Tirabrutinib (hydrochloride)_NCI-H2122 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Tirabrutinib (hydrochloride) perturbation in NCI-H2122 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Tirabrutinib (hydrochloride)_NCI-H2122 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.121119
ELL2 elongation factor, RNA polymerase II, 2 0.108406
EEF2 eukaryotic translation elongation factor 2 0.0955004
GOLGA4 golgin A4 0.0951811
NDRG1 N-myc downstream regulated 1 0.0917828
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0828896
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0800058
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0751753
MYH9 myosin, heavy chain 9, non-muscle 0.0739022
SBF2 SET binding factor 2 0.0698207
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0685309
CALU calumenin 0.0647342
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0644897
STC1 stanniocalcin 1 0.0634974
RPS3 ribosomal protein S3 0.0622088
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0620924
PGK1 phosphoglycerate kinase 1 0.0614569
NAV2 neuron navigator 2 0.0597738
PDIA3 protein disulfide isomerase family A, member 3 0.055573
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0553772
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) 0.055099
TRIO trio Rho guanine nucleotide exchange factor 0.0525678
KMT2E lysine (K)-specific methyltransferase 2E 0.052078
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0520246
KRT17 keratin 17, type I 0.0512339
SMAD3 SMAD family member 3 0.0510853
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.0507808
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0506872
NUP58 nucleoporin 58 0.0492064
COPB1 coatomer protein complex, subunit beta 1 0.0489601
RPS6 ribosomal protein S6 0.0481243
ADM adrenomedullin 0.0466949
ZNF292 zinc finger protein 292 0.0427473
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0426129
FLNB filamin B, beta 0.0425167
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0422738
HELZ helicase with zinc finger 0.0416777
HOOK2 hook microtubule-tethering protein 2 0.0407644
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.0404343
SQSTM1 sequestosome 1 0.0383005
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0377726
FTH1 ferritin, heavy polypeptide 1 0.0377368
CDC27 cell division cycle 27 0.0367464
KMT2C lysine (K)-specific methyltransferase 2C 0.0366269
KRT18 keratin 18, type I 0.0364793
MT2A metallothionein 2A 0.0360705
ZCCHC7 zinc finger, CCHC domain containing 7 0.0359243
PCNX1 pecanex 1 0.0357287
FYN FYN proto-oncogene, Src family tyrosine kinase 0.0356981
FN1 fibronectin 1 0.0352602
JARID2 jumonji, AT rich interactive domain 2 0.0346099
RBM25 RNA binding motif protein 25 0.0341676
LOC112694756 uncharaterized LOC112694756 0.0340763
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0334313
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0331283
ACTN4 actinin, alpha 4 0.032876
AP3B1 adaptor-related protein complex 3, beta 1 subunit 0.0326936
FAM13A family with sequence similarity 13, member A 0.0323827
GARS1 glycyl-tRNA synthetase 1 0.0322084
MAP3K2 mitogen-activated protein kinase kinase kinase 2 0.0320109
GPCPD1 glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) 0.0318336
ESYT2 extended synaptotagmin-like protein 2 0.0317743
RPS12 ribosomal protein S12 0.0316406
SETD5 SET domain containing 5 0.0316264
YAP1 Yes-associated protein 1 0.0315267
WDR45B WD repeat domain 45B 0.0312666
UBE2D3 ubiquitin-conjugating enzyme E2D 3 0.0309796
RBM39 RNA binding motif protein 39 0.0307645
ZMYM2 zinc finger, MYM-type 2 0.0306581
QKI QKI, KH domain containing, RNA binding 0.0305184
BHLHE40 basic helix-loop-helix family, member e40 0.0303758
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0300403
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.0298191
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0294143
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa 0.029245
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2 0.0291723
TTC3 tetratricopeptide repeat domain 3 0.0285748
ATP13A3 ATPase type 13A3 0.0282677
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha 0.0281949
SREBF2 sterol regulatory element binding transcription factor 2 0.0278855
OGA O-GlcNAcase 0.0276378
NKD1 naked cuticle homolog 1 (Drosophila) 0.0276362
USP34 ubiquitin specific peptidase 34 0.0276293
VEGFA vascular endothelial growth factor A 0.0274736
PTMA prothymosin, alpha 0.0273976
LDHA lactate dehydrogenase A 0.0273133
RLF rearranged L-myc fusion 0.0272621
ZC3HAV1 zinc finger CCCH-type, antiviral 1 0.0269128
CSDE1 cold shock domain containing E1, RNA-binding 0.0267227
PDPK1 3-phosphoinositide dependent protein kinase 1 0.026691
OPTN optineurin 0.0265687
FXR1 fragile X mental retardation, autosomal homolog 1 0.0262326
RUNX1 runt-related transcription factor 1 0.0262086
CTBP2 C-terminal binding protein 2 0.0256354
TMSB4X thymosin beta 4, X-linked 0.0256029
HSPA8 heat shock 70kDa protein 8 0.0255595
IRS2 insulin receptor substrate 2 0.0254691
MAP4K5 mitogen-activated protein kinase kinase kinase kinase 5 0.0251395
NAP1L1 nucleosome assembly protein 1-like 1 0.0248596
PTK2 protein tyrosine kinase 2 0.0246909

decreased expression

Symbol Name Standardized Value
MYO1E myosin IE -0.174473
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.153246
LMO7 LIM domain 7 -0.149734
SAMD4A sterile alpha motif domain containing 4A -0.117154
PDE4D phosphodiesterase 4D, cAMP-specific -0.112998
BACE2 beta-site APP-cleaving enzyme 2 -0.104288
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C -0.100882
LAMC2 laminin, gamma 2 -0.094258
ATOSA atos homolog A -0.0888462
OSMR oncostatin M receptor -0.084067
ATP2C2 ATPase, Ca++ transporting, type 2C, member 2 -0.0809055
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) -0.0734526
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0704724
SVIL supervillin -0.0697123
KATNBL1 katanin p80 subunit B-like 1 -0.0683714
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0680997
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0675133
S100A9 S100 calcium binding protein A9 -0.0620074
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 -0.0612039
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.0590595
KYNU kynureninase -0.0554887
RBM47 RNA binding motif protein 47 -0.055487
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0553028
TMCC3 transmembrane and coiled-coil domain family 3 -0.0537807
IGFBP3 insulin-like growth factor binding protein 3 -0.0513692
RAB11FIP1 RAB11 family interacting protein 1 (class I) -0.0506033
LIMCH1 LIM and calponin homology domains 1 -0.0499212
PATJ PATJ crumbs cell polarity complex component -0.0498917
LAMB3 laminin, beta 3 -0.0481849
SMYD3 SET and MYND domain containing 3 -0.0481075
F3 coagulation factor III (thromboplastin, tissue factor) -0.0470471
NPEPPS aminopeptidase puromycin sensitive -0.0469179
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) -0.0459002
LPP LIM domain containing preferred translocation partner in lipoma -0.045618
TM4SF1 transmembrane 4 L six family member 1 -0.0452851
ZNF217 zinc finger protein 217 -0.0450971
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0436605
CPEB4 cytoplasmic polyadenylation element binding protein 4 -0.0434106
BPTF bromodomain PHD finger transcription factor -0.0430827
MAST4 microtubule associated serine/threonine kinase family member 4 -0.0428616
IGF1R insulin-like growth factor 1 receptor -0.0427804
BZW1 basic leucine zipper and W2 domains 1 -0.0427277
ABHD17C abhydrolase domain containing 17C -0.0426753
TJP1 tight junction protein 1 -0.0425181
PLAUR plasminogen activator, urokinase receptor -0.0424361
BRIP1 BRCA1 interacting protein C-terminal helicase 1 -0.0423347
SLC38A1 solute carrier family 38, member 1 -0.0423078
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0419148
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0414573
H3-3B H3.3 histone B -0.0411023
RNF213 ring finger protein 213 -0.0404715
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0404466
VCL vinculin -0.0401669
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5 -0.0398781
EFNA5 ephrin-A5 -0.0395067
ANTXR2 anthrax toxin receptor 2 -0.0386647
BASP1 brain abundant, membrane attached signal protein 1 -0.0386224
AKAP13 A kinase (PRKA) anchor protein 13 -0.0385638
FCHSD2 FCH and double SH3 domains 2 -0.0385166
SYNE2 spectrin repeat containing, nuclear envelope 2 -0.0380432
THSD4 thrombospondin, type I, domain containing 4 -0.0376498
RSAD2 radical S-adenosyl methionine domain containing 2 -0.0368928
MAML3 mastermind-like 3 (Drosophila) -0.0366837
FOXP1 forkhead box P1 -0.0366409
KCNH8 potassium channel, voltage gated eag related subfamily H, member 8 -0.0358428
ZMYND8 zinc finger, MYND-type containing 8 -0.0357259
MRTFA myocardin related transcription factor A -0.0352769
S100A6 S100 calcium binding protein A6 -0.0352405
CDK13 cyclin-dependent kinase 13 -0.0349362
RAD51B RAD51 paralog B -0.0349215
S100A10 S100 calcium binding protein A10 -0.0339653
SOX4 SRY (sex determining region Y)-box 4 -0.0338084
GLIS3 GLIS family zinc finger 3 -0.0334872
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0330858
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme -0.0330661
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.0328914
PTPRM protein tyrosine phosphatase, receptor type, M -0.0328583
AFF1 AF4/FMR2 family, member 1 -0.0327856
TMEM87A transmembrane protein 87A -0.0320623
ZFAND6 zinc finger, AN1-type domain 6 -0.0319187
AHNAK AHNAK nucleoprotein -0.0310062
NT5C2 5'-nucleotidase, cytosolic II -0.0309719
MACC1 metastasis associated in colon cancer 1 -0.0309712
PELI1 pellino E3 ubiquitin protein ligase 1 -0.0306956
CDCP1 CUB domain containing protein 1 -0.0305339
EGFR epidermal growth factor receptor -0.0293758
MYO9A myosin IXA -0.0291364
SPAG9 sperm associated antigen 9 -0.0284438
PERP PERP, TP53 apoptosis effector -0.0283036
ERBIN erbb2 interacting protein -0.0282917
IFIH1 interferon induced with helicase C domain 1 -0.0280484
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -0.0279528
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific ) -0.0278514
CREBBP CREB binding protein -0.0278059
TPM4 tropomyosin 4 -0.0277766
S100A11 S100 calcium binding protein A11 -0.0277353
EPS8 epidermal growth factor receptor pathway substrate 8 -0.0274676
CD44 CD44 molecule (Indian blood group) -0.0274571
SLMAP sarcolemma associated protein -0.0269899
NUFIP2 nuclear fragile X mental retardation protein interacting protein 2 -0.0267364