Tirabrutinib (hydrochloride)_H4 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Tirabrutinib (hydrochloride) perturbation in H4 cell line (Tahoe Therapeutics)
Similar Terms
Downloads & Tools

Genes

200 genes differentially expressed following the Tirabrutinib (hydrochloride)_H4 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.227154
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.142578
COL6A3 collagen, type VI, alpha 3 0.106252
EEF2 eukaryotic translation elongation factor 2 0.0779045
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0769336
CANX calnexin 0.0718598
HILPDA hypoxia inducible lipid droplet-associated 0.0673949
COPA coatomer protein complex, subunit alpha 0.0671782
GOLGA4 golgin A4 0.0590636
FAM13A family with sequence similarity 13, member A 0.056417
HDAC9 histone deacetylase 9 0.0555449
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0531391
NDRG1 N-myc downstream regulated 1 0.052913
SQSTM1 sequestosome 1 0.0525556
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0505156
HELZ helicase with zinc finger 0.0475466
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0464399
CXCL8 chemokine (C-X-C motif) ligand 8 0.0463958
COPB1 coatomer protein complex, subunit beta 1 0.0458752
APP amyloid beta (A4) precursor protein 0.0447834
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0440588
DGKD diacylglycerol kinase, delta 130kDa 0.0440358
MYH9 myosin, heavy chain 9, non-muscle 0.0436472
TRA2A transformer 2 alpha homolog (Drosophila) 0.0431631
CALU calumenin 0.0429164
ZCCHC7 zinc finger, CCHC domain containing 7 0.0427467
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0425176
CADM1 cell adhesion molecule 1 0.0419702
TTC3 tetratricopeptide repeat domain 3 0.0413641
HDLBP high density lipoprotein binding protein 0.0402771
HYCC1 hyccin PI4KA lipid kinase complex subunit 1 0.0402302
DST dystonin 0.039669
RAB7A RAB7A, member RAS oncogene family 0.0394708
JUN jun proto-oncogene 0.0391871
FNIP1 folliculin interacting protein 1 0.038955
GNPDA1 glucosamine-6-phosphate deaminase 1 0.037898
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.0374025
TNKS tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 0.0369652
EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3 0.0368211
HOOK2 hook microtubule-tethering protein 2 0.0367638
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0363502
SUCO SUN domain containing ossification factor 0.0361718
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0357428
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0353047
NOP58 NOP58 ribonucleoprotein 0.0344705
GARS1 glycyl-tRNA synthetase 1 0.0338135
TRIO trio Rho guanine nucleotide exchange factor 0.033781
VMP1 vacuole membrane protein 1 0.0336714
DDIT4 DNA-damage-inducible transcript 4 0.0335802
SPAG9 sperm associated antigen 9 0.0332833
RNMT RNA (guanine-7-) methyltransferase 0.0329713
RBM39 RNA binding motif protein 39 0.032651
MARCHF6 membrane associated ring-CH-type finger 6 0.0326182
CEMIP cell migration inducing protein, hyaluronan binding 0.032415
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0322756
EIF4A2 eukaryotic translation initiation factor 4A2 0.0321692
MSN moesin 0.0321391
SEC23A Sec23 homolog A (S. cerevisiae) 0.0321361
SEC31A SEC31 homolog A (S. cerevisiae) 0.0311391
HSPA8 heat shock 70kDa protein 8 0.030754
DTNA dystrobrevin, alpha 0.030549
NUP58 nucleoporin 58 0.0298765
FTH1 ferritin, heavy polypeptide 1 0.0297976
ADM adrenomedullin 0.0291969
SRP54 signal recognition particle 54kDa 0.0290316
MAD1L1 MAD1 mitotic arrest deficient-like 1 (yeast) 0.0290199
FLNA filamin A, alpha 0.028868
CLINT1 clathrin interactor 1 0.0286195
TFG TRK-fused gene 0.0282813
SUPT5H suppressor of Ty 5 homolog (S. cerevisiae) 0.0281428
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0277966
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0274714
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0273666
INHBA inhibin, beta A 0.0271841
RLF rearranged L-myc fusion 0.0271529
LCORL ligand dependent nuclear receptor corepressor-like 0.0269746
TPM3 tropomyosin 3 0.0269159
CCDC9 coiled-coil domain containing 9 0.0268886
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0268758
TNNC1 troponin C type 1 (slow) 0.0265857
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 0.0265729
SPTY2D1 SPT2, Suppressor of Ty, domain containing 1 (S. cerevisiae) 0.0263856
HERC3 HECT and RLD domain containing E3 ubiquitin protein ligase 3 0.0263157
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa 0.0262565
SETD5 SET domain containing 5 0.0261776
WDR43 WD repeat domain 43 0.02578
TMEM39A transmembrane protein 39A 0.0253278
MIMS1 mitochondrial inner membrane scaffold 1 0.0251742
ODF2 outer dense fiber of sperm tails 2 0.0248292
LAMB1 laminin, beta 1 0.0247501
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 0.0245989
ATF3 activating transcription factor 3 0.0245743
ARF4 ADP-ribosylation factor 4 0.0242672
PAPOLA poly(A) polymerase alpha 0.0242591
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 0.0242222
USP36 ubiquitin specific peptidase 36 0.0238928
VEGFA vascular endothelial growth factor A 0.0237163
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 0.0236879
HNRNPDL heterogeneous nuclear ribonucleoprotein D-like 0.0236612
NAMPT nicotinamide phosphoribosyltransferase 0.0236132

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.411544
FTL ferritin, light polypeptide -0.176296
MT2A metallothionein 2A -0.162104
TMSB10 thymosin beta 10 -0.148951
VIM vimentin -0.138552
RPLP1 ribosomal protein, large, P1 -0.0743539
RPS8 ribosomal protein S8 -0.0696758
RPL35A ribosomal protein L35a -0.0696328
ENO1 enolase 1, (alpha) -0.0549937
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0546916
RPLP2 ribosomal protein, large, P2 -0.051616
RPS6 ribosomal protein S6 -0.0500995
RPL28 ribosomal protein L28 -0.0479024
RPS19 ribosomal protein S19 -0.0430838
HLA-B major histocompatibility complex, class I, B -0.0419144
TPM4 tropomyosin 4 -0.0416115
LGALS1 lectin, galactoside-binding, soluble, 1 -0.0399847
RPL34 ribosomal protein L34 -0.0393922
TIMP1 TIMP metallopeptidase inhibitor 1 -0.0393844
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.0357395
RPL12 ribosomal protein L12 -0.0342532
GLIS3 GLIS family zinc finger 3 -0.0339477
MT1X metallothionein 1X -0.0327704
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0321227
RPL36 ribosomal protein L36 -0.0321112
RPL37A ribosomal protein L37a -0.0321086
RPS16 ribosomal protein S16 -0.0317582
RPL31 ribosomal protein L31 -0.031526
PTMA prothymosin, alpha -0.0313713
SEC61G Sec61 gamma subunit -0.0308079
B2M beta-2-microglobulin -0.0307367
S100A6 S100 calcium binding protein A6 -0.0297386
S100A10 S100 calcium binding protein A10 -0.029534
RPL23 ribosomal protein L23 -0.0293071
RPL9 ribosomal protein L9 -0.0286705
RPS20 ribosomal protein S20 -0.0283146
TIMP3 TIMP metallopeptidase inhibitor 3 -0.0280309
TXNRD1 thioredoxin reductase 1 -0.0279098
SH3KBP1 SH3-domain kinase binding protein 1 -0.0270851
RPS3 ribosomal protein S3 -0.0268502
VCL vinculin -0.0263186
LDHA lactate dehydrogenase A -0.0257886
RPS23 ribosomal protein S23 -0.0255829
VDAC1 voltage-dependent anion channel 1 -0.0255298
PKM pyruvate kinase, muscle -0.0253331
RPL38 ribosomal protein L38 -0.02528
OSMR oncostatin M receptor -0.0249683
NAV2 neuron navigator 2 -0.0247946
ZBTB20 zinc finger and BTB domain containing 20 -0.0244022
KTN1 kinectin 1 (kinesin receptor) -0.0242837
RPS14 ribosomal protein S14 -0.0239804
WWTR1 WW domain containing transcription regulator 1 -0.0236753
RPS29 ribosomal protein S29 -0.0233879
RPL32 ribosomal protein L32 -0.0231148
CBX3 chromobox homolog 3 -0.0228276
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.0225785
ACTN4 actinin, alpha 4 -0.0225373
RPS24 ribosomal protein S24 -0.0225289
RPS27A ribosomal protein S27a -0.0222918
RPL36A ribosomal protein L36a -0.0222698
STK17A serine/threonine kinase 17a -0.0218813
NFE2L2 nuclear factor, erythroid 2-like 2 -0.021686
RPS27 ribosomal protein S27 -0.0215624
NIPBL Nipped-B homolog (Drosophila) -0.0215017
RPL37 ribosomal protein L37 -0.0214882
RPLP0 ribosomal protein, large, P0 -0.0212094
S100A9 S100 calcium binding protein A9 -0.0211569
NIBAN2 niban apoptosis regulator 2 -0.020913
ATXN1 ataxin 1 -0.0208984
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0208113
TPT1 tumor protein, translationally-controlled 1 -0.0207643
TPI1 triosephosphate isomerase 1 -0.020552
RPS17 ribosomal protein S17 -0.0203741
LMNA lamin A/C -0.0203606
KLF7 Kruppel-like factor 7 (ubiquitous) -0.0203004
RPS25 ribosomal protein S25 -0.0202474
PDE4D phosphodiesterase 4D, cAMP-specific -0.020052
UBA52 ubiquitin A-52 residue ribosomal protein fusion product 1 -0.0197747
TUBA1B tubulin, alpha 1b -0.0193244
LIMS1 LIM and senescent cell antigen-like domains 1 -0.019315
LOC112694756 uncharaterized LOC112694756 -0.019252
NDUFA4 NDUFA4, mitochondrial complex associated -0.0191094
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.01872
KPNB1 karyopherin (importin) beta 1 -0.0186333
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -0.0185918
NAV1 neuron navigator 1 -0.0183704
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) -0.0183229
RPL30 ribosomal protein L30 -0.0182784
RPL27A ribosomal protein L27a -0.018233
SH3BGRL3 SH3 domain binding glutamate-rich protein like 3 -0.0180978
TOMM7 translocase of outer mitochondrial membrane 7 homolog (yeast) -0.0179904
ENO2 enolase 2 (gamma, neuronal) -0.0178239
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa -0.0178008
NPC1 Niemann-Pick disease, type C1 -0.0177876
RPL19 ribosomal protein L19 -0.0177847
HMGB1 high mobility group box 1 -0.017783
RPS11 ribosomal protein S11 -0.0176398
EMP1 epithelial membrane protein 1 -0.0176275
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0174959
ANKRD12 ankyrin repeat domain 12 -0.0172903