Tirabrutinib (hydrochloride)_AsPC-1 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Tirabrutinib (hydrochloride) perturbation in AsPC-1 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Tirabrutinib (hydrochloride)_AsPC-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FTH1 ferritin, heavy polypeptide 1 0.299329
BAIAP2L1 BAI1-associated protein 2-like 1 0.142782
EZR ezrin 0.135822
EEF2 eukaryotic translation elongation factor 2 0.123959
KRT18 keratin 18, type I 0.11908
TXNRD1 thioredoxin reductase 1 0.114016
TMSB10 thymosin beta 10 0.102568
LAMB3 laminin, beta 3 0.101647
PLEC plectin 0.0984217
AKAP12 A kinase (PRKA) anchor protein 12 0.0923426
PTMA prothymosin, alpha 0.0901101
EMP1 epithelial membrane protein 1 0.089967
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0831727
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 0.0683078
LOC112694756 uncharaterized LOC112694756 0.0676926
POTEF POTE ankyrin domain family, member F 0.0665447
ACTG1 actin gamma 1 0.0663372
HMGA1 high mobility group AT-hook 1 0.0628636
AHNAK AHNAK nucleoprotein 0.061079
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0605037
KRT8 keratin 8, type II 0.0599303
TPT1 tumor protein, translationally-controlled 1 0.0587061
MUC17 mucin 17, cell surface associated 0.0578291
VIM vimentin 0.057107
BHLHE40 basic helix-loop-helix family, member e40 0.0555293
EIF1 eukaryotic translation initiation factor 1 0.0551547
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 0.0549526
ITPRID2 ITPR interacting domain containing 2 0.0547879
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0529748
FOS FBJ murine osteosarcoma viral oncogene homolog 0.0520962
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.0519763
RPS4X ribosomal protein S4, X-linked 0.0504686
RBM25 RNA binding motif protein 25 0.0479589
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0474678
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0460495
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0437538
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1 0.0434101
PERP PERP, TP53 apoptosis effector 0.0433335
GARS1 glycyl-tRNA synthetase 1 0.0428959
ITGB4 integrin, beta 4 0.0426299
FSCN1 fascin actin-bundling protein 1 0.0413843
LYZ lysozyme 0.0403667
LAMA4 laminin, alpha 4 0.0402216
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon 0.0390854
MATR3 matrin 3 0.0389948
FOSB FBJ murine osteosarcoma viral oncogene homolog B 0.0389931
RAD21 RAD21 homolog (S. pombe) 0.0384991
SIK3 SIK family kinase 3 0.0379055
SF3B2 splicing factor 3b, subunit 2, 145kDa 0.0378314
TRA2A transformer 2 alpha homolog (Drosophila) 0.0372217
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0371148
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.0356915
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0356728
FOSL1 FOS-like antigen 1 0.0353258
UBE2R2 ubiquitin-conjugating enzyme E2R 2 0.0350525
TES testin LIM domain protein 0.0345534
EIF4A2 eukaryotic translation initiation factor 4A2 0.0342086
PRRC2C proline-rich coiled-coil 2C 0.0340295
CANX calnexin 0.0330075
SEMA3B sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B 0.032504
RAB1A RAB1A, member RAS oncogene family 0.0324874
S100A6 S100 calcium binding protein A6 0.0321246
SFTPA2 surfactant protein A2 0.0320163
RSL1D1 ribosomal L1 domain containing 1 0.031341
ARPC1A actin related protein 2/3 complex, subunit 1A, 41kDa 0.0311665
KLF6 Kruppel-like factor 6 0.0304853
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0302878
ANXA2 annexin A2 0.0298019
ANXA1 annexin A1 0.0294701
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0292779
CALU calumenin 0.0288108
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0285479
RAB7A RAB7A, member RAS oncogene family 0.0283426
CSDE1 cold shock domain containing E1, RNA-binding 0.0283085
PGK1 phosphoglycerate kinase 1 0.0281513
SQSTM1 sequestosome 1 0.0281248
HDGF hepatoma-derived growth factor 0.0279896
YBX1 Y box binding protein 1 0.0277471
LMNA lamin A/C 0.0277264
GOLGA4 golgin A4 0.0272856
ACTN4 actinin, alpha 4 0.0267576
FXR1 fragile X mental retardation, autosomal homolog 1 0.0267011
HDLBP high density lipoprotein binding protein 0.0266184
TOP1 topoisomerase (DNA) I 0.0263014
RPL19 ribosomal protein L19 0.0262139
EPCAM epithelial cell adhesion molecule 0.0254873
RAD23B RAD23 homolog B (S. cerevisiae) 0.0253418
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma 0.0253083
GNAS GNAS complex locus 0.0251017
ABI1 abl-interactor 1 0.025072
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0249883
LDHA lactate dehydrogenase A 0.024639
PSME4 proteasome (prosome, macropain) activator subunit 4 0.0246238
KIF5B kinesin family member 5B 0.0244536
FN1 fibronectin 1 0.0239712
MYL12B myosin, light chain 12B, regulatory 0.0239391
UFM1 ubiquitin-fold modifier 1 0.0237627
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0235744
RSRC2 arginine/serine-rich coiled-coil 2 0.0233809
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0230426

decreased expression

Symbol Name Standardized Value
NDRG1 N-myc downstream regulated 1 -0.177337
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.158996
EFNA5 ephrin-A5 -0.119299
EGFR epidermal growth factor receptor -0.0966256
DOCK5 dedicator of cytokinesis 5 -0.0929066
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0824373
KCNK1 potassium channel, two pore domain subfamily K, member 1 -0.0710616
VCL vinculin -0.0612342
RPS2 ribosomal protein S2 -0.059507
DSG2 desmoglein 2 -0.0591743
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats -0.0550421
ZEB1 zinc finger E-box binding homeobox 1 -0.053112
PSD3 pleckstrin and Sec7 domain containing 3 -0.0525842
ARPC1B actin related protein 2/3 complex, subunit 1B, 41kDa -0.049816
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 -0.0478066
ARHGAP5 Rho GTPase activating protein 5 -0.0453872
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein) -0.0442461
CAB39 calcium binding protein 39 -0.0437057
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -0.0431919
NRIP1 nuclear receptor interacting protein 1 -0.0423871
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0419033
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0417146
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 -0.0413597
LAMC2 laminin, gamma 2 -0.0413458
FLNB filamin B, beta -0.040767
CDCP1 CUB domain containing protein 1 -0.0405364
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0404849
ANTXR2 anthrax toxin receptor 2 -0.0400403
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 -0.0399908
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like -0.0393129
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 -0.0388343
UBA6 ubiquitin-like modifier activating enzyme 6 -0.0381653
FAM3C family with sequence similarity 3, member C -0.0378202
APPL2 adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2 -0.0378002
FOXO1 forkhead box O1 -0.0377873
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 -0.0371845
BRIP1 BRCA1 interacting protein C-terminal helicase 1 -0.0370947
FGD6 FYVE, RhoGEF and PH domain containing 6 -0.0367115
PTPRR protein tyrosine phosphatase, receptor type, R -0.0364391
STK39 serine threonine kinase 39 -0.0364386
FNDC3B fibronectin type III domain containing 3B -0.0362632
TPM4 tropomyosin 4 -0.0355228
PRSS3 protease, serine, 3 -0.0355114
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0353718
MAML2 mastermind-like 2 (Drosophila) -0.0343064
PICALM phosphatidylinositol binding clathrin assembly protein -0.0326112
SLC41A2 solute carrier family 41 (magnesium transporter), member 2 -0.0323997
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 -0.0323179
SPATS2L spermatogenesis associated, serine-rich 2-like -0.0321944
TMCC3 transmembrane and coiled-coil domain family 3 -0.0316385
ITGA6 integrin, alpha 6 -0.0307191
DGKD diacylglycerol kinase, delta 130kDa -0.0303978
GRB10 growth factor receptor-bound protein 10 -0.0301525
PDLIM5 PDZ and LIM domain 5 -0.0301091
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 -0.030108
BCL2L1 BCL2-like 1 -0.0294198
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0291949
BCAR3 breast cancer anti-estrogen resistance 3 -0.0287514
CAPRIN2 caprin family member 2 -0.0286504
MYOF myoferlin -0.0284982
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 -0.0284582
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0280512
MACF1 microtubule-actin crosslinking factor 1 -0.0280465
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 -0.0277982
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0275057
AGPAT4 1-acylglycerol-3-phosphate O-acyltransferase 4 -0.027463
AVL9 AVL9 homolog (S. cerevisiase) -0.0270868
PRELID2 PRELI domain containing 2 -0.0269037
ABTB3 ankyrin repeat and BTB domain containing 3 -0.0268941
RAPH1 Ras association (RalGDS/AF-6) and pleckstrin homology domains 1 -0.02654
TNFRSF10D tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain -0.0264052
HPCAL1 hippocalcin-like 1 -0.0261013
SVIL supervillin -0.0252244
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) -0.0250731
SBF2 SET binding factor 2 -0.0250648
PARD3 par-3 family cell polarity regulator -0.0244101
ACTR3 ARP3 actin-related protein 3 homolog (yeast) -0.0242405
ASPH aspartate beta-hydroxylase -0.0239759
PRAG1 PEAK1 related, kinase-activating pseudokinase 1 -0.0238349
SEPTIN10 septin 10 -0.0237646
SETX senataxin -0.0234711
ERBIN erbb2 interacting protein -0.0233688
PELI1 pellino E3 ubiquitin protein ligase 1 -0.0233084
NALF1 NALCN channel auxiliary factor 1 -0.0227679
PLEK2 pleckstrin 2 -0.0226422
PLAUR plasminogen activator, urokinase receptor -0.0226081
SMAD3 SMAD family member 3 -0.0225841
IL6ST interleukin 6 signal transducer -0.0224448
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0221407
PDE8A phosphodiesterase 8A -0.0221334
ANO6 anoctamin 6 -0.0220986
NPC1 Niemann-Pick disease, type C1 -0.0220664
VCAN versican -0.0219521
SACK1A scaffolding CK1 anchoring protein A -0.0216812
SACK1B scaffolding CK1 anchoring protein B -0.021257
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 -0.0209944
SH3RF1 SH3 domain containing ring finger 1 -0.0209906
EXT1 exostosin glycosyltransferase 1 -0.0209674
JMJD1C jumonji domain containing 1C -0.0205686
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa -0.0204724