| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Tirabrutinib (hydrochloride) perturbation in HOP62 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Tirabrutinib (hydrochloride)_HOP62 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| FAM13A | family with sequence similarity 13, member A | 0.114121 |
| NDRG1 | N-myc downstream regulated 1 | 0.109482 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.104376 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0957852 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0749622 |
| FN1 | fibronectin 1 | 0.0695247 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0637165 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0623393 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.0596624 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | 0.0584933 |
| ADM | adrenomedullin | 0.0566591 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0555677 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0547356 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0532278 |
| RNMT | RNA (guanine-7-) methyltransferase | 0.0522893 |
| SPAG9 | sperm associated antigen 9 | 0.04981 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0484224 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | 0.0451121 |
| GOLGA4 | golgin A4 | 0.0447538 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.044564 |
| ZNF292 | zinc finger protein 292 | 0.0433253 |
| RNF24 | ring finger protein 24 | 0.0419645 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.0406263 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.0397864 |
| WDR45B | WD repeat domain 45B | 0.0395543 |
| NGLY1 | N-glycanase 1 | 0.0394869 |
| VEGFA | vascular endothelial growth factor A | 0.0393779 |
| HELZ | helicase with zinc finger | 0.0393201 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0390742 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0390185 |
| DDIT4 | DNA-damage-inducible transcript 4 | 0.0385371 |
| USP3 | ubiquitin specific peptidase 3 | 0.0380284 |
| FOSB | FBJ murine osteosarcoma viral oncogene homolog B | 0.0378397 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.0369597 |
| HILPDA | hypoxia inducible lipid droplet-associated | 0.0363841 |
| HOOK2 | hook microtubule-tethering protein 2 | 0.0363266 |
| KHDRBS3 | KH domain containing, RNA binding, signal transduction associated 3 | 0.0362935 |
| RLF | rearranged L-myc fusion | 0.0361195 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.036117 |
| MIMS1 | mitochondrial inner membrane scaffold 1 | 0.036075 |
| RUNX1 | runt-related transcription factor 1 | 0.0357811 |
| NUP58 | nucleoporin 58 | 0.0354086 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0351017 |
| STC1 | stanniocalcin 1 | 0.0339922 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0334251 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0329675 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.0320355 |
| JUN | jun proto-oncogene | 0.0318886 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0316512 |
| OGA | O-GlcNAcase | 0.0306574 |
| SEC24A | SEC24 family member A | 0.0303078 |
| GNPDA1 | glucosamine-6-phosphate deaminase 1 | 0.0292853 |
| RNF145 | ring finger protein 145 | 0.0288521 |
| RND3 | Rho family GTPase 3 | 0.0287636 |
| SLC6A6 | solute carrier family 6 (neurotransmitter transporter), member 6 | 0.028347 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0281663 |
| ARRDC3 | arrestin domain containing 3 | 0.0276317 |
| SHB | Src homology 2 domain containing adaptor protein B | 0.0270762 |
| JARID2 | jumonji, AT rich interactive domain 2 | 0.0270296 |
| SMAD3 | SMAD family member 3 | 0.0268319 |
| DTNA | dystrobrevin, alpha | 0.0261649 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.0260604 |
| ATP13A3 | ATPase type 13A3 | 0.0258232 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0257374 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.025589 |
| RASA3 | RAS p21 protein activator 3 | 0.0251337 |
| UGCG | UDP-glucose ceramide glucosyltransferase | 0.0246101 |
| EGLN1 | egl-9 family hypoxia-inducible factor 1 | 0.0240763 |
| CD109 | CD109 molecule | 0.0239235 |
| INSIG2 | insulin induced gene 2 | 0.0235678 |
| MYO1B | myosin IB | 0.0234628 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.023109 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0226944 |
| SETD5 | SET domain containing 5 | 0.0223671 |
| FLNB | filamin B, beta | 0.0222531 |
| PDE10A | phosphodiesterase 10A | 0.0217967 |
| FOS | FBJ murine osteosarcoma viral oncogene homolog | 0.0213957 |
| SUCO | SUN domain containing ossification factor | 0.0213252 |
| PPARD | peroxisome proliferator-activated receptor delta | 0.0212393 |
| LCORL | ligand dependent nuclear receptor corepressor-like | 0.0208817 |
| FOXO3 | forkhead box O3 | 0.0205894 |
| DOT1L | DOT1-like histone H3K79 methyltransferase | 0.0205488 |
| ENTPD7 | ectonucleoside triphosphate diphosphohydrolase 7 | 0.0204407 |
| BTAF1 | BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa | 0.0203858 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | 0.0203495 |
| HERC3 | HECT and RLD domain containing E3 ubiquitin protein ligase 3 | 0.0203168 |
| TAC4 | tachykinin 4 (hemokinin) | 0.0202236 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0201248 |
| SRP54 | signal recognition particle 54kDa | 0.0199821 |
| SFTPA2 | surfactant protein A2 | 0.0199587 |
| TNS1 | tensin 1 | 0.0199303 |
| AMPD3 | adenosine monophosphate deaminase 3 | 0.0198934 |
| SLC2A1 | solute carrier family 2 (facilitated glucose transporter), member 1 | 0.0197094 |
| PFKFB3 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 | 0.0194289 |
| PLEC | plectin | 0.0193985 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | 0.0193466 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.0189489 |
| TFRC | transferrin receptor | 0.0188938 |
| IRS2 | insulin receptor substrate 2 | 0.0188852 |
| MCL1 | myeloid cell leukemia 1 | 0.0188429 |
| Symbol | Name | Standardized Value |
|---|---|---|
| VIM | vimentin | -0.265496 |
| TMSB10 | thymosin beta 10 | -0.123843 |
| HMGA2 | high mobility group AT-hook 2 | -0.122886 |
| EXT1 | exostosin glycosyltransferase 1 | -0.100775 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0960686 |
| CD44 | CD44 molecule (Indian blood group) | -0.0929939 |
| NAV1 | neuron navigator 1 | -0.0906184 |
| ACTG1 | actin gamma 1 | -0.0894663 |
| NALF1 | NALCN channel auxiliary factor 1 | -0.0757551 |
| IGF2 | insulin-like growth factor 2 | -0.0735174 |
| COL5A1 | collagen, type V, alpha 1 | -0.071568 |
| VCL | vinculin | -0.07043 |
| GLIS3 | GLIS family zinc finger 3 | -0.0671219 |
| MYO10 | myosin X | -0.0636074 |
| CDH13 | cadherin 13 | -0.063103 |
| RAI14 | retinoic acid induced 14 | -0.0621174 |
| ASPH | aspartate beta-hydroxylase | -0.0585391 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | -0.0574152 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | -0.0561783 |
| RFX8 | RFX family member 8, lacking RFX DNA binding domain | -0.0553426 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0514205 |
| ENO1 | enolase 1, (alpha) | -0.0500273 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0488357 |
| CLMP | CXADR-like membrane protein | -0.0447694 |
| COL1A1 | collagen, type I, alpha 1 | -0.0442971 |
| AHNAK | AHNAK nucleoprotein | -0.0440477 |
| BICD1 | bicaudal D homolog 1 (Drosophila) | -0.0437922 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0432842 |
| TUBB6 | tubulin, beta 6 class V | -0.0417251 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.041725 |
| MYL12A | myosin, light chain 12A, regulatory, non-sarcomeric | -0.04044 |
| EGFR | epidermal growth factor receptor | -0.0396083 |
| PRSS23 | protease, serine, 23 | -0.0387675 |
| DST | dystonin | -0.0357043 |
| LAMB3 | laminin, beta 3 | -0.034155 |
| RAD51B | RAD51 paralog B | -0.0339175 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0338979 |
| LPP | LIM domain containing preferred translocation partner in lipoma | -0.0329809 |
| FMN1 | formin 1 | -0.0323814 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | -0.0323569 |
| SMYD3 | SET and MYND domain containing 3 | -0.0323352 |
| ITGA3 | integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) | -0.0322631 |
| CAVIN1 | caveolae associated protein 1 | -0.0318986 |
| FRMD4A | FERM domain containing 4A | -0.0318342 |
| EGR1 | early growth response 1 | -0.0297281 |
| ARHGAP22 | Rho GTPase activating protein 22 | -0.029668 |
| DIAPH2 | diaphanous-related formin 2 | -0.0296549 |
| ITPR2 | inositol 1,4,5-trisphosphate receptor, type 2 | -0.0290746 |
| CAPN2 | calpain 2, (m/II) large subunit | -0.0289141 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | -0.0283394 |
| CLIC4 | chloride intracellular channel 4 | -0.0281001 |
| ANKRD12 | ankyrin repeat domain 12 | -0.0280714 |
| CCDC91 | coiled-coil domain containing 91 | -0.0279896 |
| ATXN1 | ataxin 1 | -0.0275468 |
| PRKCA | protein kinase C, alpha | -0.0275373 |
| RRBP1 | ribosome binding protein 1 | -0.0275087 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0273908 |
| KIAA1549L | KIAA1549-like | -0.0273193 |
| ASPM | asp (abnormal spindle) homolog, microcephaly associated (Drosophila) | -0.027103 |
| TPI1 | triosephosphate isomerase 1 | -0.0269471 |
| INHBA | inhibin, beta A | -0.0268986 |
| MBD5 | methyl-CpG binding domain protein 5 | -0.0268848 |
| KCNQ5 | potassium channel, voltage gated KQT-like subfamily Q, member 5 | -0.0267371 |
| SLC16A3 | solute carrier family 16 (monocarboxylate transporter), member 3 | -0.026653 |
| BPTF | bromodomain PHD finger transcription factor | -0.0265386 |
| RPL35A | ribosomal protein L35a | -0.0262578 |
| ATRX | alpha thalassemia/mental retardation syndrome X-linked | -0.0256969 |
| S100A10 | S100 calcium binding protein A10 | -0.025561 |
| TENM2 | teneurin transmembrane protein 2 | -0.0252897 |
| CEP112 | centrosomal protein 112kDa | -0.0249875 |
| ACTN4 | actinin, alpha 4 | -0.024981 |
| ARPC2 | actin related protein 2/3 complex, subunit 2, 34kDa | -0.024748 |
| TPM4 | tropomyosin 4 | -0.0247417 |
| ZBTB38 | zinc finger and BTB domain containing 38 | -0.0246022 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0245921 |
| ERC1 | ELKS/RAB6-interacting/CAST family member 1 | -0.0242425 |
| IL1RAPL1 | interleukin 1 receptor accessory protein-like 1 | -0.0242332 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0241882 |
| COL6A3 | collagen, type VI, alpha 3 | -0.0241766 |
| RASSF8 | Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 | -0.0239743 |
| ERGIC1 | endoplasmic reticulum-golgi intermediate compartment (ERGIC) 1 | -0.0239465 |
| CUX1 | cut-like homeobox 1 | -0.0238768 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | -0.0236015 |
| EHBP1 | EH domain binding protein 1 | -0.0234665 |
| MAML3 | mastermind-like 3 (Drosophila) | -0.0234485 |
| TAS2R14 | taste receptor, type 2, member 14 | -0.0233431 |
| VASP | vasodilator-stimulated phosphoprotein | -0.0232893 |
| OSMR | oncostatin M receptor | -0.0232884 |
| VPS13B | vacuolar protein sorting 13 homolog B (yeast) | -0.0230652 |
| PLEKHA5 | pleckstrin homology domain containing, family A member 5 | -0.0230102 |
| CDK6 | cyclin-dependent kinase 6 | -0.0230022 |
| SIPA1L1 | signal-induced proliferation-associated 1 like 1 | -0.0229574 |
| MYO9A | myosin IXA | -0.0229043 |
| BRIP1 | BRCA1 interacting protein C-terminal helicase 1 | -0.022731 |
| TPM1 | tropomyosin 1 (alpha) | -0.0226297 |
| WWOX | WW domain containing oxidoreductase | -0.0223212 |
| ETV6 | ets variant 6 | -0.0220822 |
| ANTXR1 | anthrax toxin receptor 1 | -0.0220333 |
| CHD9 | chromodomain helicase DNA binding protein 9 | -0.0218843 |
| ATG7 | autophagy related 7 | -0.0216318 |
