Tirabrutinib (hydrochloride)_HCT15 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Tirabrutinib (hydrochloride) perturbation in HCT15 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Tirabrutinib (hydrochloride)_HCT15 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.100051
EEF2 eukaryotic translation elongation factor 2 0.0964999
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0737684
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0629497
AHNAK AHNAK nucleoprotein 0.0581004
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0572309
GOLGA4 golgin A4 0.0551788
MYH9 myosin, heavy chain 9, non-muscle 0.0533311
CANX calnexin 0.0502368
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0476083
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0456905
HDLBP high density lipoprotein binding protein 0.0372921
INTS6 integrator complex subunit 6 0.0355667
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0342751
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0327745
PLEC plectin 0.0321375
RNMT RNA (guanine-7-) methyltransferase 0.0319799
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0295618
DDIT4 DNA-damage-inducible transcript 4 0.0278817
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 0.0278719
TTC3 tetratricopeptide repeat domain 3 0.0276866
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0273299
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0269108
FTH1 ferritin, heavy polypeptide 1 0.0261915
SRP54 signal recognition particle 54kDa 0.0258062
ZNF638 zinc finger protein 638 0.0243355
GOLGA2 golgin A2 0.0243044
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3 0.024078
EIF1 eukaryotic translation initiation factor 1 0.0239828
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0234674
BHLHE40 basic helix-loop-helix family, member e40 0.0234193
BTBD9 BTB (POZ) domain containing 9 0.0233817
PDIA4 protein disulfide isomerase family A, member 4 0.0232707
TMED2 transmembrane emp24 domain trafficking protein 2 0.0232597
TNKS tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 0.0227652
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0224748
HSPA8 heat shock 70kDa protein 8 0.0224298
COPA coatomer protein complex, subunit alpha 0.0214399
NUP58 nucleoporin 58 0.0212817
CCDC47 coiled-coil domain containing 47 0.021218
DSPP dentin sialophosphoprotein 0.0211781
ARFGEF3 ARFGEF family member 3 0.0209385
VEGFA vascular endothelial growth factor A 0.0209052
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0203788
RUNX1 runt-related transcription factor 1 0.020333
KRT18 keratin 18, type I 0.0202142
ARCN1 archain 1 0.0200609
SUCO SUN domain containing ossification factor 0.019358
FOXO3 forkhead box O3 0.0191373
ERRFI1 ERBB receptor feedback inhibitor 1 0.0190308
USP37 ubiquitin specific peptidase 37 0.0182938
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa 0.0182239
MIMS1 mitochondrial inner membrane scaffold 1 0.0182063
HOOK2 hook microtubule-tethering protein 2 0.0182012
OGA O-GlcNAcase 0.0181673
GOLGB1 golgin B1 0.0181555
ZC3H11A zinc finger CCCH-type containing 11A 0.0180796
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.0179815
TM9SF2 transmembrane 9 superfamily member 2 0.0179812
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0176183
EGLN1 egl-9 family hypoxia-inducible factor 1 0.0176012
FDPS farnesyl diphosphate synthase 0.0175676
EIF4B eukaryotic translation initiation factor 4B 0.0170964
SFXN1 sideroflexin 1 0.0169158
COPB1 coatomer protein complex, subunit beta 1 0.0167737
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0167494
EIF4A2 eukaryotic translation initiation factor 4A2 0.0164312
TMF1 TATA element modulatory factor 1 0.0161573
PGM3 phosphoglucomutase 3 0.015994
TLN1 talin 1 0.0159245
RNF24 ring finger protein 24 0.0157641
WDR45B WD repeat domain 45B 0.0155552
CALR calreticulin 0.0154536
CFAP96 cilia and flagella associated protein 96 0.0153835
TNIP1 TNFAIP3 interacting protein 1 0.0153644
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked 0.0152824
PTGES2 prostaglandin E synthase 2 0.0151435
RYBP RING1 and YY1 binding protein 0.0150309
SEC24A SEC24 family member A 0.0149146
TFRC transferrin receptor 0.0148853
AKAP9 A kinase (PRKA) anchor protein 9 0.0148754
KDM3A lysine (K)-specific demethylase 3A 0.0148604
RPL3 ribosomal protein L3 0.0147923
HELZ helicase with zinc finger 0.0147654
ZSWIM6 zinc finger, SWIM-type containing 6 0.0145882
UBR4 ubiquitin protein ligase E3 component n-recognin 4 0.0143571
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa 0.0142163
TRPM7 transient receptor potential cation channel, subfamily M, member 7 0.0141583
CTBP2 C-terminal binding protein 2 0.0141472
TMTC2 transmembrane and tetratricopeptide repeat containing 2 0.0141114
RSL1D1 ribosomal L1 domain containing 1 0.0140966
HERC3 HECT and RLD domain containing E3 ubiquitin protein ligase 3 0.0140068
KIAA1217 KIAA1217 0.0140011
PFKP phosphofructokinase, platelet 0.0138455
TNFRSF10D tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain 0.013677
ASPH aspartate beta-hydroxylase 0.0136564
PJA2 praja ring finger 2, E3 ubiquitin protein ligase 0.013625
YEATS2 YEATS domain containing 2 0.0135984
SFTPA2 surfactant protein A2 0.0135865
EPRS1 glutamyl-prolyl-tRNA synthetase 1 0.0135005

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.246405
PTMA prothymosin, alpha -0.219833
TMSB10 thymosin beta 10 -0.168475
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.11327
FAT1 FAT atypical cadherin 1 -0.0989569
MT2A metallothionein 2A -0.0720378
RPL35A ribosomal protein L35a -0.0681328
POTEF POTE ankyrin domain family, member F -0.0616681
RPS8 ribosomal protein S8 -0.0611855
RPS6 ribosomal protein S6 -0.0558261
TPT1 tumor protein, translationally-controlled 1 -0.0543401
TUBA1B tubulin, alpha 1b -0.0515612
ACTG1 actin gamma 1 -0.0492532
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.045078
ENO1 enolase 1, (alpha) -0.0448598
S100A9 S100 calcium binding protein A9 -0.0447085
MKI67 marker of proliferation Ki-67 -0.044586
RPLP1 ribosomal protein, large, P1 -0.0399434
PKM pyruvate kinase, muscle -0.0396843
HMGA1 high mobility group AT-hook 1 -0.0395568
RPS19 ribosomal protein S19 -0.039206
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0383264
RPLP2 ribosomal protein, large, P2 -0.0379427
NQO1 NAD(P)H dehydrogenase, quinone 1 -0.0366272
RPLP0 ribosomal protein, large, P0 -0.0356027
TPI1 triosephosphate isomerase 1 -0.0354269
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0350299
TPM4 tropomyosin 4 -0.0348413
S100A10 S100 calcium binding protein A10 -0.0336693
RPS3 ribosomal protein S3 -0.0327818
CENPF centromere protein F, 350/400kDa -0.0325081
RPS24 ribosomal protein S24 -0.0312892
KTN1 kinectin 1 (kinesin receptor) -0.0312194
PFN1 profilin 1 -0.0311024
EGR1 early growth response 1 -0.0304243
EIF5B eukaryotic translation initiation factor 5B -0.0303595
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0303251
KPNB1 karyopherin (importin) beta 1 -0.0299882
RPS21 ribosomal protein S21 -0.0296272
RPS23 ribosomal protein S23 -0.0294015
TENM3 teneurin transmembrane protein 3 -0.0286921
RPS25 ribosomal protein S25 -0.0286032
RPL5 ribosomal protein L5 -0.0281403
RPL26 ribosomal protein L26 -0.0278927
RBM25 RNA binding motif protein 25 -0.027732
NOP58 NOP58 ribonucleoprotein -0.0276252
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 -0.0273986
RPL31 ribosomal protein L31 -0.026844
HMGB1 high mobility group box 1 -0.0267173
SERBP1 SERPINE1 mRNA binding protein 1 -0.0264477
RPL23 ribosomal protein L23 -0.0258938
EZR ezrin -0.0258516
EPCAM epithelial cell adhesion molecule -0.0257461
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0254232
RPL9 ribosomal protein L9 -0.0251784
CBX3 chromobox homolog 3 -0.0251342
RPL37A ribosomal protein L37a -0.0251096
RPS14 ribosomal protein S14 -0.025049
RPS29 ribosomal protein S29 -0.0249823
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 -0.0246686
S100A6 S100 calcium binding protein A6 -0.0244848
RACK1 receptor for activated C kinase 1 -0.0243341
DLG1 discs, large homolog 1 (Drosophila) -0.0241043
KRT19 keratin 19, type I -0.0238394
RPL32 ribosomal protein L32 -0.0236314
PRDX2 peroxiredoxin 2 -0.0235942
RPL34 ribosomal protein L34 -0.0234617
SMC4 structural maintenance of chromosomes 4 -0.0234356
RPS13 ribosomal protein S13 -0.0233992
RPL36A ribosomal protein L36a -0.0231994
RPS16 ribosomal protein S16 -0.0231911
PARD3 par-3 family cell polarity regulator -0.0229446
MYL12B myosin, light chain 12B, regulatory -0.0229065
TXNRD1 thioredoxin reductase 1 -0.0226749
FHIT fragile histidine triad -0.0225556
PERP PERP, TP53 apoptosis effector -0.0223761
SRSF11 serine/arginine-rich splicing factor 11 -0.0222207
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0219657
UBE2D3 ubiquitin-conjugating enzyme E2D 3 -0.0219625
RPL36 ribosomal protein L36 -0.0218761
DEK DEK proto-oncogene -0.0218519
RPS15 ribosomal protein S15 -0.0216419
RPL8 ribosomal protein L8 -0.0214057
KLF6 Kruppel-like factor 6 -0.0212494
PA2G4 proliferation-associated 2G4, 38kDa -0.0211662
PTBP3 polypyrimidine tract binding protein 3 -0.0211297
IFITM3 interferon induced transmembrane protein 3 -0.0210162
TUBB4B tubulin, beta 4B class IVb -0.0210006
RPL30 ribosomal protein L30 -0.0206279
RPS12 ribosomal protein S12 -0.0199407
RPL37 ribosomal protein L37 -0.0198832
HLA-A major histocompatibility complex, class I, A -0.0197627
FTL ferritin, light polypeptide -0.0197571
RPS27A ribosomal protein S27a -0.0197459
ERBIN erbb2 interacting protein -0.0197291
RPS17 ribosomal protein S17 -0.0196992
RPL18 ribosomal protein L18 -0.0196727
RHOA ras homolog family member A -0.0192481
TOP1 topoisomerase (DNA) I -0.0192415
LDHB lactate dehydrogenase B -0.0192077