| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Tirabrutinib (hydrochloride) perturbation in HepG2/C3A cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Tirabrutinib (hydrochloride)_HepG2/C3A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| IGF2 | insulin-like growth factor 2 | 0.195232 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.162773 |
| C3 | complement component 3 | 0.127239 |
| FN1 | fibronectin 1 | 0.111715 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0966327 |
| IGFBP1 | insulin-like growth factor binding protein 1 | 0.0937091 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0901343 |
| DSPP | dentin sialophosphoprotein | 0.0670987 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0656031 |
| TF | transferrin | 0.0631531 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.0617691 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0593518 |
| DDIT4 | DNA-damage-inducible transcript 4 | 0.0590788 |
| SERPINA3 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 | 0.0586593 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0551626 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0513807 |
| DNAJB1 | DnaJ (Hsp40) homolog, subfamily B, member 1 | 0.0496057 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0492216 |
| TNFAIP3 | tumor necrosis factor, alpha-induced protein 3 | 0.0486375 |
| APOB | apolipoprotein B | 0.039212 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0374921 |
| PEG3 | paternally expressed 3 | 0.0359081 |
| ICAM1 | intercellular adhesion molecule 1 | 0.035614 |
| VEGFA | vascular endothelial growth factor A | 0.0347513 |
| CCL20 | chemokine (C-C motif) ligand 20 | 0.0328509 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0325741 |
| MCL1 | myeloid cell leukemia 1 | 0.0323616 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | 0.0320022 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0305482 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0297163 |
| FOS | FBJ murine osteosarcoma viral oncogene homolog | 0.0296736 |
| TCIM | transcriptional and immune response regulator | 0.0287313 |
| FBF1 | Fas (TNFRSF6) binding factor 1 | 0.0277519 |
| NEDD9 | neural precursor cell expressed, developmentally down-regulated 9 | 0.0269716 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.0258932 |
| JMJD1C | jumonji domain containing 1C | 0.0255985 |
| FOSB | FBJ murine osteosarcoma viral oncogene homolog B | 0.0244278 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | 0.0235515 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | 0.0232237 |
| RPL3 | ribosomal protein L3 | 0.0231523 |
| TNS1 | tensin 1 | 0.0225985 |
| CRY1 | cryptochrome circadian clock 1 | 0.0224846 |
| GABBR1 | gamma-aminobutyric acid (GABA) B receptor, 1 | 0.0223482 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0221979 |
| HSPH1 | heat shock 105kDa/110kDa protein 1 | 0.0218292 |
| MAN1A1 | mannosidase, alpha, class 1A, member 1 | 0.0218206 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0217534 |
| SFTPA2 | surfactant protein A2 | 0.0216132 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0216027 |
| APOA1 | apolipoprotein A-I | 0.021538 |
| TNIP1 | TNFAIP3 interacting protein 1 | 0.0210188 |
| SPATA13 | spermatogenesis associated 13 | 0.0208855 |
| SEPTIN9 | septin 9 | 0.0207203 |
| DNAJA1 | DnaJ (Hsp40) homolog, subfamily A, member 1 | 0.0199626 |
| CSDE1 | cold shock domain containing E1, RNA-binding | 0.0199332 |
| GDF15 | growth differentiation factor 15 | 0.0198329 |
| TPT1 | tumor protein, translationally-controlled 1 | 0.0195174 |
| NFKBIA | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | 0.0194002 |
| ACSL4 | acyl-CoA synthetase long-chain family member 4 | 0.0188214 |
| SOX9 | SRY (sex determining region Y)-box 9 | 0.018498 |
| ATF3 | activating transcription factor 3 | 0.0184845 |
| CLU | clusterin | 0.0183086 |
| EFNA1 | ephrin-A1 | 0.0182255 |
| ADM | adrenomedullin | 0.0181731 |
| EZR | ezrin | 0.0179765 |
| DDX5 | DEAD (Asp-Glu-Ala-Asp) box helicase 5 | 0.0175736 |
| JAK1 | Janus kinase 1 | 0.0170856 |
| SYNE1 | spectrin repeat containing, nuclear envelope 1 | 0.016999 |
| BIRC3 | baculoviral IAP repeat containing 3 | 0.0165431 |
| APP | amyloid beta (A4) precursor protein | 0.0163525 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0163428 |
| AMBP | alpha-1-microglobulin/bikunin precursor | 0.0162342 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | 0.0161065 |
| RPL19 | ribosomal protein L19 | 0.0159721 |
| EIF4A2 | eukaryotic translation initiation factor 4A2 | 0.0157579 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0154805 |
| ANKRD1 | ankyrin repeat domain 1 (cardiac muscle) | 0.0154549 |
| SESTD1 | SEC14 and spectrin domains 1 | 0.0152759 |
| MATR3 | matrin 3 | 0.0152493 |
| SMAD3 | SMAD family member 3 | 0.015074 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.014978 |
| CALR | calreticulin | 0.0148288 |
| RPS3 | ribosomal protein S3 | 0.0147884 |
| CP | ceruloplasmin (ferroxidase) | 0.014726 |
| PLEC | plectin | 0.0147222 |
| RPS4X | ribosomal protein S4, X-linked | 0.014698 |
| KDM3B | lysine (K)-specific demethylase 3B | 0.0146629 |
| KIF5B | kinesin family member 5B | 0.0146408 |
| HSPA1A | heat shock 70kDa protein 1A | 0.0146004 |
| RYBP | RING1 and YY1 binding protein | 0.0143794 |
| PEG10 | paternally expressed 10 | 0.0143249 |
| GOLGB1 | golgin B1 | 0.0142686 |
| INTS6 | integrator complex subunit 6 | 0.0142558 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0141152 |
| TM9SF3 | transmembrane 9 superfamily member 3 | 0.0139626 |
| TPM3 | tropomyosin 3 | 0.0138731 |
| SERINC1 | serine incorporator 1 | 0.0138224 |
| YWHAE | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon | 0.0136558 |
| SPTAN1 | spectrin, alpha, non-erythrocytic 1 | 0.0135541 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0135365 |
| Symbol | Name | Standardized Value |
|---|---|---|
| SERPINA1 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 | -0.20466 |
| MT2A | metallothionein 2A | -0.0923257 |
| PLCB1 | phospholipase C, beta 1 (phosphoinositide-specific) | -0.0742519 |
| TIMP1 | TIMP metallopeptidase inhibitor 1 | -0.0575923 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.0575839 |
| APOA2 | apolipoprotein A-II | -0.0480654 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0474571 |
| FRMD5 | FERM domain containing 5 | -0.046573 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0409228 |
| DOCK4 | dedicator of cytokinesis 4 | -0.0408914 |
| MAML2 | mastermind-like 2 (Drosophila) | -0.0390716 |
| EHBP1 | EH domain binding protein 1 | -0.0360748 |
| DLC1 | DLC1 Rho GTPase activating protein | -0.0359565 |
| ENO1 | enolase 1, (alpha) | -0.0338443 |
| HMGA1 | high mobility group AT-hook 1 | -0.0334828 |
| PLIN2 | perilipin 2 | -0.0312227 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.0305335 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0304475 |
| MRTFA | myocardin related transcription factor A | -0.0281583 |
| SPATS2L | spermatogenesis associated, serine-rich 2-like | -0.0279007 |
| TMSB10 | thymosin beta 10 | -0.0274248 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.0271076 |
| ROBO1 | roundabout, axon guidance receptor, homolog 1 (Drosophila) | -0.0266692 |
| ITGAV | integrin, alpha V | -0.0266432 |
| UBE2D2 | ubiquitin-conjugating enzyme E2D 2 | -0.0264064 |
| KIZ | kizuna centrosomal protein | -0.026299 |
| TMEM123 | transmembrane protein 123 | -0.0260615 |
| SNTB1 | syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) | -0.0257726 |
| FNDC3A | fibronectin type III domain containing 3A | -0.0256803 |
| SAMD4A | sterile alpha motif domain containing 4A | -0.0245239 |
| RPLP1 | ribosomal protein, large, P1 | -0.0237811 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0234967 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | -0.022681 |
| MAP4K3 | mitogen-activated protein kinase kinase kinase kinase 3 | -0.0211429 |
| ABTB3 | ankyrin repeat and BTB domain containing 3 | -0.0207393 |
| PIK3C2A | phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha | -0.0206665 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0204965 |
| VCL | vinculin | -0.0203042 |
| RAB6A | RAB6A, member RAS oncogene family | -0.0202296 |
| KCMF1 | potassium channel modulatory factor 1 | -0.0201242 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | -0.0197982 |
| VEZT | vezatin, adherens junctions transmembrane protein | -0.0197311 |
| TRAM1 | translocation associated membrane protein 1 | -0.0192178 |
| SCN9A | sodium channel, voltage gated, type IX alpha subunit | -0.019193 |
| CAMTA1 | calmodulin binding transcription activator 1 | -0.0191001 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0189077 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0186156 |
| FARP1 | FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived) | -0.0186133 |
| RPL35A | ribosomal protein L35a | -0.0185651 |
| GPC6 | glypican 6 | -0.0185598 |
| MALT1 | MALT1 paracaspase | -0.0183618 |
| PCBP2 | poly(rC) binding protein 2 | -0.017923 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | -0.0173244 |
| FAM135A | family with sequence similarity 135, member A | -0.0172604 |
| EIF4G3 | eukaryotic translation initiation factor 4 gamma, 3 | -0.0170709 |
| RALGAPA2 | Ral GTPase activating protein, alpha subunit 2 (catalytic) | -0.01696 |
| ARHGAP18 | Rho GTPase activating protein 18 | -0.0168897 |
| VPS54 | vacuolar protein sorting 54 homolog (S. cerevisiae) | -0.016819 |
| ARHGEF18 | Rho/Rac guanine nucleotide exchange factor (GEF) 18 | -0.016678 |
| ITPR2 | inositol 1,4,5-trisphosphate receptor, type 2 | -0.0166174 |
| RPS21 | ribosomal protein S21 | -0.0164553 |
| KDM4C | lysine (K)-specific demethylase 4C | -0.0163389 |
| PTTG1IP | pituitary tumor-transforming 1 interacting protein | -0.0163225 |
| KIF1B | kinesin family member 1B | -0.0161338 |
| DST | dystonin | -0.0160656 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.0159579 |
| PCGF5 | polycomb group ring finger 5 | -0.0159063 |
| RPL34 | ribosomal protein L34 | -0.0158351 |
| ISG15 | ISG15 ubiquitin-like modifier | -0.0157556 |
| USP34 | ubiquitin specific peptidase 34 | -0.0157488 |
| RPS25 | ribosomal protein S25 | -0.0154783 |
| GMDS | GDP-mannose 4,6-dehydratase | -0.0154421 |
| CAPZB | capping protein (actin filament) muscle Z-line, beta | -0.0154055 |
| AFDN | afadin, adherens junction formation factor | -0.0153269 |
| IFI6 | interferon, alpha-inducible protein 6 | -0.0153183 |
| MACF1 | microtubule-actin crosslinking factor 1 | -0.0152098 |
| ITGB5 | integrin, beta 5 | -0.0151986 |
| PFN1 | profilin 1 | -0.0150632 |
| MT1X | metallothionein 1X | -0.0150435 |
| RBMS1 | RNA binding motif, single stranded interacting protein 1 | -0.0148863 |
| RPL39 | ribosomal protein L39 | -0.0148569 |
| N4BP1 | NEDD4 binding protein 1 | -0.0147842 |
| RPL28 | ribosomal protein L28 | -0.0147297 |
| PRKCA | protein kinase C, alpha | -0.0147212 |
| TPM4 | tropomyosin 4 | -0.014706 |
| ROCK2 | Rho-associated, coiled-coil containing protein kinase 2 | -0.0145365 |
| BNIP3 | BCL2/adenovirus E1B 19kDa interacting protein 3 | -0.0143997 |
| LPIN2 | lipin 2 | -0.0142634 |
| FOXP1 | forkhead box P1 | -0.014235 |
| ACTR3 | ARP3 actin-related protein 3 homolog (yeast) | -0.0141485 |
| LRRC1 | leucine rich repeat containing 1 | -0.0137326 |
| DENND1A | DENN/MADD domain containing 1A | -0.0136265 |
| FAM162A | family with sequence similarity 162, member A | -0.0132708 |
| PHF21A | PHD finger protein 21A | -0.0132481 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.0130432 |
| ETFB | electron-transfer-flavoprotein, beta polypeptide | -0.0129722 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0128945 |
| OSBPL10 | oxysterol binding protein-like 10 | -0.0128652 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0127235 |
| RPLP0 | ribosomal protein, large, P0 | -0.0126793 |
