| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Tirabrutinib (hydrochloride) perturbation in COLO 205 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Tirabrutinib (hydrochloride)_COLO 205 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| LMO7 | LIM domain 7 | 0.205851 |
| EZR | ezrin | 0.135256 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.119143 |
| MACC1 | metastasis associated in colon cancer 1 | 0.103517 |
| DSCAM | Down syndrome cell adhesion molecule | 0.101921 |
| FOS | FBJ murine osteosarcoma viral oncogene homolog | 0.0971523 |
| MYO1E | myosin IE | 0.0929824 |
| TPT1 | tumor protein, translationally-controlled 1 | 0.0826095 |
| ANXA2 | annexin A2 | 0.075969 |
| SQSTM1 | sequestosome 1 | 0.0746838 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.0719555 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0683905 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | 0.0680575 |
| IRF1 | interferon regulatory factor 1 | 0.066879 |
| NDRG1 | N-myc downstream regulated 1 | 0.0649492 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0622018 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | 0.0587525 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | 0.0586682 |
| EGR1 | early growth response 1 | 0.0585078 |
| DNAJC3 | DnaJ (Hsp40) homolog, subfamily C, member 3 | 0.0575729 |
| ZNF292 | zinc finger protein 292 | 0.0570463 |
| JUN | jun proto-oncogene | 0.0536416 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0532615 |
| GOLGB1 | golgin B1 | 0.0491193 |
| CANX | calnexin | 0.0485582 |
| EGLN3 | egl-9 family hypoxia-inducible factor 3 | 0.0485372 |
| CCNL1 | cyclin L1 | 0.0485332 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0462587 |
| RAB7A | RAB7A, member RAS oncogene family | 0.0453795 |
| CALU | calumenin | 0.0449287 |
| EPS8 | epidermal growth factor receptor pathway substrate 8 | 0.0436883 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0432137 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0428159 |
| SPAG9 | sperm associated antigen 9 | 0.0427853 |
| TNFRSF10B | tumor necrosis factor receptor superfamily, member 10b | 0.0427709 |
| ERN1 | endoplasmic reticulum to nucleus signaling 1 | 0.0419507 |
| RRBP1 | ribosome binding protein 1 | 0.0414757 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0413628 |
| TJP1 | tight junction protein 1 | 0.0412108 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0397245 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0388559 |
| PDXDC1 | pyridoxal-dependent decarboxylase domain containing 1 | 0.0383924 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | 0.0383352 |
| SLC2A1 | solute carrier family 2 (facilitated glucose transporter), member 1 | 0.0381319 |
| AHI1 | Abelson helper integration site 1 | 0.0378338 |
| B2M | beta-2-microglobulin | 0.037823 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0377092 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.0368807 |
| RAB11FIP1 | RAB11 family interacting protein 1 (class I) | 0.036732 |
| EFNB2 | ephrin-B2 | 0.0364565 |
| PHACTR4 | phosphatase and actin regulator 4 | 0.0361322 |
| VMP1 | vacuole membrane protein 1 | 0.034972 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0349093 |
| DUSP10 | dual specificity phosphatase 10 | 0.0344529 |
| AHNAK | AHNAK nucleoprotein | 0.0342442 |
| MGAT5 | mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase | 0.0337801 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0337574 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0336363 |
| UBR2 | ubiquitin protein ligase E3 component n-recognin 2 | 0.0332664 |
| SFTPA2 | surfactant protein A2 | 0.0326487 |
| BCLAF1 | BCL2-associated transcription factor 1 | 0.0323078 |
| FOSB | FBJ murine osteosarcoma viral oncogene homolog B | 0.0322611 |
| UBC | ubiquitin C | 0.0321575 |
| DSPP | dentin sialophosphoprotein | 0.0320336 |
| ITPKC | inositol-trisphosphate 3-kinase C | 0.0318828 |
| MKI67 | marker of proliferation Ki-67 | 0.0318035 |
| HLA-B | major histocompatibility complex, class I, B | 0.0317479 |
| AREG | amphiregulin | 0.0313256 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0312896 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0312448 |
| GNPDA1 | glucosamine-6-phosphate deaminase 1 | 0.0310286 |
| PDIA3 | protein disulfide isomerase family A, member 3 | 0.030934 |
| BAIAP2L1 | BAI1-associated protein 2-like 1 | 0.030858 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.0307442 |
| CTNNB1 | catenin (cadherin-associated protein), beta 1, 88kDa | 0.0299341 |
| ANXA1 | annexin A1 | 0.0294265 |
| PPP1CB | protein phosphatase 1, catalytic subunit, beta isozyme | 0.0293831 |
| CDHR2 | cadherin-related family member 2 | 0.0290495 |
| HM13 | histocompatibility (minor) 13 | 0.029032 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | 0.0285824 |
| HDLBP | high density lipoprotein binding protein | 0.0284344 |
| ARF4 | ADP-ribosylation factor 4 | 0.0280451 |
| TTC3 | tetratricopeptide repeat domain 3 | 0.0279147 |
| UBR1 | ubiquitin protein ligase E3 component n-recognin 1 | 0.0278897 |
| TM9SF2 | transmembrane 9 superfamily member 2 | 0.0277759 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | 0.0276835 |
| MCL1 | myeloid cell leukemia 1 | 0.0276678 |
| RND3 | Rho family GTPase 3 | 0.0271788 |
| PTMA | prothymosin, alpha | 0.0270697 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.0270179 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | 0.0269449 |
| GOLGA4 | golgin A4 | 0.026628 |
| RAB1A | RAB1A, member RAS oncogene family | 0.0265471 |
| COPA | coatomer protein complex, subunit alpha | 0.0262527 |
| PHF3 | PHD finger protein 3 | 0.0261187 |
| DDIT3 | DNA-damage-inducible transcript 3 | 0.0260424 |
| MORF4L2 | mortality factor 4 like 2 | 0.0258998 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.0258818 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | 0.0258493 |
| HLA-E | major histocompatibility complex, class I, E | 0.025606 |
| Symbol | Name | Standardized Value |
|---|---|---|
| SNTB1 | syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) | -0.0680147 |
| RNF43 | ring finger protein 43 | -0.0458602 |
| NCKAP5 | NCK-associated protein 5 | -0.0397072 |
| CHST11 | carbohydrate (chondroitin 4) sulfotransferase 11 | -0.0396456 |
| NRIP1 | nuclear receptor interacting protein 1 | -0.0360531 |
| HCN1 | hyperpolarization activated cyclic nucleotide gated potassium channel 1 | -0.0351022 |
| MAN1A1 | mannosidase, alpha, class 1A, member 1 | -0.0331273 |
| LRCH1 | leucine-rich repeats and calponin homology (CH) domain containing 1 | -0.0279852 |
| DDX17 | DEAD (Asp-Glu-Ala-Asp) box helicase 17 | -0.0266353 |
| ARHGAP26 | Rho GTPase activating protein 26 | -0.0264276 |
| STS | steroid sulfatase (microsomal), isozyme S | -0.0257128 |
| C6ORF132 | chromosome 6 open reading frame 132 | -0.0256176 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | -0.0253318 |
| PLCB1 | phospholipase C, beta 1 (phosphoinositide-specific) | -0.0248179 |
| PRSS3 | protease, serine, 3 | -0.0239488 |
| RABGAP1L | RAB GTPase activating protein 1-like | -0.0231463 |
| DGKH | diacylglycerol kinase, eta | -0.0223637 |
| FOXP1 | forkhead box P1 | -0.022078 |
| ATP10B | ATPase, class V, type 10B | -0.0220596 |
| B4GALT5 | UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 | -0.0218872 |
| MAP2K6 | mitogen-activated protein kinase kinase 6 | -0.0218286 |
| SSH2 | slingshot protein phosphatase 2 | -0.0218112 |
| RUNX1 | runt-related transcription factor 1 | -0.0215412 |
| ETV6 | ets variant 6 | -0.0213432 |
| PTGR1 | prostaglandin reductase 1 | -0.0205934 |
| SPRED1 | sprouty-related, EVH1 domain containing 1 | -0.0201277 |
| NAALADL2 | N-acetylated alpha-linked acidic dipeptidase-like 2 | -0.0200138 |
| ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 | -0.0197152 |
| RGS6 | regulator of G-protein signaling 6 | -0.0195967 |
| UBAC2 | UBA domain containing 2 | -0.0195152 |
| BICRAL | BICRA like chromatin remodeling complex associated protein | -0.0189895 |
| EPSTI1 | epithelial stromal interaction 1 (breast) | -0.0188866 |
| XAF1 | XIAP associated factor 1 | -0.0188395 |
| TC2N | tandem C2 domains, nuclear | -0.018746 |
| EPB41L1 | erythrocyte membrane protein band 4.1-like 1 | -0.0187029 |
| SPATS2L | spermatogenesis associated, serine-rich 2-like | -0.0185446 |
| NCOA2 | nuclear receptor coactivator 2 | -0.0181561 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | -0.0180317 |
| MAP3K1 | mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase | -0.0177422 |
| ANXA4 | annexin A4 | -0.0175596 |
| ARHGAP32 | Rho GTPase activating protein 32 | -0.0174141 |
| TRERF1 | transcriptional regulating factor 1 | -0.0172311 |
| ACSL3 | acyl-CoA synthetase long-chain family member 3 | -0.0171319 |
| H1-0 | H1.0 linker histone | -0.0169767 |
| STEAP2 | STEAP family member 2, metalloreductase | -0.016897 |
| CAMK2D | calcium/calmodulin-dependent protein kinase II delta | -0.0165285 |
| IFI6 | interferon, alpha-inducible protein 6 | -0.01616 |
| PLEKHA5 | pleckstrin homology domain containing, family A member 5 | -0.0157838 |
| ZFAND3 | zinc finger, AN1-type domain 3 | -0.0155768 |
| ABCC3 | ATP-binding cassette, sub-family C (CFTR/MRP), member 3 | -0.0155461 |
| MICU2 | mitochondrial calcium uptake 2 | -0.0155404 |
| ITGA1 | integrin, alpha 1 | -0.0152379 |
| PRKCA | protein kinase C, alpha | -0.0149898 |
| PTBP3 | polypyrimidine tract binding protein 3 | -0.0149575 |
| PTK2 | protein tyrosine kinase 2 | -0.0148735 |
| USP54 | ubiquitin specific peptidase 54 | -0.0145077 |
| PCED1B | PC-esterase domain containing 1B | -0.0143359 |
| UTRN | utrophin | -0.0143229 |
| TSHZ2 | teashirt zinc finger homeobox 2 | -0.0142933 |
| MSI2 | musashi RNA-binding protein 2 | -0.0142752 |
| LCN2 | lipocalin 2 | -0.0141395 |
| FMN1 | formin 1 | -0.014123 |
| FHIT | fragile histidine triad | -0.0140738 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.0140695 |
| GTF2IRD1 | GTF2I repeat domain containing 1 | -0.0140117 |
| CATSPERB | catsper channel auxiliary subunit beta | -0.0139914 |
| B3GALT5 | UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 5 | -0.0138808 |
| CLYBL | citrate lyase beta like | -0.0137934 |
| RNF149 | ring finger protein 149 | -0.0132814 |
| ZNFX1 | zinc finger, NFX1-type containing 1 | -0.0131673 |
| KIAA1217 | KIAA1217 | -0.0131078 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0130393 |
| IFI27 | interferon, alpha-inducible protein 27 | -0.0128187 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | -0.0127879 |
| INPP4B | inositol polyphosphate-4-phosphatase, type II, 105kDa | -0.0127336 |
| ZNRF3 | zinc and ring finger 3 | -0.012724 |
| MEF2A | myocyte enhancer factor 2A | -0.012621 |
| SPATA6L | spermatogenesis associated 6-like | -0.0125376 |
| AGR2 | anterior gradient 2 | -0.0124218 |
| GMDS | GDP-mannose 4,6-dehydratase | -0.0121166 |
| SLC2A12 | solute carrier family 2 (facilitated glucose transporter), member 12 | -0.0118764 |
| RAPGEF5 | Rap guanine nucleotide exchange factor (GEF) 5 | -0.0115874 |
| MAML2 | mastermind-like 2 (Drosophila) | -0.0115858 |
| PRELID2 | PRELI domain containing 2 | -0.0115629 |
| TBPL1 | TBP-like 1 | -0.0115528 |
| LPP | LIM domain containing preferred translocation partner in lipoma | -0.0113312 |
| RABGAP1 | RAB GTPase activating protein 1 | -0.01112 |
| TNFSF10 | tumor necrosis factor (ligand) superfamily, member 10 | -0.01109 |
| LLGL2 | lethal giant larvae homolog 2 (Drosophila) | -0.0110268 |
| PARP4 | poly (ADP-ribose) polymerase family, member 4 | -0.0110192 |
| CERS6 | ceramide synthase 6 | -0.0109357 |
| CDC42BPA | CDC42 binding protein kinase alpha (DMPK-like) | -0.0108037 |
| ESRP1 | epithelial splicing regulatory protein 1 | -0.0107763 |
| GLCE | glucuronic acid epimerase | -0.0107585 |
| CTBP2 | C-terminal binding protein 2 | -0.0107061 |
| MT2A | metallothionein 2A | -0.0106784 |
| ARHGAP12 | Rho GTPase activating protein 12 | -0.0106239 |
| CPEB4 | cytoplasmic polyadenylation element binding protein 4 | -0.0106103 |
| SAMD12 | sterile alpha motif domain containing 12 | -0.0105801 |
| RPL7L1 | ribosomal protein L7-like 1 | -0.0105701 |
