| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Tirabrutinib (hydrochloride) perturbation in NCI-H1792 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Tirabrutinib (hydrochloride)_NCI-H1792 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.134757 |
| GOLGA4 | golgin A4 | 0.101919 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0950611 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.0790101 |
| KDM2A | lysine (K)-specific demethylase 2A | 0.0693288 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0655602 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0652619 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0645447 |
| FAM13A | family with sequence similarity 13, member A | 0.0632304 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0579768 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.055261 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.052859 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.0513655 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.0504908 |
| OGA | O-GlcNAcase | 0.0455045 |
| PCBP2 | poly(rC) binding protein 2 | 0.0443722 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0436378 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0435751 |
| NDRG1 | N-myc downstream regulated 1 | 0.0434515 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.042587 |
| BASP1 | brain abundant, membrane attached signal protein 1 | 0.0419502 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.0404743 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.0394685 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.0393524 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0389498 |
| FHIP1A | FHF complex subunit HOOK interacting protein 1A | 0.0388792 |
| RBM39 | RNA binding motif protein 39 | 0.0383841 |
| SPAG9 | sperm associated antigen 9 | 0.0381716 |
| SRP54 | signal recognition particle 54kDa | 0.0369456 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.035814 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0351031 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | 0.0344911 |
| HELZ | helicase with zinc finger | 0.0344291 |
| DDIT3 | DNA-damage-inducible transcript 3 | 0.0342644 |
| PDK3 | pyruvate dehydrogenase kinase, isozyme 3 | 0.0332973 |
| RIOK3 | RIO kinase 3 | 0.0325813 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0315088 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | 0.0314582 |
| CALU | calumenin | 0.0313783 |
| ZNF292 | zinc finger protein 292 | 0.0313606 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0311052 |
| FTL | ferritin, light polypeptide | 0.0307287 |
| ANXA1 | annexin A1 | 0.0303537 |
| SMAD3 | SMAD family member 3 | 0.0302432 |
| CANX | calnexin | 0.0302205 |
| PIK3C2A | phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha | 0.0301735 |
| SETD5 | SET domain containing 5 | 0.029379 |
| YBX1 | Y box binding protein 1 | 0.0290943 |
| PDIA3 | protein disulfide isomerase family A, member 3 | 0.0290159 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | 0.0286439 |
| SEC24A | SEC24 family member A | 0.0282461 |
| PTMA | prothymosin, alpha | 0.028237 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0281766 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0276827 |
| RAB1A | RAB1A, member RAS oncogene family | 0.0276291 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.027515 |
| ADM | adrenomedullin | 0.0274324 |
| COPA | coatomer protein complex, subunit alpha | 0.027353 |
| FLNB | filamin B, beta | 0.0272031 |
| SUCO | SUN domain containing ossification factor | 0.0269277 |
| COG5 | component of oligomeric golgi complex 5 | 0.0264094 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0262965 |
| ARF4 | ADP-ribosylation factor 4 | 0.02619 |
| HILPDA | hypoxia inducible lipid droplet-associated | 0.0261794 |
| USP3 | ubiquitin specific peptidase 3 | 0.0260362 |
| SEC23A | Sec23 homolog A (S. cerevisiae) | 0.0257829 |
| CNOT2 | CCR4-NOT transcription complex, subunit 2 | 0.0252474 |
| WAC | WW domain containing adaptor with coiled-coil | 0.0252405 |
| RAB8B | RAB8B, member RAS oncogene family | 0.0251993 |
| YBX3 | Y box binding protein 3 | 0.0251142 |
| ACBD3 | acyl-CoA binding domain containing 3 | 0.0247512 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | 0.0246967 |
| OS9 | osteosarcoma amplified 9, endoplasmic reticulum lectin | 0.0245458 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0241779 |
| LMAN1 | lectin, mannose-binding, 1 | 0.0238376 |
| RNF145 | ring finger protein 145 | 0.0236187 |
| ATP13A3 | ATPase type 13A3 | 0.0235144 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0235028 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0234234 |
| WDR45B | WD repeat domain 45B | 0.023332 |
| NBAS | neuroblastoma amplified sequence | 0.0232825 |
| MORF4L2 | mortality factor 4 like 2 | 0.0227359 |
| HDLBP | high density lipoprotein binding protein | 0.022709 |
| MYC | v-myc avian myelocytomatosis viral oncogene homolog | 0.0226086 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | 0.0224068 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | 0.0223997 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0221402 |
| RUNX1 | runt-related transcription factor 1 | 0.0220768 |
| FBXL13 | F-box and leucine-rich repeat protein 13 | 0.0219442 |
| PTPN14 | protein tyrosine phosphatase, non-receptor type 14 | 0.0217524 |
| YME1L1 | YME1-like 1 ATPase | 0.0216754 |
| GARS1 | glycyl-tRNA synthetase 1 | 0.0216681 |
| RAB5A | RAB5A, member RAS oncogene family | 0.0212332 |
| TAF15 | TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa | 0.0209579 |
| TTC3 | tetratricopeptide repeat domain 3 | 0.0209453 |
| RLF | rearranged L-myc fusion | 0.0208616 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0208371 |
| CALR | calreticulin | 0.0208032 |
| PJA2 | praja ring finger 2, E3 ubiquitin protein ligase | 0.0207852 |
| CSDE1 | cold shock domain containing E1, RNA-binding | 0.0206058 |
| Symbol | Name | Standardized Value |
|---|---|---|
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.114596 |
| GLCCI1 | glucocorticoid induced 1 | -0.0936925 |
| HMGA2 | high mobility group AT-hook 2 | -0.0917505 |
| FN1 | fibronectin 1 | -0.0846267 |
| NRG1 | neuregulin 1 | -0.0801831 |
| DPYD | dihydropyrimidine dehydrogenase | -0.0798794 |
| CAMK1D | calcium/calmodulin-dependent protein kinase ID | -0.0777449 |
| ITPR1 | inositol 1,4,5-trisphosphate receptor, type 1 | -0.0747225 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0697029 |
| CDH13 | cadherin 13 | -0.0681099 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | -0.0618213 |
| MAGI2 | membrane associated guanylate kinase, WW and PDZ domain containing 2 | -0.0580112 |
| NRP1 | neuropilin 1 | -0.0577979 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.0569444 |
| ANTXR2 | anthrax toxin receptor 2 | -0.0566411 |
| MTSS1 | metastasis suppressor 1 | -0.0480097 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | -0.0428017 |
| OSMR | oncostatin M receptor | -0.0419053 |
| MSRB3 | methionine sulfoxide reductase B3 | -0.0418233 |
| DST | dystonin | -0.0408038 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.0403555 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0384613 |
| NHS | Nance-Horan syndrome (congenital cataracts and dental anomalies) | -0.0381087 |
| MECOM | MDS1 and EVI1 complex locus | -0.0379888 |
| APBB2 | amyloid beta (A4) precursor protein-binding, family B, member 2 | -0.0379789 |
| CD44 | CD44 molecule (Indian blood group) | -0.0372177 |
| RAI14 | retinoic acid induced 14 | -0.0362645 |
| NTN4 | netrin 4 | -0.0362016 |
| FAM20C | family with sequence similarity 20, member C | -0.0358747 |
| SIPA1L1 | signal-induced proliferation-associated 1 like 1 | -0.0358047 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0351179 |
| ZNF804A | zinc finger protein 804A | -0.0351114 |
| TIMP1 | TIMP metallopeptidase inhibitor 1 | -0.0348471 |
| LRMDA | leucine rich melanocyte differentiation associated | -0.0346784 |
| RAD51B | RAD51 paralog B | -0.0343957 |
| SYT1 | synaptotagmin I | -0.0341205 |
| LOX | lysyl oxidase | -0.0340931 |
| ARHGAP5 | Rho GTPase activating protein 5 | -0.0340058 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | -0.0338149 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.0336319 |
| CLMP | CXADR-like membrane protein | -0.0335877 |
| ETV6 | ets variant 6 | -0.0325748 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | -0.0323582 |
| ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 | -0.0323572 |
| CDK14 | cyclin-dependent kinase 14 | -0.031863 |
| MAML3 | mastermind-like 3 (Drosophila) | -0.0317482 |
| TFPI2 | tissue factor pathway inhibitor 2 | -0.0317462 |
| EDIL3 | EGF-like repeats and discoidin I-like domains 3 | -0.0316537 |
| STXBP5 | syntaxin binding protein 5 (tomosyn) | -0.0295695 |
| TRPS1 | trichorhinophalangeal syndrome I | -0.0294419 |
| SDK1 | sidekick cell adhesion molecule 1 | -0.0293122 |
| LTBP1 | latent transforming growth factor beta binding protein 1 | -0.0290631 |
| EFNA5 | ephrin-A5 | -0.0287147 |
| SAMD9 | sterile alpha motif domain containing 9 | -0.0284782 |
| GLIS3 | GLIS family zinc finger 3 | -0.0283776 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0271599 |
| GPC6 | glypican 6 | -0.0269304 |
| ZEB2 | zinc finger E-box binding homeobox 2 | -0.0268042 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | -0.0267392 |
| FBN1 | fibrillin 1 | -0.0263029 |
| EHBP1 | EH domain binding protein 1 | -0.0262478 |
| KYNU | kynureninase | -0.0262083 |
| PAPPA | pregnancy-associated plasma protein A, pappalysin 1 | -0.0260224 |
| IFI44L | interferon-induced protein 44-like | -0.0257219 |
| RNF213 | ring finger protein 213 | -0.0255373 |
| OXR1 | oxidation resistance 1 | -0.0254911 |
| VRK2 | vaccinia related kinase 2 | -0.025401 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | -0.0252925 |
| ENOSF1 | enolase superfamily member 1 | -0.0251696 |
| PRRX1 | paired related homeobox 1 | -0.0251616 |
| ITGB3 | integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) | -0.0250077 |
| RASAL2 | RAS protein activator like 2 | -0.0249012 |
| RAB27B | RAB27B, member RAS oncogene family | -0.0243922 |
| SUMF1 | sulfatase modifying factor 1 | -0.0238976 |
| CUX1 | cut-like homeobox 1 | -0.0235579 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.0224341 |
| BMPR2 | bone morphogenetic protein receptor, type II (serine/threonine kinase) | -0.0222225 |
| ANK3 | ankyrin 3, node of Ranvier (ankyrin G) | -0.0221273 |
| ANXA10 | annexin A10 | -0.0220995 |
| MACF1 | microtubule-actin crosslinking factor 1 | -0.0220888 |
| HIPK2 | homeodomain interacting protein kinase 2 | -0.0216139 |
| WLS | wntless Wnt ligand secretion mediator | -0.0215032 |
| R3HDM2 | R3H domain containing 2 | -0.021353 |
| NAV3 | neuron navigator 3 | -0.0212099 |
| PTGIS | prostaglandin I2 (prostacyclin) synthase | -0.0208013 |
| ABCA6 | ATP-binding cassette, sub-family A (ABC1), member 6 | -0.0207481 |
| DDX60L | DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like | -0.0206877 |
| HS2ST1 | heparan sulfate 2-O-sulfotransferase 1 | -0.0205876 |
| LHFPL2 | lipoma HMGIC fusion partner-like 2 | -0.0204593 |
| PLCB1 | phospholipase C, beta 1 (phosphoinositide-specific) | -0.0203976 |
| TBL1X | transducin (beta)-like 1X-linked | -0.0201646 |
| PRG2 | proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein) | -0.0197372 |
| RASSF8 | Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 | -0.0197215 |
| DIP2C | DIP2 disco-interacting protein 2 homolog C (Drosophila) | -0.0196531 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0193513 |
| CACNA2D3 | calcium channel, voltage-dependent, alpha 2/delta subunit 3 | -0.0192108 |
| BMERB1 | bMERB domain containing 1 | -0.0191929 |
| IL1B | interleukin 1, beta | -0.0190174 |
| PRKCA | protein kinase C, alpha | -0.0189061 |
| RBMS1 | RNA binding motif, single stranded interacting protein 1 | -0.0188923 |
