Tirabrutinib (hydrochloride)_MIA PaCa-2 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Tirabrutinib (hydrochloride) perturbation in MIA PaCa-2 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Tirabrutinib (hydrochloride)_MIA PaCa-2 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.306414
VIM vimentin 0.122212
FTH1 ferritin, heavy polypeptide 1 0.0820962
POTEF POTE ankyrin domain family, member F 0.0784394
EEF2 eukaryotic translation elongation factor 2 0.0454683
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 0.0431439
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0395018
LOC112694756 uncharaterized LOC112694756 0.0384897
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0372294
TXNRD1 thioredoxin reductase 1 0.0335444
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0314411
EGR1 early growth response 1 0.0313277
FTL ferritin, light polypeptide 0.0311464
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0301154
UBC ubiquitin C 0.029071
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0279915
MT2A metallothionein 2A 0.0274525
CENPF centromere protein F, 350/400kDa 0.0269685
PKM pyruvate kinase, muscle 0.0268261
ITGB4 integrin, beta 4 0.0267577
ENO2 enolase 2 (gamma, neuronal) 0.0265333
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0251932
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0247368
KRT18 keratin 18, type I 0.0242684
AKAP9 A kinase (PRKA) anchor protein 9 0.0233136
ZFP36L1 ZFP36 ring finger protein-like 1 0.0229352
DDX41 DEAD (Asp-Glu-Ala-Asp) box polypeptide 41 0.0226765
GNPDA1 glucosamine-6-phosphate deaminase 1 0.0226519
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.022581
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma 0.0218955
TXNIP thioredoxin interacting protein 0.0218198
AHNAK AHNAK nucleoprotein 0.0216386
RAI1 retinoic acid induced 1 0.0215757
RPS8 ribosomal protein S8 0.0214086
KTN1 kinectin 1 (kinesin receptor) 0.0210158
PCDH1 protocadherin 1 0.020654
PLK2 polo-like kinase 2 0.0206009
TMSB10 thymosin beta 10 0.0203246
RPL19 ribosomal protein L19 0.020018
EMP1 epithelial membrane protein 1 0.0198909
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0195928
HMGA1 high mobility group AT-hook 1 0.0194661
GOLGA4 golgin A4 0.0194391
CALR calreticulin 0.0194322
MYH9 myosin, heavy chain 9, non-muscle 0.0191855
PODXL podocalyxin-like 0.018947
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.0189144
YBX1 Y box binding protein 1 0.0188915
RAP2B RAP2B, member of RAS oncogene family 0.0187692
MSN moesin 0.0187662
RPS17 ribosomal protein S17 0.0184042
SHC1 SHC (Src homology 2 domain containing) transforming protein 1 0.0176298
RPL8 ribosomal protein L8 0.0168739
SLC38A2 solute carrier family 38, member 2 0.0168138
ADAM17 ADAM metallopeptidase domain 17 0.0166024
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0164674
MIDEAS mitotic deacetylase associated SANT domain protein 0.0163976
HELZ helicase with zinc finger 0.0163238
RPL23 ribosomal protein L23 0.0161853
TPM3 tropomyosin 3 0.0159858
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1 0.0157719
SRRM2 serine/arginine repetitive matrix 2 0.0156154
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2 0.0154731
PYGB phosphorylase, glycogen; brain 0.0154574
SLK STE20-like kinase 0.0153401
RPS2 ribosomal protein S2 0.0153233
ERBIN erbb2 interacting protein 0.0151483
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 0.0150052
DOCK11 dedicator of cytokinesis 11 0.0148811
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1 0.0147797
TNFRSF6B tumor necrosis factor receptor superfamily, member 6b, decoy 0.0144975
KDM2A lysine (K)-specific demethylase 2A 0.0143365
MT1E metallothionein 1E 0.0142818
KMT2C lysine (K)-specific methyltransferase 2C 0.0142623
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta 0.014236
RPS23 ribosomal protein S23 0.0141634
PLIN2 perilipin 2 0.0141089
RPS12 ribosomal protein S12 0.0140078
KMT2E lysine (K)-specific methyltransferase 2E 0.0139973
PRDX1 peroxiredoxin 1 0.0139397
EPRS1 glutamyl-prolyl-tRNA synthetase 1 0.013866
SEC24A SEC24 family member A 0.0137055
PDIA6 protein disulfide isomerase family A, member 6 0.0136025
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0135189
OPTN optineurin 0.0134213
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4 0.0134071
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0132989
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0132114
EIF1 eukaryotic translation initiation factor 1 0.0130153
KLHL24 kelch-like family member 24 0.0130142
EEF1G eukaryotic translation elongation factor 1 gamma 0.012991
RPL3 ribosomal protein L3 0.0129126
FLNB filamin B, beta 0.0129009
RPL17-C18ORF32 RPL17-C18orf32 readthrough 0.0128408
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0127085
FOSL1 FOS-like antigen 1 0.0127073
VEGFA vascular endothelial growth factor A 0.0126711
PLEC plectin 0.0126704
RACK1 receptor for activated C kinase 1 0.0126237
SFTPA2 surfactant protein A2 0.0124585

decreased expression

Symbol Name Standardized Value
TP63 tumor protein p63 -0.157163
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.108852
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.092635
CD44 CD44 molecule (Indian blood group) -0.0851823
CADM2 cell adhesion molecule 2 -0.0611414
RIGI RNA sensor RIG-I -0.0586304
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 -0.0538604
HLA-B major histocompatibility complex, class I, B -0.0507563
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 -0.0503868
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0494297
IFIH1 interferon induced with helicase C domain 1 -0.0488941
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0481035
TNS3 tensin 3 -0.0477372
PDE10A phosphodiesterase 10A -0.0476122
RNF213 ring finger protein 213 -0.0464003
TPT1 tumor protein, translationally-controlled 1 -0.0443222
ZDHHC14 zinc finger, DHHC-type containing 14 -0.0437701
TMSB4X thymosin beta 4, X-linked -0.042986
RAD51B RAD51 paralog B -0.0429168
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0423791
WARS1 tryptophanyl-tRNA synthetase 1 -0.0400099
SP100 SP100 nuclear antigen -0.0399458
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0389137
DPYD dihydropyrimidine dehydrogenase -0.0361369
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0360709
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like -0.0349944
DNER delta/notch-like EGF repeat containing -0.0348442
PTK2 protein tyrosine kinase 2 -0.0341327
EXOC4 exocyst complex component 4 -0.0329483
PSD3 pleckstrin and Sec7 domain containing 3 -0.0307881
DPH6 diphthamine biosynthesis 6 -0.0302513
PLSCR1 phospholipid scramblase 1 -0.0287378
DST dystonin -0.0287313
VCL vinculin -0.0283492
EHBP1 EH domain binding protein 1 -0.0282387
LPP LIM domain containing preferred translocation partner in lipoma -0.0281304
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0276718
DLG1 discs, large homolog 1 (Drosophila) -0.0275818
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C -0.0274437
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 -0.0256437
DENND1A DENN/MADD domain containing 1A -0.0251159
EPHA4 EPH receptor A4 -0.0250011
PRRC2B proline-rich coiled-coil 2B -0.0244989
NAP1L1 nucleosome assembly protein 1-like 1 -0.0242973
SMYD3 SET and MYND domain containing 3 -0.0240256
GNGT1 guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1 -0.0231892
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.0228187
RBM39 RNA binding motif protein 39 -0.022431
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0219875
CSMD3 CUB and Sushi multiple domains 3 -0.0214809
TPRG1 tumor protein p63 regulated 1 -0.0211836
DNAH14 dynein, axonemal, heavy chain 14 -0.0211481
TRIM56 tripartite motif containing 56 -0.0206122
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 -0.0205469
EFNA5 ephrin-A5 -0.0205244
PRELID2 PRELI domain containing 2 -0.0202532
RBM25 RNA binding motif protein 25 -0.0199764
FUS FUS RNA binding protein -0.0199058
CAVIN1 caveolae associated protein 1 -0.0196295
KPNB1 karyopherin (importin) beta 1 -0.019583
ENOSF1 enolase superfamily member 1 -0.0195267
WSB1 WD repeat and SOCS box containing 1 -0.0193725
HDAC9 histone deacetylase 9 -0.0192006
OAS3 2'-5'-oligoadenylate synthetase 3, 100kDa -0.0191395
TFRC transferrin receptor -0.0186459
AEBP2 AE binding protein 2 -0.0186374
TTC28 tetratricopeptide repeat domain 28 -0.0184254
KDM3A lysine (K)-specific demethylase 3A -0.0180414
FMNL2 formin-like 2 -0.0179524
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 -0.0179318
PMP22 peripheral myelin protein 22 -0.0178704
CMSS1 cms1 ribosomal small subunit homolog (yeast) -0.0177619
BICD1 bicaudal D homolog 1 (Drosophila) -0.0176855
SMCHD1 structural maintenance of chromosomes flexible hinge domain containing 1 -0.0176481
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 -0.0174469
UBE3C ubiquitin protein ligase E3C -0.0172598
TBC1D5 TBC1 domain family, member 5 -0.0171456
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0170158
ZNF217 zinc finger protein 217 -0.0168927
XAF1 XIAP associated factor 1 -0.0166508
ZMYND8 zinc finger, MYND-type containing 8 -0.0162577
RPL35A ribosomal protein L35a -0.0162343
SDK1 sidekick cell adhesion molecule 1 -0.0162274
RPL26 ribosomal protein L26 -0.0160692
PNPT1 polyribonucleotide nucleotidyltransferase 1 -0.0160304
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 -0.016015
ACACA acetyl-CoA carboxylase alpha -0.0159191
GCNT2 glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group) -0.015814
TFDP2 transcription factor Dp-2 (E2F dimerization partner 2) -0.0156908
WDR27 WD repeat domain 27 -0.0155386
IQCJ-SCHIP1 IQCJ-SCHIP1 readthrough -0.0155315
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0153286
CFAP299 cilia and flagella associated protein 299 -0.0152728
RPL38 ribosomal protein L38 -0.0150595
FAF1 Fas (TNFRSF6) associated factor 1 -0.0150582
BRINP3 bone morphogenetic protein/retinoic acid inducible neural-specific 3 -0.0150447
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) -0.0150232
NT5E 5'-nucleotidase, ecto (CD73) -0.0149842
SUCLG2 succinate-CoA ligase, GDP-forming, beta subunit -0.0149072
SUMF1 sulfatase modifying factor 1 -0.0148826