| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Tirabrutinib (hydrochloride) perturbation in LS 180 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Tirabrutinib (hydrochloride)_LS 180 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| EEF2 | eukaryotic translation elongation factor 2 | 0.159301 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.109207 |
| EZR | ezrin | 0.106464 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0920939 |
| KRT18 | keratin 18, type I | 0.0846637 |
| LMO7 | LIM domain 7 | 0.0817903 |
| PTMA | prothymosin, alpha | 0.0796958 |
| ANXA1 | annexin A1 | 0.0791143 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | 0.0714454 |
| VEGFA | vascular endothelial growth factor A | 0.0708571 |
| GOLGA4 | golgin A4 | 0.0683763 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0676309 |
| SLC12A2 | solute carrier family 12 (sodium/potassium/chloride transporter), member 2 | 0.0568195 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0556652 |
| AFF1 | AF4/FMR2 family, member 1 | 0.0535362 |
| TPT1 | tumor protein, translationally-controlled 1 | 0.051215 |
| FOS | FBJ murine osteosarcoma viral oncogene homolog | 0.0484893 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.046727 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0466592 |
| EIF4A2 | eukaryotic translation initiation factor 4A2 | 0.0453321 |
| EMP1 | epithelial membrane protein 1 | 0.0443935 |
| TTC3 | tetratricopeptide repeat domain 3 | 0.0441656 |
| TNFRSF21 | tumor necrosis factor receptor superfamily, member 21 | 0.0434661 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0420823 |
| AHNAK | AHNAK nucleoprotein | 0.0415598 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | 0.0411845 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.0404836 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0397458 |
| DDIT4 | DNA-damage-inducible transcript 4 | 0.0385701 |
| PIGR | polymeric immunoglobulin receptor | 0.0382916 |
| DSPP | dentin sialophosphoprotein | 0.0378494 |
| LMNA | lamin A/C | 0.0377655 |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | 0.0366083 |
| MBNL2 | muscleblind-like splicing regulator 2 | 0.0362657 |
| RNF145 | ring finger protein 145 | 0.0362252 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0358116 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0349378 |
| HSPA8 | heat shock 70kDa protein 8 | 0.034795 |
| APP | amyloid beta (A4) precursor protein | 0.034432 |
| TNFRSF10B | tumor necrosis factor receptor superfamily, member 10b | 0.0343326 |
| ZFAND3 | zinc finger, AN1-type domain 3 | 0.0343171 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | 0.0339151 |
| BRD2 | bromodomain containing 2 | 0.0334595 |
| ATXN1 | ataxin 1 | 0.0331991 |
| TMSB4X | thymosin beta 4, X-linked | 0.0327514 |
| IARS1 | isoleucyl-tRNA synthetase 1 | 0.0327114 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0326831 |
| TES | testin LIM domain protein | 0.0323121 |
| RPL11 | ribosomal protein L11 | 0.0320741 |
| CANX | calnexin | 0.0320208 |
| LOC102724023 | ES1 protein homolog, mitochondrial | 0.0319733 |
| ATF3 | activating transcription factor 3 | 0.0317759 |
| RORA | RAR-related orphan receptor A | 0.0317183 |
| EREG | epiregulin | 0.0315628 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | 0.0314751 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | 0.0310134 |
| FOSB | FBJ murine osteosarcoma viral oncogene homolog B | 0.0309406 |
| ANKRD17 | ankyrin repeat domain 17 | 0.0307402 |
| DNAJA1 | DnaJ (Hsp40) homolog, subfamily A, member 1 | 0.03058 |
| WAC | WW domain containing adaptor with coiled-coil | 0.0305588 |
| CTNNB1 | catenin (cadherin-associated protein), beta 1, 88kDa | 0.0304649 |
| HDLBP | high density lipoprotein binding protein | 0.0302665 |
| ATP1A4 | ATPase, Na+/K+ transporting, alpha 4 polypeptide | 0.0301101 |
| LOC112694756 | uncharaterized LOC112694756 | 0.0290542 |
| TPD52 | tumor protein D52 | 0.028622 |
| NEDD9 | neural precursor cell expressed, developmentally down-regulated 9 | 0.0285049 |
| TXNRD1 | thioredoxin reductase 1 | 0.0283769 |
| PER2 | period circadian clock 2 | 0.0281463 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0278038 |
| MUC13 | mucin 13, cell surface associated | 0.0275761 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | 0.0273604 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0269894 |
| RPL13A | ribosomal protein L13a | 0.0268538 |
| SQSTM1 | sequestosome 1 | 0.0262851 |
| FBXO32 | F-box protein 32 | 0.026051 |
| RBM39 | RNA binding motif protein 39 | 0.0258734 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.0255288 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0254575 |
| ETS2 | v-ets avian erythroblastosis virus E26 oncogene homolog 2 | 0.0254287 |
| SLC38A2 | solute carrier family 38, member 2 | 0.0250823 |
| SMARCA5 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5 | 0.024964 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | 0.0248706 |
| RPS4X | ribosomal protein S4, X-linked | 0.0247893 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0247235 |
| SFTPA2 | surfactant protein A2 | 0.0246942 |
| RRBP1 | ribosome binding protein 1 | 0.0246049 |
| TXNIP | thioredoxin interacting protein | 0.024519 |
| COG5 | component of oligomeric golgi complex 5 | 0.0243848 |
| RSRC2 | arginine/serine-rich coiled-coil 2 | 0.024377 |
| YTHDC1 | YTH domain containing 1 | 0.0242984 |
| CSDE1 | cold shock domain containing E1, RNA-binding | 0.0242605 |
| KITLG | KIT ligand | 0.0242215 |
| RPL19 | ribosomal protein L19 | 0.0241409 |
| RAB1A | RAB1A, member RAS oncogene family | 0.0241273 |
| NCKAP1 | NCK-associated protein 1 | 0.0238925 |
| YBX1 | Y box binding protein 1 | 0.0238919 |
| RPS12 | ribosomal protein S12 | 0.0237528 |
| ATP2B1 | ATPase, Ca++ transporting, plasma membrane 1 | 0.0236749 |
| RPS2 | ribosomal protein S2 | 0.0233553 |
| YWHAE | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon | 0.0233506 |
| Symbol | Name | Standardized Value |
|---|---|---|
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.169227 |
| CEMIP | cell migration inducing protein, hyaluronan binding | -0.100355 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.098872 |
| TNS4 | tensin 4 | -0.0984728 |
| NPSR1 | neuropeptide S receptor 1 | -0.0760419 |
| PRSS3 | protease, serine, 3 | -0.0672347 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | -0.0632982 |
| RNF43 | ring finger protein 43 | -0.0536087 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0523938 |
| NALF1 | NALCN channel auxiliary factor 1 | -0.0500745 |
| SERPINB1 | serpin peptidase inhibitor, clade B (ovalbumin), member 1 | -0.0420218 |
| VCL | vinculin | -0.0409102 |
| NDRG1 | N-myc downstream regulated 1 | -0.0400865 |
| GMDS | GDP-mannose 4,6-dehydratase | -0.0389423 |
| ONECUT3 | one cut homeobox 3 | -0.0347251 |
| FERMT1 | fermitin family member 1 | -0.0325715 |
| PPARG | peroxisome proliferator-activated receptor gamma | -0.0323422 |
| SLCO1B3 | solute carrier organic anion transporter family, member 1B3 | -0.0304417 |
| GPHN | gephyrin | -0.0294771 |
| ANXA2 | annexin A2 | -0.0289578 |
| ITGB4 | integrin, beta 4 | -0.0280314 |
| LGALS4 | lectin, galactoside-binding, soluble, 4 | -0.0270243 |
| S100A6 | S100 calcium binding protein A6 | -0.0266972 |
| MUC5AC | mucin 5AC, oligomeric mucus/gel-forming | -0.0261311 |
| TMSB10 | thymosin beta 10 | -0.0258915 |
| ANTXR2 | anthrax toxin receptor 2 | -0.0257204 |
| SAMD5 | sterile alpha motif domain containing 5 | -0.0256987 |
| CALB1 | calbindin 1, 28kDa | -0.0253106 |
| VDR | vitamin D (1,25- dihydroxyvitamin D3) receptor | -0.0244468 |
| PLAUR | plasminogen activator, urokinase receptor | -0.0242032 |
| TMEM45B | transmembrane protein 45B | -0.023337 |
| AGR2 | anterior gradient 2 | -0.0227543 |
| SEMA4B | sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B | -0.0225706 |
| LRCH1 | leucine-rich repeats and calponin homology (CH) domain containing 1 | -0.0224688 |
| RPL35A | ribosomal protein L35a | -0.0224454 |
| MAML2 | mastermind-like 2 (Drosophila) | -0.0224302 |
| CADPS | Ca++-dependent secretion activator | -0.0217789 |
| ABHD2 | abhydrolase domain containing 2 | -0.0216742 |
| PKP2 | plakophilin 2 | -0.0215763 |
| KLF3 | Kruppel-like factor 3 (basic) | -0.0214921 |
| FLNB | filamin B, beta | -0.0209246 |
| FOSL1 | FOS-like antigen 1 | -0.020721 |
| RPLP1 | ribosomal protein, large, P1 | -0.0207068 |
| FHIT | fragile histidine triad | -0.0206137 |
| KRT19 | keratin 19, type I | -0.0205458 |
| SH3D19 | SH3 domain containing 19 | -0.0204213 |
| JUP | junction plakoglobin | -0.0199932 |
| S100A10 | S100 calcium binding protein A10 | -0.019361 |
| SLC20A1 | solute carrier family 20 (phosphate transporter), member 1 | -0.0191778 |
| TPM4 | tropomyosin 4 | -0.0191302 |
| NOSTRIN | nitric oxide synthase trafficking | -0.0190608 |
| CD46 | CD46 molecule, complement regulatory protein | -0.0188488 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0188305 |
| MYO1D | myosin ID | -0.0185075 |
| TFF3 | trefoil factor 3 (intestinal) | -0.0182011 |
| ARHGAP32 | Rho GTPase activating protein 32 | -0.0179893 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.0178691 |
| ABHD17C | abhydrolase domain containing 17C | -0.0174742 |
| EHBP1 | EH domain binding protein 1 | -0.017465 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.0173562 |
| MUC17 | mucin 17, cell surface associated | -0.0172807 |
| SHB | Src homology 2 domain containing adaptor protein B | -0.0171216 |
| GRIN2B | glutamate receptor, ionotropic, N-methyl D-aspartate 2B | -0.0169934 |
| CYP3A5 | cytochrome P450, family 3, subfamily A, polypeptide 5 | -0.0167542 |
| FHL2 | four and a half LIM domains 2 | -0.016563 |
| INSIG1 | insulin induced gene 1 | -0.0165571 |
| PTEN | phosphatase and tensin homolog | -0.0162146 |
| ITPR2 | inositol 1,4,5-trisphosphate receptor, type 2 | -0.0160969 |
| RAD51B | RAD51 paralog B | -0.0160296 |
| SEL1L | sel-1 suppressor of lin-12-like (C. elegans) | -0.0158892 |
| PTBP3 | polypyrimidine tract binding protein 3 | -0.0156055 |
| DNAJC15 | DnaJ (Hsp40) homolog, subfamily C, member 15 | -0.0154862 |
| HMGCS1 | 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) | -0.0154797 |
| PCDHB16 | protocadherin beta 16 | -0.0153334 |
| IBTK | inhibitor of Bruton agammaglobulinemia tyrosine kinase | -0.01526 |
| POTEF | POTE ankyrin domain family, member F | -0.015085 |
| PLEK2 | pleckstrin 2 | -0.0150761 |
| DIP2B | DIP2 disco-interacting protein 2 homolog B (Drosophila) | -0.0148495 |
| IGFL2 | IGF-like family member 2 | -0.0147332 |
| EGR1 | early growth response 1 | -0.01462 |
| TJP2 | tight junction protein 2 | -0.0145955 |
| GREB1L | growth regulation by estrogen in breast cancer-like | -0.0145538 |
| PALLD | palladin, cytoskeletal associated protein | -0.0143902 |
| CEACAM5 | carcinoembryonic antigen-related cell adhesion molecule 5 | -0.0143421 |
| ANXA3 | annexin A3 | -0.0142384 |
| F3 | coagulation factor III (thromboplastin, tissue factor) | -0.0139744 |
| BCL2L1 | BCL2-like 1 | -0.0139729 |
| SLC2A1 | solute carrier family 2 (facilitated glucose transporter), member 1 | -0.0139377 |
| FRMD3 | FERM domain containing 3 | -0.0139136 |
| SLC35A3 | solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member A3 | -0.0137656 |
| ACSL5 | acyl-CoA synthetase long-chain family member 5 | -0.0137405 |
| ZNF518A | zinc finger protein 518A | -0.0137024 |
| PHGR1 | proline/histidine/glycine-rich 1 | -0.0136029 |
| PERP | PERP, TP53 apoptosis effector | -0.0135758 |
| RPL23 | ribosomal protein L23 | -0.0135205 |
| ITGB5 | integrin, beta 5 | -0.0134206 |
| ACTN4 | actinin, alpha 4 | -0.0132202 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | -0.0131999 |
| RPS19 | ribosomal protein S19 | -0.0131745 |
| SNTB1 | syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) | -0.0131731 |
