Tirabrutinib (hydrochloride)_CFPAC-1 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Tirabrutinib (hydrochloride) perturbation in CFPAC-1 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Tirabrutinib (hydrochloride)_CFPAC-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.104317
FTH1 ferritin, heavy polypeptide 1 0.0996898
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0910465
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0801191
MYH9 myosin, heavy chain 9, non-muscle 0.0647096
NAMPT nicotinamide phosphoribosyltransferase 0.0638572
AKAP12 A kinase (PRKA) anchor protein 12 0.0637823
FAM13A family with sequence similarity 13, member A 0.0583392
APLP2 amyloid beta (A4) precursor-like protein 2 0.0536811
TSC22D2 TSC22 domain family, member 2 0.053483
NDRG1 N-myc downstream regulated 1 0.0525393
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0504276
EZR ezrin 0.0482651
SPAG9 sperm associated antigen 9 0.046626
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0448974
AHNAK AHNAK nucleoprotein 0.0440479
ASPH aspartate beta-hydroxylase 0.0435608
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0420449
FNDC3B fibronectin type III domain containing 3B 0.0420108
ELL2 elongation factor, RNA polymerase II, 2 0.0417504
SMAD3 SMAD family member 3 0.0414207
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0394799
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0393104
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.0392246
VEGFA vascular endothelial growth factor A 0.0386747
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0386084
ERRFI1 ERBB receptor feedback inhibitor 1 0.0381706
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 0.0380881
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0362345
TGM2 transglutaminase 2 0.0362008
MEF2A myocyte enhancer factor 2A 0.0361938
FLNB filamin B, beta 0.0356569
TMSB4X thymosin beta 4, X-linked 0.0355967
IGFBP3 insulin-like growth factor binding protein 3 0.0348865
LAMB3 laminin, beta 3 0.0342677
KRT18 keratin 18, type I 0.0339061
CANX calnexin 0.0336419
HELZ helicase with zinc finger 0.0336096
TNIP1 TNFAIP3 interacting protein 1 0.0334929
DTNA dystrobrevin, alpha 0.0333879
APP amyloid beta (A4) precursor protein 0.0331042
EEF2 eukaryotic translation elongation factor 2 0.0323727
CCNY cyclin Y 0.0323268
ANXA2 annexin A2 0.0311085
UBA6 ubiquitin-like modifier activating enzyme 6 0.0306518
ADAM9 ADAM metallopeptidase domain 9 0.0306452
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0300862
HOOK2 hook microtubule-tethering protein 2 0.029829
HLA-A major histocompatibility complex, class I, A 0.0292031
DDIT4 DNA-damage-inducible transcript 4 0.0291975
OPTN optineurin 0.0288752
PDIA3 protein disulfide isomerase family A, member 3 0.028554
HILPDA hypoxia inducible lipid droplet-associated 0.028142
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0271133
PGK1 phosphoglycerate kinase 1 0.0270251
CALR calreticulin 0.0269509
OGA O-GlcNAcase 0.0268443
KMT2E lysine (K)-specific methyltransferase 2E 0.0267035
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 0.0266009
ANXA1 annexin A1 0.0265604
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0259634
ESYT2 extended synaptotagmin-like protein 2 0.0256494
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide 0.0247774
UBC ubiquitin C 0.0244638
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0240557
LAMC2 laminin, gamma 2 0.0237787
PLAU plasminogen activator, urokinase 0.0236373
BHLHE40 basic helix-loop-helix family, member e40 0.0236108
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.0235296
PLEC plectin 0.0235104
RLF rearranged L-myc fusion 0.0234763
TPM3 tropomyosin 3 0.0233184
AKAP13 A kinase (PRKA) anchor protein 13 0.0232949
BRD2 bromodomain containing 2 0.0232747
MATR3 matrin 3 0.0230395
PPARD peroxisome proliferator-activated receptor delta 0.0229688
GRB10 growth factor receptor-bound protein 10 0.022801
KDM3A lysine (K)-specific demethylase 3A 0.0225582
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0224878
ZNF292 zinc finger protein 292 0.0223871
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0223764
RIOK3 RIO kinase 3 0.0220506
BIRC3 baculoviral IAP repeat containing 3 0.0220203
CCNL1 cyclin L1 0.0220094
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0215984
KDM5B lysine (K)-specific demethylase 5B 0.0213733
KMT2C lysine (K)-specific methyltransferase 2C 0.021262
LOC112694756 uncharaterized LOC112694756 0.0210319
PTPN14 protein tyrosine phosphatase, non-receptor type 14 0.0210229
ADM adrenomedullin 0.021014
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0209355
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0208794
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0208449
MYO1B myosin IB 0.0207524
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.020729
COPA coatomer protein complex, subunit alpha 0.0206304
FLNA filamin A, alpha 0.0206137
SUCO SUN domain containing ossification factor 0.0205898
GNPDA1 glucosamine-6-phosphate deaminase 1 0.0204967
FNBP1L formin binding protein 1-like 0.0204895

decreased expression

Symbol Name Standardized Value
TMSB10 thymosin beta 10 -0.06147
HLA-B major histocompatibility complex, class I, B -0.0488436
RPL35A ribosomal protein L35a -0.0415733
CP ceruloplasmin (ferroxidase) -0.0364408
TPT1 tumor protein, translationally-controlled 1 -0.036254
IFI27 interferon, alpha-inducible protein 27 -0.0347034
ISG15 ISG15 ubiquitin-like modifier -0.0325747
MT2A metallothionein 2A -0.0308212
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0290967
MMP7 matrix metallopeptidase 7 -0.0284612
RPLP1 ribosomal protein, large, P1 -0.0260462
PTMA prothymosin, alpha -0.025172
RPS8 ribosomal protein S8 -0.023497
EFNA5 ephrin-A5 -0.0227235
FTL ferritin, light polypeptide -0.0227
RPL34 ribosomal protein L34 -0.0224883
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0224776
RPL23 ribosomal protein L23 -0.0221088
RPS29 ribosomal protein S29 -0.0213904
NRG3 neuregulin 3 -0.0208845
RPS24 ribosomal protein S24 -0.0200153
IFI6 interferon, alpha-inducible protein 6 -0.0198825
MX2 MX dynamin-like GTPase 2 -0.0197265
PMP22 peripheral myelin protein 22 -0.0184284
RPL31 ribosomal protein L31 -0.0176704
ZBTB20 zinc finger and BTB domain containing 20 -0.0175507
S100A6 S100 calcium binding protein A6 -0.0174806
RPL37A ribosomal protein L37a -0.0174068
RPL9 ribosomal protein L9 -0.0172141
SP100 SP100 nuclear antigen -0.0172085
NT5C2 5'-nucleotidase, cytosolic II -0.0171275
ALCAM activated leukocyte cell adhesion molecule -0.0168423
MT1E metallothionein 1E -0.0161215
RPS21 ribosomal protein S21 -0.0159532
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0158669
PCDH7 protocadherin 7 -0.0157857
RPS25 ribosomal protein S25 -0.0156789
RPS19 ribosomal protein S19 -0.0155723
RPS23 ribosomal protein S23 -0.0152417
RAD51B RAD51 paralog B -0.0150708
RNF213 ring finger protein 213 -0.0147722
C15ORF48 chromosome 15 open reading frame 48 -0.0147287
S100P S100 calcium binding protein P -0.0144946
RIGI RNA sensor RIG-I -0.0141965
BICC1 BicC family RNA binding protein 1 -0.0141033
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -0.0139625
EXT1 exostosin glycosyltransferase 1 -0.013908
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0136354
RPL28 ribosomal protein L28 -0.01356
NABP1 nucleic acid binding protein 1 -0.0134512
INTS6 integrator complex subunit 6 -0.0131522
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like -0.0130518
CSTB cystatin B (stefin B) -0.0129828
EGR1 early growth response 1 -0.0129824
CNRIP1 cannabinoid receptor interacting protein 1 -0.0126425
CATSPERB catsper channel auxiliary subunit beta -0.0125849
OSMR oncostatin M receptor -0.0124128
EHBP1 EH domain binding protein 1 -0.0123594
TJP1 tight junction protein 1 -0.0120295
IFITM3 interferon induced transmembrane protein 3 -0.0117553
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0116484
RPS14 ribosomal protein S14 -0.0115578
RPLP2 ribosomal protein, large, P2 -0.0115174
ST8SIA6 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 6 -0.0114928
RPL36A ribosomal protein L36a -0.0113729
TMC5 transmembrane channel-like 5 -0.0113306
MUC4 mucin 4, cell surface associated -0.0113104
PCNX4 pecanex 4 -0.0111616
S100A11 S100 calcium binding protein A11 -0.011132
GLIS3 GLIS family zinc finger 3 -0.0108356
RPL37 ribosomal protein L37 -0.0108267
ADAM8 ADAM metallopeptidase domain 8 -0.0108176
B2M beta-2-microglobulin -0.0104416
GCC2 GRIP and coiled-coil domain containing 2 -0.0103621
RSAD2 radical S-adenosyl methionine domain containing 2 -0.0102501
RABGAP1L RAB GTPase activating protein 1-like -0.0102357
BPTF bromodomain PHD finger transcription factor -0.0100509
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.0100455
RPL38 ribosomal protein L38 -0.0100316
RPS13 ribosomal protein S13 -0.0100186
NFE2L2 nuclear factor, erythroid 2-like 2 -0.00999733
ZNFX1 zinc finger, NFX1-type containing 1 -0.0099861
GPATCH8 G patch domain containing 8 -0.00993022
SLC6A14 solute carrier family 6 (amino acid transporter), member 14 -0.00982956
WARS1 tryptophanyl-tRNA synthetase 1 -0.00968972
S100A10 S100 calcium binding protein A10 -0.00963735
IFIH1 interferon induced with helicase C domain 1 -0.00957996
RASAL2 RAS protein activator like 2 -0.00953261
RPS27A ribosomal protein S27a -0.00950089
RPL36AL ribosomal protein L36a-like -0.00941304
PRKCA protein kinase C, alpha -0.00928929
RPS27 ribosomal protein S27 -0.00923683
RPL36 ribosomal protein L36 -0.00913007
NRP1 neuropilin 1 -0.0091218
ZSWIM6 zinc finger, SWIM-type containing 6 -0.00897594
LCN2 lipocalin 2 -0.00893814
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0089041
VIM vimentin -0.0087901
NRG1 neuregulin 1 -0.00875343
XAF1 XIAP associated factor 1 -0.00874577