| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Tirabrutinib (hydrochloride) perturbation in NCI-H2030 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Tirabrutinib (hydrochloride)_NCI-H2030 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| FTH1 | ferritin, heavy polypeptide 1 | 0.189547 |
| MT2A | metallothionein 2A | 0.144007 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0871479 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0773166 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0499926 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0461247 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.0433675 |
| NFKBIA | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | 0.0373658 |
| ZFAND3 | zinc finger, AN1-type domain 3 | 0.0363886 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0338446 |
| YBX1 | Y box binding protein 1 | 0.03375 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0333707 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0328353 |
| RPS12 | ribosomal protein S12 | 0.0324861 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0319792 |
| TRA2A | transformer 2 alpha homolog (Drosophila) | 0.0315512 |
| RBM25 | RNA binding motif protein 25 | 0.0304834 |
| ZNF292 | zinc finger protein 292 | 0.0302592 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0297662 |
| FAM168A | family with sequence similarity 168, member A | 0.0297084 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0290998 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0278219 |
| FXR1 | fragile X mental retardation, autosomal homolog 1 | 0.0278074 |
| TFPI2 | tissue factor pathway inhibitor 2 | 0.0273958 |
| SLC38A1 | solute carrier family 38, member 1 | 0.0273393 |
| DENND4A | DENN/MADD domain containing 4A | 0.027069 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0267014 |
| CALR | calreticulin | 0.0257346 |
| B2M | beta-2-microglobulin | 0.0256599 |
| RPS6 | ribosomal protein S6 | 0.025601 |
| TFG | TRK-fused gene | 0.0254657 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0251733 |
| JAK1 | Janus kinase 1 | 0.0250997 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | 0.0247057 |
| PSMD14 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 | 0.024653 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0244151 |
| FOSB | FBJ murine osteosarcoma viral oncogene homolog B | 0.0240116 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | 0.0239788 |
| NUP58 | nucleoporin 58 | 0.0237058 |
| RNF145 | ring finger protein 145 | 0.0235874 |
| RPL19 | ribosomal protein L19 | 0.0232507 |
| TPM3 | tropomyosin 3 | 0.0228805 |
| CCNL1 | cyclin L1 | 0.0228022 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0225542 |
| HLA-B | major histocompatibility complex, class I, B | 0.0222862 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | 0.022031 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0220025 |
| IL6 | interleukin 6 | 0.0218981 |
| ANXA1 | annexin A1 | 0.0217338 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.0216032 |
| OSBPL9 | oxysterol binding protein-like 9 | 0.0214373 |
| SFTPA2 | surfactant protein A2 | 0.0210617 |
| HLA-A | major histocompatibility complex, class I, A | 0.0210508 |
| IER3 | immediate early response 3 | 0.0208579 |
| UPP1 | uridine phosphorylase 1 | 0.0208565 |
| NOP58 | NOP58 ribonucleoprotein | 0.0201102 |
| YBX3 | Y box binding protein 3 | 0.0200829 |
| FOS | FBJ murine osteosarcoma viral oncogene homolog | 0.019915 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0198473 |
| TAF15 | TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa | 0.0197389 |
| PDIA3 | protein disulfide isomerase family A, member 3 | 0.0192933 |
| CTNNB1 | catenin (cadherin-associated protein), beta 1, 88kDa | 0.0192521 |
| PLEC | plectin | 0.0190475 |
| RBM39 | RNA binding motif protein 39 | 0.0186506 |
| EIF4A3 | eukaryotic translation initiation factor 4A3 | 0.0181888 |
| PRPF40A | PRP40 pre-mRNA processing factor 40 homolog A (S. cerevisiae) | 0.0176848 |
| CALU | calumenin | 0.017452 |
| ADAM17 | ADAM metallopeptidase domain 17 | 0.0174382 |
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | 0.0174262 |
| USP3 | ubiquitin specific peptidase 3 | 0.017415 |
| OLA1 | Obg-like ATPase 1 | 0.0172503 |
| FLNA | filamin A, alpha | 0.0171488 |
| MLF1 | myeloid leukemia factor 1 | 0.0170225 |
| RPL11 | ribosomal protein L11 | 0.016952 |
| PDIA6 | protein disulfide isomerase family A, member 6 | 0.0168626 |
| HNRNPM | heterogeneous nuclear ribonucleoprotein M | 0.0167995 |
| EZR | ezrin | 0.016687 |
| RPL37A | ribosomal protein L37a | 0.0165797 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0165796 |
| WDR43 | WD repeat domain 43 | 0.0165487 |
| OPTN | optineurin | 0.0165263 |
| RPS2 | ribosomal protein S2 | 0.0165072 |
| MAP4K5 | mitogen-activated protein kinase kinase kinase kinase 5 | 0.0164174 |
| CXCL1 | chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) | 0.0164035 |
| RPLP1 | ribosomal protein, large, P1 | 0.0163325 |
| BCLAF1 | BCL2-associated transcription factor 1 | 0.0161597 |
| ADM | adrenomedullin | 0.0160647 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0159724 |
| RPL13A | ribosomal protein L13a | 0.0159378 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.015885 |
| PNN | pinin, desmosome associated protein | 0.0158764 |
| GOLGA4 | golgin A4 | 0.0153841 |
| DNAJC3 | DnaJ (Hsp40) homolog, subfamily C, member 3 | 0.0153615 |
| CLU | clusterin | 0.0153261 |
| PNISR | PNN-interacting serine/arginine-rich protein | 0.0151989 |
| PAPOLA | poly(A) polymerase alpha | 0.014926 |
| DHX9 | DEAH (Asp-Glu-Ala-His) box helicase 9 | 0.0148874 |
| RPL17-C18ORF32 | RPL17-C18orf32 readthrough | 0.0148642 |
| DDIT4 | DNA-damage-inducible transcript 4 | 0.0147047 |
| RSRP1 | arginine/serine-rich protein 1 | 0.0146305 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.162873 |
| PM20D1 | peptidase M20 domain containing 1 | -0.108366 |
| TXNRD1 | thioredoxin reductase 1 | -0.0840957 |
| ROBO2 | roundabout, axon guidance receptor, homolog 2 (Drosophila) | -0.0815573 |
| GRAMD1B | GRAM domain containing 1B | -0.074399 |
| THSD4 | thrombospondin, type I, domain containing 4 | -0.0714062 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0709875 |
| VIM | vimentin | -0.0705592 |
| CMIP | c-Maf inducing protein | -0.0616074 |
| TMSB10 | thymosin beta 10 | -0.0615508 |
| BICC1 | BicC family RNA binding protein 1 | -0.0597602 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0581542 |
| HDAC9 | histone deacetylase 9 | -0.0559217 |
| ERBIN | erbb2 interacting protein | -0.0548579 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0524221 |
| UTRN | utrophin | -0.047322 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | -0.0472845 |
| UBASH3B | ubiquitin associated and SH3 domain containing B | -0.0461891 |
| DOCK4 | dedicator of cytokinesis 4 | -0.0454458 |
| BASP1 | brain abundant, membrane attached signal protein 1 | -0.0450718 |
| SVIL | supervillin | -0.0422727 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | -0.0420729 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.04082 |
| LANCL1 | LanC lantibiotic synthetase component C-like 1 (bacterial) | -0.0398065 |
| MAML3 | mastermind-like 3 (Drosophila) | -0.039693 |
| LDHA | lactate dehydrogenase A | -0.0393217 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | -0.0381906 |
| DOCK5 | dedicator of cytokinesis 5 | -0.0379536 |
| ACTG1 | actin gamma 1 | -0.0361438 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | -0.0354422 |
| EFNA5 | ephrin-A5 | -0.0346379 |
| MTHFD1L | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like | -0.0344663 |
| SIPA1L1 | signal-induced proliferation-associated 1 like 1 | -0.0343418 |
| CITED2 | Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 | -0.0330358 |
| MBNL1 | muscleblind-like splicing regulator 1 | -0.0329649 |
| NEGR1 | neuronal growth regulator 1 | -0.0328836 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0327442 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.0323914 |
| KCNQ5 | potassium channel, voltage gated KQT-like subfamily Q, member 5 | -0.0315053 |
| TTC28 | tetratricopeptide repeat domain 28 | -0.0309598 |
| ARHGEF28 | Rho guanine nucleotide exchange factor (GEF) 28 | -0.0308263 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | -0.0306795 |
| STC1 | stanniocalcin 1 | -0.0296141 |
| KYNU | kynureninase | -0.0294832 |
| GLIS3 | GLIS family zinc finger 3 | -0.0282189 |
| SPIDR | scaffolding protein involved in DNA repair | -0.0275312 |
| SLC35F3 | solute carrier family 35, member F3 | -0.027134 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.0270202 |
| PLS3 | plastin 3 | -0.0269497 |
| VPS13B | vacuolar protein sorting 13 homolog B (yeast) | -0.0269127 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | -0.0261253 |
| TBC1D5 | TBC1 domain family, member 5 | -0.0259846 |
| CSGALNACT1 | chondroitin sulfate N-acetylgalactosaminyltransferase 1 | -0.0254229 |
| PAWR | PRKC, apoptosis, WT1, regulator | -0.024908 |
| S100A6 | S100 calcium binding protein A6 | -0.0246966 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | -0.0241322 |
| NQO1 | NAD(P)H dehydrogenase, quinone 1 | -0.0238235 |
| AHR | aryl hydrocarbon receptor | -0.0237794 |
| CHD9 | chromodomain helicase DNA binding protein 9 | -0.0237698 |
| IGF2 | insulin-like growth factor 2 | -0.023704 |
| SHANK2 | SH3 and multiple ankyrin repeat domains 2 | -0.0236291 |
| LPP | LIM domain containing preferred translocation partner in lipoma | -0.0232871 |
| RAD51B | RAD51 paralog B | -0.0229268 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | -0.0228687 |
| EGR1 | early growth response 1 | -0.0227441 |
| NCEH1 | neutral cholesterol ester hydrolase 1 | -0.0226811 |
| EHBP1 | EH domain binding protein 1 | -0.0226156 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0225014 |
| BABAM2 | BRISC and BRCA1 A complex member 2 | -0.0223961 |
| AK1 | adenylate kinase 1 | -0.0222808 |
| SMOC1 | SPARC related modular calcium binding 1 | -0.0222346 |
| RHOA | ras homolog family member A | -0.0215715 |
| PRR16 | proline rich 16 | -0.0215502 |
| ECT2 | epithelial cell transforming 2 | -0.0215096 |
| ACACA | acetyl-CoA carboxylase alpha | -0.0213619 |
| ARHGAP29 | Rho GTPase activating protein 29 | -0.0208912 |
| RASAL2 | RAS protein activator like 2 | -0.0208454 |
| ZFHX3 | zinc finger homeobox 3 | -0.0207011 |
| PARD3 | par-3 family cell polarity regulator | -0.0206013 |
| MAP3K5 | mitogen-activated protein kinase kinase kinase 5 | -0.0205759 |
| CNKSR3 | CNKSR family member 3 | -0.0197134 |
| DDAH1 | dimethylarginine dimethylaminohydrolase 1 | -0.0195756 |
| ANKRD17 | ankyrin repeat domain 17 | -0.0193129 |
| VCL | vinculin | -0.0192389 |
| RPTOR | regulatory associated protein of MTOR, complex 1 | -0.0192116 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | -0.0191832 |
| IGF2BP3 | insulin-like growth factor 2 mRNA binding protein 3 | -0.0191118 |
| ARPC2 | actin related protein 2/3 complex, subunit 2, 34kDa | -0.0190789 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | -0.0189681 |
| NTN4 | netrin 4 | -0.0189592 |
| BCAR3 | breast cancer anti-estrogen resistance 3 | -0.0188849 |
| PTPRG | protein tyrosine phosphatase, receptor type, G | -0.0187637 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.0185923 |
| USP34 | ubiquitin specific peptidase 34 | -0.0185473 |
| EIF4G3 | eukaryotic translation initiation factor 4 gamma, 3 | -0.0183158 |
| EYA4 | EYA transcriptional coactivator and phosphatase 4 | -0.0183122 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0181869 |
| SMAD2 | SMAD family member 2 | -0.0180847 |
| FOXP1 | forkhead box P1 | -0.0177806 |
| EGFR | epidermal growth factor receptor | -0.0177648 |
