| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Tirabrutinib (hydrochloride) perturbation in J82 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Tirabrutinib (hydrochloride)_J82 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.110111 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.101108 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0849314 |
| AHNAK | AHNAK nucleoprotein | 0.0783363 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0668212 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.0586091 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0542954 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.052909 |
| CANX | calnexin | 0.0441144 |
| UGCG | UDP-glucose ceramide glucosyltransferase | 0.0439089 |
| ZNF841 | zinc finger protein 841 | 0.0437514 |
| ANXA1 | annexin A1 | 0.0429668 |
| ATP13A3 | ATPase type 13A3 | 0.0418567 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0399166 |
| SPAG9 | sperm associated antigen 9 | 0.0385666 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0382704 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0382494 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0357931 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | 0.034796 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0323251 |
| TPD52 | tumor protein D52 | 0.0322851 |
| NUP58 | nucleoporin 58 | 0.0309106 |
| HLA-C | major histocompatibility complex, class I, C | 0.0308038 |
| HMGB2 | high mobility group box 2 | 0.030438 |
| ARFGEF2 | ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) | 0.030156 |
| JUN | jun proto-oncogene | 0.0301029 |
| SMAD3 | SMAD family member 3 | 0.0294334 |
| ANKRD10 | ankyrin repeat domain 10 | 0.0291316 |
| RLF | rearranged L-myc fusion | 0.0289471 |
| TXNRD1 | thioredoxin reductase 1 | 0.0284467 |
| FLNB | filamin B, beta | 0.0282213 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.0280968 |
| HLA-E | major histocompatibility complex, class I, E | 0.0278119 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.0262708 |
| FSTL1 | follistatin-like 1 | 0.02556 |
| AFAP1 | actin filament associated protein 1 | 0.0252517 |
| ZNF292 | zinc finger protein 292 | 0.0252033 |
| SUCO | SUN domain containing ossification factor | 0.024497 |
| PLEC | plectin | 0.024489 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | 0.0239661 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | 0.0235188 |
| CAVIN1 | caveolae associated protein 1 | 0.0227762 |
| CALR | calreticulin | 0.0225029 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.022233 |
| WAC | WW domain containing adaptor with coiled-coil | 0.0221206 |
| ADM | adrenomedullin | 0.0219355 |
| B4GALT5 | UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 | 0.021926 |
| TRPM7 | transient receptor potential cation channel, subfamily M, member 7 | 0.0218017 |
| RAD21 | RAD21 homolog (S. pombe) | 0.0215072 |
| ZFAND3 | zinc finger, AN1-type domain 3 | 0.021281 |
| OGA | O-GlcNAcase | 0.021194 |
| ANKRD33B | ankyrin repeat domain 33B | 0.0210643 |
| YWHAE | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon | 0.020871 |
| BZW1 | basic leucine zipper and W2 domains 1 | 0.0207912 |
| RAD23B | RAD23 homolog B (S. cerevisiae) | 0.0206303 |
| COL4A2 | collagen, type IV, alpha 2 | 0.0206156 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.020483 |
| DPM1 | dolichyl-phosphate mannosyltransferase polypeptide 1, catalytic subunit | 0.0204568 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0201179 |
| USP9X | ubiquitin specific peptidase 9, X-linked | 0.0199459 |
| EIF4A2 | eukaryotic translation initiation factor 4A2 | 0.019844 |
| ECT2 | epithelial cell transforming 2 | 0.0196536 |
| ANO6 | anoctamin 6 | 0.0195238 |
| QKI | QKI, KH domain containing, RNA binding | 0.0194913 |
| LOX | lysyl oxidase | 0.0192775 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0191858 |
| RBM39 | RNA binding motif protein 39 | 0.0191045 |
| KRT18 | keratin 18, type I | 0.0190359 |
| NPEPPS | aminopeptidase puromycin sensitive | 0.0188224 |
| USP3 | ubiquitin specific peptidase 3 | 0.0187458 |
| TFRC | transferrin receptor | 0.0187402 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | 0.0186887 |
| ZFR | zinc finger RNA binding protein | 0.0184451 |
| EGLN1 | egl-9 family hypoxia-inducible factor 1 | 0.0184329 |
| MLF1 | myeloid leukemia factor 1 | 0.0182727 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0182514 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | 0.0182138 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0181786 |
| SF3B2 | splicing factor 3b, subunit 2, 145kDa | 0.0180539 |
| PRKDC | protein kinase, DNA-activated, catalytic polypeptide | 0.0180071 |
| MXI1 | MAX interactor 1, dimerization protein | 0.0179971 |
| HDLBP | high density lipoprotein binding protein | 0.0179365 |
| ANXA2 | annexin A2 | 0.0179131 |
| FXR1 | fragile X mental retardation, autosomal homolog 1 | 0.0175724 |
| GOLGA4 | golgin A4 | 0.0175204 |
| IL1RAP | interleukin 1 receptor accessory protein | 0.0174844 |
| APP | amyloid beta (A4) precursor protein | 0.0173722 |
| PFKFB3 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 | 0.0172065 |
| FLNA | filamin A, alpha | 0.0172005 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | 0.017177 |
| SLC12A8 | solute carrier family 12, member 8 | 0.0171576 |
| DENND4C | DENN/MADD domain containing 4C | 0.0169857 |
| TRAM2 | translocation associated membrane protein 2 | 0.0168189 |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | 0.0167157 |
| ZMYM2 | zinc finger, MYM-type 2 | 0.0166114 |
| UBQLN1 | ubiquilin 1 | 0.0165324 |
| TFG | TRK-fused gene | 0.0164479 |
| SPTAN1 | spectrin, alpha, non-erythrocytic 1 | 0.0163994 |
| NCKAP1 | NCK-associated protein 1 | 0.0163569 |
| FAR1 | fatty acyl CoA reductase 1 | 0.0163063 |
| Symbol | Name | Standardized Value |
|---|---|---|
| MT2A | metallothionein 2A | -0.194159 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -0.173461 |
| NALF1 | NALCN channel auxiliary factor 1 | -0.133441 |
| POTEF | POTE ankyrin domain family, member F | -0.107378 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0887346 |
| FTL | ferritin, light polypeptide | -0.0862849 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0807171 |
| TMSB10 | thymosin beta 10 | -0.0759342 |
| VIM | vimentin | -0.0714531 |
| HLA-B | major histocompatibility complex, class I, B | -0.0710503 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0665401 |
| PFN1 | profilin 1 | -0.0611974 |
| RPL35A | ribosomal protein L35a | -0.0591387 |
| RPS6 | ribosomal protein S6 | -0.055337 |
| CD44 | CD44 molecule (Indian blood group) | -0.0548713 |
| MT1X | metallothionein 1X | -0.0468224 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.0439298 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.0424389 |
| ACTG1 | actin gamma 1 | -0.0403505 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0387894 |
| F3 | coagulation factor III (thromboplastin, tissue factor) | -0.0372862 |
| B2M | beta-2-microglobulin | -0.0367935 |
| YWHAB | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta | -0.0363765 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | -0.036176 |
| RPLP2 | ribosomal protein, large, P2 | -0.0343184 |
| ENO1 | enolase 1, (alpha) | -0.0336496 |
| HMGA1 | high mobility group AT-hook 1 | -0.0323033 |
| KRT7 | keratin 7, type II | -0.0308816 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0303867 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0296337 |
| TPM1 | tropomyosin 1 (alpha) | -0.0295565 |
| TPI1 | triosephosphate isomerase 1 | -0.0282475 |
| RPS8 | ribosomal protein S8 | -0.0279213 |
| LDHA | lactate dehydrogenase A | -0.0276772 |
| ERBIN | erbb2 interacting protein | -0.0276247 |
| DEK | DEK proto-oncogene | -0.0271783 |
| S100A6 | S100 calcium binding protein A6 | -0.0267209 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0265202 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.0259365 |
| SDK1 | sidekick cell adhesion molecule 1 | -0.0256032 |
| TUBA1C | tubulin, alpha 1c | -0.024633 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | -0.024412 |
| PKM | pyruvate kinase, muscle | -0.0241924 |
| FOSL1 | FOS-like antigen 1 | -0.0241632 |
| MSN | moesin | -0.0238661 |
| TIMP2 | TIMP metallopeptidase inhibitor 2 | -0.0238452 |
| PHACTR1 | phosphatase and actin regulator 1 | -0.0235902 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | -0.0232913 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0231222 |
| RPS19 | ribosomal protein S19 | -0.0230622 |
| SIPA1L3 | signal-induced proliferation-associated 1 like 3 | -0.0229416 |
| RPL23 | ribosomal protein L23 | -0.0227732 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0226216 |
| PSMA7 | proteasome (prosome, macropain) subunit, alpha type, 7 | -0.0223673 |
| VCL | vinculin | -0.0222879 |
| CENPF | centromere protein F, 350/400kDa | -0.022071 |
| TUBA1B | tubulin, alpha 1b | -0.0217694 |
| C6ORF62 | chromosome 6 open reading frame 62 | -0.0215648 |
| AXL | AXL receptor tyrosine kinase | -0.0211255 |
| RPLP1 | ribosomal protein, large, P1 | -0.0210227 |
| S100A11 | S100 calcium binding protein A11 | -0.0208254 |
| RAP1B | RAP1B, member of RAS oncogene family | -0.0205942 |
| OSMR | oncostatin M receptor | -0.0202878 |
| RPL9 | ribosomal protein L9 | -0.0194724 |
| IFI6 | interferon, alpha-inducible protein 6 | -0.0194533 |
| RAD51B | RAD51 paralog B | -0.0194179 |
| CALD1 | caldesmon 1 | -0.0193282 |
| MAP1B | microtubule-associated protein 1B | -0.0192885 |
| SEMA5A | sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A | -0.0190014 |
| RPS13 | ribosomal protein S13 | -0.0188445 |
| DIAPH3 | diaphanous-related formin 3 | -0.0186935 |
| CYB5R3 | cytochrome b5 reductase 3 | -0.018625 |
| EGR1 | early growth response 1 | -0.018443 |
| UQCRB | ubiquinol-cytochrome c reductase binding protein | -0.0184039 |
| POMP | proteasome maturation protein | -0.018297 |
| DTNA | dystrobrevin, alpha | -0.0182921 |
| HDAC9 | histone deacetylase 9 | -0.0181749 |
| CBX3 | chromobox homolog 3 | -0.0180118 |
| ATP5F1E | ATP synthase F1 subunit epsilon | -0.0180114 |
| RPL37 | ribosomal protein L37 | -0.0178196 |
| SLIT2 | slit homolog 2 (Drosophila) | -0.0177516 |
| DDAH1 | dimethylarginine dimethylaminohydrolase 1 | -0.0177163 |
| RPL12 | ribosomal protein L12 | -0.0177011 |
| IFI27 | interferon, alpha-inducible protein 27 | -0.017689 |
| TPM4 | tropomyosin 4 | -0.0175822 |
| CCDC80 | coiled-coil domain containing 80 | -0.0175752 |
| RPS21 | ribosomal protein S21 | -0.0175346 |
| RPL30 | ribosomal protein L30 | -0.0175121 |
| PPDPF | pancreatic progenitor cell differentiation and proliferation factor | -0.0174785 |
| RPL11 | ribosomal protein L11 | -0.0174523 |
| RPL37A | ribosomal protein L37a | -0.0172623 |
| HMGB1 | high mobility group box 1 | -0.017194 |
| RPL7A | ribosomal protein L7a | -0.0170911 |
| S100A9 | S100 calcium binding protein A9 | -0.0169392 |
| EIF5B | eukaryotic translation initiation factor 5B | -0.0169057 |
| SH3BGRL3 | SH3 domain binding glutamate-rich protein like 3 | -0.0168248 |
| LDHB | lactate dehydrogenase B | -0.0168188 |
| RPS3 | ribosomal protein S3 | -0.0168063 |
| CD59 | CD59 molecule, complement regulatory protein | -0.0167162 |
| TAGLN2 | transgelin 2 | -0.0165801 |
