| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Tirabrutinib (hydrochloride) perturbation in C-33 A cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Tirabrutinib (hydrochloride)_C-33 A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| EEF2 | eukaryotic translation elongation factor 2 | 0.153924 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.118824 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0914616 |
| NR4A3 | nuclear receptor subfamily 4, group A, member 3 | 0.0841191 |
| RPS4X | ribosomal protein S4, X-linked | 0.0811507 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0776495 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | 0.0747636 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | 0.066115 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0654929 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0642653 |
| RPS6 | ribosomal protein S6 | 0.0633644 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | 0.0597426 |
| ZNF638 | zinc finger protein 638 | 0.0575694 |
| EGLN1 | egl-9 family hypoxia-inducible factor 1 | 0.0565053 |
| PTMA | prothymosin, alpha | 0.0555526 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0507603 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | 0.0506376 |
| MLLT10 | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 | 0.0498631 |
| GNAS | GNAS complex locus | 0.0474852 |
| DST | dystonin | 0.0470153 |
| RPLP1 | ribosomal protein, large, P1 | 0.0462047 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0455058 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.0437495 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.0430911 |
| SYAP1 | synapse associated protein 1 | 0.0422707 |
| DNAJA1 | DnaJ (Hsp40) homolog, subfamily A, member 1 | 0.0419711 |
| SRRM1 | serine/arginine repetitive matrix 1 | 0.0416601 |
| NR2F1 | nuclear receptor subfamily 2, group F, member 1 | 0.040642 |
| TPM3 | tropomyosin 3 | 0.0396221 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0389104 |
| FN1 | fibronectin 1 | 0.0371011 |
| RPL23 | ribosomal protein L23 | 0.0370251 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0359847 |
| TTC3 | tetratricopeptide repeat domain 3 | 0.0359792 |
| MATR3 | matrin 3 | 0.035434 |
| PARD3 | par-3 family cell polarity regulator | 0.035106 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0350141 |
| SETD5 | SET domain containing 5 | 0.0343539 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0338695 |
| BPTF | bromodomain PHD finger transcription factor | 0.033779 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | 0.0333903 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0330598 |
| SRSF11 | serine/arginine-rich splicing factor 11 | 0.032858 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.032788 |
| PDIA6 | protein disulfide isomerase family A, member 6 | 0.0326784 |
| CSDE1 | cold shock domain containing E1, RNA-binding | 0.0324314 |
| FXR1 | fragile X mental retardation, autosomal homolog 1 | 0.0323671 |
| RPL11 | ribosomal protein L11 | 0.0320751 |
| TAOK1 | TAO kinase 1 | 0.0317118 |
| ZNF292 | zinc finger protein 292 | 0.0316832 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0316136 |
| ANKRD36 | ankyrin repeat domain 36 | 0.0311687 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0309742 |
| QKI | QKI, KH domain containing, RNA binding | 0.0309184 |
| RPS12 | ribosomal protein S12 | 0.0308159 |
| GPBP1 | GC-rich promoter binding protein 1 | 0.030761 |
| NFIB | nuclear factor I/B | 0.0307503 |
| RAD51B | RAD51 paralog B | 0.0307429 |
| EEF1G | eukaryotic translation elongation factor 1 gamma | 0.0307335 |
| RPS11 | ribosomal protein S11 | 0.0303214 |
| DOCK7 | dedicator of cytokinesis 7 | 0.0301637 |
| WWC2 | WW and C2 domain containing 2 | 0.030085 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0298403 |
| CANX | calnexin | 0.0297068 |
| RSL1D1 | ribosomal L1 domain containing 1 | 0.0296192 |
| ATP5F1A | ATP synthase F1 subunit alpha | 0.0295697 |
| BMPR2 | bone morphogenetic protein receptor, type II (serine/threonine kinase) | 0.029473 |
| NBEAL1 | neurobeachin-like 1 | 0.029034 |
| TAF15 | TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa | 0.0290161 |
| HNRNPR | heterogeneous nuclear ribonucleoprotein R | 0.0290028 |
| EZR | ezrin | 0.028953 |
| RSRC2 | arginine/serine-rich coiled-coil 2 | 0.0288065 |
| MAP1LC3B | microtubule-associated protein 1 light chain 3 beta | 0.0287942 |
| PTK2 | protein tyrosine kinase 2 | 0.028514 |
| APP | amyloid beta (A4) precursor protein | 0.028356 |
| RPS17 | ribosomal protein S17 | 0.0281629 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | 0.0277881 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0276328 |
| USP34 | ubiquitin specific peptidase 34 | 0.0275816 |
| CALU | calumenin | 0.0274383 |
| PNN | pinin, desmosome associated protein | 0.0273008 |
| RLF | rearranged L-myc fusion | 0.027236 |
| ACACA | acetyl-CoA carboxylase alpha | 0.0269067 |
| MINDY2 | MINDY lysine 48 deubiquitinase 2 | 0.0268315 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0266647 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0266481 |
| RPL19 | ribosomal protein L19 | 0.0265993 |
| MED13L | mediator complex subunit 13-like | 0.0264918 |
| GOLGA4 | golgin A4 | 0.0263196 |
| YBX1 | Y box binding protein 1 | 0.0263003 |
| EIF4A2 | eukaryotic translation initiation factor 4A2 | 0.0262109 |
| NEBL | nebulette | 0.0261308 |
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | 0.0261283 |
| G3BP2 | GTPase activating protein (SH3 domain) binding protein 2 | 0.0259226 |
| PAFAH1B1 | platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa) | 0.0258183 |
| HNRNPH3 | heterogeneous nuclear ribonucleoprotein H3 (2H9) | 0.0257895 |
| AHI1 | Abelson helper integration site 1 | 0.0257504 |
| USP15 | ubiquitin specific peptidase 15 | 0.0257408 |
| RPS8 | ribosomal protein S8 | 0.0256459 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0256319 |
| Symbol | Name | Standardized Value |
|---|---|---|
| SLIT2 | slit homolog 2 (Drosophila) | -0.132336 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.126573 |
| APBB2 | amyloid beta (A4) precursor protein-binding, family B, member 2 | -0.10674 |
| SHROOM3 | shroom family member 3 | -0.0944704 |
| COL5A2 | collagen, type V, alpha 2 | -0.0730684 |
| TOX | thymocyte selection-associated high mobility group box | -0.0650366 |
| SEMA3D | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3D | -0.0640087 |
| VCL | vinculin | -0.0462931 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.039881 |
| ZNF644 | zinc finger protein 644 | -0.0388746 |
| GAB2 | GRB2-associated binding protein 2 | -0.0358311 |
| NR5A2 | nuclear receptor subfamily 5, group A, member 2 | -0.0353451 |
| CACNB4 | calcium channel, voltage-dependent, beta 4 subunit | -0.0339426 |
| IFI6 | interferon, alpha-inducible protein 6 | -0.0314697 |
| ADGRG6 | adhesion G protein-coupled receptor G6 | -0.0312421 |
| RAPGEF2 | Rap guanine nucleotide exchange factor (GEF) 2 | -0.0299997 |
| PRRC2B | proline-rich coiled-coil 2B | -0.02778 |
| MCTP1 | multiple C2 domains, transmembrane 1 | -0.0277155 |
| WLS | wntless Wnt ligand secretion mediator | -0.0274973 |
| CAPZB | capping protein (actin filament) muscle Z-line, beta | -0.0272019 |
| CELF2 | CUGBP, Elav-like family member 2 | -0.0259075 |
| NRG1 | neuregulin 1 | -0.0257757 |
| GPR137B | G protein-coupled receptor 137B | -0.0253326 |
| HMGA1 | high mobility group AT-hook 1 | -0.0247007 |
| RIGI | RNA sensor RIG-I | -0.0237023 |
| XRCC5 | X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining) | -0.0234514 |
| PTTG1IP | pituitary tumor-transforming 1 interacting protein | -0.0232654 |
| PHLPP1 | PH domain and leucine rich repeat protein phosphatase 1 | -0.0226699 |
| MLIP | muscular LMNA-interacting protein | -0.0226556 |
| ATP9A | ATPase, class II, type 9A | -0.0225101 |
| TENT4A | terminal nucleotidyltransferase 4A | -0.0223568 |
| CTNND1 | catenin (cadherin-associated protein), delta 1 | -0.0215527 |
| RABGAP1L | RAB GTPase activating protein 1-like | -0.021468 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | -0.0213553 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | -0.0209915 |
| HS2ST1 | heparan sulfate 2-O-sulfotransferase 1 | -0.0202134 |
| UBE3C | ubiquitin protein ligase E3C | -0.0200253 |
| CTNNA2 | catenin (cadherin-associated protein), alpha 2 | -0.0196988 |
| HMGB1 | high mobility group box 1 | -0.0194938 |
| ADARB1 | adenosine deaminase, RNA-specific, B1 | -0.0189399 |
| MAP3K14 | mitogen-activated protein kinase kinase kinase 14 | -0.0184646 |
| NOC3L | nucleolar complex associated 3 homolog (S. cerevisiae) | -0.0178845 |
| RAP1B | RAP1B, member of RAS oncogene family | -0.0177822 |
| ITSN1 | intersectin 1 (SH3 domain protein) | -0.0174408 |
| KIAA1328 | KIAA1328 | -0.0173176 |
| TAS2R14 | taste receptor, type 2, member 14 | -0.0169113 |
| PIK3C2A | phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha | -0.0165807 |
| BLTP2 | bridge-like lipid transfer protein family member 2 | -0.0165739 |
| AFG2A | AFG2 AAA ATPase homolog A | -0.0165138 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | -0.0164976 |
| PTPN14 | protein tyrosine phosphatase, non-receptor type 14 | -0.01648 |
| MTAP | methylthioadenosine phosphorylase | -0.0163341 |
| RNGTT | RNA guanylyltransferase and 5'-phosphatase | -0.016156 |
| RABGAP1 | RAB GTPase activating protein 1 | -0.0160348 |
| LIMS1 | LIM and senescent cell antigen-like domains 1 | -0.0159997 |
| NF1 | neurofibromin 1 | -0.015784 |
| PDSS2 | prenyl (decaprenyl) diphosphate synthase, subunit 2 | -0.0154817 |
| RNF19A | ring finger protein 19A, RBR E3 ubiquitin protein ligase | -0.0153401 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | -0.015335 |
| NBAS | neuroblastoma amplified sequence | -0.0153016 |
| SOX5 | SRY (sex determining region Y)-box 5 | -0.0151819 |
| FBXO34 | F-box protein 34 | -0.0150993 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0149951 |
| IQCB1 | IQ motif containing B1 | -0.0147978 |
| KCNH7 | potassium channel, voltage gated eag related subfamily H, member 7 | -0.0147535 |
| ZDHHC3 | zinc finger, DHHC-type containing 3 | -0.0147513 |
| CHST11 | carbohydrate (chondroitin 4) sulfotransferase 11 | -0.0147263 |
| METTL16 | methyltransferase like 16 | -0.0146766 |
| CDC27 | cell division cycle 27 | -0.0144175 |
| HS6ST2 | heparan sulfate 6-O-sulfotransferase 2 | -0.0144008 |
| SYNE1 | spectrin repeat containing, nuclear envelope 1 | -0.0143874 |
| ZFX | zinc finger protein, X-linked | -0.0143647 |
| DMTF1 | cyclin D binding myb-like transcription factor 1 | -0.0142065 |
| DIPK2A | divergent protein kinase domain 2A | -0.0141174 |
| NTN1 | netrin 1 | -0.013969 |
| SALL4 | spalt-like transcription factor 4 | -0.0139176 |
| BUB1B | BUB1 mitotic checkpoint serine/threonine kinase B | -0.0138027 |
| EWSR1 | EWS RNA-binding protein 1 | -0.0136911 |
| SETX | senataxin | -0.0135298 |
| AGTPBP1 | ATP/GTP binding protein 1 | -0.013483 |
| ANKRD33B | ankyrin repeat domain 33B | -0.013388 |
| EGR1 | early growth response 1 | -0.0131723 |
| MICU2 | mitochondrial calcium uptake 2 | -0.0131569 |
| RBFOX2 | RNA binding protein, fox-1 homolog (C. elegans) 2 | -0.0130413 |
| CACHD1 | cache domain containing 1 | -0.0129743 |
| MON2 | MON2 homolog (S. cerevisiae) | -0.0128816 |
| FAM169A | family with sequence similarity 169, member A | -0.0128225 |
| ZNFX1 | zinc finger, NFX1-type containing 1 | -0.0126652 |
| NFE2L2 | nuclear factor, erythroid 2-like 2 | -0.0125785 |
| NR2C1 | nuclear receptor subfamily 2, group C, member 1 | -0.0124969 |
| FBXW7 | F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase | -0.0124083 |
| GCLC | glutamate-cysteine ligase, catalytic subunit | -0.0123732 |
| WDR75 | WD repeat domain 75 | -0.0123603 |
| CENPE | centromere protein E, 312kDa | -0.0122823 |
| FGFR1 | fibroblast growth factor receptor 1 | -0.0122814 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0122591 |
| ABI2 | abl-interactor 2 | -0.012175 |
| TPST1 | tyrosylprotein sulfotransferase 1 | -0.0121724 |
| FERMT2 | fermitin family member 2 | -0.012168 |
| DSTYK | dual serine/threonine and tyrosine protein kinase | -0.0121254 |
