1 intercellular adhesion molecule 1 0.0429695
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0413765
ANKRD33B ankyrin repeat domain 33B 0.0399726
FLNA filamin A, alpha 0.0392154
SPAG9 sperm associated antigen 9 0.0388157
CXCL8 chemokine (C-X-C motif) ligand 8 0.0362471
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta 0.0354165
G0S2 G0/G1 switch 2 0.0351958
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0347644
NAMPT nicotinamide phosphoribosyltransferase 0.0346465
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0343554
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 0.0325238
APP amyloid beta (A4) precursor protein 0.0312372
MARCHF6 membrane associated ring-CH-type finger 6 0.0308759
PLK2 polo-like kinase 2 0.0298747
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide 0.0292464
SUCO SUN domain containing ossification factor 0.0291438
WDR43 WD repeat domain 43 0.0290801
TNIP1 TNFAIP3 interacting protein 1 0.0289718
MSN moesin 0.028691
GOLGA4 golgin A4 0.028442
BHLHE40 basic helix-loop-helix family, member e40 0.0283657
PLEC plectin 0.0283113
CADM1 cell adhesion molecule 1 0.028287
ANXA1 annexin A1 0.0282008
WAC WW domain containing adaptor with coiled-coil 0.0278456
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0277162
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0276629
FMNL2 formin-like 2 0.0269185
ZFAND3 zinc finger, AN1-type domain 3 0.0261662
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.025093
RAB1A RAB1A, member RAS oncogene family 0.0242586
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma 0.023982
TPM3 tropomyosin 3 0.0239371
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0238785
ATP13A3 ATPase type 13A3 0.0235274
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0235196
GLS2 glutaminase 2 (liver, mitochondrial) 0.0232091
LRRFIP2 leucine rich repeat (in FLII) interacting protein 2 0.0231579
RPS4X ribosomal protein S4, X-linked 0.0230347
NOP58 NOP58 ribonucleoprotein 0.0228977
PTPRJ protein tyrosine phosphatase, receptor type, J 0.0228599
DENND2B DENN domain containing 2B 0.0228364
RHEB Ras homolog enriched in brain 0.0225495
KMT2C lysine (K)-specific methyltransferase 2C 0.0224732
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0223826
COPA coatomer protein complex, subunit alpha 0.0221746
TM9SF2 transmembrane 9 superfamily member 2 0.0219516
ACBD3 acyl-CoA binding domain containing 3 0.0219321
FXR1 fragile X mental retardation, autosomal homolog 1 0.0219084
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.0219031
DENND4A DENN/MADD domain containing 4A 0.021836
RAD23B RAD23 homolog B (S. cerevisiae) 0.0216296
PPP1R15B protein phosphatase 1, regulatory subunit 15B 0.0215003
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b 0.0212718
EPB41L2 erythrocyte membrane protein band 4.1-like 2 0.0211417
TSC22D2 TSC22 domain family, member 2 0.021039
PPP1CB protein phosphatase 1, catalytic subunit, beta isozyme 0.0207521
TFG TRK-fused gene 0.0206344
IFRD1 interferon-related developmental regulator 1 0.0204993
HELZ helicase with zinc finger 0.0203369
ADM adrenomedullin 0.0202306
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0201013
QKI QKI, KH domain containing, RNA binding 0.0200654
RIPK2 receptor-interacting serine-threonine kinase 2 0.019875
PRRC1 proline-rich coiled-coil 1 0.0196442
CLINT1 clathrin interactor 1 0.0196305
CRY1 cryptochrome circadian clock 1 0.0196284
TRIO trio Rho guanine nucleotide exchange factor 0.0194135
CXCL3 chemokine (C-X-C motif) ligand 3 0.0193765
CALU calumenin 0.0192719
ADAM9 ADAM metallopeptidase domain 9 0.0192158
RAD21 RAD21 homolog (S. pombe) 0.0190296
PSME4 proteasome (prosome, macropain) activator subunit 4 0.0188633
SQSTM1 sequestosome 1 0.0184708
XPO1 exportin 1 0.0184391
RBM39 RNA binding motif protein 39 0.0182668
HBP1 HMG-box transcription factor 1 0.0182652
USP3 ubiquitin specific peptidase 3 0.018191
TRA2A transformer 2 alpha homolog (Drosophila) 0.0181052
SMG7 SMG7 nonsense mediated mRNA decay factor 0.0179421
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0178807
ADAM17 ADAM metallopeptidase domain 17 0.0178602
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon 0.0178406
ALDH1A1 aldehyde dehydrogenase 1 family, member A1 0.0178
NCKAP1 NCK-associated protein 1 0.0177817
KDM6A lysine (K)-specific demethylase 6A 0.0177705
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0176367
FSCN1 fascin actin-bundling protein 1 0.0176224
CXCL2 chemokine (C-X-C motif) ligand 2 0.0175968

decreased expression

Symbol Name Standardized Value
FRMD4A FERM domain containing 4A -0.12057
IGFBP3 insulin-like growth factor binding protein 3 -0.0959375
TMSB10 thymosin beta 10 -0.0750491
VIM vimentin -0.0615913
GPC6 glypican 6 -0.0504499
FTL ferritin, light polypeptide -0.0385644
TSHZ2 teashirt zinc finger homeobox 2 -0.0381072
GLIS3 GLIS family zinc finger 3 -0.0350177
CP ceruloplasmin (ferroxidase) -0.03461
RPL35A ribosomal protein L35a -0.0334594
MT2A metallothionein 2A -0.032592
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0303834
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.027662
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.0276495
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0261197
RNF213 ring finger protein 213 -0.0258928
HLA-B major histocompatibility complex, class I, B -0.0248767
EHBP1 EH domain binding protein 1 -0.024256
RAI14 retinoic acid induced 14 -0.0241386
ZBTB20 zinc finger and BTB domain containing 20 -0.0230612
IFI44L interferon-induced protein 44-like -0.0228554
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0222649
OSMR oncostatin M receptor -0.0219782
RPLP1 ribosomal protein, large, P1 -0.0211214
CD44 CD44 molecule (Indian blood group) -0.0210003
RPL28 ribosomal protein L28 -0.0208953
PDE4D phosphodiesterase 4D, cAMP-specific -0.0202422
RPS19 ribosomal protein S19 -0.0201875
EXT1 exostosin glycosyltransferase 1 -0.0201526
PBX1 pre-B-cell leukemia homeobox 1 -0.0201131
IFI16 interferon, gamma-inducible protein 16 -0.0192545
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 -0.0191907
CMIP c-Maf inducing protein -0.0187874
BICD1 bicaudal D homolog 1 (Drosophila) -0.0187593
APOL1 apolipoprotein L, 1 -0.0186552
EFNA5 ephrin-A5 -0.0186058
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.018577
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.018505
RPS8 ribosomal protein S8 -0.0179345
ZMYND8 zinc finger, MYND-type containing 8 -0.0178516
CUX1 cut-like homeobox 1 -0.0174221
CTSD cathepsin D -0.0173342
CA12 carbonic anhydrase XII -0.0171917
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0167628
EXOC4 exocyst complex component 4 -0.0165152
IFITM3 interferon induced transmembrane protein 3 -0.016265
RPL34 ribosomal protein L34 -0.0160607
NRP1 neuropilin 1 -0.0160344
PLIN2 perilipin 2 -0.0158736
RIGI RNA sensor RIG-I -0.0158471
RPL23 ribosomal protein L23 -0.0154762
IFI6 interferon, alpha-inducible protein 6 -0.0153702
PFN1 profilin 1 -0.0148687
EGFR epidermal growth factor receptor -0.0147939
HM13 histocompatibility (minor) 13 -0.0147701
PRKCA protein kinase C, alpha -0.0146546
STAT1 signal transducer and activator of transcription 1, 91kDa -0.014576
IFI27 interferon, alpha-inducible protein 27 -0.0143535
MX1 MX dynamin-like GTPase 1 -0.0140485
ASPH aspartate beta-hydroxylase -0.0139533
RPS6 ribosomal protein S6 -0.013675
OXR1 oxidation resistance 1 -0.0135998
VCL vinculin -0.0135092
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.0135055
CDCP1 CUB domain containing protein 1 -0.013434
BNC2 basonuclin 2 -0.0133797
SP100 SP100 nuclear antigen -0.0133355
LY6E lymphocyte antigen 6 complex, locus E -0.0132804
ARL4C ADP-ribosylation factor-like 4C -0.0130973
RPL31 ribosomal protein L31 -0.0130463
S100A6 S100 calcium binding protein A6 -0.013002
S100A11 S100 calcium binding protein A11 -0.0129147
RPL37A ribosomal protein L37a -0.0128885
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.012622
ANXA4 annexin A4 -0.0124252
NSMCE2 non-SMC element 2, MMS21 homolog (S. cerevisiae) -0.0123525
RAD51B RAD51 paralog B -0.0123149
CYBA cytochrome b-245, alpha polypeptide -0.0122514
MRPS6 mitochondrial ribosomal protein S6 -0.0122114
RHEX regulator of hemoglobinization and erythroid cell expansion -0.0121988
CLMP CXADR-like membrane protein -0.012186
RPS24 ribosomal protein S24 -0.0121825
UBE2D2 ubiquitin-conjugating enzyme E2D 2 -0.0121474
NSRP1 nuclear speckle splicing regulatory protein 1 -0.012145
RPS21 ribosomal protein S21 -0.0121266
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 -0.0120972
TNS3 tensin 3 -0.0120969
VPS13B vacuolar protein sorting 13 homolog B (yeast) -0.0120213
PTGR1 prostaglandin reductase 1 -0.0119514
LGALS1 lectin, galactoside-binding, soluble, 1 -0.011909
PTH2R parathyroid hormone 2 receptor -0.0117397
TENM3 teneurin transmembrane protein 3 -0.01171
SPIDR scaffolding protein involved in DNA repair -0.0116758
RPL36A ribosomal protein L36a -0.0116612
CYB5R3 cytochrome b5 reductase 3 -0.0115272
RPL36 ribosomal protein L36 -0.0115219
ETV6 ets variant 6 -0.0115151
RPLP2 ribosomal protein, large, P2 -0.0114047
RPL9 ribosomal protein L9 -0.0113673
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0113536