Tirabrutinib (hydrochloride)_KATO III Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Tirabrutinib (hydrochloride) perturbation in KATO III cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Tirabrutinib (hydrochloride)_KATO III drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
KRT18 keratin 18, type I 0.11936
EMP1 epithelial membrane protein 1 0.100495
MAML2 mastermind-like 2 (Drosophila) 0.0913826
NPSR1 neuropeptide S receptor 1 0.0860641
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0743532
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0735319
FTH1 ferritin, heavy polypeptide 1 0.0650634
MYH9 myosin, heavy chain 9, non-muscle 0.0542651
EZR ezrin 0.0537076
ANXA1 annexin A1 0.0509775
MBNL2 muscleblind-like splicing regulator 2 0.0480654
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.046569
EIF4A2 eukaryotic translation initiation factor 4A2 0.0437116
VEGFA vascular endothelial growth factor A 0.042609
EEF2 eukaryotic translation elongation factor 2 0.0410613
PLEC plectin 0.0401016
TPT1 tumor protein, translationally-controlled 1 0.0383994
RPS6 ribosomal protein S6 0.0380041
APLP2 amyloid beta (A4) precursor-like protein 2 0.0379088
DSPP dentin sialophosphoprotein 0.0339197
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0334209
DSTN destrin (actin depolymerizing factor) 0.0330661
PTMA prothymosin, alpha 0.032545
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa 0.0321833
MBNL1 muscleblind-like splicing regulator 1 0.0305898
ANKRD11 ankyrin repeat domain 11 0.0298185
INTS6 integrator complex subunit 6 0.0296064
PDLIM5 PDZ and LIM domain 5 0.0287057
AHNAK AHNAK nucleoprotein 0.0281199
LPP LIM domain containing preferred translocation partner in lipoma 0.0278918
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0278037
FLNB filamin B, beta 0.0274358
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.0268801
POF1B premature ovarian failure, 1B 0.0257911
AGR3 anterior gradient 3 0.02571
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0254608
ZSWIM6 zinc finger, SWIM-type containing 6 0.0246691
HLA-B major histocompatibility complex, class I, B 0.0246207
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1 0.0244206
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0243476
GOLGA4 golgin A4 0.0242997
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0231903
ATF7IP2 activating transcription factor 7 interacting protein 2 0.023096
RPS12 ribosomal protein S12 0.0230354
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5 0.0229985
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0228524
VMP1 vacuole membrane protein 1 0.0227605
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide 0.0225935
KLHL29 kelch-like family member 29 0.0224384
FNDC3B fibronectin type III domain containing 3B 0.0223674
HSPA8 heat shock 70kDa protein 8 0.0223397
EEPD1 endonuclease/exonuclease/phosphatase family domain containing 1 0.0222532
C6ORF132 chromosome 6 open reading frame 132 0.0221427
AREG amphiregulin 0.0216979
TES testin LIM domain protein 0.0216572
LCN2 lipocalin 2 0.0215809
EGLN3 egl-9 family hypoxia-inducible factor 3 0.0213856
SLCO1B3-SLCO1B7 SLCO1B3-SLCO1B7 readthrough 0.0213083
VCL vinculin 0.0211082
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0208523
BCL2L1 BCL2-like 1 0.0203111
GRB10 growth factor receptor-bound protein 10 0.020202
RPS4X ribosomal protein S4, X-linked 0.0196048
KLF5 Kruppel-like factor 5 (intestinal) 0.0192495
TRPS1 trichorhinophalangeal syndrome I 0.0187689
CDK6 cyclin-dependent kinase 6 0.0183868
DOCK5 dedicator of cytokinesis 5 0.0177562
SFTPA2 surfactant protein A2 0.0175127
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0175045
CATSPERB catsper channel auxiliary subunit beta 0.0174844
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0174782
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0174559
UBASH3B ubiquitin associated and SH3 domain containing B 0.0172904
IFRD1 interferon-related developmental regulator 1 0.0172188
PHF3 PHD finger protein 3 0.0171912
FNIP1 folliculin interacting protein 1 0.0170453
SLC20A2 solute carrier family 20 (phosphate transporter), member 2 0.0169806
RPL19 ribosomal protein L19 0.01695
ITGB4 integrin, beta 4 0.0165958
SETD5 SET domain containing 5 0.0162898
SLC38A2 solute carrier family 38, member 2 0.016189
RAD51B RAD51 paralog B 0.0160613
ZKSCAN1 zinc finger with KRAB and SCAN domains 1 0.0160576
HLA-A major histocompatibility complex, class I, A 0.0160294
SMC1A structural maintenance of chromosomes 1A 0.0160197
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0159863
EXOC4 exocyst complex component 4 0.0156385
FOSB FBJ murine osteosarcoma viral oncogene homolog B 0.0155752
BTBD9 BTB (POZ) domain containing 9 0.0154002
ESYT2 extended synaptotagmin-like protein 2 0.0153756
TPM3 tropomyosin 3 0.0153535
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.0150162
RPL11 ribosomal protein L11 0.0149993
FOS FBJ murine osteosarcoma viral oncogene homolog 0.0149865
LAMB3 laminin, beta 3 0.0149583
TNIK TRAF2 and NCK interacting kinase 0.0147985
ANXA2 annexin A2 0.0147928
ATP1A4 ATPase, Na+/K+ transporting, alpha 4 polypeptide 0.0147515
ATRX alpha thalassemia/mental retardation syndrome X-linked 0.0145728
BACE2 beta-site APP-cleaving enzyme 2 0.0144685

decreased expression

Symbol Name Standardized Value
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0885542
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0752601
FGFR2 fibroblast growth factor receptor 2 -0.0573843
H1-0 H1.0 linker histone -0.0526362
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0468186
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5 -0.044008
AGR2 anterior gradient 2 -0.0373176
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) -0.0362106
TMC5 transmembrane channel-like 5 -0.035452
PRSS3 protease, serine, 3 -0.0298014
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa -0.0295585
S100A6 S100 calcium binding protein A6 -0.0271398
PDIA3 protein disulfide isomerase family A, member 3 -0.0264825
GMDS GDP-mannose 4,6-dehydratase -0.0252838
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0246791
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.0245213
TMSB10 thymosin beta 10 -0.0230637
CD2AP CD2-associated protein -0.0212867
S100A10 S100 calcium binding protein A10 -0.0212836
CEMIP cell migration inducing protein, hyaluronan binding -0.0204526
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0184027
FAT1 FAT atypical cadherin 1 -0.0181186
WDR45B WD repeat domain 45B -0.016955
STK24 serine/threonine kinase 24 -0.0168621
MUC17 mucin 17, cell surface associated -0.016313
GPX2 glutathione peroxidase 2 -0.0161886
RRBP1 ribosome binding protein 1 -0.0157521
PARP4 poly (ADP-ribose) polymerase family, member 4 -0.0155771
LMAN1 lectin, mannose-binding, 1 -0.0155627
ASNS asparagine synthetase (glutamine-hydrolyzing) -0.0153222
SH3RF1 SH3 domain containing ring finger 1 -0.0152481
TMEM45B transmembrane protein 45B -0.0148189
TMEM123 transmembrane protein 123 -0.0141508
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 -0.0140425
SMC4 structural maintenance of chromosomes 4 -0.0139638
RAB1A RAB1A, member RAS oncogene family -0.0139231
PHIP pleckstrin homology domain interacting protein -0.0138818
MUC13 mucin 13, cell surface associated -0.0137274
MED13 mediator complex subunit 13 -0.013696
SPINT2 serine peptidase inhibitor, Kunitz type, 2 -0.013439
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 -0.0134081
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0132705
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0131237
AOPEP aminopeptidase O (putative) -0.0126822
IFI27 interferon, alpha-inducible protein 27 -0.0125732
ACTN4 actinin, alpha 4 -0.0123668
EIF2AK1 eukaryotic translation initiation factor 2-alpha kinase 1 -0.0123219
PAN3 PAN3 poly(A) specific ribonuclease subunit -0.0122688
CLDN7 claudin 7 -0.0121512
SEL1L sel-1 suppressor of lin-12-like (C. elegans) -0.012136
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 -0.0120467
EVI5 ecotropic viral integration site 5 -0.0119507
ZFAND3 zinc finger, AN1-type domain 3 -0.0118923
ST14 suppression of tumorigenicity 14 (colon carcinoma) -0.011876
S100A11 S100 calcium binding protein A11 -0.0116934
MTUS1 microtubule associated tumor suppressor 1 -0.0116277
ALDH3A2 aldehyde dehydrogenase 3 family, member A2 -0.0116163
H3-3B H3.3 histone B -0.0116154
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 -0.0115593
ANKIB1 ankyrin repeat and IBR domain containing 1 -0.0114595
NFE2L2 nuclear factor, erythroid 2-like 2 -0.0113235
PIAS1 protein inhibitor of activated STAT, 1 -0.0111951
LOC112694756 uncharaterized LOC112694756 -0.0110835
UBE3C ubiquitin protein ligase E3C -0.0109853
ECT2 epithelial cell transforming 2 -0.0109774
SELENOK selenoprotein K -0.0109737
MTCL1 microtubule crosslinking factor 1 -0.0108032
PLS1 plastin 1 -0.0107836
NPEPPS aminopeptidase puromycin sensitive -0.0107699
RAB2A RAB2A, member RAS oncogene family -0.0107657
PLEKHA5 pleckstrin homology domain containing, family A member 5 -0.0107077
ACACA acetyl-CoA carboxylase alpha -0.0106774
MAL2 mal, T-cell differentiation protein 2 (gene/pseudogene) -0.0104935
NEK7 NIMA-related kinase 7 -0.0104792
TENT5A terminal nucleotidyltransferase 5A -0.0103736
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 -0.0102286
GSTP1 glutathione S-transferase pi 1 -0.0102285
HMGB1 high mobility group box 1 -0.0101822
MGAM2 maltase-glucoamylase 2 (putative) -0.0100518
ITFG1 integrin alpha FG-GAP repeat containing 1 -0.00984971
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein) -0.00980778
LY6E lymphocyte antigen 6 complex, locus E -0.00976074
RAB14 RAB14, member RAS oncogene family -0.00961375
PHTF2 putative homeodomain transcription factor 2 -0.00951611
RPLP1 ribosomal protein, large, P1 -0.00947904
RNF43 ring finger protein 43 -0.00940519
NAMPT nicotinamide phosphoribosyltransferase -0.00940187
SLC31A1 solute carrier family 31 (copper transporter), member 1 -0.00934604
UGGT2 UDP-glucose glycoprotein glucosyltransferase 2 -0.00928361
CBL Cbl proto-oncogene, E3 ubiquitin protein ligase -0.00927947
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific ) -0.009269
CASK calcium/calmodulin-dependent serine protein kinase (MAGUK family) -0.00918384
ITM2B integral membrane protein 2B -0.00918109
DLG1 discs, large homolog 1 (Drosophila) -0.00912344
RHPN2 rhophilin, Rho GTPase binding protein 2 -0.00910842
LMTK2 lemur tyrosine kinase 2 -0.00908783
RPL28 ribosomal protein L28 -0.00905705
DNAJC1 DnaJ (Hsp40) homolog, subfamily C, member 1 -0.00902481
RSPRY1 ring finger and SPRY domain containing 1 -0.00898393
UBE2V1 ubiquitin-conjugating enzyme E2 variant 1 -0.00898228