Tirabrutinib (hydrochloride)_AN3 CA Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Tirabrutinib (hydrochloride) perturbation in AN3 CA cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Tirabrutinib (hydrochloride)_AN3 CA drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
EEF2 eukaryotic translation elongation factor 2 0.0935045
VEGFA vascular endothelial growth factor A 0.0754145
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0518097
EGFR epidermal growth factor receptor 0.0503507
PRKG1 protein kinase, cGMP-dependent, type I 0.0485389
FN1 fibronectin 1 0.0440864
FLNB filamin B, beta 0.0433339
NDRG1 N-myc downstream regulated 1 0.0421627
ASPH aspartate beta-hydroxylase 0.0419529
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) 0.0412491
FTH1 ferritin, heavy polypeptide 1 0.0403498
APLP2 amyloid beta (A4) precursor-like protein 2 0.0353604
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0347709
TPK1 thiamin pyrophosphokinase 1 0.0346519
PKM pyruvate kinase, muscle 0.0340463
EFNA5 ephrin-A5 0.0325183
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0321863
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0304786
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0296116
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0283296
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0281669
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0281364
ERRFI1 ERBB receptor feedback inhibitor 1 0.0274783
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.0273763
UBE2E1 ubiquitin-conjugating enzyme E2E 1 0.0270614
TPD52 tumor protein D52 0.0270519
FNDC3B fibronectin type III domain containing 3B 0.025827
RBM39 RNA binding motif protein 39 0.0254829
EGLN1 egl-9 family hypoxia-inducible factor 1 0.0254223
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0253177
FGFR1 fibroblast growth factor receptor 1 0.0251337
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0249523
TSHZ2 teashirt zinc finger homeobox 2 0.0247845
TMF1 TATA element modulatory factor 1 0.0247432
NAMPT nicotinamide phosphoribosyltransferase 0.0245428
MEIS2 Meis homeobox 2 0.0242002
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa 0.0241015
RAB7A RAB7A, member RAS oncogene family 0.0238261
LPP LIM domain containing preferred translocation partner in lipoma 0.0233901
ATP11A ATPase, class VI, type 11A 0.0231654
SF3B1 splicing factor 3b, subunit 1, 155kDa 0.022893
SEPTIN9 septin 9 0.0225156
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0224821
SEC31A SEC31 homolog A (S. cerevisiae) 0.0224167
TBC1D5 TBC1 domain family, member 5 0.0224026
FOS FBJ murine osteosarcoma viral oncogene homolog 0.0222191
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0220828
TIPARP TCDD-inducible poly(ADP-ribose) polymerase 0.0219202
RNF130 ring finger protein 130 0.0217092
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0217011
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.021519
EGR1 early growth response 1 0.0215045
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0212273
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0209678
LGR4 leucine-rich repeat containing G protein-coupled receptor 4 0.020957
TCF12 transcription factor 12 0.0206408
NPAS2 neuronal PAS domain protein 2 0.0205287
CSNK1A1 casein kinase 1, alpha 1 0.0204162
FLNA filamin A, alpha 0.0203985
MIMS1 mitochondrial inner membrane scaffold 1 0.0203406
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.020232
FAM13A family with sequence similarity 13, member A 0.0202092
VCL vinculin 0.0201109
BRD2 bromodomain containing 2 0.0199792
FKBP10 FK506 binding protein 10, 65 kDa 0.0199596
CTBP2 C-terminal binding protein 2 0.0198233
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0197035
RAD51B RAD51 paralog B 0.0195249
COG6 component of oligomeric golgi complex 6 0.0192667
SOD2 superoxide dismutase 2, mitochondrial 0.0191688
STC1 stanniocalcin 1 0.0190358
MYH9 myosin, heavy chain 9, non-muscle 0.0188275
TNIP1 TNFAIP3 interacting protein 1 0.0188261
ELL2 elongation factor, RNA polymerase II, 2 0.0188029
RRBP1 ribosome binding protein 1 0.0187667
EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3 0.0187135
RAD23B RAD23 homolog B (S. cerevisiae) 0.0184885
DIPK2A divergent protein kinase domain 2A 0.0184387
HELZ helicase with zinc finger 0.0183967
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.0183419
DSCAM Down syndrome cell adhesion molecule 0.0182001
TMSB4X thymosin beta 4, X-linked 0.0181409
SLC38A2 solute carrier family 38, member 2 0.0180816
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit 0.0180749
PLEC plectin 0.0179157
RLF rearranged L-myc fusion 0.0177645
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha 0.0177443
SLC13A3 solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 3 0.017296
JUN jun proto-oncogene 0.0172506
ABCF1 ATP-binding cassette, sub-family F (GCN20), member 1 0.0172252
ASXL1 additional sex combs like transcriptional regulator 1 0.0171428
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0170565
PDIA3 protein disulfide isomerase family A, member 3 0.0170527
MAML3 mastermind-like 3 (Drosophila) 0.0169233
TCOF1 Treacher Collins-Franceschetti syndrome 1 0.0168896
PSMD2 proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 0.0168762
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide 0.0168715
GPC6 glypican 6 0.0168326
LSM14A LSM14A, SCD6 homolog A (S. cerevisiae) 0.0168297
IRF1 interferon regulatory factor 1 0.0167724

decreased expression

Symbol Name Standardized Value
VIM vimentin -0.283419
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0780347
MEST mesoderm specific transcript -0.0751728
PTMA prothymosin, alpha -0.0629216
RPS6 ribosomal protein S6 -0.0570192
UBC ubiquitin C -0.0552845
CENPF centromere protein F, 350/400kDa -0.0549636
HMGB2 high mobility group box 2 -0.051159
RPS8 ribosomal protein S8 -0.0463509
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0430621
PCBP2 poly(rC) binding protein 2 -0.0404744
RPLP1 ribosomal protein, large, P1 -0.0394728
RPS27A ribosomal protein S27a -0.0386448
MGP matrix Gla protein -0.0385645
BCOR BCL6 corepressor -0.0369239
RPS12 ribosomal protein S12 -0.0366198
IER3 immediate early response 3 -0.0360033
SMC4 structural maintenance of chromosomes 4 -0.0346543
PEG10 paternally expressed 10 -0.0338263
NIPBL Nipped-B homolog (Drosophila) -0.0335856
TPX2 TPX2, microtubule-associated -0.0335574
ENO1 enolase 1, (alpha) -0.0325739
SRPK2 SRSF protein kinase 2 -0.0314826
HMGA2 high mobility group AT-hook 2 -0.0312852
RPL23 ribosomal protein L23 -0.031258
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0310584
ARID1B AT rich interactive domain 1B (SWI1-like) -0.0295373
RANBP17 RAN binding protein 17 -0.0295312
TMSB10 thymosin beta 10 -0.0295152
RAD21 RAD21 homolog (S. pombe) -0.0292709
GSE1 Gse1 coiled-coil protein -0.0289108
RPL28 ribosomal protein L28 -0.0286374
MED13L mediator complex subunit 13-like -0.0285277
TNPO1 transportin 1 -0.0281466
RPS10 ribosomal protein S10 -0.0278938
CENPE centromere protein E, 312kDa -0.0278862
ZFAND3 zinc finger, AN1-type domain 3 -0.0277617
ZNF292 zinc finger protein 292 -0.0271074
DEPDC1B DEP domain containing 1B -0.0270995
ACTG1 actin gamma 1 -0.0269522
RPL35A ribosomal protein L35a -0.0268369
RPL26 ribosomal protein L26 -0.0264482
FAF1 Fas (TNFRSF6) associated factor 1 -0.0259882
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0259544
HMGB1 high mobility group box 1 -0.0257995
KIF11 kinesin family member 11 -0.0257015
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) -0.0255923
MKI67 marker of proliferation Ki-67 -0.0255205
SEMA6A sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A -0.0253251
RPS14 ribosomal protein S14 -0.0250867
RPS24 ribosomal protein S24 -0.0248846
ENAH enabled homolog (Drosophila) -0.0245895
AKR1C2 aldo-keto reductase family 1, member C2 -0.0240924
MSRB3 methionine sulfoxide reductase B3 -0.0239175
PHTF2 putative homeodomain transcription factor 2 -0.0237885
SYNE2 spectrin repeat containing, nuclear envelope 2 -0.0235883
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0234715
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.023282
RACK1 receptor for activated C kinase 1 -0.0229406
KIF20B kinesin family member 20B -0.0228652
MIS18BP1 MIS18 binding protein 1 -0.0228061
PCM1 pericentriolar material 1 -0.0227233
RPLP2 ribosomal protein, large, P2 -0.0225097
MT2A metallothionein 2A -0.0223
SEPTIN7 septin 7 -0.0222966
AKR1C1 aldo-keto reductase family 1, member C1 -0.0219821
CKAP5 cytoskeleton associated protein 5 -0.021935
HSPA9 heat shock 70kDa protein 9 (mortalin) -0.0219106
KPNB1 karyopherin (importin) beta 1 -0.0218752
SMC1A structural maintenance of chromosomes 1A -0.0218618
NAP1L1 nucleosome assembly protein 1-like 1 -0.0217623
ELF2 E74-like factor 2 (ets domain transcription factor) -0.0217173
TBL1X transducin (beta)-like 1X-linked -0.0215931
KIF4A kinesin family member 4A -0.0214638
MATR3 matrin 3 -0.0214045
DIAPH3 diaphanous-related formin 3 -0.0212147
TUBA1B tubulin, alpha 1b -0.0211237
SHOC2 soc-2 suppressor of clear homolog (C. elegans) -0.0211052
CDK6 cyclin-dependent kinase 6 -0.0210702
RDX radixin -0.0210665
FOXC1 forkhead box C1 -0.0206327
PDIA6 protein disulfide isomerase family A, member 6 -0.0205794
CWC27 CWC27 spliceosome-associated protein homolog (S. cerevisiae) -0.0202808
KIF18A kinesin family member 18A -0.020274
XPR1 xenotropic and polytropic retrovirus receptor 1 -0.02014
MYO9A myosin IXA -0.019985
RPS23 ribosomal protein S23 -0.0199141
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0197059
NT5C2 5'-nucleotidase, cytosolic II -0.0196132
KLHDC10 kelch domain containing 10 -0.0196056
RSF1 remodeling and spacing factor 1 -0.0195673
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0195329
CCNI cyclin I -0.0193738
IGF2R insulin-like growth factor 2 receptor -0.0189804
RBM25 RNA binding motif protein 25 -0.0189069
RPL10A ribosomal protein L10a -0.0188535
RFC3 replication factor C (activator 1) 3, 38kDa -0.0187861
SKP1 S-phase kinase-associated protein 1 -0.0187456
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 -0.0187007
CDCA2 cell division cycle associated 2 -0.0186674