| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Tirabrutinib (hydrochloride) perturbation in HEC-1-A cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Tirabrutinib (hydrochloride)_HEC-1-A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| EEF2 | eukaryotic translation elongation factor 2 | 0.151424 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.147891 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.138813 |
| ASPH | aspartate beta-hydroxylase | 0.112519 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.10334 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0931678 |
| APP | amyloid beta (A4) precursor protein | 0.0900958 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0895254 |
| AHNAK | AHNAK nucleoprotein | 0.0828264 |
| FLNA | filamin A, alpha | 0.0809854 |
| PLEC | plectin | 0.0791073 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0783724 |
| LAMB3 | laminin, beta 3 | 0.0740658 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0732137 |
| TJP1 | tight junction protein 1 | 0.0704483 |
| VCL | vinculin | 0.0669109 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0657551 |
| SQSTM1 | sequestosome 1 | 0.0600666 |
| EMP1 | epithelial membrane protein 1 | 0.058376 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0580285 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0580222 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | 0.0578122 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | 0.0566677 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.055243 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | 0.0552311 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0543124 |
| DIAPH1 | diaphanous-related formin 1 | 0.0531495 |
| ALCAM | activated leukocyte cell adhesion molecule | 0.0509687 |
| RPS4X | ribosomal protein S4, X-linked | 0.0504633 |
| EPB41L2 | erythrocyte membrane protein band 4.1-like 2 | 0.049209 |
| INTS6 | integrator complex subunit 6 | 0.0489106 |
| YBX1 | Y box binding protein 1 | 0.0484914 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | 0.0474127 |
| WWC1 | WW and C2 domain containing 1 | 0.0466155 |
| ELF3 | E74-like factor 3 (ets domain transcription factor, epithelial-specific ) | 0.0464896 |
| SPTAN1 | spectrin, alpha, non-erythrocytic 1 | 0.0464605 |
| SET | SET nuclear proto-oncogene | 0.046449 |
| HNRNPC | heterogeneous nuclear ribonucleoprotein C (C1/C2) | 0.0442796 |
| RUNX1 | runt-related transcription factor 1 | 0.0438009 |
| ACTN4 | actinin, alpha 4 | 0.0434891 |
| YWHAG | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma | 0.0431261 |
| YWHAE | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon | 0.0424128 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0424125 |
| DSPP | dentin sialophosphoprotein | 0.0417471 |
| MYO1E | myosin IE | 0.0412314 |
| MPRIP | myosin phosphatase Rho interacting protein | 0.0412133 |
| ITPR3 | inositol 1,4,5-trisphosphate receptor, type 3 | 0.0411497 |
| SPAG9 | sperm associated antigen 9 | 0.0409657 |
| ANXA1 | annexin A1 | 0.0407984 |
| DNAJA1 | DnaJ (Hsp40) homolog, subfamily A, member 1 | 0.0407875 |
| SMAD3 | SMAD family member 3 | 0.0398787 |
| PMEPA1 | prostate transmembrane protein, androgen induced 1 | 0.0398718 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0398469 |
| EZR | ezrin | 0.0394785 |
| BRD2 | bromodomain containing 2 | 0.0394245 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0388918 |
| TMSB4X | thymosin beta 4, X-linked | 0.0388538 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0384869 |
| RPL23 | ribosomal protein L23 | 0.0382317 |
| ANXA2 | annexin A2 | 0.0380717 |
| EIF4A2 | eukaryotic translation initiation factor 4A2 | 0.0380703 |
| WAC | WW domain containing adaptor with coiled-coil | 0.0374488 |
| RPS2 | ribosomal protein S2 | 0.0371203 |
| EIF4G1 | eukaryotic translation initiation factor 4 gamma, 1 | 0.0367581 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.036731 |
| RAD23B | RAD23 homolog B (S. cerevisiae) | 0.0366044 |
| ANXA11 | annexin A11 | 0.0365505 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.0365234 |
| MATR3 | matrin 3 | 0.0364854 |
| TBL1XR1 | transducin (beta)-like 1 X-linked receptor 1 | 0.0364192 |
| WWOX | WW domain containing oxidoreductase | 0.03636 |
| KDM6A | lysine (K)-specific demethylase 6A | 0.0363137 |
| LAMC2 | laminin, gamma 2 | 0.0362352 |
| TPT1 | tumor protein, translationally-controlled 1 | 0.0361964 |
| NCKAP1 | NCK-associated protein 1 | 0.0361835 |
| PCSK5 | proprotein convertase subtilisin/kexin type 5 | 0.0361657 |
| FXR1 | fragile X mental retardation, autosomal homolog 1 | 0.0361351 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | 0.036093 |
| CTNNB1 | catenin (cadherin-associated protein), beta 1, 88kDa | 0.0360899 |
| ZNF644 | zinc finger protein 644 | 0.035617 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | 0.0355387 |
| FHIP1A | FHF complex subunit HOOK interacting protein 1A | 0.0352391 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0351944 |
| SFTPA2 | surfactant protein A2 | 0.0349301 |
| NCEH1 | neutral cholesterol ester hydrolase 1 | 0.0346687 |
| OSBPL10 | oxysterol binding protein-like 10 | 0.0345049 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | 0.0343994 |
| KRT18 | keratin 18, type I | 0.0339209 |
| MICAL3 | microtubule associated monooxygenase, calponin and LIM domain containing 3 | 0.0338589 |
| PPL | periplakin | 0.0327728 |
| IRF1 | interferon regulatory factor 1 | 0.0327686 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0326021 |
| RYK | receptor-like tyrosine kinase | 0.032287 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0320735 |
| EPB41L5 | erythrocyte membrane protein band 4.1 like 5 | 0.0320179 |
| RPL31 | ribosomal protein L31 | 0.0319808 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0319259 |
| ECT2 | epithelial cell transforming 2 | 0.0316364 |
| PPP2R2A | protein phosphatase 2, regulatory subunit B, alpha | 0.0315586 |
| ITGA6 | integrin, alpha 6 | 0.0312064 |
| Symbol | Name | Standardized Value |
|---|---|---|
| MT2A | metallothionein 2A | -0.0934855 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0799284 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0697897 |
| LIMCH1 | LIM and calponin homology domains 1 | -0.0660116 |
| NDRG1 | N-myc downstream regulated 1 | -0.0590104 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0436932 |
| TMSB10 | thymosin beta 10 | -0.0425041 |
| HMGA1 | high mobility group AT-hook 1 | -0.0421455 |
| LMAN1 | lectin, mannose-binding, 1 | -0.040055 |
| ARHGAP29 | Rho GTPase activating protein 29 | -0.0397924 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | -0.0343122 |
| BICD1 | bicaudal D homolog 1 (Drosophila) | -0.033632 |
| ZNF652 | zinc finger protein 652 | -0.0330044 |
| ENO1 | enolase 1, (alpha) | -0.0328305 |
| GRAMD2B | GRAM domain containing 2B | -0.0311322 |
| SIPA1L3 | signal-induced proliferation-associated 1 like 3 | -0.0304725 |
| DLC1 | DLC1 Rho GTPase activating protein | -0.0301534 |
| PLEKHA1 | pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1 | -0.0295775 |
| TTC3 | tetratricopeptide repeat domain 3 | -0.0283725 |
| CDC42BPA | CDC42 binding protein kinase alpha (DMPK-like) | -0.0262538 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | -0.0249823 |
| TXNRD1 | thioredoxin reductase 1 | -0.0240649 |
| ADAM10 | ADAM metallopeptidase domain 10 | -0.0240354 |
| WASF2 | WAS protein family, member 2 | -0.0234592 |
| DLG1 | discs, large homolog 1 (Drosophila) | -0.0231734 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.022788 |
| MINDY2 | MINDY lysine 48 deubiquitinase 2 | -0.0225853 |
| MT1X | metallothionein 1X | -0.0224877 |
| PAX8 | paired box 8 | -0.0223163 |
| THOC2 | THO complex 2 | -0.0222223 |
| PGK1 | phosphoglycerate kinase 1 | -0.022196 |
| TRAM1 | translocation associated membrane protein 1 | -0.0221673 |
| ITGB8 | integrin, beta 8 | -0.0220887 |
| PLEKHA2 | pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 2 | -0.0213745 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0209442 |
| S100A6 | S100 calcium binding protein A6 | -0.0209363 |
| CDC27 | cell division cycle 27 | -0.0207637 |
| KIF18B | kinesin family member 18B | -0.0206834 |
| WASHC4 | WASH complex subunit 4 | -0.0204114 |
| GAS2L3 | growth arrest-specific 2 like 3 | -0.0200323 |
| GOSR1 | golgi SNAP receptor complex member 1 | -0.0200125 |
| RAPGEF5 | Rap guanine nucleotide exchange factor (GEF) 5 | -0.0198507 |
| CCNI | cyclin I | -0.0198142 |
| SFXN1 | sideroflexin 1 | -0.0197986 |
| UBE2D2 | ubiquitin-conjugating enzyme E2D 2 | -0.0195872 |
| KCTD9 | potassium channel tetramerization domain containing 9 | -0.0194232 |
| NPEPPS | aminopeptidase puromycin sensitive | -0.019289 |
| NEMF | nuclear export mediator factor | -0.0192734 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.01903 |
| RHEX | regulator of hemoglobinization and erythroid cell expansion | -0.0190087 |
| PHC3 | polyhomeotic homolog 3 (Drosophila) | -0.0188088 |
| HKDC1 | hexokinase domain containing 1 | -0.0183978 |
| PTPRF | protein tyrosine phosphatase, receptor type, F | -0.0183593 |
| GCC2 | GRIP and coiled-coil domain containing 2 | -0.0183363 |
| REV1 | REV1, polymerase (DNA directed) | -0.0181804 |
| U2SURP | U2 snRNP-associated SURP domain containing | -0.0181113 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | -0.0180341 |
| RGL3 | ral guanine nucleotide dissociation stimulator-like 3 | -0.0179167 |
| ATG7 | autophagy related 7 | -0.0178801 |
| FAM222B | family with sequence similarity 222, member B | -0.0178249 |
| PHIP | pleckstrin homology domain interacting protein | -0.0178148 |
| TNRC6B | trinucleotide repeat containing 6B | -0.017802 |
| CD47 | CD47 molecule | -0.0177901 |
| ZBTB7A | zinc finger and BTB domain containing 7A | -0.0176874 |
| URI1 | URI1, prefoldin-like chaperone | -0.0174902 |
| PRKRIP1 | PRKR interacting protein 1 (IL11 inducible) | -0.0174221 |
| ITCH | itchy E3 ubiquitin protein ligase | -0.0173771 |
| HELZ | helicase with zinc finger | -0.0172707 |
| DSCAML1 | Down syndrome cell adhesion molecule like 1 | -0.0172547 |
| RBL1 | retinoblastoma-like 1 | -0.0172091 |
| EGFR | epidermal growth factor receptor | -0.0171991 |
| FARP1 | FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived) | -0.0170511 |
| ESRP1 | epithelial splicing regulatory protein 1 | -0.0167707 |
| SEC14L1 | SEC14-like 1 (S. cerevisiae) | -0.0166519 |
| COPB2 | coatomer protein complex, subunit beta 2 (beta prime) | -0.0165631 |
| LDHA | lactate dehydrogenase A | -0.0165388 |
| GARS1 | glycyl-tRNA synthetase 1 | -0.0163742 |
| FBXO42 | F-box protein 42 | -0.0163738 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0163587 |
| TUBA1B | tubulin, alpha 1b | -0.0162805 |
| GOLGA4 | golgin A4 | -0.0160423 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | -0.0159104 |
| ENO2 | enolase 2 (gamma, neuronal) | -0.0158693 |
| CAPZA1 | capping protein (actin filament) muscle Z-line, alpha 1 | -0.0158674 |
| NKTR | natural killer cell triggering receptor | -0.0158623 |
| FBXL2 | F-box and leucine-rich repeat protein 2 | -0.0158089 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | -0.0155871 |
| IBTK | inhibitor of Bruton agammaglobulinemia tyrosine kinase | -0.0153523 |
| VDAC1 | voltage-dependent anion channel 1 | -0.015138 |
| NSD1 | nuclear receptor binding SET domain protein 1 | -0.0151219 |
| INVS | inversin | -0.0150837 |
| KRT19 | keratin 19, type I | -0.0149714 |
| ZFHX3 | zinc finger homeobox 3 | -0.0148796 |
| BPTF | bromodomain PHD finger transcription factor | -0.0147803 |
| MIS18BP1 | MIS18 binding protein 1 | -0.0147159 |
| ARHGAP18 | Rho GTPase activating protein 18 | -0.0146793 |
| SEC24D | SEC24 family member D | -0.0146678 |
| RBM26 | RNA binding motif protein 26 | -0.0145658 |
| SRP54 | signal recognition particle 54kDa | -0.0145287 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0144524 |
