Tirabrutinib (hydrochloride)_HS-578T Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Tirabrutinib (hydrochloride) perturbation in HS-578T cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Tirabrutinib (hydrochloride)_HS-578T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
SPARC secreted protein, acidic, cysteine-rich (osteonectin) 0.121848
EEF2 eukaryotic translation elongation factor 2 0.106771
MYH9 myosin, heavy chain 9, non-muscle 0.09879
PABPC1 poly(A) binding protein, cytoplasmic 1 0.094823
FN1 fibronectin 1 0.0831389
FTH1 ferritin, heavy polypeptide 1 0.0814984
VIM vimentin 0.0753278
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0736696
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0651264
COL6A3 collagen, type VI, alpha 3 0.0624926
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0569694
CALR calreticulin 0.0529685
PTMA prothymosin, alpha 0.0524935
RPS6 ribosomal protein S6 0.0470983
MT2A metallothionein 2A 0.0461271
COL1A1 collagen, type I, alpha 1 0.0458863
VEGFA vascular endothelial growth factor A 0.0454297
COL1A2 collagen, type I, alpha 2 0.0441902
EIF1 eukaryotic translation initiation factor 1 0.0420448
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0414657
SOD2 superoxide dismutase 2, mitochondrial 0.0409936
CALU calumenin 0.0409113
YBX1 Y box binding protein 1 0.0370535
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0370117
TNIP1 TNFAIP3 interacting protein 1 0.0354757
PLEC plectin 0.0316783
GOLGA4 golgin A4 0.0315923
RPL11 ribosomal protein L11 0.03154
CSDE1 cold shock domain containing E1, RNA-binding 0.030586
FLNA filamin A, alpha 0.0298427
RPS8 ribosomal protein S8 0.0292325
TPM2 tropomyosin 2 (beta) 0.0290026
ACTG1 actin gamma 1 0.0282019
RPL19 ribosomal protein L19 0.0276458
DSTN destrin (actin depolymerizing factor) 0.0275939
ICAM1 intercellular adhesion molecule 1 0.0271359
BHLHE40 basic helix-loop-helix family, member e40 0.0264282
ZFAND3 zinc finger, AN1-type domain 3 0.0259722
RPL7 ribosomal protein L7 0.0250606
CANX calnexin 0.0249822
ANKRD11 ankyrin repeat domain 11 0.0242267
APP amyloid beta (A4) precursor protein 0.0236592
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.023433
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0229563
FTL ferritin, light polypeptide 0.0227955
NAP1L1 nucleosome assembly protein 1-like 1 0.0226579
NAMPT nicotinamide phosphoribosyltransferase 0.022603
B2M beta-2-microglobulin 0.0224549
CSF1 colony stimulating factor 1 (macrophage) 0.0221463
RPL5 ribosomal protein L5 0.0219727
COL6A1 collagen, type VI, alpha 1 0.0218922
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0213558
SPTBN1 spectrin, beta, non-erythrocytic 1 0.021208
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.020768
RPL8 ribosomal protein L8 0.0205953
TPM4 tropomyosin 4 0.0204618
ADM adrenomedullin 0.0200735
FXR1 fragile X mental retardation, autosomal homolog 1 0.0199118
GARS1 glycyl-tRNA synthetase 1 0.0198152
RPS12 ribosomal protein S12 0.0195411
POTEF POTE ankyrin domain family, member F 0.0192101
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0191346
RPS3 ribosomal protein S3 0.0189083
GNAI3 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 0.0187442
EIF4A2 eukaryotic translation initiation factor 4A2 0.0178703
MTDH metadherin 0.0178394
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa 0.017661
SFTPA2 surfactant protein A2 0.0175937
RACK1 receptor for activated C kinase 1 0.0175901
TSC22D2 TSC22 domain family, member 2 0.0175208
RPS4X ribosomal protein S4, X-linked 0.0170533
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0169832
CLINT1 clathrin interactor 1 0.0168473
ACSL3 acyl-CoA synthetase long-chain family member 3 0.0167107
MT1X metallothionein 1X 0.0164754
RPL12 ribosomal protein L12 0.0164646
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0162197
IRF1 interferon regulatory factor 1 0.0162073
PTK2 protein tyrosine kinase 2 0.0161306
RLF rearranged L-myc fusion 0.0160964
CXCL3 chemokine (C-X-C motif) ligand 3 0.015998
CALM1 calmodulin 1 (phosphorylase kinase, delta) 0.0159705
MATR3 matrin 3 0.0159289
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0158599
QKI QKI, KH domain containing, RNA binding 0.0158294
SF3B2 splicing factor 3b, subunit 2, 145kDa 0.0157567
SQLE squalene epoxidase 0.0156973
ALCAM activated leukocyte cell adhesion molecule 0.0156805
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.015633
COL4A1 collagen, type IV, alpha 1 0.0155503
RPS2 ribosomal protein S2 0.0155467
LAMB1 laminin, beta 1 0.0153883
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0153158
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0153038
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 0.015302
RPL37A ribosomal protein L37a 0.0152285
RPS19 ribosomal protein S19 0.0150962
RND3 Rho family GTPase 3 0.0150804
SPAG9 sperm associated antigen 9 0.014964
TMSB4X thymosin beta 4, X-linked 0.0148645

decreased expression

Symbol Name Standardized Value
IGFBP3 insulin-like growth factor binding protein 3 -0.12089
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0401812
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0380953
NDRG1 N-myc downstream regulated 1 -0.0375872
PRELID2 PRELI domain containing 2 -0.0351809
EXT1 exostosin glycosyltransferase 1 -0.0345271
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.0334698
UBR5 ubiquitin protein ligase E3 component n-recognin 5 -0.0297128
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0291745
ELL2 elongation factor, RNA polymerase II, 2 -0.0275307
TIMP3 TIMP metallopeptidase inhibitor 3 -0.0261512
NAV1 neuron navigator 1 -0.0240412
LOXL2 lysyl oxidase-like 2 -0.0230831
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0229494
LTBP1 latent transforming growth factor beta binding protein 1 -0.0215849
PSD3 pleckstrin and Sec7 domain containing 3 -0.0215569
CDH13 cadherin 13 -0.0209892
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0208364
WWTR1 WW domain containing transcription regulator 1 -0.0207543
JARID2 jumonji, AT rich interactive domain 2 -0.0179921
ASPH aspartate beta-hydroxylase -0.0171824
NKAIN3 Na+/K+ transporting ATPase interacting 3 -0.0170323
VCL vinculin -0.017026
OSMR oncostatin M receptor -0.0166723
PDE10A phosphodiesterase 10A -0.0166619
KLF7 Kruppel-like factor 7 (ubiquitous) -0.0160582
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide) -0.0157897
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0151409
SMYD3 SET and MYND domain containing 3 -0.0149666
ST3GAL1 ST3 beta-galactoside alpha-2,3-sialyltransferase 1 -0.0147473
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0140461
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0139587
EGFR epidermal growth factor receptor -0.0133943
PDLIM5 PDZ and LIM domain 5 -0.0133862
F3 coagulation factor III (thromboplastin, tissue factor) -0.0129207
CD44 CD44 molecule (Indian blood group) -0.0128375
CLIC4 chloride intracellular channel 4 -0.012737
ZBTB20 zinc finger and BTB domain containing 20 -0.0126906
GLIS3 GLIS family zinc finger 3 -0.0125511
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) -0.0125298
ATXN1 ataxin 1 -0.0122971
DLG1 discs, large homolog 1 (Drosophila) -0.0122156
HMGA2 high mobility group AT-hook 2 -0.0121734
PDE4D phosphodiesterase 4D, cAMP-specific -0.0117196
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0116454
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2 -0.0111688
TENT5A terminal nucleotidyltransferase 5A -0.0110631
GRB10 growth factor receptor-bound protein 10 -0.0107509
LOX lysyl oxidase -0.0107114
MAML2 mastermind-like 2 (Drosophila) -0.0106609
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A -0.0106383
EGR1 early growth response 1 -0.0104274
RERE arginine-glutamic acid dipeptide (RE) repeats -0.00996324
ADAM12 ADAM metallopeptidase domain 12 -0.00994216
IFI6 interferon, alpha-inducible protein 6 -0.00964689
GPC6 glypican 6 -0.00952121
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.00948561
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.00939846
NALF1 NALCN channel auxiliary factor 1 -0.00923024
LHFPL2 lipoma HMGIC fusion partner-like 2 -0.00922794
KIAA1217 KIAA1217 -0.00918508
PALLD palladin, cytoskeletal associated protein -0.00917757
KDM7A lysine (K)-specific demethylase 7A -0.00907071
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 -0.00904237
NRIP1 nuclear receptor interacting protein 1 -0.00896439
FRMD4A FERM domain containing 4A -0.00887051
FAM20C family with sequence similarity 20, member C -0.0088307
RAD51B RAD51 paralog B -0.00877952
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 -0.00875443
CAMTA1 calmodulin binding transcription activator 1 -0.00873891
TRPS1 trichorhinophalangeal syndrome I -0.00871941
PPP2R3A protein phosphatase 2, regulatory subunit B'', alpha -0.00869929
RIGI RNA sensor RIG-I -0.00865847
ADAM19 ADAM metallopeptidase domain 19 -0.00855503
RUNX1 runt-related transcription factor 1 -0.00836369
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 -0.00831461
ZEB2 zinc finger E-box binding homeobox 2 -0.0082556
FBXL7 F-box and leucine-rich repeat protein 7 -0.00811249
RAI14 retinoic acid induced 14 -0.00810247
UBE2E2 ubiquitin-conjugating enzyme E2E 2 -0.00809077
SDC2 syndecan 2 -0.00803091
RARB retinoic acid receptor, beta -0.00797592
STK10 serine/threonine kinase 10 -0.00768627
NRP1 neuropilin 1 -0.00766428
TRIO trio Rho guanine nucleotide exchange factor -0.00766041
DPYSL3 dihydropyrimidinase-like 3 -0.00760028
CDON cell adhesion associated, oncogene regulated -0.00759408
EPHB1 EPH receptor B1 -0.00755457
H1-0 H1.0 linker histone -0.00750108
DTNA dystrobrevin, alpha -0.00741151
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 -0.00739874
RBPMS RNA binding protein with multiple splicing -0.00736496
DPYD dihydropyrimidine dehydrogenase -0.00721779
KLF12 Kruppel-like factor 12 -0.00710567
SAMD9 sterile alpha motif domain containing 9 -0.00710421
HDAC9 histone deacetylase 9 -0.00710116
TUBB6 tubulin, beta 6 class V -0.00709746
CPQ carboxypeptidase Q -0.00705349
ARHGAP29 Rho GTPase activating protein 29 -0.00692945
CD109 CD109 molecule -0.00692112