Tirabrutinib (hydrochloride)_BT-474 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Tirabrutinib (hydrochloride) perturbation in BT-474 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Tirabrutinib (hydrochloride)_BT-474 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FTH1 ferritin, heavy polypeptide 1 0.121943
NDRG1 N-myc downstream regulated 1 0.0766644
ACSS2 acyl-CoA synthetase short-chain family member 2 0.0524764
VEGFA vascular endothelial growth factor A 0.0422603
GRB10 growth factor receptor-bound protein 10 0.0387144
CEP250 centrosomal protein 250kDa 0.0353909
NCOA3 nuclear receptor coactivator 3 0.0352361
FAM13A family with sequence similarity 13, member A 0.0350429
TMEM123 transmembrane protein 123 0.0329324
GNPDA1 glucosamine-6-phosphate deaminase 1 0.0322794
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0315233
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0280592
FBXL20 F-box and leucine-rich repeat protein 20 0.0259232
ZNF292 zinc finger protein 292 0.0222301
TPD52 tumor protein D52 0.0221379
ZMYND8 zinc finger, MYND-type containing 8 0.021527
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0215028
LASP1 LIM and SH3 protein 1 0.0210038
ESYT2 extended synaptotagmin-like protein 2 0.0206968
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0202736
PDK3 pyruvate dehydrogenase kinase, isozyme 3 0.0183765
PRELID2 PRELI domain containing 2 0.018117
TOB1 transducer of ERBB2, 1 0.0178927
ZBTB20 zinc finger and BTB domain containing 20 0.0177466
KRT18 keratin 18, type I 0.0174849
FAM219A family with sequence similarity 219, member A 0.0170332
AFF1 AF4/FMR2 family, member 1 0.0169132
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1 0.016208
HELZ helicase with zinc finger 0.0154949
PLEC plectin 0.015304
SEC23A Sec23 homolog A (S. cerevisiae) 0.0151461
SLC22A23 solute carrier family 22, member 23 0.0150892
SEMA4A sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A 0.0150758
HILPDA hypoxia inducible lipid droplet-associated 0.0144482
HOOK2 hook microtubule-tethering protein 2 0.0142383
SEC31A SEC31 homolog A (S. cerevisiae) 0.0140785
DSCAM Down syndrome cell adhesion molecule 0.0136448
KDM5B lysine (K)-specific demethylase 5B 0.0136429
RTN3 reticulon 3 0.0134469
BBX bobby sox homolog (Drosophila) 0.0134017
CCNY cyclin Y 0.01334
FAM168A family with sequence similarity 168, member A 0.0133006
MIDEAS mitotic deacetylase associated SANT domain protein 0.0131611
TSC22D2 TSC22 domain family, member 2 0.0131609
CLMN calmin (calponin-like, transmembrane) 0.0130983
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.0130981
RAB6A RAB6A, member RAS oncogene family 0.0130309
FDPS farnesyl diphosphate synthase 0.0130027
YEATS2 YEATS domain containing 2 0.0128932
PFKFB4 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 0.0128066
ZNF395 zinc finger protein 395 0.0127232
FOXO3 forkhead box O3 0.0126616
TMEM165 transmembrane protein 165 0.0125743
FCHSD2 FCH and double SH3 domains 2 0.0124573
SETD5 SET domain containing 5 0.0123413
SEC24A SEC24 family member A 0.0122993
COPB1 coatomer protein complex, subunit beta 1 0.012291
SNX14 sorting nexin 14 0.0120924
EEF2 eukaryotic translation elongation factor 2 0.012012
KMT2E lysine (K)-specific methyltransferase 2E 0.0118733
KIF1A kinesin family member 1A 0.0117473
SCARB1 scavenger receptor class B, member 1 0.0115346
ECT2 epithelial cell transforming 2 0.0114209
GOLGA2 golgin A2 0.0111751
ARFGEF3 ARFGEF family member 3 0.0111309
RNF24 ring finger protein 24 0.0110505
NUFIP2 nuclear fragile X mental retardation protein interacting protein 2 0.0109911
TOP6BL TOP6B like initiator of meiotic double strand breaks 0.0109503
INSIG1 insulin induced gene 1 0.010938
TMEM65 transmembrane protein 65 0.0108954
KDM3A lysine (K)-specific demethylase 3A 0.0108838
FOS FBJ murine osteosarcoma viral oncogene homolog 0.0108259
AKAP9 A kinase (PRKA) anchor protein 9 0.010813
USP37 ubiquitin specific peptidase 37 0.0107789
KDM7A lysine (K)-specific demethylase 7A 0.0105796
LOC112694756 uncharaterized LOC112694756 0.0105711
SREBF2 sterol regulatory element binding transcription factor 2 0.0105412
ABHD3 abhydrolase domain containing 3 0.0103029
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 0.0102884
ANLN anillin, actin binding protein 0.0101925
RAD23B RAD23 homolog B (S. cerevisiae) 0.00977216
RYBP RING1 and YY1 binding protein 0.00970296
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1 0.00965443
SRP54 signal recognition particle 54kDa 0.00963857
PLEKHG4B pleckstrin homology domain containing, family G (with RhoGef domain) member 4B 0.00951309
DGKD diacylglycerol kinase, delta 130kDa 0.00950306
BIRC3 baculoviral IAP repeat containing 3 0.00946817
MIMS1 mitochondrial inner membrane scaffold 1 0.00946033
SEC24D SEC24 family member D 0.00932363
FLNA filamin A, alpha 0.00922725
INSIG2 insulin induced gene 2 0.00919562
PFKP phosphofructokinase, platelet 0.00894356
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.00893889
KIF16B kinesin family member 16B 0.00891723
SPAG9 sperm associated antigen 9 0.00890334
TTC3 tetratricopeptide repeat domain 3 0.00888415
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.00879439
NCOR2 nuclear receptor corepressor 2 0.00876902
TMEM39A transmembrane protein 39A 0.00872606
PPME1 protein phosphatase methylesterase 1 0.00868894

decreased expression

Symbol Name Standardized Value
RPL23 ribosomal protein L23 -0.199172
VMP1 vacuole membrane protein 1 -0.0999055
RPL19 ribosomal protein L19 -0.0964954
CDK12 cyclin-dependent kinase 12 -0.0870073
PTMA prothymosin, alpha -0.069969
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0678915
THSD4 thrombospondin, type I, domain containing 4 -0.0676046
ACACA acetyl-CoA carboxylase alpha -0.0645991
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0610516
SRCIN1 SRC kinase signaling inhibitor 1 -0.055827
ERBB2 erb-b2 receptor tyrosine kinase 2 -0.0519407
TRPS1 trichorhinophalangeal syndrome I -0.0517377
UBC ubiquitin C -0.0514397
CATSPERB catsper channel auxiliary subunit beta -0.0503723
MT2A metallothionein 2A -0.0464137
TMSB10 thymosin beta 10 -0.0420682
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3 -0.0402059
S100A9 S100 calcium binding protein A9 -0.0391916
EXT1 exostosin glycosyltransferase 1 -0.0385297
SLC38A1 solute carrier family 38, member 1 -0.0384724
NTN4 netrin 4 -0.0383629
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase -0.0383502
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0371685
S100A8 S100 calcium binding protein A8 -0.0361096
ANKRD36C ankyrin repeat domain 36C -0.0339729
CTNND1 catenin (cadherin-associated protein), delta 1 -0.033593
PSMD3 proteasome (prosome, macropain) 26S subunit, non-ATPase, 3 -0.0335284
ASPH aspartate beta-hydroxylase -0.0332641
OSMR oncostatin M receptor -0.0326121
RIMS2 regulating synaptic membrane exocytosis 2 -0.0323627
RPS3 ribosomal protein S3 -0.0322447
PBX1 pre-B-cell leukemia homeobox 1 -0.0312371
PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma) -0.0308816
NRIP1 nuclear receptor interacting protein 1 -0.0307821
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa -0.0304639
PMEPA1 prostate transmembrane protein, androgen induced 1 -0.0302092
ENAH enabled homolog (Drosophila) -0.0300434
PAWR PRKC, apoptosis, WT1, regulator -0.0298568
FNDC3A fibronectin type III domain containing 3A -0.0295465
LOC102724023 ES1 protein homolog, mitochondrial -0.0280752
IGFBP5 insulin-like growth factor binding protein 5 -0.0277886
SERPINB4 serpin peptidase inhibitor, clade B (ovalbumin), member 4 -0.0276611
VCP valosin containing protein -0.027514
PTPRK protein tyrosine phosphatase, receptor type, K -0.0273953
CEMIP cell migration inducing protein, hyaluronan binding -0.0273834
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 -0.0272092
SERPINB3 serpin peptidase inhibitor, clade B (ovalbumin), member 3 -0.0269736
SET SET nuclear proto-oncogene -0.0267417
TRAPPC9 trafficking protein particle complex 9 -0.0262982
MED13L mediator complex subunit 13-like -0.0259596
RARRES1 retinoic acid receptor responder (tazarotene induced) 1 -0.0258034
ELOVL5 ELOVL fatty acid elongase 5 -0.0256679
ST3GAL1 ST3 beta-galactoside alpha-2,3-sialyltransferase 1 -0.0255031
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) -0.0251231
ARID5B AT rich interactive domain 5B (MRF1-like) -0.02509
DUSP16 dual specificity phosphatase 16 -0.0249525
ZFAND3 zinc finger, AN1-type domain 3 -0.0249491
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 -0.0246159
APP amyloid beta (A4) precursor protein -0.0244021
BCAS3 breast carcinoma amplified sequence 3 -0.0242979
CEMIP2 cell migration inducing hyaluronidase 2 -0.0241634
ACSL3 acyl-CoA synthetase long-chain family member 3 -0.0241171
FNDC3B fibronectin type III domain containing 3B -0.0238853
LGALS12 lectin, galactoside-binding, soluble, 12 -0.0237864
PRRC2C proline-rich coiled-coil 2C -0.0237153
MLPH melanophilin -0.0236111
SDC4 syndecan 4 -0.0234786
RPS27A ribosomal protein S27a -0.0234065
EHMT1 euchromatic histone-lysine N-methyltransferase 1 -0.0231371
DNAH14 dynein, axonemal, heavy chain 14 -0.0231182
RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3 -0.0226765
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) -0.0225006
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0224764
KAZN kazrin, periplakin interacting protein -0.0224531
AHNAK AHNAK nucleoprotein -0.0221293
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0219312
SHANK2 SH3 and multiple ankyrin repeat domains 2 -0.0219298
DOCK5 dedicator of cytokinesis 5 -0.0218452
CDH15 cadherin 15, type 1, M-cadherin (myotubule) -0.0213835
RAB22A RAB22A, member RAS oncogene family -0.0212838
SMYD3 SET and MYND domain containing 3 -0.0210276
STRBP spermatid perinuclear RNA binding protein -0.0207773
PSMB3 proteasome (prosome, macropain) subunit, beta type, 3 -0.0206965
TENM2 teneurin transmembrane protein 2 -0.0206581
SLC7A2 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 -0.0205169
SFPQ splicing factor proline/glutamine-rich -0.020494
INSR insulin receptor -0.0201389
MLLT6 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 6 -0.0200697
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 -0.0199904
TC2N tandem C2 domains, nuclear -0.0198616
MYL12B myosin, light chain 12B, regulatory -0.0197101
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0196625
S100P S100 calcium binding protein P -0.0195642
RPL35A ribosomal protein L35a -0.0195642
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle -0.0194676
LUC7L3 LUC7-like 3 (S. cerevisiae) -0.0193014
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0191072
AREG amphiregulin -0.0190362
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0190324
IFI6 interferon, alpha-inducible protein 6 -0.0188569