| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Tirabrutinib (hydrochloride) perturbation in Hs 766T cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Tirabrutinib (hydrochloride)_Hs 766T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| NDRG1 | N-myc downstream regulated 1 | 0.222031 |
| FLNB | filamin B, beta | 0.151444 |
| CLU | clusterin | 0.142982 |
| MEF2A | myocyte enhancer factor 2A | 0.133622 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.116357 |
| ANXA1 | annexin A1 | 0.0959366 |
| GOLGA4 | golgin A4 | 0.0880797 |
| KRT17 | keratin 17, type I | 0.0855444 |
| EZR | ezrin | 0.0841001 |
| PGK1 | phosphoglycerate kinase 1 | 0.0837936 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0832136 |
| EMP1 | epithelial membrane protein 1 | 0.0822213 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.075915 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0754147 |
| TGM2 | transglutaminase 2 | 0.0710983 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0680503 |
| ENO1 | enolase 1, (alpha) | 0.0657395 |
| SQLE | squalene epoxidase | 0.065653 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.0636903 |
| ITCH | itchy E3 ubiquitin protein ligase | 0.0629917 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | 0.0617372 |
| MBNL2 | muscleblind-like splicing regulator 2 | 0.0612322 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0610195 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0609315 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0609217 |
| OGA | O-GlcNAcase | 0.0599432 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0558757 |
| DSTN | destrin (actin depolymerizing factor) | 0.053115 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0509751 |
| LMNA | lamin A/C | 0.0508022 |
| LOC112694756 | uncharaterized LOC112694756 | 0.049866 |
| CANX | calnexin | 0.0495076 |
| SLC2A1 | solute carrier family 2 (facilitated glucose transporter), member 1 | 0.0474617 |
| NFATC2 | nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 | 0.0473792 |
| ARRDC3 | arrestin domain containing 3 | 0.0467107 |
| STC1 | stanniocalcin 1 | 0.0462195 |
| COPA | coatomer protein complex, subunit alpha | 0.0460916 |
| LDHA | lactate dehydrogenase A | 0.0455752 |
| SUCO | SUN domain containing ossification factor | 0.0454667 |
| PLEC | plectin | 0.0449218 |
| ANXA2 | annexin A2 | 0.0442608 |
| CD44 | CD44 molecule (Indian blood group) | 0.0438094 |
| EFHD2 | EF-hand domain family, member D2 | 0.0433609 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0428572 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | 0.0427818 |
| PDK3 | pyruvate dehydrogenase kinase, isozyme 3 | 0.0426272 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.0424971 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | 0.0421685 |
| FSCN1 | fascin actin-bundling protein 1 | 0.0418737 |
| SPAG9 | sperm associated antigen 9 | 0.0415359 |
| RBM39 | RNA binding motif protein 39 | 0.0414848 |
| FHIP1A | FHF complex subunit HOOK interacting protein 1A | 0.041269 |
| CALU | calumenin | 0.0405506 |
| MXI1 | MAX interactor 1, dimerization protein | 0.0405288 |
| MINDY2 | MINDY lysine 48 deubiquitinase 2 | 0.0403638 |
| WASF2 | WAS protein family, member 2 | 0.0399097 |
| COPB1 | coatomer protein complex, subunit beta 1 | 0.0399005 |
| ANLN | anillin, actin binding protein | 0.0394393 |
| MSN | moesin | 0.0391582 |
| TNIP1 | TNFAIP3 interacting protein 1 | 0.0384772 |
| ARFGEF2 | ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) | 0.0383597 |
| KRT14 | keratin 14, type I | 0.0381957 |
| SLC6A6 | solute carrier family 6 (neurotransmitter transporter), member 6 | 0.0381955 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.037251 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | 0.0371195 |
| PODXL | podocalyxin-like | 0.0370615 |
| FLNA | filamin A, alpha | 0.0367186 |
| SRP54 | signal recognition particle 54kDa | 0.0366594 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | 0.0363314 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0362598 |
| HLA-E | major histocompatibility complex, class I, E | 0.0358283 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0356045 |
| MORF4L2 | mortality factor 4 like 2 | 0.0353564 |
| HERC3 | HECT and RLD domain containing E3 ubiquitin protein ligase 3 | 0.0353027 |
| H1-0 | H1.0 linker histone | 0.0352998 |
| HELZ | helicase with zinc finger | 0.0352844 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | 0.0352011 |
| OPTN | optineurin | 0.0351603 |
| YBX3 | Y box binding protein 3 | 0.0350988 |
| SLK | STE20-like kinase | 0.0350205 |
| PPFIBP1 | PTPRF interacting protein, binding protein 1 (liprin beta 1) | 0.0349919 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.034592 |
| ITGA6 | integrin, alpha 6 | 0.0341085 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | 0.0340089 |
| ACBD3 | acyl-CoA binding domain containing 3 | 0.0339212 |
| DPM1 | dolichyl-phosphate mannosyltransferase polypeptide 1, catalytic subunit | 0.0337593 |
| KDM6A | lysine (K)-specific demethylase 6A | 0.0337 |
| RNF145 | ring finger protein 145 | 0.0335246 |
| EGLN1 | egl-9 family hypoxia-inducible factor 1 | 0.032887 |
| SERINC3 | serine incorporator 3 | 0.0327375 |
| NPEPPS | aminopeptidase puromycin sensitive | 0.0324818 |
| PJA2 | praja ring finger 2, E3 ubiquitin protein ligase | 0.0324603 |
| ZNF292 | zinc finger protein 292 | 0.0322754 |
| KDM5B | lysine (K)-specific demethylase 5B | 0.0320398 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | 0.0319491 |
| KRT6A | keratin 6A, type II | 0.0318969 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0318577 |
| LMAN1 | lectin, mannose-binding, 1 | 0.0317507 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | 0.0315668 |
| PTMA | prothymosin, alpha | 0.0312461 |
| Symbol | Name | Standardized Value |
|---|---|---|
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.192389 |
| IL1RAPL1 | interleukin 1 receptor accessory protein-like 1 | -0.128751 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0843984 |
| PALM2AKAP2 | PALM2 and AKAP2 fusion | -0.0794044 |
| INTS6 | integrator complex subunit 6 | -0.0636549 |
| DPYD | dihydropyrimidine dehydrogenase | -0.0636202 |
| HMGA2 | high mobility group AT-hook 2 | -0.0525968 |
| PDLIM5 | PDZ and LIM domain 5 | -0.0504679 |
| BCAR3 | breast cancer anti-estrogen resistance 3 | -0.0495272 |
| SLC35F3 | solute carrier family 35, member F3 | -0.0476986 |
| RAD51B | RAD51 paralog B | -0.0465237 |
| RABGAP1L | RAB GTPase activating protein 1-like | -0.0449202 |
| ST3GAL6 | ST3 beta-galactoside alpha-2,3-sialyltransferase 6 | -0.0438274 |
| HIVEP3 | human immunodeficiency virus type I enhancer binding protein 3 | -0.0412077 |
| EFNA5 | ephrin-A5 | -0.040606 |
| RIGI | RNA sensor RIG-I | -0.0401399 |
| MECOM | MDS1 and EVI1 complex locus | -0.037831 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0375932 |
| FOXP1 | forkhead box P1 | -0.0373906 |
| OSMR | oncostatin M receptor | -0.0371655 |
| SULF2 | sulfatase 2 | -0.0363795 |
| TIMP3 | TIMP metallopeptidase inhibitor 3 | -0.0352628 |
| ANO1 | anoctamin 1, calcium activated chloride channel | -0.0344536 |
| SMYD3 | SET and MYND domain containing 3 | -0.0344167 |
| RALY | RALY heterogeneous nuclear ribonucleoprotein | -0.0335469 |
| MACF1 | microtubule-actin crosslinking factor 1 | -0.0331374 |
| RASAL2 | RAS protein activator like 2 | -0.0329724 |
| AOPEP | aminopeptidase O (putative) | -0.03203 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0313577 |
| MTAP | methylthioadenosine phosphorylase | -0.0292058 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | -0.0288568 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | -0.0286664 |
| DDX60L | DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like | -0.0286256 |
| EPB41L1 | erythrocyte membrane protein band 4.1-like 1 | -0.0280333 |
| EIF4G3 | eukaryotic translation initiation factor 4 gamma, 3 | -0.0280068 |
| CDK6 | cyclin-dependent kinase 6 | -0.0277171 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | -0.0270415 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0265282 |
| BRIP1 | BRCA1 interacting protein C-terminal helicase 1 | -0.0263803 |
| EXOC4 | exocyst complex component 4 | -0.0260603 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0255439 |
| FAF1 | Fas (TNFRSF6) associated factor 1 | -0.0254045 |
| CNTNAP3 | contactin associated protein-like 3 | -0.0253259 |
| CSMD2 | CUB and Sushi multiple domains 2 | -0.0251951 |
| HDAC9 | histone deacetylase 9 | -0.0251046 |
| RPS24 | ribosomal protein S24 | -0.0249025 |
| CORO2A | coronin, actin binding protein, 2A | -0.0241878 |
| DGKH | diacylglycerol kinase, eta | -0.0240974 |
| RPL35A | ribosomal protein L35a | -0.0237877 |
| MAML2 | mastermind-like 2 (Drosophila) | -0.0236155 |
| RPLP1 | ribosomal protein, large, P1 | -0.0229864 |
| ACTG1 | actin gamma 1 | -0.0226022 |
| THSD4 | thrombospondin, type I, domain containing 4 | -0.0222823 |
| WNT2B | wingless-type MMTV integration site family, member 2B | -0.0219663 |
| TTC28 | tetratricopeptide repeat domain 28 | -0.0219062 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0218563 |
| SLCO1B3-SLCO1B7 | SLCO1B3-SLCO1B7 readthrough | -0.0217995 |
| CFLAR | CASP8 and FADD-like apoptosis regulator | -0.0217174 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0217095 |
| NSMCE2 | non-SMC element 2, MMS21 homolog (S. cerevisiae) | -0.0216646 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0216191 |
| RPS8 | ribosomal protein S8 | -0.0214877 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.0212756 |
| KIAA1671 | KIAA1671 | -0.0206234 |
| IFI44L | interferon-induced protein 44-like | -0.0205497 |
| SPIDR | scaffolding protein involved in DNA repair | -0.0203155 |
| PLXNA2 | plexin A2 | -0.02022 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.020032 |
| RPL26 | ribosomal protein L26 | -0.0200259 |
| RPLP2 | ribosomal protein, large, P2 | -0.0199546 |
| ZNFX1 | zinc finger, NFX1-type containing 1 | -0.0198488 |
| CDC42BPA | CDC42 binding protein kinase alpha (DMPK-like) | -0.0197373 |
| CTBP2 | C-terminal binding protein 2 | -0.0197168 |
| EGFR | epidermal growth factor receptor | -0.0195924 |
| CUX1 | cut-like homeobox 1 | -0.0195042 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.0194189 |
| TRAPPC9 | trafficking protein particle complex 9 | -0.0191888 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | -0.0187463 |
| ALCAM | activated leukocyte cell adhesion molecule | -0.0185926 |
| RPL37A | ribosomal protein L37a | -0.0184671 |
| CDH11 | cadherin 11, type 2, OB-cadherin (osteoblast) | -0.0182662 |
| SEMA4A | sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A | -0.0182489 |
| SOX5 | SRY (sex determining region Y)-box 5 | -0.0181535 |
| PALLD | palladin, cytoskeletal associated protein | -0.0180032 |
| FRMD4B | FERM domain containing 4B | -0.0179581 |
| PRSS23 | protease, serine, 23 | -0.0178959 |
| ZC3H12C | zinc finger CCCH-type containing 12C | -0.0178653 |
| IQCJ-SCHIP1 | IQCJ-SCHIP1 readthrough | -0.017832 |
| LAMC2 | laminin, gamma 2 | -0.0177651 |
| UTRN | utrophin | -0.0177371 |
| RPL34 | ribosomal protein L34 | -0.0173016 |
| DNAJC18 | DnaJ (Hsp40) homolog, subfamily C, member 18 | -0.0170457 |
| MAML3 | mastermind-like 3 (Drosophila) | -0.0169215 |
| LUZP1 | leucine zipper protein 1 | -0.0168605 |
| RPL36A | ribosomal protein L36a | -0.0167462 |
| VTI1A | vesicle transport through interaction with t-SNAREs 1A | -0.0167438 |
| PCDH9 | protocadherin 9 | -0.0165876 |
| SP100 | SP100 nuclear antigen | -0.0165484 |
| TENM4 | teneurin transmembrane protein 4 | -0.0165332 |
| WARS1 | tryptophanyl-tRNA synthetase 1 | -0.0163638 |
