| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Tirabrutinib (hydrochloride) perturbation in C32 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Tirabrutinib (hydrochloride)_C32 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| VGF | VGF nerve growth factor inducible | 0.240662 |
| ASPH | aspartate beta-hydroxylase | 0.13817 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.132853 |
| MDGA2 | MAM domain containing glycosylphosphatidylinositol anchor 2 | 0.113984 |
| CALU | calumenin | 0.110129 |
| IFRD1 | interferon-related developmental regulator 1 | 0.101038 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0984872 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.0945499 |
| NDRG1 | N-myc downstream regulated 1 | 0.0876513 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0864104 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.079729 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | 0.0778441 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0722548 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | 0.071592 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0692708 |
| SFTPA2 | surfactant protein A2 | 0.0691162 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0682591 |
| ADM | adrenomedullin | 0.067469 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | 0.0612793 |
| PKM | pyruvate kinase, muscle | 0.0606549 |
| ANXA2 | annexin A2 | 0.0599807 |
| ZNF292 | zinc finger protein 292 | 0.0565515 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.056249 |
| YWHAG | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma | 0.0543812 |
| FNDC3B | fibronectin type III domain containing 3B | 0.054199 |
| LOC112694756 | uncharaterized LOC112694756 | 0.0517261 |
| CD74 | CD74 molecule, major histocompatibility complex, class II invariant chain | 0.0508204 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.050579 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0503814 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0496187 |
| FOS | FBJ murine osteosarcoma viral oncogene homolog | 0.0494988 |
| SEPTIN9 | septin 9 | 0.0487862 |
| APP | amyloid beta (A4) precursor protein | 0.047853 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | 0.0477158 |
| RYBP | RING1 and YY1 binding protein | 0.0469655 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0461044 |
| CENPF | centromere protein F, 350/400kDa | 0.0459777 |
| DDIT4 | DNA-damage-inducible transcript 4 | 0.0452355 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0439073 |
| RHEB | Ras homolog enriched in brain | 0.0438872 |
| RLF | rearranged L-myc fusion | 0.0436965 |
| BACE2 | beta-site APP-cleaving enzyme 2 | 0.043696 |
| ZMIZ1 | zinc finger, MIZ-type containing 1 | 0.0435096 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0434065 |
| LDHA | lactate dehydrogenase A | 0.0432601 |
| BRD2 | bromodomain containing 2 | 0.0425203 |
| ICAM1 | intercellular adhesion molecule 1 | 0.0415404 |
| NUP58 | nucleoporin 58 | 0.0415381 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0408921 |
| PACSIN2 | protein kinase C and casein kinase substrate in neurons 2 | 0.0404433 |
| CD109 | CD109 molecule | 0.0397504 |
| HILPDA | hypoxia inducible lipid droplet-associated | 0.0394038 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0391038 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0390367 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0385681 |
| JUN | jun proto-oncogene | 0.0384121 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | 0.0381947 |
| YBX1 | Y box binding protein 1 | 0.0377929 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0377165 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | 0.0376874 |
| ATP1A4 | ATPase, Na+/K+ transporting, alpha 4 polypeptide | 0.0376165 |
| LRRC23 | leucine rich repeat containing 23 | 0.0375594 |
| VIM | vimentin | 0.0371823 |
| KIRREL1 | kirre like nephrin family adhesion molecule 1 | 0.0371584 |
| INSIG1 | insulin induced gene 1 | 0.0366499 |
| HIVEP3 | human immunodeficiency virus type I enhancer binding protein 3 | 0.0361354 |
| MIDEAS | mitotic deacetylase associated SANT domain protein | 0.0360308 |
| FOSB | FBJ murine osteosarcoma viral oncogene homolog B | 0.0357943 |
| NAV1 | neuron navigator 1 | 0.035762 |
| SMAD3 | SMAD family member 3 | 0.0355746 |
| MRTFA | myocardin related transcription factor A | 0.0354713 |
| B2M | beta-2-microglobulin | 0.0354184 |
| RAB7A | RAB7A, member RAS oncogene family | 0.0353953 |
| VEGFA | vascular endothelial growth factor A | 0.0352764 |
| CABIN1 | calcineurin binding protein 1 | 0.0350886 |
| CTNNB1 | catenin (cadherin-associated protein), beta 1, 88kDa | 0.034803 |
| SND1 | staphylococcal nuclease and tudor domain containing 1 | 0.0347487 |
| EMP1 | epithelial membrane protein 1 | 0.0345643 |
| UBC | ubiquitin C | 0.0344182 |
| PHF21A | PHD finger protein 21A | 0.0342036 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | 0.0333266 |
| DCT | dopachrome tautomerase | 0.0333255 |
| PCDH7 | protocadherin 7 | 0.0329695 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0325483 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | 0.032421 |
| CDC73 | cell division cycle 73 | 0.0317955 |
| FLNA | filamin A, alpha | 0.0317695 |
| RNASE12 | ribonuclease, RNase A family, 12 (non-active) | 0.0316147 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | 0.0314773 |
| AHNAK | AHNAK nucleoprotein | 0.0312007 |
| COPA | coatomer protein complex, subunit alpha | 0.0311722 |
| CCNL1 | cyclin L1 | 0.0310507 |
| EIF4A2 | eukaryotic translation initiation factor 4A2 | 0.0310466 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0308834 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.0303676 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0303505 |
| MYO1E | myosin IE | 0.0302616 |
| SSBP3 | single stranded DNA binding protein 3 | 0.0302234 |
| MTPN | myotrophin | 0.0300519 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0300405 |
| Symbol | Name | Standardized Value |
|---|---|---|
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0737967 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0717848 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | -0.0684194 |
| FN1 | fibronectin 1 | -0.0671116 |
| COL19A1 | collagen, type XIX, alpha 1 | -0.0553854 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0474363 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0457099 |
| PLCB1 | phospholipase C, beta 1 (phosphoinositide-specific) | -0.0439388 |
| CPEB2 | cytoplasmic polyadenylation element binding protein 2 | -0.0434108 |
| GDF15 | growth differentiation factor 15 | -0.0410488 |
| MARK3 | MAP/microtubule affinity-regulating kinase 3 | -0.0351951 |
| AHR | aryl hydrocarbon receptor | -0.0337011 |
| PRKD1 | protein kinase D1 | -0.0322773 |
| TMTC2 | transmembrane and tetratricopeptide repeat containing 2 | -0.0319327 |
| IL1RAPL1 | interleukin 1 receptor accessory protein-like 1 | -0.0298797 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | -0.0290998 |
| PLA2G4A | phospholipase A2, group IVA (cytosolic, calcium-dependent) | -0.028485 |
| ANKRD28 | ankyrin repeat domain 28 | -0.0263538 |
| BRWD1 | bromodomain and WD repeat domain containing 1 | -0.0260998 |
| HMCN1 | hemicentin 1 | -0.0259001 |
| ITPR2 | inositol 1,4,5-trisphosphate receptor, type 2 | -0.0258265 |
| OGA | O-GlcNAcase | -0.0254473 |
| AHCYL2 | adenosylhomocysteinase-like 2 | -0.0249273 |
| SMURF1 | SMAD specific E3 ubiquitin protein ligase 1 | -0.0248443 |
| RASSF8 | Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 | -0.0244978 |
| MRPS6 | mitochondrial ribosomal protein S6 | -0.0242477 |
| FBXL7 | F-box and leucine-rich repeat protein 7 | -0.0241477 |
| MMP16 | matrix metallopeptidase 16 (membrane-inserted) | -0.0236911 |
| NF1 | neurofibromin 1 | -0.0234791 |
| C10ORF90 | chromosome 10 open reading frame 90 | -0.0233483 |
| ZC3H7A | zinc finger CCCH-type containing 7A | -0.0233064 |
| EHBP1 | EH domain binding protein 1 | -0.0230188 |
| AKAP6 | A kinase (PRKA) anchor protein 6 | -0.0229371 |
| RNF19A | ring finger protein 19A, RBR E3 ubiquitin protein ligase | -0.0228283 |
| ANK2 | ankyrin 2, neuronal | -0.0226616 |
| PYGB | phosphorylase, glycogen; brain | -0.022539 |
| PDE4B | phosphodiesterase 4B, cAMP-specific | -0.0224594 |
| FRMD5 | FERM domain containing 5 | -0.022134 |
| NCOA1 | nuclear receptor coactivator 1 | -0.0221098 |
| PAN3 | PAN3 poly(A) specific ribonuclease subunit | -0.0217509 |
| CHSY1 | chondroitin sulfate synthase 1 | -0.0216328 |
| PTTG1IP | pituitary tumor-transforming 1 interacting protein | -0.0211838 |
| FMN1 | formin 1 | -0.020053 |
| MAML2 | mastermind-like 2 (Drosophila) | -0.0197726 |
| CDK19 | cyclin-dependent kinase 19 | -0.0196273 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0189839 |
| MITF | microphthalmia-associated transcription factor | -0.0188925 |
| STRIP2 | striatin interacting protein 2 | -0.0188842 |
| ANK3 | ankyrin 3, node of Ranvier (ankyrin G) | -0.0188201 |
| GHR | growth hormone receptor | -0.0187551 |
| TMEM123 | transmembrane protein 123 | -0.0182533 |
| CDH19 | cadherin 19, type 2 | -0.0176231 |
| FAM3C | family with sequence similarity 3, member C | -0.0173847 |
| NSMCE2 | non-SMC element 2, MMS21 homolog (S. cerevisiae) | -0.0173272 |
| ARHGAP21 | Rho GTPase activating protein 21 | -0.0172373 |
| TNFRSF19 | tumor necrosis factor receptor superfamily, member 19 | -0.0172185 |
| GPAT3 | glycerol-3-phosphate acyltransferase 3 | -0.0171229 |
| JAZF1 | JAZF zinc finger 1 | -0.0166645 |
| OXR1 | oxidation resistance 1 | -0.0159226 |
| ESYT2 | extended synaptotagmin-like protein 2 | -0.0158926 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.0158131 |
| NAV3 | neuron navigator 3 | -0.01561 |
| DOCK4 | dedicator of cytokinesis 4 | -0.0155014 |
| ZFYVE16 | zinc finger, FYVE domain containing 16 | -0.0152821 |
| BAIAP2L1 | BAI1-associated protein 2-like 1 | -0.0152358 |
| ITGB8 | integrin, beta 8 | -0.0151007 |
| ARHGAP5 | Rho GTPase activating protein 5 | -0.015082 |
| PTCHD4 | patched domain containing 4 | -0.0147651 |
| ITFG1 | integrin alpha FG-GAP repeat containing 1 | -0.0147048 |
| MBNL2 | muscleblind-like splicing regulator 2 | -0.0146847 |
| SERINC5 | serine incorporator 5 | -0.0146672 |
| SWAP70 | SWAP switching B-cell complex 70kDa subunit | -0.0145646 |
| ZKSCAN1 | zinc finger with KRAB and SCAN domains 1 | -0.0145391 |
| PI15 | peptidase inhibitor 15 | -0.0142643 |
| AOPEP | aminopeptidase O (putative) | -0.0141821 |
| WWTR1 | WW domain containing transcription regulator 1 | -0.0141294 |
| PTAR1 | protein prenyltransferase alpha subunit repeat containing 1 | -0.0140785 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | -0.0140677 |
| ATP11B | ATPase, class VI, type 11B | -0.0140168 |
| SDC2 | syndecan 2 | -0.014012 |
| TAS2R14 | taste receptor, type 2, member 14 | -0.0139281 |
| NRIP1 | nuclear receptor interacting protein 1 | -0.0139249 |
| ADAM19 | ADAM metallopeptidase domain 19 | -0.0138406 |
| RC3H1 | ring finger and CCCH-type domains 1 | -0.0138152 |
| SKIC3 | SKI3 subunit of superkiller complex | -0.0137463 |
| TENT5A | terminal nucleotidyltransferase 5A | -0.0137443 |
| FBXL2 | F-box and leucine-rich repeat protein 2 | -0.0137278 |
| TRPS1 | trichorhinophalangeal syndrome I | -0.0136519 |
| COPG2 | coatomer protein complex, subunit gamma 2 | -0.0136314 |
| LNPK | lunapark, ER junction formation factor | -0.01361 |
| GULP1 | GULP, engulfment adaptor PTB domain containing 1 | -0.0134935 |
| DPYD | dihydropyrimidine dehydrogenase | -0.0134912 |
| ZCCHC7 | zinc finger, CCHC domain containing 7 | -0.0134856 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | -0.0134751 |
| PDE10A | phosphodiesterase 10A | -0.0133797 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0131954 |
| SSH1 | slingshot protein phosphatase 1 | -0.0130838 |
| ATXN10 | ataxin 10 | -0.0130793 |
| ABHD17C | abhydrolase domain containing 17C | -0.0129286 |
| MAP4K3 | mitogen-activated protein kinase kinase kinase kinase 3 | -0.0127754 |
