| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Tirabrutinib (hydrochloride) perturbation in CHP-212 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Tirabrutinib (hydrochloride)_CHP-212 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| NRG1 | neuregulin 1 | 0.0945542 |
| FAM13A | family with sequence similarity 13, member A | 0.067013 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0594787 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.0551407 |
| COL3A1 | collagen, type III, alpha 1 | 0.0542903 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0542484 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0524096 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0476544 |
| LSAMP | limbic system-associated membrane protein | 0.0451617 |
| NDRG1 | N-myc downstream regulated 1 | 0.0433582 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0427087 |
| VCL | vinculin | 0.0390637 |
| SEPTIN9 | septin 9 | 0.0382491 |
| TPT1 | tumor protein, translationally-controlled 1 | 0.0372824 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0359977 |
| GOLGA4 | golgin A4 | 0.0353241 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.035101 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | 0.0350303 |
| HELZ | helicase with zinc finger | 0.0350271 |
| GNPDA1 | glucosamine-6-phosphate deaminase 1 | 0.0344671 |
| LMNA | lamin A/C | 0.0342349 |
| BIRC6 | baculoviral IAP repeat containing 6 | 0.0341423 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0337235 |
| FN1 | fibronectin 1 | 0.0314852 |
| CALU | calumenin | 0.0313467 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.0309152 |
| ZCCHC7 | zinc finger, CCHC domain containing 7 | 0.0304102 |
| COL4A2 | collagen, type IV, alpha 2 | 0.0303901 |
| FXR1 | fragile X mental retardation, autosomal homolog 1 | 0.0303022 |
| TIMP3 | TIMP metallopeptidase inhibitor 3 | 0.0302722 |
| VEGFA | vascular endothelial growth factor A | 0.030211 |
| TRIB2 | tribbles pseudokinase 2 | 0.0293195 |
| DDIT4 | DNA-damage-inducible transcript 4 | 0.0289408 |
| CSDE1 | cold shock domain containing E1, RNA-binding | 0.0288971 |
| KIF5B | kinesin family member 5B | 0.0288738 |
| NFKBIA | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | 0.0288642 |
| HIP1 | huntingtin interacting protein 1 | 0.0288592 |
| CDH2 | cadherin 2, type 1, N-cadherin (neuronal) | 0.0284046 |
| CADM2 | cell adhesion molecule 2 | 0.0283995 |
| FLNB | filamin B, beta | 0.0267125 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0266115 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | 0.0264571 |
| SLC6A6 | solute carrier family 6 (neurotransmitter transporter), member 6 | 0.0264455 |
| CALD1 | caldesmon 1 | 0.0258255 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.025797 |
| PPM1D | protein phosphatase, Mg2+/Mn2+ dependent, 1D | 0.0253932 |
| NALF1 | NALCN channel auxiliary factor 1 | 0.0253873 |
| WDR43 | WD repeat domain 43 | 0.0253147 |
| PRKDC | protein kinase, DNA-activated, catalytic polypeptide | 0.0245307 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | 0.0245276 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0243295 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | 0.0243026 |
| MXI1 | MAX interactor 1, dimerization protein | 0.0236993 |
| MATR3 | matrin 3 | 0.0236856 |
| CPED1 | cadherin-like and PC-esterase domain containing 1 | 0.0231673 |
| PRKAR1A | protein kinase, cAMP-dependent, regulatory, type I, alpha | 0.0231628 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.022518 |
| REST | RE1-silencing transcription factor | 0.0224951 |
| ARF1 | ADP-ribosylation factor 1 | 0.0223077 |
| CKAP5 | cytoskeleton associated protein 5 | 0.0219872 |
| PTMA | prothymosin, alpha | 0.0219627 |
| GPC5 | glypican 5 | 0.0219125 |
| COL6A1 | collagen, type VI, alpha 1 | 0.0217823 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0217661 |
| PALM2AKAP2 | PALM2 and AKAP2 fusion | 0.0216625 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0215117 |
| TPR | translocated promoter region, nuclear basket protein | 0.0214586 |
| EGLN1 | egl-9 family hypoxia-inducible factor 1 | 0.021201 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.0210616 |
| TPM4 | tropomyosin 4 | 0.020962 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0206659 |
| COL1A1 | collagen, type I, alpha 1 | 0.0205997 |
| NPAS2 | neuronal PAS domain protein 2 | 0.0205963 |
| RNF145 | ring finger protein 145 | 0.0202927 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | 0.0201685 |
| TXNRD1 | thioredoxin reductase 1 | 0.0200951 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | 0.0200788 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | 0.0200372 |
| SEC23A | Sec23 homolog A (S. cerevisiae) | 0.0199693 |
| SF3B2 | splicing factor 3b, subunit 2, 145kDa | 0.0199543 |
| CANX | calnexin | 0.0199474 |
| TENT2 | terminal nucleotidyltransferase 2 | 0.0198384 |
| CUX1 | cut-like homeobox 1 | 0.0198324 |
| CDON | cell adhesion associated, oncogene regulated | 0.0197126 |
| SLMAP | sarcolemma associated protein | 0.0192149 |
| FKBP10 | FK506 binding protein 10, 65 kDa | 0.0191148 |
| CCND1 | cyclin D1 | 0.0189735 |
| NCOR1 | nuclear receptor corepressor 1 | 0.0186977 |
| IST1 | increased sodium tolerance 1 homolog (yeast) | 0.0186971 |
| NOP58 | NOP58 ribonucleoprotein | 0.0186033 |
| B3GALT1 | UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1 | 0.0185848 |
| TLK2 | tousled-like kinase 2 | 0.0185152 |
| NREP | neuronal regeneration related protein | 0.0183811 |
| DYRK1A | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A | 0.0183654 |
| CALR | calreticulin | 0.0183188 |
| PLEC | plectin | 0.0182728 |
| LRPPRC | leucine-rich pentatricopeptide repeat containing | 0.0182241 |
| SBNO1 | strawberry notch homolog 1 (Drosophila) | 0.0181718 |
| CEMIP | cell migration inducing protein, hyaluronan binding | 0.0178977 |
| TET2 | tet methylcytosine dioxygenase 2 | 0.0178463 |
| Symbol | Name | Standardized Value |
|---|---|---|
| DDX1 | DEAD (Asp-Glu-Ala-Asp) box helicase 1 | -0.3086 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.106106 |
| LGR5 | leucine-rich repeat containing G protein-coupled receptor 5 | -0.0712821 |
| VIM | vimentin | -0.0588922 |
| RPL23 | ribosomal protein L23 | -0.0475681 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | -0.037844 |
| PCBP2 | poly(rC) binding protein 2 | -0.0360362 |
| FMN1 | formin 1 | -0.0332902 |
| AOPEP | aminopeptidase O (putative) | -0.0332267 |
| UBC | ubiquitin C | -0.0293156 |
| WDR26 | WD repeat domain 26 | -0.0292241 |
| PTPRD | protein tyrosine phosphatase, receptor type, D | -0.0292034 |
| DGKH | diacylglycerol kinase, eta | -0.0291598 |
| MEIS2 | Meis homeobox 2 | -0.0291328 |
| GNG2 | guanine nucleotide binding protein (G protein), gamma 2 | -0.028178 |
| MMAB | methylmalonic aciduria (cobalamin deficiency) cblB type | -0.0275003 |
| NCAM2 | neural cell adhesion molecule 2 | -0.0273765 |
| RPS12 | ribosomal protein S12 | -0.0273725 |
| RNF213 | ring finger protein 213 | -0.0263009 |
| NRP1 | neuropilin 1 | -0.0256873 |
| DDX60L | DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like | -0.024485 |
| DPH6 | diphthamine biosynthesis 6 | -0.0240252 |
| TBX2 | T-box 2 | -0.0239899 |
| LPIN1 | lipin 1 | -0.0237182 |
| MAP3K1 | mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase | -0.0234729 |
| CHD9 | chromodomain helicase DNA binding protein 9 | -0.0233281 |
| AUTS2 | autism susceptibility candidate 2 | -0.0231124 |
| ANTXR1 | anthrax toxin receptor 1 | -0.0229761 |
| PLPP1 | phospholipid phosphatase 1 | -0.0221555 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0215219 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | -0.0214002 |
| MBD5 | methyl-CpG binding domain protein 5 | -0.0210386 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | -0.0207173 |
| SYT1 | synaptotagmin I | -0.0205653 |
| LIMS1 | LIM and senescent cell antigen-like domains 1 | -0.0201858 |
| VMP1 | vacuole membrane protein 1 | -0.0200851 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.0200739 |
| IFI16 | interferon, gamma-inducible protein 16 | -0.0188421 |
| GLI3 | GLI family zinc finger 3 | -0.0188074 |
| NRIP1 | nuclear receptor interacting protein 1 | -0.0186634 |
| PNISR | PNN-interacting serine/arginine-rich protein | -0.0185852 |
| HAS2 | hyaluronan synthase 2 | -0.0184932 |
| RPL34 | ribosomal protein L34 | -0.0183254 |
| MAPK8 | mitogen-activated protein kinase 8 | -0.0181725 |
| RPS24 | ribosomal protein S24 | -0.018096 |
| RNF144A | ring finger protein 144A | -0.0180793 |
| COX16 | COX16 cytochrome c oxidase assembly homolog (S. cerevisiae) | -0.0180486 |
| PLAT | plasminogen activator, tissue | -0.0178128 |
| SAMD4B | sterile alpha motif domain containing 4B | -0.0177221 |
| CCSER2 | coiled-coil serine-rich protein 2 | -0.0177081 |
| IGF2 | insulin-like growth factor 2 | -0.0176829 |
| RBMX | RNA binding motif protein, X-linked | -0.0173007 |
| MX2 | MX dynamin-like GTPase 2 | -0.0170152 |
| LONRF2 | LON peptidase N-terminal domain and ring finger 2 | -0.0168495 |
| ITGA1 | integrin, alpha 1 | -0.0168161 |
| RIGI | RNA sensor RIG-I | -0.0166452 |
| PLAGL1 | pleiomorphic adenoma gene-like 1 | -0.0165375 |
| PTEN | phosphatase and tensin homolog | -0.0164823 |
| RUNX1T1 | runt-related transcription factor 1; translocated to, 1 (cyclin D-related) | -0.0164548 |
| MAGI2 | membrane associated guanylate kinase, WW and PDZ domain containing 2 | -0.0158585 |
| KLHL13 | kelch-like family member 13 | -0.0153835 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.0153608 |
| PUM2 | pumilio RNA-binding family member 2 | -0.015347 |
| ASPM | asp (abnormal spindle) homolog, microcephaly associated (Drosophila) | -0.015109 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | -0.014662 |
| TMTC2 | transmembrane and tetratricopeptide repeat containing 2 | -0.0145569 |
| UBE2E1 | ubiquitin-conjugating enzyme E2E 1 | -0.0145311 |
| CACNA2D1 | calcium channel, voltage-dependent, alpha 2/delta subunit 1 | -0.0144755 |
| PITPNB | phosphatidylinositol transfer protein, beta | -0.0143477 |
| TCF7L2 | transcription factor 7-like 2 (T-cell specific, HMG-box) | -0.0142844 |
| DENND4C | DENN/MADD domain containing 4C | -0.0142534 |
| WIPF2 | WAS/WASL interacting protein family, member 2 | -0.0142296 |
| TRIM25 | tripartite motif containing 25 | -0.0142115 |
| TRPS1 | trichorhinophalangeal syndrome I | -0.0140864 |
| FKBP1A | FK506 binding protein 1A, 12kDa | -0.0139593 |
| AEBP2 | AE binding protein 2 | -0.0139012 |
| ARHGAP12 | Rho GTPase activating protein 12 | -0.0137381 |
| PLSCR1 | phospholipid scramblase 1 | -0.0137107 |
| ZFC3H1 | zinc finger, C3H1-type containing | -0.0136554 |
| RPL7L1 | ribosomal protein L7-like 1 | -0.0135711 |
| TNPO1 | transportin 1 | -0.0135701 |
| TAS2R14 | taste receptor, type 2, member 14 | -0.0134887 |
| MAP2K5 | mitogen-activated protein kinase kinase 5 | -0.0134345 |
| IL6ST | interleukin 6 signal transducer | -0.013358 |
| RPL37A | ribosomal protein L37a | -0.0132638 |
| STAT3 | signal transducer and activator of transcription 3 (acute-phase response factor) | -0.013258 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | -0.0132496 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0132342 |
| FHIT | fragile histidine triad | -0.0132137 |
| EIF3E | eukaryotic translation initiation factor 3, subunit E | -0.0131405 |
| SNX14 | sorting nexin 14 | -0.0129235 |
| MARCHF7 | membrane associated ring-CH-type finger 7 | -0.0129087 |
| UBR3 | ubiquitin protein ligase E3 component n-recognin 3 (putative) | -0.0128695 |
| DDX50 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 50 | -0.0127309 |
| RPS3 | ribosomal protein S3 | -0.0126706 |
| HS2ST1 | heparan sulfate 2-O-sulfotransferase 1 | -0.0126201 |
| TENT4A | terminal nucleotidyltransferase 4A | -0.0125722 |
| ITGAV | integrin, alpha V | -0.0123456 |
| MYO9A | myosin IXA | -0.012336 |
| FLT1 | fms-related tyrosine kinase 1 | -0.0123237 |
