| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Tirabrutinib (hydrochloride) perturbation in LoVo cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Tirabrutinib (hydrochloride)_LoVo drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| EEF2 | eukaryotic translation elongation factor 2 | 0.164607 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.110465 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | 0.0712893 |
| GOLGA4 | golgin A4 | 0.0699022 |
| TXNRD1 | thioredoxin reductase 1 | 0.065481 |
| FAT1 | FAT atypical cadherin 1 | 0.0615624 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0609524 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0586647 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0577526 |
| CALB1 | calbindin 1, 28kDa | 0.0570889 |
| FLNB | filamin B, beta | 0.0543888 |
| EPS8 | epidermal growth factor receptor pathway substrate 8 | 0.0528574 |
| RPL3 | ribosomal protein L3 | 0.052052 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | 0.0450899 |
| RNF145 | ring finger protein 145 | 0.0429016 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0416007 |
| RPL21 | ribosomal protein L21 | 0.0414519 |
| GARS1 | glycyl-tRNA synthetase 1 | 0.0400743 |
| RPS2 | ribosomal protein S2 | 0.0389165 |
| TRIM2 | tripartite motif containing 2 | 0.038813 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.0386953 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.037395 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.036595 |
| RPS12 | ribosomal protein S12 | 0.0361829 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0361738 |
| TNIP1 | TNFAIP3 interacting protein 1 | 0.0356042 |
| RFX3 | regulatory factor X, 3 (influences HLA class II expression) | 0.0355853 |
| ITGA6 | integrin, alpha 6 | 0.035415 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.0351398 |
| ITGB4 | integrin, beta 4 | 0.035104 |
| PTBP3 | polypyrimidine tract binding protein 3 | 0.0346497 |
| PTEN | phosphatase and tensin homolog | 0.0332737 |
| MLEC | malectin | 0.0325197 |
| KIF5B | kinesin family member 5B | 0.0317867 |
| GCNT3 | glucosaminyl (N-acetyl) transferase 3, mucin type | 0.0316288 |
| POTEF | POTE ankyrin domain family, member F | 0.0309762 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.0303012 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0301147 |
| TRIM31 | tripartite motif containing 31 | 0.0295524 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.029406 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0287694 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | 0.0286584 |
| SLCO1B3 | solute carrier organic anion transporter family, member 1B3 | 0.0285308 |
| PCDHB16 | protocadherin beta 16 | 0.0284658 |
| KRT18 | keratin 18, type I | 0.0277627 |
| CDK19 | cyclin-dependent kinase 19 | 0.0276925 |
| RPS6 | ribosomal protein S6 | 0.0273602 |
| GDF15 | growth differentiation factor 15 | 0.0270646 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.0268475 |
| AVL9 | AVL9 homolog (S. cerevisiase) | 0.0266431 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | 0.0265259 |
| CENPF | centromere protein F, 350/400kDa | 0.0263669 |
| ERBIN | erbb2 interacting protein | 0.0262865 |
| TAF15 | TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa | 0.0259402 |
| ARHGAP26 | Rho GTPase activating protein 26 | 0.0259231 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | 0.0259192 |
| MKI67 | marker of proliferation Ki-67 | 0.0256948 |
| ANO6 | anoctamin 6 | 0.0256314 |
| LRRC1 | leucine rich repeat containing 1 | 0.0255709 |
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | 0.0252269 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0251757 |
| MINDY2 | MINDY lysine 48 deubiquitinase 2 | 0.0250131 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | 0.0247369 |
| RPS4X | ribosomal protein S4, X-linked | 0.0247015 |
| YBX1 | Y box binding protein 1 | 0.0246961 |
| MTHFD2 | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase | 0.0245254 |
| WWC1 | WW and C2 domain containing 1 | 0.024339 |
| RBCK1 | RanBP-type and C3HC4-type zinc finger containing 1 | 0.024263 |
| MED13L | mediator complex subunit 13-like | 0.0240649 |
| RTN4 | reticulon 4 | 0.0237634 |
| COPA | coatomer protein complex, subunit alpha | 0.0237574 |
| SHROOM3 | shroom family member 3 | 0.0236661 |
| XPC | xeroderma pigmentosum, complementation group C | 0.0233601 |
| RPL11 | ribosomal protein L11 | 0.0233561 |
| VEGFA | vascular endothelial growth factor A | 0.0231955 |
| ARHGEF12 | Rho guanine nucleotide exchange factor (GEF) 12 | 0.0230628 |
| PAG1 | phosphoprotein membrane anchor with glycosphingolipid microdomains 1 | 0.0230135 |
| FOXO1 | forkhead box O1 | 0.0229819 |
| BRD2 | bromodomain containing 2 | 0.0229664 |
| PNN | pinin, desmosome associated protein | 0.022958 |
| LRP6 | low density lipoprotein receptor-related protein 6 | 0.0229456 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0229372 |
| UGT1A6 | UDP glucuronosyltransferase 1 family, polypeptide A6 | 0.0228403 |
| PKP2 | plakophilin 2 | 0.0226727 |
| MGAT5 | mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase | 0.022596 |
| UBE3A | ubiquitin protein ligase E3A | 0.022453 |
| LOC112694756 | uncharaterized LOC112694756 | 0.0221466 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0221102 |
| GPHN | gephyrin | 0.0221089 |
| TMTC2 | transmembrane and tetratricopeptide repeat containing 2 | 0.0220969 |
| ASNS | asparagine synthetase (glutamine-hydrolyzing) | 0.0219688 |
| DDIT4 | DNA-damage-inducible transcript 4 | 0.0217577 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | 0.0217565 |
| HERC1 | HECT and RLD domain containing E3 ubiquitin protein ligase family member 1 | 0.0215885 |
| EIF4B | eukaryotic translation initiation factor 4B | 0.0215015 |
| PLAC8 | placenta-specific 8 | 0.0214672 |
| ATP5F1B | ATP synthase F1 subunit beta | 0.021421 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | 0.0213626 |
| SETD5 | SET domain containing 5 | 0.0213091 |
| ZNF292 | zinc finger protein 292 | 0.0211781 |
| Symbol | Name | Standardized Value |
|---|---|---|
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.226923 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.203035 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.127029 |
| LMO7 | LIM domain 7 | -0.120152 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.103634 |
| KLF5 | Kruppel-like factor 5 (intestinal) | -0.0788381 |
| FRMD5 | FERM domain containing 5 | -0.070694 |
| GMDS | GDP-mannose 4,6-dehydratase | -0.0706571 |
| RPLP1 | ribosomal protein, large, P1 | -0.069226 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.068236 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0649446 |
| LGR5 | leucine-rich repeat containing G protein-coupled receptor 5 | -0.059115 |
| ANXA2 | annexin A2 | -0.0583509 |
| MYO1E | myosin IE | -0.057895 |
| SERINC5 | serine incorporator 5 | -0.0528533 |
| RPS24 | ribosomal protein S24 | -0.0484583 |
| INTS6 | integrator complex subunit 6 | -0.0483131 |
| LAMB3 | laminin, beta 3 | -0.047702 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | -0.0468594 |
| CEACAM5 | carcinoembryonic antigen-related cell adhesion molecule 5 | -0.0454077 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.0436766 |
| IL1RAPL1 | interleukin 1 receptor accessory protein-like 1 | -0.0435945 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.0427526 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0421208 |
| RPS6KA5 | ribosomal protein S6 kinase, 90kDa, polypeptide 5 | -0.0417306 |
| F3 | coagulation factor III (thromboplastin, tissue factor) | -0.0404978 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0402583 |
| RPL38 | ribosomal protein L38 | -0.0400418 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.0398513 |
| CATSPERB | catsper channel auxiliary subunit beta | -0.0394355 |
| SP100 | SP100 nuclear antigen | -0.0385167 |
| DDX5 | DEAD (Asp-Glu-Ala-Asp) box helicase 5 | -0.0384558 |
| AGR2 | anterior gradient 2 | -0.038325 |
| SLCO1B3-SLCO1B7 | SLCO1B3-SLCO1B7 readthrough | -0.0381335 |
| CTBP2 | C-terminal binding protein 2 | -0.0361056 |
| NPSR1 | neuropeptide S receptor 1 | -0.035562 |
| RPL34 | ribosomal protein L34 | -0.0354012 |
| RPL35A | ribosomal protein L35a | -0.0350077 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | -0.0349971 |
| XAF1 | XIAP associated factor 1 | -0.0347706 |
| SERPINB5 | serpin peptidase inhibitor, clade B (ovalbumin), member 5 | -0.0334448 |
| FUS | FUS RNA binding protein | -0.033324 |
| FBXO11 | F-box protein 11 | -0.0333021 |
| ACTN4 | actinin, alpha 4 | -0.0327573 |
| PTPRB | protein tyrosine phosphatase, receptor type, B | -0.032706 |
| CLIC5 | chloride intracellular channel 5 | -0.0326524 |
| RRBP1 | ribosome binding protein 1 | -0.0325853 |
| MYO5B | myosin VB | -0.0324404 |
| PIK3AP1 | phosphoinositide-3-kinase adaptor protein 1 | -0.0320984 |
| DSPP | dentin sialophosphoprotein | -0.0319895 |
| SLC12A2 | solute carrier family 12 (sodium/potassium/chloride transporter), member 2 | -0.0317975 |
| AOPEP | aminopeptidase O (putative) | -0.0309348 |
| IFI6 | interferon, alpha-inducible protein 6 | -0.0308639 |
| BRIP1 | BRCA1 interacting protein C-terminal helicase 1 | -0.030188 |
| CUX1 | cut-like homeobox 1 | -0.0298014 |
| EGFR | epidermal growth factor receptor | -0.0296457 |
| CANX | calnexin | -0.0291017 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0290246 |
| ALCAM | activated leukocyte cell adhesion molecule | -0.0288239 |
| PTPRR | protein tyrosine phosphatase, receptor type, R | -0.0287485 |
| DENND1A | DENN/MADD domain containing 1A | -0.0286071 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | -0.0286068 |
| TAS2R14 | taste receptor, type 2, member 14 | -0.0285591 |
| VCL | vinculin | -0.0284498 |
| ST13 | suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein) | -0.028228 |
| RPL4 | ribosomal protein L4 | -0.0280655 |
| RIGI | RNA sensor RIG-I | -0.0279773 |
| THSD4 | thrombospondin, type I, domain containing 4 | -0.0277565 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0275114 |
| SLC5A3 | solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 | -0.0270428 |
| IGF1R | insulin-like growth factor 1 receptor | -0.0269923 |
| RPL37A | ribosomal protein L37a | -0.0269384 |
| DSG2 | desmoglein 2 | -0.0268936 |
| NABP1 | nucleic acid binding protein 1 | -0.0264548 |
| PPP3CA | protein phosphatase 3, catalytic subunit, alpha isozyme | -0.0264464 |
| MCU | mitochondrial calcium uniporter | -0.0263821 |
| RPS21 | ribosomal protein S21 | -0.0263526 |
| RIMKLB | ribosomal modification protein rimK-like family member B | -0.0263039 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0262712 |
| DNAJA1 | DnaJ (Hsp40) homolog, subfamily A, member 1 | -0.0259118 |
| MTAP | methylthioadenosine phosphorylase | -0.0258606 |
| RPS8 | ribosomal protein S8 | -0.0258482 |
| TRMT11 | tRNA methyltransferase 11 homolog (S. cerevisiae) | -0.0257104 |
| GALNT5 | polypeptide N-acetylgalactosaminyltransferase 5 | -0.0253568 |
| NPR2 | natriuretic peptide receptor 2 | -0.0252905 |
| TMSB10 | thymosin beta 10 | -0.0250492 |
| VTI1A | vesicle transport through interaction with t-SNAREs 1A | -0.0249916 |
| RPS27A | ribosomal protein S27a | -0.0247867 |
| HDLBP | high density lipoprotein binding protein | -0.0247054 |
| UBAP2 | ubiquitin associated protein 2 | -0.0246612 |
| NT5C2 | 5'-nucleotidase, cytosolic II | -0.0238934 |
| CEACAM6 | carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) | -0.0237526 |
| FHIT | fragile histidine triad | -0.0236854 |
| MSI2 | musashi RNA-binding protein 2 | -0.0236519 |
| SKP1 | S-phase kinase-associated protein 1 | -0.0236066 |
| ACTG1 | actin gamma 1 | -0.0233877 |
| LARP1B | La ribonucleoprotein domain family, member 1B | -0.023201 |
| FOXO3 | forkhead box O3 | -0.0231785 |
| LAMA4 | laminin, alpha 4 | -0.0230347 |
| SPINK13 | serine peptidase inhibitor, Kazal type 13 (putative) | -0.0229415 |
