| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Tirabrutinib (hydrochloride) perturbation in HT-29 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Tirabrutinib (hydrochloride)_HT-29 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| FTH1 | ferritin, heavy polypeptide 1 | 0.239064 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.160341 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.118209 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.107201 |
| NDRG1 | N-myc downstream regulated 1 | 0.101551 |
| GOLGA4 | golgin A4 | 0.094231 |
| FOSB | FBJ murine osteosarcoma viral oncogene homolog B | 0.0907323 |
| VEGFA | vascular endothelial growth factor A | 0.0855599 |
| EZR | ezrin | 0.083619 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0791628 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0712327 |
| KRT18 | keratin 18, type I | 0.0677671 |
| GCLC | glutamate-cysteine ligase, catalytic subunit | 0.0660748 |
| YBX1 | Y box binding protein 1 | 0.0597188 |
| BRD2 | bromodomain containing 2 | 0.0595281 |
| ANXA1 | annexin A1 | 0.0537792 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0518578 |
| EIF4A2 | eukaryotic translation initiation factor 4A2 | 0.0508702 |
| SPAG9 | sperm associated antigen 9 | 0.0505213 |
| GNPDA1 | glucosamine-6-phosphate deaminase 1 | 0.0504869 |
| DDIT3 | DNA-damage-inducible transcript 3 | 0.0500149 |
| FBXO32 | F-box protein 32 | 0.0473509 |
| FOS | FBJ murine osteosarcoma viral oncogene homolog | 0.0473325 |
| TMEM65 | transmembrane protein 65 | 0.0473147 |
| MBNL2 | muscleblind-like splicing regulator 2 | 0.0469081 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0452587 |
| TAF15 | TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa | 0.0444679 |
| HNRNPDL | heterogeneous nuclear ribonucleoprotein D-like | 0.0443352 |
| OGA | O-GlcNAcase | 0.0427946 |
| HMGCS1 | 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) | 0.0426159 |
| TNFRSF10B | tumor necrosis factor receptor superfamily, member 10b | 0.041979 |
| EMP1 | epithelial membrane protein 1 | 0.0418721 |
| RND3 | Rho family GTPase 3 | 0.0414234 |
| TNIP1 | TNFAIP3 interacting protein 1 | 0.0412173 |
| MACC1 | metastasis associated in colon cancer 1 | 0.0402583 |
| TXNRD1 | thioredoxin reductase 1 | 0.0392633 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0389481 |
| DNAJA1 | DnaJ (Hsp40) homolog, subfamily A, member 1 | 0.0379587 |
| RPS4X | ribosomal protein S4, X-linked | 0.0379526 |
| JUN | jun proto-oncogene | 0.0377797 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0375491 |
| CCNL1 | cyclin L1 | 0.0372011 |
| RNF145 | ring finger protein 145 | 0.0366833 |
| JMJD1C | jumonji domain containing 1C | 0.036125 |
| ST14 | suppression of tumorigenicity 14 (colon carcinoma) | 0.0360869 |
| WEE1 | WEE1 G2 checkpoint kinase | 0.035337 |
| B2M | beta-2-microglobulin | 0.0353214 |
| ARF4 | ADP-ribosylation factor 4 | 0.0350976 |
| KDM2A | lysine (K)-specific demethylase 2A | 0.0349848 |
| RPL3 | ribosomal protein L3 | 0.0348743 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0348546 |
| LMO7 | LIM domain 7 | 0.0345632 |
| HELZ | helicase with zinc finger | 0.0344477 |
| SFTPA2 | surfactant protein A2 | 0.03441 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.0333634 |
| CALU | calumenin | 0.0330075 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0329246 |
| CEMIP2 | cell migration inducing hyaluronidase 2 | 0.0324272 |
| FN1 | fibronectin 1 | 0.0323255 |
| FAM13A | family with sequence similarity 13, member A | 0.0322053 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | 0.0320149 |
| OPTN | optineurin | 0.0317729 |
| ATF3 | activating transcription factor 3 | 0.031722 |
| KRT20 | keratin 20, type I | 0.0316467 |
| NUP58 | nucleoporin 58 | 0.0311739 |
| SUPT5H | suppressor of Ty 5 homolog (S. cerevisiae) | 0.03112 |
| DSPP | dentin sialophosphoprotein | 0.0307655 |
| PPP1CB | protein phosphatase 1, catalytic subunit, beta isozyme | 0.0307346 |
| LOC112694756 | uncharaterized LOC112694756 | 0.0303253 |
| HYOU1 | hypoxia up-regulated 1 | 0.0302528 |
| SQLE | squalene epoxidase | 0.0290302 |
| TSC22D2 | TSC22 domain family, member 2 | 0.0288592 |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | 0.0287156 |
| PLEC | plectin | 0.0285294 |
| FXR1 | fragile X mental retardation, autosomal homolog 1 | 0.0284981 |
| PRKCI | protein kinase C, iota | 0.0284378 |
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | 0.0283381 |
| PFKP | phosphofructokinase, platelet | 0.0279981 |
| DNAJC3 | DnaJ (Hsp40) homolog, subfamily C, member 3 | 0.0277567 |
| OSBP | oxysterol binding protein | 0.0275375 |
| RPL11 | ribosomal protein L11 | 0.0272858 |
| NT5DC3 | 5'-nucleotidase domain containing 3 | 0.0270307 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.0269481 |
| ZBTB43 | zinc finger and BTB domain containing 43 | 0.0269442 |
| EXPH5 | exophilin 5 | 0.0269057 |
| POTEF | POTE ankyrin domain family, member F | 0.0268512 |
| CREBRF | CREB3 regulatory factor | 0.0266739 |
| MTHFD2 | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase | 0.0266329 |
| RAD23B | RAD23 homolog B (S. cerevisiae) | 0.0266157 |
| CARS1 | cysteinyl-tRNA synthetase 1 | 0.02653 |
| HDGF | hepatoma-derived growth factor | 0.0264807 |
| RPS2 | ribosomal protein S2 | 0.0263868 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | 0.0258179 |
| AFDN | afadin, adherens junction formation factor | 0.0258059 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0257181 |
| FHIP1A | FHF complex subunit HOOK interacting protein 1A | 0.0257024 |
| IARS1 | isoleucyl-tRNA synthetase 1 | 0.0256823 |
| PELI1 | pellino E3 ubiquitin protein ligase 1 | 0.0254889 |
| DHFR | dihydrofolate reductase | 0.0253931 |
| SFPQ | splicing factor proline/glutamine-rich | 0.0249874 |
| Symbol | Name | Standardized Value |
|---|---|---|
| ACTN4 | actinin, alpha 4 | -0.126261 |
| SLC12A2 | solute carrier family 12 (sodium/potassium/chloride transporter), member 2 | -0.123134 |
| ST3GAL1 | ST3 beta-galactoside alpha-2,3-sialyltransferase 1 | -0.120409 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.103203 |
| CYP3A5 | cytochrome P450, family 3, subfamily A, polypeptide 5 | -0.0810653 |
| RPLP1 | ribosomal protein, large, P1 | -0.0789071 |
| RPS24 | ribosomal protein S24 | -0.0773194 |
| TMSB10 | thymosin beta 10 | -0.072542 |
| RPL35A | ribosomal protein L35a | -0.071876 |
| SAMD12 | sterile alpha motif domain containing 12 | -0.0705647 |
| NAALADL2 | N-acetylated alpha-linked acidic dipeptidase-like 2 | -0.0666824 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0649856 |
| RPL23 | ribosomal protein L23 | -0.0645208 |
| WWC1 | WW and C2 domain containing 1 | -0.0617909 |
| SEMA4B | sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B | -0.0612838 |
| ACTG1 | actin gamma 1 | -0.0605063 |
| PATJ | PATJ crumbs cell polarity complex component | -0.0587702 |
| STK24 | serine/threonine kinase 24 | -0.0587307 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.058444 |
| S100A10 | S100 calcium binding protein A10 | -0.0558407 |
| TRAPPC9 | trafficking protein particle complex 9 | -0.0541733 |
| C6ORF132 | chromosome 6 open reading frame 132 | -0.0539349 |
| SLC45A4 | solute carrier family 45, member 4 | -0.0531472 |
| NIBAN2 | niban apoptosis regulator 2 | -0.0529596 |
| LPP | LIM domain containing preferred translocation partner in lipoma | -0.0517915 |
| B4GALT5 | UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 | -0.0516671 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.051289 |
| RPL34 | ribosomal protein L34 | -0.0507659 |
| SMAD3 | SMAD family member 3 | -0.050584 |
| RPS8 | ribosomal protein S8 | -0.0499024 |
| DIAPH2 | diaphanous-related formin 2 | -0.0467281 |
| TMEM123 | transmembrane protein 123 | -0.0453852 |
| GMDS | GDP-mannose 4,6-dehydratase | -0.0450451 |
| ITGA6 | integrin, alpha 6 | -0.0449573 |
| ABCC3 | ATP-binding cassette, sub-family C (CFTR/MRP), member 3 | -0.0447891 |
| PTMA | prothymosin, alpha | -0.0443337 |
| NECTIN2 | nectin cell adhesion molecule 2 | -0.0430721 |
| ANXA2 | annexin A2 | -0.0427336 |
| CCSER1 | coiled-coil serine-rich protein 1 | -0.042019 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.041771 |
| RPL28 | ribosomal protein L28 | -0.041755 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.04107 |
| SDC4 | syndecan 4 | -0.0404684 |
| RAD21 | RAD21 homolog (S. pombe) | -0.0404306 |
| BCL2L1 | BCL2-like 1 | -0.0403151 |
| PRKN | parkin RBR E3 ubiquitin protein ligase | -0.0400203 |
| BAIAP2L1 | BAI1-associated protein 2-like 1 | -0.0396979 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | -0.0392584 |
| NSMCE2 | non-SMC element 2, MMS21 homolog (S. cerevisiae) | -0.0387948 |
| ETV6 | ets variant 6 | -0.0386556 |
| RPLP0 | ribosomal protein, large, P0 | -0.0384312 |
| PARD3 | par-3 family cell polarity regulator | -0.0382931 |
| KLF3 | Kruppel-like factor 3 (basic) | -0.0373661 |
| SERINC5 | serine incorporator 5 | -0.0369239 |
| ARHGAP32 | Rho GTPase activating protein 32 | -0.0365928 |
| ID1 | inhibitor of DNA binding 1, dominant negative helix-loop-helix protein | -0.0364115 |
| EXOC4 | exocyst complex component 4 | -0.0363234 |
| RPS25 | ribosomal protein S25 | -0.036312 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | -0.0357744 |
| HMGB1 | high mobility group box 1 | -0.0357564 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0357058 |
| NF1 | neurofibromin 1 | -0.035394 |
| PTPRK | protein tyrosine phosphatase, receptor type, K | -0.0351811 |
| RPS21 | ribosomal protein S21 | -0.0350499 |
| RPLP2 | ribosomal protein, large, P2 | -0.0347625 |
| DGKH | diacylglycerol kinase, eta | -0.0343285 |
| RPS19 | ribosomal protein S19 | -0.0342305 |
| VCL | vinculin | -0.0341074 |
| KRT8 | keratin 8, type II | -0.0340571 |
| CAPZB | capping protein (actin filament) muscle Z-line, beta | -0.0328888 |
| CYRIB | CYFIP related Rac1 interactor B | -0.0326288 |
| AGR2 | anterior gradient 2 | -0.032467 |
| GCC2 | GRIP and coiled-coil domain containing 2 | -0.0324273 |
| RHPN2 | rhophilin, Rho GTPase binding protein 2 | -0.0321975 |
| MAML3 | mastermind-like 3 (Drosophila) | -0.0318753 |
| LGALS4 | lectin, galactoside-binding, soluble, 4 | -0.031658 |
| NT5C2 | 5'-nucleotidase, cytosolic II | -0.0314824 |
| CTBP2 | C-terminal binding protein 2 | -0.0314215 |
| EIF4G3 | eukaryotic translation initiation factor 4 gamma, 3 | -0.0312999 |
| CTTNBP2NL | CTTNBP2 N-terminal like | -0.0312006 |
| YWHAB | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta | -0.0311924 |
| SMYD3 | SET and MYND domain containing 3 | -0.0310896 |
| FRY | furry homolog (Drosophila) | -0.0310222 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0309933 |
| KIAA0232 | KIAA0232 | -0.0308538 |
| RPL27A | ribosomal protein L27a | -0.0306445 |
| LIMA1 | LIM domain and actin binding 1 | -0.0306409 |
| KLF10 | Kruppel-like factor 10 | -0.0303086 |
| ARPC2 | actin related protein 2/3 complex, subunit 2, 34kDa | -0.0302012 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0301787 |
| STAU1 | staufen double-stranded RNA binding protein 1 | -0.0301501 |
| TBL1XR1 | transducin (beta)-like 1 X-linked receptor 1 | -0.0299395 |
| LATS2 | large tumor suppressor kinase 2 | -0.0299253 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0297357 |
| PRELID2 | PRELI domain containing 2 | -0.0294164 |
| RAPGEF5 | Rap guanine nucleotide exchange factor (GEF) 5 | -0.0293299 |
| RPL9 | ribosomal protein L9 | -0.0292095 |
| SMURF1 | SMAD specific E3 ubiquitin protein ligase 1 | -0.0287745 |
| PYGB | phosphorylase, glycogen; brain | -0.0287628 |
| RPL38 | ribosomal protein L38 | -0.0285942 |
