| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Tirabrutinib (hydrochloride) perturbation in NCI-H1573 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Tirabrutinib (hydrochloride)_NCI-H1573 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| FTH1 | ferritin, heavy polypeptide 1 | 0.171534 |
| CES1 | carboxylesterase 1 | 0.104811 |
| NDRG1 | N-myc downstream regulated 1 | 0.0898225 |
| SLTM | SAFB-like, transcription modulator | 0.0816566 |
| GNPDA1 | glucosamine-6-phosphate deaminase 1 | 0.0788172 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0753556 |
| PLEC | plectin | 0.0688613 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.0684517 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0652279 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.061065 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | 0.0592653 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0571627 |
| FAM13A | family with sequence similarity 13, member A | 0.0516197 |
| KRT18 | keratin 18, type I | 0.051161 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0485798 |
| INTS6 | integrator complex subunit 6 | 0.0479016 |
| EIF4A2 | eukaryotic translation initiation factor 4A2 | 0.0442536 |
| ARRDC3 | arrestin domain containing 3 | 0.0440343 |
| LOC112694756 | uncharaterized LOC112694756 | 0.0409916 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0391427 |
| HOOK2 | hook microtubule-tethering protein 2 | 0.0381037 |
| HOMER1 | homer scaffolding protein 1 | 0.0378774 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0375617 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0367174 |
| TNIP1 | TNFAIP3 interacting protein 1 | 0.0361004 |
| MCL1 | myeloid cell leukemia 1 | 0.035874 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0345891 |
| EGFR | epidermal growth factor receptor | 0.0341863 |
| ANXA1 | annexin A1 | 0.0336944 |
| ANO6 | anoctamin 6 | 0.0334294 |
| FOS | FBJ murine osteosarcoma viral oncogene homolog | 0.0330428 |
| PDLIM5 | PDZ and LIM domain 5 | 0.0327191 |
| SLC2A1 | solute carrier family 2 (facilitated glucose transporter), member 1 | 0.0317455 |
| DSPP | dentin sialophosphoprotein | 0.0312788 |
| ANXA2 | annexin A2 | 0.0312258 |
| BRD2 | bromodomain containing 2 | 0.0304672 |
| EZR | ezrin | 0.0298447 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0293252 |
| ZNF638 | zinc finger protein 638 | 0.0287177 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0283211 |
| FOSB | FBJ murine osteosarcoma viral oncogene homolog B | 0.0281367 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0278155 |
| FHIP1A | FHF complex subunit HOOK interacting protein 1A | 0.0276412 |
| SPAG9 | sperm associated antigen 9 | 0.0276232 |
| HDLBP | high density lipoprotein binding protein | 0.0276205 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | 0.026982 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0269156 |
| LAMB3 | laminin, beta 3 | 0.0268534 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0264064 |
| LMO7 | LIM domain 7 | 0.0259941 |
| PAPOLA | poly(A) polymerase alpha | 0.0259119 |
| NGLY1 | N-glycanase 1 | 0.0258043 |
| NR4A3 | nuclear receptor subfamily 4, group A, member 3 | 0.025442 |
| GOLGB1 | golgin B1 | 0.0248342 |
| DHFR | dihydrofolate reductase | 0.0247667 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0243378 |
| JUN | jun proto-oncogene | 0.0231019 |
| AHNAK | AHNAK nucleoprotein | 0.0228953 |
| VEGFA | vascular endothelial growth factor A | 0.0227781 |
| MYO5B | myosin VB | 0.0225411 |
| SMAD3 | SMAD family member 3 | 0.0222722 |
| MSN | moesin | 0.0222529 |
| NSUN6 | NOP2/Sun domain family, member 6 | 0.0222017 |
| PKM | pyruvate kinase, muscle | 0.0219533 |
| EGLN1 | egl-9 family hypoxia-inducible factor 1 | 0.0218191 |
| PYGL | phosphorylase, glycogen, liver | 0.0216634 |
| RPS4X | ribosomal protein S4, X-linked | 0.0216172 |
| ITGB4 | integrin, beta 4 | 0.0214216 |
| ARF4 | ADP-ribosylation factor 4 | 0.0213658 |
| TUFT1 | tuftelin 1 | 0.0213076 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0212161 |
| ATP11A | ATPase, class VI, type 11A | 0.0210811 |
| PFKFB3 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 | 0.020991 |
| FNIP1 | folliculin interacting protein 1 | 0.0208943 |
| EMP1 | epithelial membrane protein 1 | 0.0207135 |
| RPL3 | ribosomal protein L3 | 0.020638 |
| FZR1 | fizzy/cell division cycle 20 related 1 (Drosophila) | 0.0204768 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0204313 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0202328 |
| FLNA | filamin A, alpha | 0.0199405 |
| ATP1A4 | ATPase, Na+/K+ transporting, alpha 4 polypeptide | 0.0194839 |
| TSC22D2 | TSC22 domain family, member 2 | 0.0193768 |
| SLCO4A1 | solute carrier organic anion transporter family, member 4A1 | 0.0189909 |
| ZC3H11A | zinc finger CCCH-type containing 11A | 0.0188072 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | 0.0187009 |
| ASPH | aspartate beta-hydroxylase | 0.0186998 |
| MGAT5 | mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase | 0.0186966 |
| F11R | F11 receptor | 0.0185301 |
| ARCN1 | archain 1 | 0.0182554 |
| HUWE1 | HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase | 0.0182452 |
| VMP1 | vacuole membrane protein 1 | 0.01817 |
| NR4A1 | nuclear receptor subfamily 4, group A, member 1 | 0.0181374 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0180987 |
| DNAJC3 | DnaJ (Hsp40) homolog, subfamily C, member 3 | 0.01809 |
| EGLN3 | egl-9 family hypoxia-inducible factor 3 | 0.0177822 |
| EGR1 | early growth response 1 | 0.0177152 |
| BACE2 | beta-site APP-cleaving enzyme 2 | 0.0176041 |
| AGO2 | argonaute RISC catalytic component 2 | 0.0175167 |
| NFKBIA | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | 0.0174475 |
| CNOT1 | CCR4-NOT transcription complex, subunit 1 | 0.0171478 |
| Symbol | Name | Standardized Value |
|---|---|---|
| TMSB10 | thymosin beta 10 | -0.196126 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.170195 |
| TXNRD1 | thioredoxin reductase 1 | -0.152688 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.104504 |
| MT2A | metallothionein 2A | -0.100593 |
| LRP1B | low density lipoprotein receptor-related protein 1B | -0.0906502 |
| PTMA | prothymosin, alpha | -0.0870341 |
| FTL | ferritin, light polypeptide | -0.076629 |
| RPL35A | ribosomal protein L35a | -0.0760427 |
| CYP24A1 | cytochrome P450, family 24, subfamily A, polypeptide 1 | -0.0683498 |
| SEC61G | Sec61 gamma subunit | -0.067715 |
| RPLP1 | ribosomal protein, large, P1 | -0.0643284 |
| OSMR | oncostatin M receptor | -0.0629114 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.057796 |
| S100A10 | S100 calcium binding protein A10 | -0.0571029 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0555101 |
| RPS24 | ribosomal protein S24 | -0.0548858 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.051583 |
| PTGS2 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | -0.0496833 |
| GRAMD1B | GRAM domain containing 1B | -0.0494596 |
| H1-0 | H1.0 linker histone | -0.0477303 |
| NFE2L2 | nuclear factor, erythroid 2-like 2 | -0.0462224 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0459344 |
| RPL34 | ribosomal protein L34 | -0.0454372 |
| RPS25 | ribosomal protein S25 | -0.0453766 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.0445889 |
| AKR1C1 | aldo-keto reductase family 1, member C1 | -0.0442775 |
| RAP1B | RAP1B, member of RAS oncogene family | -0.0432037 |
| RPS8 | ribosomal protein S8 | -0.0421369 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | -0.0418625 |
| CAV1 | caveolin 1, caveolae protein, 22kDa | -0.0417744 |
| CST3 | cystatin C | -0.0409196 |
| RPS6 | ribosomal protein S6 | -0.0408694 |
| RAB10 | RAB10, member RAS oncogene family | -0.0402055 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | -0.0400381 |
| CEACAM6 | carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) | -0.0395384 |
| S100A9 | S100 calcium binding protein A9 | -0.0387494 |
| IER3 | immediate early response 3 | -0.0385047 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.038116 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0376624 |
| ANKRD12 | ankyrin repeat domain 12 | -0.0366482 |
| RPL37A | ribosomal protein L37a | -0.0362302 |
| TMEM165 | transmembrane protein 165 | -0.0356988 |
| IFI6 | interferon, alpha-inducible protein 6 | -0.0355942 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | -0.0347895 |
| UVRAG | UV radiation resistance associated | -0.0343394 |
| KRT7 | keratin 7, type II | -0.0340582 |
| RPL12 | ribosomal protein L12 | -0.0339787 |
| C15ORF48 | chromosome 15 open reading frame 48 | -0.0337111 |
| RPS3 | ribosomal protein S3 | -0.0336923 |
| RPLP0 | ribosomal protein, large, P0 | -0.0333466 |
| CSTB | cystatin B (stefin B) | -0.0331135 |
| TRIM56 | tripartite motif containing 56 | -0.0330322 |
| DDX17 | DEAD (Asp-Glu-Ala-Asp) box helicase 17 | -0.0329054 |
| LANCL2 | LanC lantibiotic synthetase component C-like 2 (bacterial) | -0.0326677 |
| RPS21 | ribosomal protein S21 | -0.032217 |
| ACSL3 | acyl-CoA synthetase long-chain family member 3 | -0.0316241 |
| SEMA4B | sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B | -0.0316053 |
| ARHGAP32 | Rho GTPase activating protein 32 | -0.0314775 |
| MT1X | metallothionein 1X | -0.0313915 |
| RPS23 | ribosomal protein S23 | -0.0311977 |
| SMURF1 | SMAD specific E3 ubiquitin protein ligase 1 | -0.0305056 |
| PGK1 | phosphoglycerate kinase 1 | -0.0304993 |
| RAB27B | RAB27B, member RAS oncogene family | -0.0302594 |
| BTG1 | B-cell translocation gene 1, anti-proliferative | -0.0293951 |
| PRRC2C | proline-rich coiled-coil 2C | -0.0291475 |
| RPL31 | ribosomal protein L31 | -0.0291083 |
| UBE2D3 | ubiquitin-conjugating enzyme E2D 3 | -0.0290378 |
| B2M | beta-2-microglobulin | -0.0290179 |
| ACTG1 | actin gamma 1 | -0.0289099 |
| S100A11 | S100 calcium binding protein A11 | -0.0287353 |
| RPS19 | ribosomal protein S19 | -0.0286063 |
| RPL36A | ribosomal protein L36a | -0.0285464 |
| KTN1 | kinectin 1 (kinesin receptor) | -0.0280412 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0280075 |
| RPS29 | ribosomal protein S29 | -0.0271053 |
| S100P | S100 calcium binding protein P | -0.0267842 |
| RBM39 | RNA binding motif protein 39 | -0.0267656 |
| RPS14 | ribosomal protein S14 | -0.0266573 |
| LAMA4 | laminin, alpha 4 | -0.0262513 |
| RNF145 | ring finger protein 145 | -0.0260537 |
| MGST1 | microsomal glutathione S-transferase 1 | -0.0259699 |
| MYL12A | myosin, light chain 12A, regulatory, non-sarcomeric | -0.0259466 |
| YWHAB | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta | -0.0255746 |
| TOP1 | topoisomerase (DNA) I | -0.0248995 |
| RPLP2 | ribosomal protein, large, P2 | -0.024784 |
| NT5C2 | 5'-nucleotidase, cytosolic II | -0.024579 |
| ARPC2 | actin related protein 2/3 complex, subunit 2, 34kDa | -0.0245508 |
| GNAS | GNAS complex locus | -0.0244105 |
| RPS27A | ribosomal protein S27a | -0.0241445 |
| TMEM87A | transmembrane protein 87A | -0.0241132 |
| RPL37 | ribosomal protein L37 | -0.0240623 |
| RNF213 | ring finger protein 213 | -0.0238789 |
| CD163L1 | CD163 molecule-like 1 | -0.0234752 |
| S100A6 | S100 calcium binding protein A6 | -0.0232758 |
| RAB1A | RAB1A, member RAS oncogene family | -0.023012 |
| SEPTIN2 | septin 2 | -0.0229752 |
| RPL23 | ribosomal protein L23 | -0.0228591 |
| CEACAM5 | carcinoembryonic antigen-related cell adhesion molecule 5 | -0.0223748 |
| KPNB1 | karyopherin (importin) beta 1 | -0.0221964 |
