| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Tirabrutinib (hydrochloride) perturbation in A549 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Tirabrutinib (hydrochloride)_A549 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.141775 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.139838 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.136396 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.110675 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.103003 |
| TNIP1 | TNFAIP3 interacting protein 1 | 0.0977487 |
| NDRG1 | N-myc downstream regulated 1 | 0.0975941 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0936195 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0901806 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0883314 |
| FTL | ferritin, light polypeptide | 0.0810733 |
| SPAG9 | sperm associated antigen 9 | 0.0776204 |
| ANXA2 | annexin A2 | 0.0767193 |
| PLEC | plectin | 0.076356 |
| KRT18 | keratin 18, type I | 0.0759897 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0749412 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.0742778 |
| USP3 | ubiquitin specific peptidase 3 | 0.0729038 |
| FLNB | filamin B, beta | 0.0719616 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0712767 |
| GOLGA4 | golgin A4 | 0.0708708 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0700552 |
| AHNAK | AHNAK nucleoprotein | 0.0655887 |
| ANXA1 | annexin A1 | 0.0623804 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0601219 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0592015 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.0589454 |
| PGK1 | phosphoglycerate kinase 1 | 0.0563929 |
| FMNL2 | formin-like 2 | 0.0555411 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | 0.0518399 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0508578 |
| TM4SF1 | transmembrane 4 L six family member 1 | 0.0490608 |
| HELZ | helicase with zinc finger | 0.0489458 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0479849 |
| ALDH1A1 | aldehyde dehydrogenase 1 family, member A1 | 0.0476058 |
| KCTD9 | potassium channel tetramerization domain containing 9 | 0.0473457 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.0469045 |
| PKM | pyruvate kinase, muscle | 0.046404 |
| NUP58 | nucleoporin 58 | 0.0462373 |
| PTK2 | protein tyrosine kinase 2 | 0.0456783 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0456025 |
| STC1 | stanniocalcin 1 | 0.0454689 |
| FLNA | filamin A, alpha | 0.0451441 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0450212 |
| WDR43 | WD repeat domain 43 | 0.0449639 |
| EZR | ezrin | 0.0446647 |
| RPS4X | ribosomal protein S4, X-linked | 0.0432049 |
| MYOF | myoferlin | 0.0431127 |
| NAV2 | neuron navigator 2 | 0.0429868 |
| TKT | transketolase | 0.0428573 |
| RND3 | Rho family GTPase 3 | 0.0426543 |
| UBA2 | ubiquitin-like modifier activating enzyme 2 | 0.0423453 |
| FAM107B | family with sequence similarity 107, member B | 0.0410373 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.0396984 |
| TPM4 | tropomyosin 4 | 0.0389106 |
| POTEF | POTE ankyrin domain family, member F | 0.0388439 |
| ADAM9 | ADAM metallopeptidase domain 9 | 0.0387388 |
| ASPH | aspartate beta-hydroxylase | 0.0386699 |
| ADM | adrenomedullin | 0.0381042 |
| KLF6 | Kruppel-like factor 6 | 0.0378384 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | 0.0369179 |
| UBC | ubiquitin C | 0.0367595 |
| PFKFB3 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 | 0.0367224 |
| MAP1B | microtubule-associated protein 1B | 0.0365945 |
| WAC | WW domain containing adaptor with coiled-coil | 0.0362728 |
| DDIT4 | DNA-damage-inducible transcript 4 | 0.0361213 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.0356642 |
| MT1X | metallothionein 1X | 0.0354616 |
| FOS | FBJ murine osteosarcoma viral oncogene homolog | 0.0347645 |
| IQGAP1 | IQ motif containing GTPase activating protein 1 | 0.0343901 |
| SFTPA2 | surfactant protein A2 | 0.0343573 |
| MSN | moesin | 0.0340456 |
| DSTN | destrin (actin depolymerizing factor) | 0.0339201 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0337127 |
| GNPDA1 | glucosamine-6-phosphate deaminase 1 | 0.0336589 |
| RTN4 | reticulon 4 | 0.0335432 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0333565 |
| CALU | calumenin | 0.033278 |
| LDHA | lactate dehydrogenase A | 0.0331089 |
| TXNRD1 | thioredoxin reductase 1 | 0.0330614 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | 0.0329252 |
| MT2A | metallothionein 2A | 0.0326238 |
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | 0.0326066 |
| CANX | calnexin | 0.0323999 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0322866 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.0317378 |
| GRB10 | growth factor receptor-bound protein 10 | 0.0315536 |
| FBL | fibrillarin | 0.0315062 |
| PFN1 | profilin 1 | 0.0313525 |
| IPO7 | importin 7 | 0.0311076 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.031088 |
| CA12 | carbonic anhydrase XII | 0.0310319 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | 0.0308901 |
| NEDD4 | neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase | 0.0308369 |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | 0.0306759 |
| WDR45B | WD repeat domain 45B | 0.0303939 |
| RSL1D1 | ribosomal L1 domain containing 1 | 0.0303515 |
| PPP2R2A | protein phosphatase 2, regulatory subunit B, alpha | 0.0302518 |
| EGLN1 | egl-9 family hypoxia-inducible factor 1 | 0.0302352 |
| ARL5B | ADP-ribosylation factor-like 5B | 0.0301912 |
| Symbol | Name | Standardized Value |
|---|---|---|
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | -0.0826447 |
| NRIP1 | nuclear receptor interacting protein 1 | -0.0815267 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0653369 |
| CYP24A1 | cytochrome P450, family 24, subfamily A, polypeptide 1 | -0.063859 |
| PDE10A | phosphodiesterase 10A | -0.059545 |
| RIGI | RNA sensor RIG-I | -0.0371579 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.0357604 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.0348485 |
| OSMR | oncostatin M receptor | -0.0335896 |
| VCL | vinculin | -0.0325166 |
| SP100 | SP100 nuclear antigen | -0.0276523 |
| RPL35A | ribosomal protein L35a | -0.0261015 |
| RPLP1 | ribosomal protein, large, P1 | -0.0260542 |
| WWOX | WW domain containing oxidoreductase | -0.0253479 |
| DDX60L | DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like | -0.0250331 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | -0.0230321 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.0224768 |
| ERN1 | endoplasmic reticulum to nucleus signaling 1 | -0.0216083 |
| KIAA1217 | KIAA1217 | -0.0202092 |
| NCOA7 | nuclear receptor coactivator 7 | -0.0201761 |
| PMP22 | peripheral myelin protein 22 | -0.0199456 |
| RNF213 | ring finger protein 213 | -0.0198595 |
| TDRD7 | tudor domain containing 7 | -0.0197249 |
| RAD51B | RAD51 paralog B | -0.0191742 |
| ETV6 | ets variant 6 | -0.0185931 |
| ETNK1 | ethanolamine kinase 1 | -0.0184074 |
| RPL38 | ribosomal protein L38 | -0.0177409 |
| INTS6 | integrator complex subunit 6 | -0.0174918 |
| TRIM25 | tripartite motif containing 25 | -0.0174636 |
| NRP1 | neuropilin 1 | -0.0170172 |
| NPAS2 | neuronal PAS domain protein 2 | -0.0169575 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0166333 |
| CMIP | c-Maf inducing protein | -0.0165985 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | -0.0165129 |
| RPS24 | ribosomal protein S24 | -0.0165049 |
| PNPT1 | polyribonucleotide nucleotidyltransferase 1 | -0.0161949 |
| WWTR1 | WW domain containing transcription regulator 1 | -0.0161157 |
| UBASH3B | ubiquitin associated and SH3 domain containing B | -0.016064 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.015984 |
| TAS2R14 | taste receptor, type 2, member 14 | -0.0158455 |
| PLSCR1 | phospholipid scramblase 1 | -0.0157932 |
| PRKCE | protein kinase C, epsilon | -0.0157329 |
| SP3 | Sp3 transcription factor | -0.0156749 |
| DOCK5 | dedicator of cytokinesis 5 | -0.0155862 |
| BTBD10 | BTB (POZ) domain containing 10 | -0.0155424 |
| SPIDR | scaffolding protein involved in DNA repair | -0.0154345 |
| IFI6 | interferon, alpha-inducible protein 6 | -0.0153737 |
| TGM2 | transglutaminase 2 | -0.015298 |
| MYO9A | myosin IXA | -0.0151935 |
| NPC1 | Niemann-Pick disease, type C1 | -0.0148494 |
| IFIH1 | interferon induced with helicase C domain 1 | -0.0146808 |
| XPC | xeroderma pigmentosum, complementation group C | -0.0143768 |
| RPL28 | ribosomal protein L28 | -0.0143403 |
| GPRIN3 | GPRIN family member 3 | -0.0140468 |
| RPS29 | ribosomal protein S29 | -0.014022 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | -0.0138038 |
| PAPPA | pregnancy-associated plasma protein A, pappalysin 1 | -0.0137201 |
| TMTC2 | transmembrane and tetratricopeptide repeat containing 2 | -0.0137184 |
| BCAS3 | breast carcinoma amplified sequence 3 | -0.0136314 |
| TMSB10 | thymosin beta 10 | -0.0136273 |
| GRAMD1B | GRAM domain containing 1B | -0.0136196 |
| TLE4 | transducin-like enhancer of split 4 | -0.0129799 |
| STAT2 | signal transducer and activator of transcription 2, 113kDa | -0.0129554 |
| NSRP1 | nuclear speckle splicing regulatory protein 1 | -0.0128944 |
| RPL34 | ribosomal protein L34 | -0.0127623 |
| ISG15 | ISG15 ubiquitin-like modifier | -0.0124156 |
| SEC22A | SEC22 vesicle trafficking protein homolog A (S. cerevisiae) | -0.012373 |
| PDE8A | phosphodiesterase 8A | -0.0121261 |
| ZC3H12C | zinc finger CCCH-type containing 12C | -0.01188 |
| RBBP6 | retinoblastoma binding protein 6 | -0.0117403 |
| RPL30 | ribosomal protein L30 | -0.0116891 |
| PCNX4 | pecanex 4 | -0.0116502 |
| ITGB5 | integrin, beta 5 | -0.0116111 |
| GLIS3 | GLIS family zinc finger 3 | -0.0115852 |
| HGSNAT | heparan-alpha-glucosaminide N-acetyltransferase | -0.0115748 |
| STAT3 | signal transducer and activator of transcription 3 (acute-phase response factor) | -0.0115486 |
| WDPCP | WD repeat containing planar cell polarity effector | -0.011512 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0114325 |
| RBMS1 | RNA binding motif, single stranded interacting protein 1 | -0.0114049 |
| TRIM56 | tripartite motif containing 56 | -0.0113693 |
| MACROD2 | MACRO domain containing 2 | -0.0111604 |
| ZFAND6 | zinc finger, AN1-type domain 6 | -0.011133 |
| KYNU | kynureninase | -0.0111207 |
| OASL | 2'-5'-oligoadenylate synthetase-like | -0.0111176 |
| APPBP2 | amyloid beta precursor protein (cytoplasmic tail) binding protein 2 | -0.011112 |
| P3H2 | prolyl 3-hydroxylase 2 | -0.0111054 |
| MX1 | MX dynamin-like GTPase 1 | -0.0110887 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | -0.0108605 |
| PPM1D | protein phosphatase, Mg2+/Mn2+ dependent, 1D | -0.0107142 |
| NECTIN2 | nectin cell adhesion molecule 2 | -0.0106469 |
| RARB | retinoic acid receptor, beta | -0.0105961 |
| SLC41A2 | solute carrier family 41 (magnesium transporter), member 2 | -0.0105682 |
| N4BP1 | NEDD4 binding protein 1 | -0.0104373 |
| EPC1 | enhancer of polycomb homolog 1 (Drosophila) | -0.010434 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | -0.0104166 |
| VPS13B | vacuolar protein sorting 13 homolog B (yeast) | -0.0103996 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0102176 |
| ATG7 | autophagy related 7 | -0.0100826 |
| GRAMD1A | GRAM domain containing 1A | -0.010078 |
| SLC25A51 | solute carrier family 25, member 51 | -0.0100722 |
