| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Tirabrutinib (hydrochloride) perturbation in LOX-IMVI cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Tirabrutinib (hydrochloride)_LOX-IMVI drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| EEF2 | eukaryotic translation elongation factor 2 | 0.185817 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.130055 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.111615 |
| DTNA | dystrobrevin, alpha | 0.110373 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.103635 |
| LSAMP | limbic system-associated membrane protein | 0.0918513 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0879 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0797674 |
| FN1 | fibronectin 1 | 0.0769054 |
| ANXA2 | annexin A2 | 0.0760996 |
| MMP12 | matrix metallopeptidase 12 | 0.0750444 |
| EFNA5 | ephrin-A5 | 0.0746996 |
| JUN | jun proto-oncogene | 0.0709551 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0700233 |
| CD109 | CD109 molecule | 0.0682981 |
| NDRG1 | N-myc downstream regulated 1 | 0.0680223 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0668159 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | 0.0663572 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0628319 |
| DST | dystonin | 0.0603688 |
| MYO10 | myosin X | 0.057631 |
| ADM | adrenomedullin | 0.0568653 |
| SLC8A1 | solute carrier family 8 (sodium/calcium exchanger), member 1 | 0.0558795 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.0558455 |
| SPAG9 | sperm associated antigen 9 | 0.0544094 |
| HILPDA | hypoxia inducible lipid droplet-associated | 0.0526515 |
| RNF145 | ring finger protein 145 | 0.0521459 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.0514824 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | 0.0514586 |
| WDR45B | WD repeat domain 45B | 0.0504663 |
| RUNX1 | runt-related transcription factor 1 | 0.0495416 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0492327 |
| LOC112694756 | uncharaterized LOC112694756 | 0.048715 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | 0.0472043 |
| MCL1 | myeloid cell leukemia 1 | 0.0467691 |
| HELZ | helicase with zinc finger | 0.0466592 |
| FMNL2 | formin-like 2 | 0.0462168 |
| RPS4X | ribosomal protein S4, X-linked | 0.0460119 |
| EGR1 | early growth response 1 | 0.0460046 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0459356 |
| ADAM9 | ADAM metallopeptidase domain 9 | 0.0448857 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.044735 |
| PHACTR1 | phosphatase and actin regulator 1 | 0.0435852 |
| EPB41L2 | erythrocyte membrane protein band 4.1-like 2 | 0.0431012 |
| FLNA | filamin A, alpha | 0.0426466 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0426453 |
| VIM | vimentin | 0.0420955 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0420268 |
| UGCG | UDP-glucose ceramide glucosyltransferase | 0.0419837 |
| SIPA1L3 | signal-induced proliferation-associated 1 like 3 | 0.0416199 |
| MXI1 | MAX interactor 1, dimerization protein | 0.041523 |
| QKI | QKI, KH domain containing, RNA binding | 0.041 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.040737 |
| RND3 | Rho family GTPase 3 | 0.0399874 |
| ZNF292 | zinc finger protein 292 | 0.0398083 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0395685 |
| ATF3 | activating transcription factor 3 | 0.0395616 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | 0.0387445 |
| GNPDA1 | glucosamine-6-phosphate deaminase 1 | 0.0387222 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0355464 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0349247 |
| FGFR1 | fibroblast growth factor receptor 1 | 0.0345342 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.0341811 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0340717 |
| FOS | FBJ murine osteosarcoma viral oncogene homolog | 0.0335099 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.0334967 |
| HOOK2 | hook microtubule-tethering protein 2 | 0.0334945 |
| NFATC2 | nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 | 0.0331126 |
| NUP58 | nucleoporin 58 | 0.0328504 |
| SFTPA2 | surfactant protein A2 | 0.0328256 |
| CDH13 | cadherin 13 | 0.0327086 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | 0.0318 |
| JMJD1C | jumonji domain containing 1C | 0.0317147 |
| EGLN1 | egl-9 family hypoxia-inducible factor 1 | 0.0316877 |
| COL6A1 | collagen, type VI, alpha 1 | 0.0314934 |
| WAC | WW domain containing adaptor with coiled-coil | 0.0313922 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.0309271 |
| CNOT2 | CCR4-NOT transcription complex, subunit 2 | 0.0307952 |
| HDAC9 | histone deacetylase 9 | 0.0303807 |
| ADAMTS1 | ADAM metallopeptidase with thrombospondin type 1 motif, 1 | 0.0303007 |
| ANXA1 | annexin A1 | 0.0302513 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0299634 |
| LIMCH1 | LIM and calponin homology domains 1 | 0.0295614 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | 0.0292808 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | 0.0292085 |
| PBX3 | pre-B-cell leukemia homeobox 3 | 0.0286549 |
| CORO1C | coronin, actin binding protein, 1C | 0.0285454 |
| ABI1 | abl-interactor 1 | 0.0282786 |
| RLF | rearranged L-myc fusion | 0.0280403 |
| ENO2 | enolase 2 (gamma, neuronal) | 0.0277946 |
| GNAS | GNAS complex locus | 0.0276921 |
| YBX1 | Y box binding protein 1 | 0.0276709 |
| MGAT5 | mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase | 0.0276524 |
| PFKFB3 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 | 0.0275591 |
| VGF | VGF nerve growth factor inducible | 0.027519 |
| COL6A2 | collagen, type VI, alpha 2 | 0.0274182 |
| SLC2A1 | solute carrier family 2 (facilitated glucose transporter), member 1 | 0.0272153 |
| PLEC | plectin | 0.0270184 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | 0.0264784 |
| APP | amyloid beta (A4) precursor protein | 0.0264229 |
| Symbol | Name | Standardized Value |
|---|---|---|
| VCL | vinculin | -0.0790766 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0643747 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | -0.0618843 |
| ALCAM | activated leukocyte cell adhesion molecule | -0.0591998 |
| ADAM19 | ADAM metallopeptidase domain 19 | -0.056411 |
| ACTG1 | actin gamma 1 | -0.0477568 |
| BCAR3 | breast cancer anti-estrogen resistance 3 | -0.0417485 |
| ENKUR | enkurin, TRPC channel interacting protein | -0.03969 |
| ASPH | aspartate beta-hydroxylase | -0.0389586 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | -0.0382016 |
| NALF1 | NALCN channel auxiliary factor 1 | -0.0378174 |
| RPS2 | ribosomal protein S2 | -0.0345807 |
| RPS6 | ribosomal protein S6 | -0.0339251 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.033711 |
| OSMR | oncostatin M receptor | -0.0326373 |
| RIGI | RNA sensor RIG-I | -0.0325939 |
| DPYD | dihydropyrimidine dehydrogenase | -0.0325575 |
| CALD1 | caldesmon 1 | -0.0323037 |
| BDNF | brain-derived neurotrophic factor | -0.0315531 |
| TXNRD1 | thioredoxin reductase 1 | -0.0311494 |
| MAML2 | mastermind-like 2 (Drosophila) | -0.0303607 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.030347 |
| KLF7 | Kruppel-like factor 7 (ubiquitous) | -0.0302245 |
| NLGN1 | neuroligin 1 | -0.0300582 |
| DDAH1 | dimethylarginine dimethylaminohydrolase 1 | -0.0297346 |
| RPL26 | ribosomal protein L26 | -0.0289757 |
| ANTXR2 | anthrax toxin receptor 2 | -0.0287744 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0283265 |
| RPL38 | ribosomal protein L38 | -0.0275104 |
| FRMD6 | FERM domain containing 6 | -0.0264419 |
| RBMS1 | RNA binding motif, single stranded interacting protein 1 | -0.0264184 |
| RFX8 | RFX family member 8, lacking RFX DNA binding domain | -0.0263485 |
| RPLP1 | ribosomal protein, large, P1 | -0.0262634 |
| RTN4 | reticulon 4 | -0.0261868 |
| NPC1 | Niemann-Pick disease, type C1 | -0.0260723 |
| STK17A | serine/threonine kinase 17a | -0.0247689 |
| BMAL2 | basic helix-loop-helix ARNT like 2 | -0.0246582 |
| SAMD3 | sterile alpha motif domain containing 3 | -0.0244443 |
| SIPA1L1 | signal-induced proliferation-associated 1 like 1 | -0.0244055 |
| RPS8 | ribosomal protein S8 | -0.0241887 |
| PLEKHA5 | pleckstrin homology domain containing, family A member 5 | -0.0239525 |
| NAV1 | neuron navigator 1 | -0.0237451 |
| VGLL3 | vestigial-like family member 3 | -0.023687 |
| MT2A | metallothionein 2A | -0.0234874 |
| ANKRD12 | ankyrin repeat domain 12 | -0.023054 |
| VPS13B | vacuolar protein sorting 13 homolog B (yeast) | -0.0230179 |
| RPL23 | ribosomal protein L23 | -0.0221346 |
| PCNX4 | pecanex 4 | -0.0220081 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.0219591 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | -0.0217416 |
| ACTN1 | actinin, alpha 1 | -0.0213626 |
| RPLP2 | ribosomal protein, large, P2 | -0.0210846 |
| ACTR2 | ARP2 actin-related protein 2 homolog (yeast) | -0.0208988 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0206859 |
| WDPCP | WD repeat containing planar cell polarity effector | -0.0200751 |
| EIF4G3 | eukaryotic translation initiation factor 4 gamma, 3 | -0.0200029 |
| ANKRD28 | ankyrin repeat domain 28 | -0.0199504 |
| RPS23 | ribosomal protein S23 | -0.0197333 |
| SDCCAG8 | serologically defined colon cancer antigen 8 | -0.0197196 |
| CLIC4 | chloride intracellular channel 4 | -0.0196606 |
| FMN1 | formin 1 | -0.0196449 |
| ARPC2 | actin related protein 2/3 complex, subunit 2, 34kDa | -0.0194546 |
| PMP22 | peripheral myelin protein 22 | -0.0192219 |
| RPS25 | ribosomal protein S25 | -0.0190413 |
| TUBB6 | tubulin, beta 6 class V | -0.0190203 |
| RPS20 | ribosomal protein S20 | -0.0189044 |
| RIMS2 | regulating synaptic membrane exocytosis 2 | -0.0187842 |
| NLK | nemo-like kinase | -0.0187599 |
| PHC2 | polyhomeotic homolog 2 (Drosophila) | -0.0187522 |
| NT5E | 5'-nucleotidase, ecto (CD73) | -0.0184623 |
| SPRED1 | sprouty-related, EVH1 domain containing 1 | -0.0183526 |
| MARCHF4 | membrane associated ring-CH-type finger 4 | -0.0182966 |
| CD163L1 | CD163 molecule-like 1 | -0.0179842 |
| RPS12 | ribosomal protein S12 | -0.0177601 |
| RPL7 | ribosomal protein L7 | -0.0177362 |
| RPS21 | ribosomal protein S21 | -0.017723 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | -0.0170941 |
| RPL32 | ribosomal protein L32 | -0.0170834 |
| MAP1B | microtubule-associated protein 1B | -0.0170825 |
| KYNU | kynureninase | -0.0168685 |
| ETV6 | ets variant 6 | -0.0168475 |
| CCDC91 | coiled-coil domain containing 91 | -0.0163784 |
| ACTR3 | ARP3 actin-related protein 3 homolog (yeast) | -0.0163516 |
| YWHAB | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta | -0.0161214 |
| IL1RAPL1 | interleukin 1 receptor accessory protein-like 1 | -0.0160169 |
| FTL | ferritin, light polypeptide | -0.0159829 |
| CDK17 | cyclin-dependent kinase 17 | -0.0159016 |
| RPL30 | ribosomal protein L30 | -0.0158286 |
| EXOC6B | exocyst complex component 6B | -0.0157638 |
| RPL27 | ribosomal protein L27 | -0.0157454 |
| KIAA1549L | KIAA1549-like | -0.0157132 |
| CLTC | clathrin, heavy chain (Hc) | -0.0156523 |
| BCAS3 | breast carcinoma amplified sequence 3 | -0.0155798 |
| BRIP1 | BRCA1 interacting protein C-terminal helicase 1 | -0.0155352 |
| KDM5A | lysine (K)-specific demethylase 5A | -0.0152832 |
| ALPK2 | alpha-kinase 2 | -0.0152621 |
| PTPRG | protein tyrosine phosphatase, receptor type, G | -0.0151745 |
| IFI16 | interferon, gamma-inducible protein 16 | -0.0147615 |
| STAU2 | staufen double-stranded RNA binding protein 2 | -0.014745 |
| ITGAV | integrin, alpha V | -0.0145956 |
